This document describes research into synthesizing a novel phospholipid layer/mesoporous carbon nanoparticles (MCNs) structure for efficient drug loading and delivery. MCNs were synthesized and coated with a phospholipid layer to control drug loading and release. Doxorubicin was loaded as a model drug and showed higher loading without the phospholipid coating, demonstrating the coating's role in controlling drug behavior. The MCN/phospholipid core/shell structure has potential as a next-generation drug nanocarrier for bio-medical applications.
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The last decade have witnessed an increasing interest in biobased organic-inorganic hybrid materials, where properties of each component are
combined giving remarkable characteristics. However, some of the basic parameters which dominate the formation of such materials are still unclear. In this
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New Technique for Measuring and Controlling the Permeability of Polymeric Mem...Editor IJCATR
Membranes have wide uses in industry and medicine applications. Polymer membranes are important materials because of their high chemical resistance, but they are of weak mechanical resistance against high pressures. Therefore, it was essential to modify a permeability measuring technique free from high pressure application. The current work represented a modification for the permeability measuring technique of membranes, where ionic salt was added with known concentration to water as common solvent and the electrolyte current was measured behind the membrane. The electrolysis current was correlated to the flow rate of water across a polyvinyl alcohol (PVA) membrane. Some other problems were raised such that polarization on electrodes and changes in electrolyte contents during the long time of the slow process. Pulsed potential on electrodes resolved these problems and other associated problems like rush in current and the double layer capacitance effect. An empirical equation was suggested to evaluate the permeability of polymer membranes by this modified method. Easy and accurate measurement of permeability helped authors to change the permeability of PVA membranes by adding copper nano particles in membrane to reduce its permeability, and adding silicone dioxide micro particles to the PVA membranes to increase its permeability. Authors suggested a mechanism for these permeability changes. Scanning electron microscope images for the filled PVA membranes supported the suggested mechanism.
Microscopic Characterization of Nanofibrillated Cellulose - Inorganic Nanopar...Jokin Hidalgo
The last decade have witnessed an increasing interest in biobased organic-inorganic hybrid materials, where properties of each component are
combined giving remarkable characteristics. However, some of the basic parameters which dominate the formation of such materials are still unclear. In this
work, we develop and characterize new organic-inorganic hybrids made of micro/nano fibrillated cellulose (MFC/NFC) and inorganic nanoparticles (NP),
trying to better understand the fundamentals operating behind the assembling of the different constituents.
New Technique for Measuring and Controlling the Permeability of Polymeric Mem...Editor IJCATR
Membranes have wide uses in industry and medicine applications. Polymer membranes are important materials because of their high chemical resistance, but they are of weak mechanical resistance against high pressures. Therefore, it was essential to modify a permeability measuring technique free from high pressure application. The current work represented a modification for the permeability measuring technique of membranes, where ionic salt was added with known concentration to water as common solvent and the electrolyte current was measured behind the membrane. The electrolysis current was correlated to the flow rate of water across a polyvinyl alcohol (PVA) membrane. Some other problems were raised such that polarization on electrodes and changes in electrolyte contents during the long time of the slow process. Pulsed potential on electrodes resolved these problems and other associated problems like rush in current and the double layer capacitance effect. An empirical equation was suggested to evaluate the permeability of polymer membranes by this modified method. Easy and accurate measurement of permeability helped authors to change the permeability of PVA membranes by adding copper nano particles in membrane to reduce its permeability, and adding silicone dioxide micro particles to the PVA membranes to increase its permeability. Authors suggested a mechanism for these permeability changes. Scanning electron microscope images for the filled PVA membranes supported the suggested mechanism.
Peter Budd (University of Manchester) - Organic Mixed Matrix Membrane Technologies (ORGMENT) for Post-Combustion CO2 Capture - UKCCSRC Cranfield Biannual 21-22 April 2015
Nanoparticles are solid colloidal particles ranging in size from 10 to 1000 nm.
Nanoparticles are made of a macromolecular material which can be of synthetic or natural origin.
Peter Budd (University of Manchester) - Organic Mixed Matrix Membrane Technologies (ORGMENT) for Post-Combustion CO2 Capture - UKCCSRC Cranfield Biannual 21-22 April 2015
Nanoparticles are solid colloidal particles ranging in size from 10 to 1000 nm.
Nanoparticles are made of a macromolecular material which can be of synthetic or natural origin.
Nano porous membranes for water purification by shrinath ghadgeShrinath Ghadge
Continuous population growth and urbanization as well as rapid industrialization, causing huge contamination of potable water or underground water, has been a serious concern all over the world. Due to incompetency of conventional water purification technologies to deliver complete pollutants free water at an economical price, a high performance, cost-effective and environmentally acceptable separation system is an urgent need which should not only remove macro-, micro- and nano-pollutants but also desalinate water to a significant extent. In this milieu, nanotechnology based carbon nanotube (CNT) membranes have shown impressive breakthroughs towards water purification as compared to existing energy intensive water purification systems and thus, this technology has immense potential for large scale commercial water purification in a cost effective manner.
SYNTHESIS OF NICKEL NANOPARTICLES AND APPLICATION IN MALACHITE GREEN DYE COLO...
YUAN-YUN LIN_ISOMRM
1. Yuan-Yun Lin , Ling Chao*, Kevin C.-W. Wu*
Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan
Discussions
Objective
Acknowledgements
Characterization
SEM of MCNs
E-mail :lingchao@ntu.edu.tw and kevinwu@ntu.edu.tw
Synthesis of A Novel Phospholipid Layer/Mesoporous Carbon Nanoparticles (MCNs)
Core/Shell Structure as An Anticancer Drug Nanovehicle
for Efficient Drug Loading
Synthesis of a Novel Phospholipid Layer/MCNs
Experimental
Doxorubicin
Hydrophobic Drug Loading
Lipid coating
MCNs
Vial DOPC@CCl4
Remove organic solvent
under N2
Mix well
Add solution
Drug Loading Testing
centrifugation
Optical MicroscopeFluorescence Photometer
Analysis
TEM of MCNs
50 nm
BET of MCNs
Relative Pressure (p/p0)
VolumeAbsorbed(cm3g-1)
Pore Diameter (nm)VP
0
50
100
150
200
250
300
350
0 0.2 0.4 0.6 0.8 1 1.2
0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
0.4
0.45
0.5
0 50 100 150 200
Drug Loading
0
20
40
60
80
100
Loading(%)
Results
Because of their high surface area and the hydrophobicity,
mesoporous carbon nanoparticles (MCN) were successfully
synthesized and utilized as a potential drug nanocarrier. In
addition, a phospholipid layer was applied as a gate-keeper to
control the load/release behavior of drugs. The MCN/
phospholipid core/shell structure here provides a new
alternative for next-generation bio-medical applications.
The research was supported by the National Taiwan University.
Synthesis of a Novel Phospholipid Layer/Mesoporous Carbon Nanoparticles for Intracellular Drug Delivery.
MCNs
Drug loading Lipids mixing
!
Cell Culture
(a)
(b)
drug
100 nm
5 µm
MCN+doxo.:
16.23 µmole/ doxo./g MCN
MCN+doxo.+lipid:
8.76 µmole/ doxo./g MCN
MCN+doxo. MCN+doxo.+lipid
Texas Red @DHPE
MCN
fluorescence