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消炎藥 / 保健食
品交互作用
周孫鴻藥師
心臟用
精胺酸( L-Arginine)
• L-Arginine 刺激身體產生胃泌素,進而增加
胃酸,會刺激胃部
AHFS Drug Information. Bethesda, MD: American Society of
Health-System Pharmacists; 2000:2306-2307.
頭痛用
小白菊 (Feverfew)
• Feverfew 會影響 prostaglandins , 增加消
炎藥對胃的傷害
Collier HO, Butt NM, McDonald-Gibson WJ, et al. Extract of
feverfew inhibits prostaglandin
biosynthesis. Lancet. 1980;2:922-923
Sumner H, Salan U, Knight DW, et al. Inhibition of 5-
lipoxygenase and cyclo-oxygenase in leukocytes by
feverfew. Involvement of sesquiterpene lactones and other
components. Biochem Pharmacol. 1992;43:2313-2320.
Williams CA, Hoult JR, Harborne JB, et al. A biologically
active lipophilic flavonol from Tanacetum
parthenium.Phytochemistry.1995;38:267-270.
失智用
銀杏
• 抗凝血效果
Matthews MK. Association of Ginkgo biloba with intracerebral
hemorrhage. Neurology. 1998;50:1933-1934.
Gilbert GJ. Ginkgo biloba.Neurology. 1997;48:1137.
長春西汀 (Vinpocetine)
• 會抑制血小板凝集
Kiss B, Karpati E. Mechanism of action of vinpocetine [in
Hungarian; English abstract]. Acta Pharm Hung. 1996;66:213-
214.
感冒用
蒜 (Garlic)
• 會增加出血機率
European Scientific Cooperative on Phytotherapy. Allii
sativi bulbus (garlic). Exeter, UK: ESCOP; 1997.
Monographs on the Medicinal Uses of Plant Drugs,
Fascicule 3.
Burnham BE. Garlic as a possible risk for
postoperative bleeding . Plast Reconstr Surg .
1995;95:213.
German K, Kumar U, Blackford HN. Garlic and the risk
of TURP bleeding. Br J Urol. 1995;76:518.
降血脂用
甘蔗原素 (Policosanol)
• 本身有抗凝血效果 ~ 劑量越高效果越明顯
Arruzazabala ML, Valdes S, Mas R, et al.
Comparative study of policosanol, aspirin and the
combination therapy policosanol-aspirin on platelet
aggregation in healthy volunteers. Pharmacol
Res. 1997;36:293-297.
癌症用
PC-SPES
• 內含甘草、三七、靈芝、菊花、黃芩、板
藍根、冬凌草和美洲棕櫚子
• 增加出血風險
Weinrobe MC, Montgomery B. Acquired bleeding
diathesis in a patient taking PC-SPES [letter]. N
Engl J Med. 2001;345:1213-1214.
抗壓力用
靈芝
• 有抗凝血效果
Su C, Shiao M, Wang C. Potentiation of ganodermic acid S
on prostaglandin E(1)-induced cyclic AMP elevation in
human platelets.Thromb Res. 2000;99:135-145.
生理期用
當歸
• 會加乘消炎藥 piroxicam 的光敏感度 , 增加
曬傷機率
• 服用 piroxicam+ 當歸期間 , 要防曬
停經用
  紅花苜蓿( Red clover )
• 增加出血風險
憂鬱用
聖約翰草( St John's wort )
• 會加乘消炎藥 piroxicam 的光敏感度 , 增加
曬傷機率
• 服用 piroxicam+ St John's wort 期間 , 要防
曬
關節炎用
白柳樹 (White willow)
• 內含物質在體內會轉化成 salicylate, 類似
aspirin
軟骨素 (Chondroitin)
• 類似抗凝血劑 heparin 的結構 , 有些許抗凝
血效果
AbdelFattah W, Hammad T. Chondroitin sulfate and
glucosamine: A review of their safety
profile. JANA. 2001;3:16-23.
促血液循環用
原花色素多酚 (OPCs)
• OPCs = oligomeric proanthocyanidins
• 增加出血風險
  间质聚糖 ( Mesoglycan)
• 增加出血風險
  七葉樹( Horse chestnut )
• 增加出血風險
眼睛用
魚油
• 增加出血風險

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