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Ppt chapter 59
- 1. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Antiemetic Agents
Chapter 59
- 2. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Nausea and Vomiting
• Most common and most uncomfortable complaints.
• Vomiting is a complex reflex reaction to various stimuli.
• In some cases, it may be desired to induce vomiting.
• In many clinical conditions, the reflex reaction of
vomiting is not beneficial.
- 3. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Managing Nausea and Vomiting
• Emetics
– Cause vomiting
– No longer recommended for at-home poison control
• Antiemetics
– Decrease or prevent nausea and vomiting
– Centrally acting or locally acting
– Varying degrees of effectiveness
- 4. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Sites of Action of Emetics/Antiemetics
- 5. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Groups of Centrally Acting Antiemetics
• Phenothiazines
• Nonphenothiazines
• Anticholinergics/Antihistamines
• Serotonin (5-HT3
) Receptor Blockers
• Substance P/Neurokinin 1 Receptor Antagonists
• Miscellaneous Group
- 6. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Phenothiazines
• Actions
– Depresses various areas of the central nervous
system (CNS)
• Indications
– Treatment of nausea and vomiting
• Adverse Effects
– Drowsiness
- 7. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Nonphenothiazines
• Actions
– Acts to reduce the responsiveness of the nerve cells
in the CTZ to circulating chemicals that induce
vomiting
• Indications
– Prevention of nausea and vomiting
• Adverse Effects
– Drowsiness
– Fatigue
– Restlessness
– Extrapyramidal symptoms
- 8. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Anticholinergics/Antihistamines
• Actions
– Anticholinergics that act as antihistamines and block the
transmission of impulses to the CTZ
• Indications
– Prevention and treatment of nausea and vomiting
• Adverse Effects
– Drowsiness
– Confusion
– Dry mouth
– Anorexia
– Urinary frequency
- 9. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Serotonin (5-HT3
) Receptor Blockers
• Actions
– Block those receptors associated with nausea and
vomiting in the CTZ and locally
• Indications
– Control of nausea and vomiting
• Pharmacokinetics
– Rapidly absorbed, metabolized in the liver, and
excreted in urine and feces
• Caution
– Pregnancy and lactation
- 10. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Serotonin (5-HT3
) Receptor Blockers
(cont.)
• Adverse Effects
– Headache, drowsiness, myalgia, urinary retention,
constipation, pain at the injection site
- 11. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Question
Please answer the following statement as true or false.
Emetic medications are used to induce vomiting and should
be kept in the home in case of an accidental poisoning.
- 12. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Answer
False
Rationale: Emetics cause vomiting and are no longer
recommended for at-home poison control.
- 13. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Substance P/Neurokinin 1 Receptor
Antagonists
• Actions
– Act directly in the CNS to block receptors associated
with nausea and vomiting
• Indications
– In combination with other agents to prevent nausea
and vomiting
• Pharmacokinetics
– Given orally, metabolized in the liver, and excreted in
urine and feces
- 14. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Substance P/Neurokinin 1 Receptor
Antagonists (cont.)
• Adverse Effects
– Anorexia, fatigue, constipation, diarrhea, liver
enzyme elevation, dehydration
- 15. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Miscellaneous Antiemetics
• Actions
– Varies with agent
• Indications
– Treatment and prevention of nausea and vomiting
• Pharmacokinetics
– Varies according to agent
- 16. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Miscellaneous Agents (cont.)
• Contraindications
– Coma
– Severe CNS depression
– Brain damage or injury
– Hypotension or hypertension
– Severe liver dysfunction
- 17. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Miscellaneous Antiemetics (cont.)
• Caution
– Renal dysfunction
– Active peptic ulcer disease
– Pregnancy
– Lactation
• Adverse Effects
– Linked to interference with normal CNS stimulation or
response
• Drowsiness
• Dizziness
• Weakness
- 18. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Miscellaneous Antiemetics (cont.)
• Adverse Effects (cont.)
– Photosensitivity
– Hypotension, hypertension, and cardiac arrhythmias
• Drug-to-Drug Interactions
– Alcohol
- 19. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Use of Drugs Affecting the Female
Reproductive System Antiemetic Agents
Across the Lifespan
- 20. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Prototype Phenothiazines
- 21. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Prototype Nonphenothiazines
- 22. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Prototype Anticholinergics/
Antihistamines
- 23. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Prototype Serotonin (5-HT3
) Receptor
Blockers
- 24. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Prototype Substance P/Neurokinin 1
Receptor Antagonists
- 25. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Nursing Considerations for Antiemetics
• Assessment: History and Physical Exam
• Nursing Diagnosis
• Implementation
• Evaluation
- 26. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Question
What is an anticholinergic antiemetic recommended for
vestibular (inner ear) problems?
A. Granisetron
B. Meclizine
C. Palonosetron
D. Perphenazine
- 27. Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Answer
B. Meclizine
Rationale: These drugs—buclizine, cyclizine and meclizine -
are anticholinergics that act as antihistamines and block
the transmission of impulses to the CTZ. They are
recommended for the nausea and vomiting associated
with motion sickness or vestibular (inner ear) problems.