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Why hyaluronic acid for wound
          healing?

         HA is responsible for
       scarless healing in fetus

      „Healing by regeneration“
What is hyaluronic acid (HA) ?
• Natural part of human body (tissue, eyes , joints)
  Part of extracellular matrix

• Important for Migration, Differentiation and
  Proliferation of cells (fibroblasts, keratinocytes)

• Has high affinity for water, creates moist environment




     HA HAS UNIQUE REGENERATIVE PROPERTIES
Hyiodine
COMPOSITION


    • 1,50 % HA
    • 0,10 % I2   0,25%
                  IODINE COMPLEX
    • 0,15 % KI
HYIODINE based on SYNERGY
Unique wound healing
and regeneration properties   ACTIVELY STIMULATES THE
of HYALURONIC ACID            HEALING PROCESS

&                             SUITABLE FOR HEALING
                              CHRONIC AND INFECTED
Antimicrobial properties      WOUNDS
of IODINE
How Hyiodine works ?
INDICATIONS
1) CHRONIC, STAGNATING WOUNDS MAKING NO PROGRESS
• Diabetic ulcers
• Deep wounds, fistulae, sinuses
• Infected, dehisced wounds after surgery
• Leg ulcers (venous, arterial)
• Pressure ulcers

2) ACUTE, TRAUMATIC WOUNDS
APPLICATION METHODS
• Via carrier dressing          • Directly to the wound
  for all kinds of wounds         for small wounds, fistulae,
                                  sinuses
 very effective and versatile
 application                      can be injected in wounds
COMBINATION WITH OTHER DRESSINGS

     • Parafin (oily) gauze   • Alginate
       Dry wounds.              Infected, sloughy wounds.




     • PU foam                • Inadine
       Clean, non-infected      infected wounds
       wounds only !            To reduce requency of
                                dressings.
DRESSING CHANGES

• After first application         • In infected wounds
  next change within 24 hrs         DAILY dressings needed


• In non-infected, clean wounds   • MRSA infected wounds
  dressings every 2-3 days          antibiotics NOT needed
HYIODINE SAFETY
                  In clinical use for over 5 years

                  No adverse effects or alergic
                  reactions reported

                  May be used for indefinite period
                  of time due to the very low
                  content of iodine
STIMULATES GRANULATION GROWTH




WK 0                            WK 12

56 year old male, non healing wound after amputation of the forefoot
Indicated therapy by negative pressure, which failed
PREVENTS LEG AMPUTATION




WK 1                      WK 5                      WK 12


48 year old female, deep, heavily infected diabetic ulcer, 30% blood vessel blocked,
affected tendons, leg amputation recomended
STIMULATES THE HEALING PROCESS




WK 1                       WK 2                            WK 23

Deep infected wound after aorto-coronary bypass in obese diabetic patient.
Hyiodine 2012 presentation for clinicians and nurses

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Hyiodine 2012 presentation for clinicians and nurses

  • 1.
  • 2. Why hyaluronic acid for wound healing? HA is responsible for scarless healing in fetus „Healing by regeneration“
  • 3. What is hyaluronic acid (HA) ? • Natural part of human body (tissue, eyes , joints) Part of extracellular matrix • Important for Migration, Differentiation and Proliferation of cells (fibroblasts, keratinocytes) • Has high affinity for water, creates moist environment HA HAS UNIQUE REGENERATIVE PROPERTIES
  • 4. Hyiodine COMPOSITION • 1,50 % HA • 0,10 % I2 0,25% IODINE COMPLEX • 0,15 % KI
  • 5. HYIODINE based on SYNERGY Unique wound healing and regeneration properties ACTIVELY STIMULATES THE of HYALURONIC ACID HEALING PROCESS & SUITABLE FOR HEALING CHRONIC AND INFECTED Antimicrobial properties WOUNDS of IODINE
  • 7. INDICATIONS 1) CHRONIC, STAGNATING WOUNDS MAKING NO PROGRESS • Diabetic ulcers • Deep wounds, fistulae, sinuses • Infected, dehisced wounds after surgery • Leg ulcers (venous, arterial) • Pressure ulcers 2) ACUTE, TRAUMATIC WOUNDS
  • 8. APPLICATION METHODS • Via carrier dressing • Directly to the wound for all kinds of wounds for small wounds, fistulae, sinuses very effective and versatile application can be injected in wounds
  • 9. COMBINATION WITH OTHER DRESSINGS • Parafin (oily) gauze • Alginate Dry wounds. Infected, sloughy wounds. • PU foam • Inadine Clean, non-infected infected wounds wounds only ! To reduce requency of dressings.
  • 10. DRESSING CHANGES • After first application • In infected wounds next change within 24 hrs DAILY dressings needed • In non-infected, clean wounds • MRSA infected wounds dressings every 2-3 days antibiotics NOT needed
  • 11. HYIODINE SAFETY In clinical use for over 5 years No adverse effects or alergic reactions reported May be used for indefinite period of time due to the very low content of iodine
  • 12. STIMULATES GRANULATION GROWTH WK 0 WK 12 56 year old male, non healing wound after amputation of the forefoot Indicated therapy by negative pressure, which failed
  • 13. PREVENTS LEG AMPUTATION WK 1 WK 5 WK 12 48 year old female, deep, heavily infected diabetic ulcer, 30% blood vessel blocked, affected tendons, leg amputation recomended
  • 14. STIMULATES THE HEALING PROCESS WK 1 WK 2 WK 23 Deep infected wound after aorto-coronary bypass in obese diabetic patient.

Editor's Notes

  1. A: limited use of HA due to its sensitivity to bacteria enzymes, HA can be easily degradated high price of HA as a raw material for production (Contipro is HA manufacturer what eliminates this disadvantage)
  2. The first group of indication is the best target for Hyiodine, in red colour the best target from marketing point of view The second group of indications is also good, but with lower rate of efficacy,