The document discusses poly(glycerol sebacate) (PGS), a tough biodegradable elastomer formed from the polycondensation of glycerol and sebacic acid. PGS exhibits mechanical properties similar to soft tissue and has superior biocompatibility and structural integrity compared to PLGA. PGS has been incorporated into scaffolds for vascular tissue engineering and is being developed as biodegradable stents for the heart.

1. M.SundaraRajan
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2. There is considerable need and interest to
develop tough biodegradable elastomers,
which exhibit mechanical properties similar
to that of soft tissue

3. Poly (glycerol–sebacate) (PGS) is an
elastomeric biodegradable polymer

4. PGS is said to be have a superior biocompatibility
in vitro and in vivo when compared to PLGA, as
well as demonstrated a surface degradation profile
with subsequent superior structural integrity and
form stability

5. A tough biodegradable elastomer, based on the
polycondensation reaction of glycerol and sebacic
acid into a gelled, cross linked network, designated
poly(glycerol sebacate) (PGS)

6. PGS was incorporated into a scaffold for vascular
tissue
engineering and its hemocompatibility in vitro
relative to ePTFE, PLGA, TCP, and glass was
evaluated

7. PGS Stents for the Heart are being
developed

8.  Background Information
 Product Information
 Applications
 Technology Sources
 Research Scholars
 Patents
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