3. Tramadol
Tramadol is in a class of medications
called opiate (narcotic) analgesics
Tramadol is used worldwide and is
listed in many medical guidelines for
pain treatment. It is mentioned as a
step-2 analgesic in the WHO
guidelines for cancer pain relief.
Tramadol is also listed on several
national essential medicines lists. It
is, however, not listed on the WHO
Model List of Essential Medicines
(April 2013).
4. Tramadol
INDIA IS A SIGNIFICANT SOURCE OF
TRAFFICKED, FALSIFIED, SUB-
STANDARD OR ILLICITLY
MANUFACTURED PRODUCTS BRANDED
AND MARKETED AS ‘TRAMADOL,’ THAT
ARE SEIZED WORLDWIDE.
5. Tramadol
Tramadol is widely
available via the
Internet without a
prescription.
Websites provide
many
user reports on the
non-medicinal use of
tramadol
6. Synthesis
Tramadol was first synthesized in
1962 by Grünenthal GmbH in
Germany by coupling of the
corresponding cyclohexanon
with 3-methoxyphenylmagnesium
bromide in a Grignard
reaction.20;21 More recently, the
chemical synthesis oftramadol
and two of its metabolites has
been described by the same
couplingreaction using
organolithium derivatives.
8. Alternative
Is there another alternative to
tramadol? Just recently an
alternative to tramadol became
available. This new drug is
called Nucynta. Like tramadol,
Nucynta has the both the opioid
binding ability and the
serotonin/norepinephrine
reuptake inhibiting effect. With
fewer side effects than tramadol,
Nucynta is a great drug in the pain
relief arsenal.
9. Tramadol
Products in the Market TOP Manufacturers
Par Pharmaceutical
Amneal Pharmaceuticals
Mundipharma
Rompharm Company
Labopharm
Pliva Pharma
CSPC
Grnenthal GmbH
Kosher Pharmaceuticals
Xinhua Pharmaceutical
Tianlong Shiye
Atoz Pharmaceuticals
Hexal AG
Southwest Pharmaceutical
Nippon Shinyaku