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Noon Conference
Daniel Carson MS3
02/20/2019
© 2016 Virginia Mason Medical Center 2
Objectives
Acquired Immunodeficiency Syndrome
• Review diagnostic criteria
• Discuss clinical presentation
• Discuss diagnostic tests
• Review illness script
• Discuss treatment/prophylaxis
© 2016 Virginia Mason Medical Center
Diagnostic criteria
CDC Criteria and Classification
HIV diagnosis - Positive ab or ab/ag assay + supplemental test, or
positive HIV virology
Stage 0:
• Early infection (indeterminate or neg confirmatory test)
Stage 1:
• CD4 count > 500 cells/microl (CD4% >26)
Stage 2:
• CD4 count 200-499 cells/microl (CD4% 14-25)
Stage 3:
• CD4 count < 200 cells/microl (CD4% <14)
• Or AIDS defining illness
WHO classification uses both virologic or clinical classification
3
© 2016 Virginia Mason Medical Center
Progression
4AAFP 2010.
© 2016 Virginia Mason Medical Center
MCQ #1
Which of the following sets of three are all
considered AIDS defining illness? (CDC
criteria)
A. Oral thrush, lymphoma, recurrent bacterial
sinusitis
B. PJP Pneumonia, CMV disease, PML
C. Pulmonary histoplasmosis, MAC, Kaposi's
D. CIN, cryptosporidiosis, HSV1 ulcer
5CDC 2008
© 2016 Virginia Mason Medical Center
Clinical presentation
6
Acute HIV Infection:
• “Acute antiretroviral syndrome”
• Fever, fatigue, myalgia
• Adenopathy, sore throat, rash
• GI, neurologic
AIDS:
• Fevers, weight loss, fatigue etc..
• Related to specific opportunistic infections
© 2016 Virginia Mason Medical Center
MCQ #2
Which OIs do we worry about at a CD4 count
of <200? <100? <50?
A. PJP, MAC, Cryptococcus
B. Histoplasmosis, PJP, MAC
C. PJP, Toxoplasmosis, MAC
D. Coccidioidomycosis, PJP, CMV
7uptodate
© 2016 Virginia Mason Medical Center
Diagnostic tests
• HIV testing
• Diagnostic testing for AIDS-defining illness
• CXR/CT chest
• CT/MRI head
• Cultures
• Stool studies
• Ophthalmic exam for retinitis
• Endoscopic exam for esophagitis/candidiasis
• Biopsies for CMV inclusions
8
CD4 count is not a diagnostic test
© 2016 Virginia Mason Medical Center
Illness Scripts
9
Pneumocystis Jirovecii Pneumonia Community Acquired Pneumonia
Pathophysiology Fungal infection of LRT Bacterial/Viral infection of LRT
Epidemiology
Immunocompromised
M = F
Extremely rare in immunocompetent patients
General Population (Age >65)
M = F
2nd Most Common Cause for Hospitalization in
US
Time course Acute/subacute Acute
Clinical
presentation
Fever, non-productive cough, dyspnea,
fatigue, chills, chest pain, weight loss
Fever, cough (+- productive), dyspnea,
pleuritic chest pain, tachypnea, tachycardia
Diagnostics
Labs: CD4 count <200, elevated LDH,
elevated 1-3-beta-D-glucan, hypoxia
Specimen: (Sputum/BAL) direct visualization
with staining (gomori-methenamine silver,
cresyl violet, etc.. -> trophic and cystic forms
CXR: diffuse, bilateral, interstitial or alveolar
infiltrates
CT: Patchy or nodular ground-glass opacity
Labs: leukocytosis with left shift
CXR: Lobar consolidation, interstitial infiltrates,
cavitation
CT: As above – can be used in setting of
negative CXR
Therapeutics TMP-SMX +- corticosteroids + HAART
Commonly azithromycin, doxycycline,
amoxicillin, etc..
© 2016 Virginia Mason Medical Center
Prophylaxis
Start with HAART
• Prophylaxis is guided by current CD4 count
• CD4 <50: azithromycin, clarithromycin, rifabutin
• CD4 <100 (+IgG Serology): 1 DS TMP-SMX,
dapsone/pyrimethamine + leucovorin
• CD4 <150: In US – no recommended ppx
• CD4 <200: 1 SS TMP-SMX
10
AIDS (Stage 3 HIV) – Reversible with HAART
© 2016 Virginia Mason Medical Center
Acknowledgements
Team C!!
11

