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Tramadol
Presentation by
Primary Information Services
www.primaryinfo.com
mailto:primaryinfo@gmail.com
Tramadol
Tramadol is in a class of medications
called opiate (narcotic) analgesics
Tramadol is used worldwide and is
listed in many medical guidelines for
pain treatment. It is mentioned as a
step-2 analgesic in the WHO
guidelines for cancer pain relief.
Tramadol is also listed on several
national essential medicines lists. It
is, however, not listed on the WHO
Model List of Essential Medicines
(April 2013).
Tramadol
INDIA IS A SIGNIFICANT SOURCE OF
TRAFFICKED, FALSIFIED, SUB-
STANDARD OR ILLICITLY
MANUFACTURED PRODUCTS BRANDED
AND MARKETED AS ‘TRAMADOL,’ THAT
ARE SEIZED WORLDWIDE.
Tramadol
Tramadol is widely
available via the
Internet without a
prescription.
Websites provide
many
user reports on the
non-medicinal use of
tramadol
Synthesis
Tramadol was first synthesized in
1962 by Grünenthal GmbH in
Germany by coupling of the
corresponding cyclohexanon
with 3-methoxyphenylmagnesium
bromide in a Grignard
reaction.20;21 More recently, the
chemical synthesis oftramadol
and two of its metabolites has
been described by the same
couplingreaction using
organolithium derivatives.
Abuse….Dependence
Alternative
Is there another alternative to
tramadol? Just recently an
alternative to tramadol became
available. This new drug is
called Nucynta. Like tramadol,
Nucynta has the both the opioid
binding ability and the
serotonin/norepinephrine
reuptake inhibiting effect. With
fewer side effects than tramadol,
Nucynta is a great drug in the pain
relief arsenal.
Tramadol
Products in the Market TOP Manufacturers
Par Pharmaceutical
Amneal Pharmaceuticals
Mundipharma
Rompharm Company
Labopharm
Pliva Pharma
CSPC
Grnenthal GmbH
Kosher Pharmaceuticals
Xinhua Pharmaceutical
Tianlong Shiye
Atoz Pharmaceuticals
Hexal AG
Southwest Pharmaceutical
Nippon Shinyaku
Questions?
Primary Information Services
www.primaryinfo.com
mailto:primaryinfo@gmail.com

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Tramadol - data base

  • 1. Tramadol Presentation by Primary Information Services www.primaryinfo.com mailto:primaryinfo@gmail.com
  • 2.
  • 3. Tramadol Tramadol is in a class of medications called opiate (narcotic) analgesics Tramadol is used worldwide and is listed in many medical guidelines for pain treatment. It is mentioned as a step-2 analgesic in the WHO guidelines for cancer pain relief. Tramadol is also listed on several national essential medicines lists. It is, however, not listed on the WHO Model List of Essential Medicines (April 2013).
  • 4. Tramadol INDIA IS A SIGNIFICANT SOURCE OF TRAFFICKED, FALSIFIED, SUB- STANDARD OR ILLICITLY MANUFACTURED PRODUCTS BRANDED AND MARKETED AS ‘TRAMADOL,’ THAT ARE SEIZED WORLDWIDE.
  • 5. Tramadol Tramadol is widely available via the Internet without a prescription. Websites provide many user reports on the non-medicinal use of tramadol
  • 6. Synthesis Tramadol was first synthesized in 1962 by Grünenthal GmbH in Germany by coupling of the corresponding cyclohexanon with 3-methoxyphenylmagnesium bromide in a Grignard reaction.20;21 More recently, the chemical synthesis oftramadol and two of its metabolites has been described by the same couplingreaction using organolithium derivatives.
  • 8. Alternative Is there another alternative to tramadol? Just recently an alternative to tramadol became available. This new drug is called Nucynta. Like tramadol, Nucynta has the both the opioid binding ability and the serotonin/norepinephrine reuptake inhibiting effect. With fewer side effects than tramadol, Nucynta is a great drug in the pain relief arsenal.
  • 9. Tramadol Products in the Market TOP Manufacturers Par Pharmaceutical Amneal Pharmaceuticals Mundipharma Rompharm Company Labopharm Pliva Pharma CSPC Grnenthal GmbH Kosher Pharmaceuticals Xinhua Pharmaceutical Tianlong Shiye Atoz Pharmaceuticals Hexal AG Southwest Pharmaceutical Nippon Shinyaku