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3. Process flow diagram
Process Description:
Stage-I: m-Chloropropiophenone is
reaced with Tert-butylamine,
hydrogenchloride and
bromine in presence of sodium
bisulphate in methylene chloride to
yield Bupropion
Hydrochloride (Crude).
Stage-II: Bupropion Hydrochloride
(Crude) is purified in presence of
Methanol and
acetone to give Bupropion
Hydrochloride (Pharma). Schematic
diagram of Bupropion
8. Bupropion Hydrochloride tablets USP
have an estimated market size of
$37 million.
Bupropion hydrochloride is
marketed under the following
names:
• Wellbutrin
• Wellbutrin SR
• Wellbutrin XL
• Zyban
• bupropion hydrochloride