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Noon conference dc

  • 2. © 2016 Virginia Mason Medical Center 2 Objectives Acquired Immunodeficiency Syndrome • Review diagnostic criteria • Discuss clinical presentation • Discuss diagnostic tests • Review illness script • Discuss treatment/prophylaxis
  • 3. © 2016 Virginia Mason Medical Center Diagnostic criteria CDC Criteria and Classification HIV diagnosis - Positive ab or ab/ag assay + supplemental test, or positive HIV virology Stage 0: • Early infection (indeterminate or neg confirmatory test) Stage 1: • CD4 count > 500 cells/microl (CD4% >26) Stage 2: • CD4 count 200-499 cells/microl (CD4% 14-25) Stage 3: • CD4 count < 200 cells/microl (CD4% <14) • Or AIDS defining illness WHO classification uses both virologic or clinical classification 3
  • 4. © 2016 Virginia Mason Medical Center Progression 4AAFP 2010.
  • 5. © 2016 Virginia Mason Medical Center MCQ #1 Which of the following sets of three are all considered AIDS defining illness? (CDC criteria) A. Oral thrush, lymphoma, recurrent bacterial sinusitis B. PJP Pneumonia, CMV disease, PML C. Pulmonary histoplasmosis, MAC, Kaposi's D. CIN, cryptosporidiosis, HSV1 ulcer 5CDC 2008
  • 6. © 2016 Virginia Mason Medical Center Clinical presentation 6 Acute HIV Infection: • “Acute antiretroviral syndrome” • Fever, fatigue, myalgia • Adenopathy, sore throat, rash • GI, neurologic AIDS: • Fevers, weight loss, fatigue etc.. • Related to specific opportunistic infections
  • 7. © 2016 Virginia Mason Medical Center MCQ #2 Which OIs do we worry about at a CD4 count of <200? <100? <50? A. PJP, MAC, Cryptococcus B. Histoplasmosis, PJP, MAC C. PJP, Toxoplasmosis, MAC D. Coccidioidomycosis, PJP, CMV 7uptodate
  • 8. © 2016 Virginia Mason Medical Center Diagnostic tests • HIV testing • Diagnostic testing for AIDS-defining illness • CXR/CT chest • CT/MRI head • Cultures • Stool studies • Ophthalmic exam for retinitis • Endoscopic exam for esophagitis/candidiasis • Biopsies for CMV inclusions 8 CD4 count is not a diagnostic test
  • 9. © 2016 Virginia Mason Medical Center Illness Scripts 9 Pneumocystis Jirovecii Pneumonia Community Acquired Pneumonia Pathophysiology Fungal infection of LRT Bacterial/Viral infection of LRT Epidemiology Immunocompromised M = F Extremely rare in immunocompetent patients General Population (Age >65) M = F 2nd Most Common Cause for Hospitalization in US Time course Acute/subacute Acute Clinical presentation Fever, non-productive cough, dyspnea, fatigue, chills, chest pain, weight loss Fever, cough (+- productive), dyspnea, pleuritic chest pain, tachypnea, tachycardia Diagnostics Labs: CD4 count <200, elevated LDH, elevated 1-3-beta-D-glucan, hypoxia Specimen: (Sputum/BAL) direct visualization with staining (gomori-methenamine silver, cresyl violet, etc.. -> trophic and cystic forms CXR: diffuse, bilateral, interstitial or alveolar infiltrates CT: Patchy or nodular ground-glass opacity Labs: leukocytosis with left shift CXR: Lobar consolidation, interstitial infiltrates, cavitation CT: As above – can be used in setting of negative CXR Therapeutics TMP-SMX +- corticosteroids + HAART Commonly azithromycin, doxycycline, amoxicillin, etc..
  • 10. © 2016 Virginia Mason Medical Center Prophylaxis Start with HAART • Prophylaxis is guided by current CD4 count • CD4 <50: azithromycin, clarithromycin, rifabutin • CD4 <100 (+IgG Serology): 1 DS TMP-SMX, dapsone/pyrimethamine + leucovorin • CD4 <150: In US – no recommended ppx • CD4 <200: 1 SS TMP-SMX 10 AIDS (Stage 3 HIV) – Reversible with HAART
  • 11. © 2016 Virginia Mason Medical Center Acknowledgements Team C!! 11

Editor's Notes

  1. Title your presentation “Noon Conference” Prevents inadvertently giving away the case.
  2. Virologic tests: HIV NAAT (qualitative or quantitative), HIV-1 p24 antigen, HIV isolation or HIV nucleotide sequence Stage 0 : positive first test with indeterminate or negative confirmatory test within 180 days of first. Regardless of CD4 count. Above is for people greater than 6 years of age.
  3. Bacterial infections, multiple (several) or recurrent (repeated) (only for children less than 13 years old) Candidiasis (type of yeast infection) of bronchi, trachea, or lungs (respiratory system) Candidiasis, esophageal (throat) Cervical cancer, invasive (only among people 13 years old or older) Coccidioidomycosis (a type of fungal infection), disseminated (spread out) or extrapulmonary (outside the lungs) Cryptococcosis (a type of fungal infection), extrapulmonary Cryptosporidiosis (infection with a specific parasite), chronic intestinal (in the gut) (for longer than 1 month) Cytomegalovirus disease (other than liver, spleen, or nodes), beginning when older than one month Cytomegalovirus retinitis (with loss of vision) Encephalopathy (a type of brain disease), HIV-related Herpes simplex: chronic ulcers (lasting longer than 1 month); or bronchitis, pneumonitis, or esophagitis (beginning when older than one month) Histoplasmosis (a type of fungal infection), disseminated or extrapulmonary Isosporiasis (infection with a specific parasite), chronic intestinal (for longer than 1 month) Kaposi sarcoma (a type of cancer) Lymphoma (a type of cancer), Burkitt (or equivalent term) Lymphoma, immunoblastic (or equivalent term) Lymphoma, primary, of brain Mycobacterium avium complex (type of bacterial infection) or M. kansasii, disseminated or extrapulmonary Mycobacterium tuberculosis, of any site, pulmonary (in lungs) (only among people 13 years old or older), disseminated, or extrapulmonary Mycobacterium, other species or unidentified species, disseminated or extrapulmonary Pneumocystis jirovecii pneumonia (PCP) Pneumonia, recurrent (only among people 13 years old or older) Progressive multifocal leukoencephalopathy (a type of brain disease) Salmonella septicemia (a type of bacterial infection), recurrent Toxoplasmosis of brain, beginning when older than one month Wasting syndrome due to HIV
  4. Tuberculosis at any CD4 count
  5. CD4 count not diagnostic – can be low without HIV and can be high with HIV+
  6. Tissue Biopsy also possible TMP Treatments: Pentamidine, Trimethoprim + Dapsone, Clindamycin + Primaquine
  7. Immune reconstitution syndrome Azithromycin 1200mg q weekly Clarithromycin 500mg BID Rifabutin 300mg daily Rule out TB Cryptococcus – they do not recommend treatment, but screening in certain pop with preemptive tx. Histoplasmosis - itraconazole