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NIH Institutional Training Programs:
Preparing a Successful T32 Application
Alison K. Hall, Ph.D.
Deputy Director
Division of Training, Workforce Development and Diversity
National Institute of General Medical Sciences
National Institutes of Health
June 28, 2013
PhD Training Continues to Evolve
2 NIH Regional Seminar June 28, 2013
NIH has supported research training since 1930s
fellowships thru the 1950s
National Research Service Award 1975
(i.e. T32, F30/31, F32; MARC)
Ruth L. Kirschstein
-funding to scientists, not health professionals
-to enhance research training
-in scientific areas with need for researchers
-good curricula, facilities, program in addā€™n to research
-dedication to developing talent
3
PhD support is largely on research grants
Consider differences in apprenticeship vs a program
Source: Graduate Student Survey, NSF
4
Training In light of Multiple Career Outcomes
Employment of Biomedical Science PhDs by Sector
-
20,000
40,000
60,000
80,000
100,000
120,000
140,000
1973 1977 1981 1985 1989 1991 1993 1993
NEW
1995 1997 1999 2001 2003 2006 2008
Number
Other Government
Industrial All Academic
Source: http://sestat.nsf.gov/
5
Training in light of limited diversity in workforce
Source: US Census; NSF, 2007
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Temp. Res.
non-URM
URM
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
2008 2050
US Population Biomedical Workforce
6
http://acd.od.nih.gov/Biomedical_research_wgreport.pdf
ļ‚§Total of ~150,000 Biomedical US-trained PhDā€™s
Postdoctoral
Training
2009 Total: 37,000 to
68,000
Median Length: 4 years
International
Post-Training Workforce
College Graduates
8% of
graduates
leave the US
Of graduates who stay in the US
skip a postdoc
do a postdoc
1,900 to 3,900
in 2009
4,000 in 2009
Graduate Education
& Training
2009 Total: 83,000
Time to Degree :5.5-7yrs
2009 Graduates: 9,000
16,000 in 2009
5,800 in 2009
18%
Biomedical
US- trained
PhD 2008
~22,500
Industrial
Research
43%
(23% tenured)
Biomedical
US- trained
PhD
2008
~55,000
Academic
Research
or Teaching
6%
Biomedical
US- trained
PhD 2008
~7,000
Governmen
t Research
18%
Biomedical
US- trained
PhD 2008
~24,000
Science
Related
Non-
Research
13%
Biomedical
US- trained
PhD 2008
~17,000
Non-
Science
Related
2%
Biomedical
US- trained
PhD 2008
~2,500
Unemployed
(128,000 Biomedical US-trained PhDs)
NOTE: The color of
the numbers
reflects the
confidence in the
accuracy of the
data.
Snapshot of the PhD Biomedical Workforce
7
Institutional Training Programs
ā€¢ Enhance research training through a coordinated
programmatic approach
ā€¢ Involve many faculty, multiple departments
ā€¢ Trainees are selected by the institution
ā€¢ Parent Announcement Update
T32 FOA updates expected July
ļƒ appl due January 2014
8
Strategies to Develop a Strong Proposal
1. Start Early
2. Consider why a TG is important for your
program
3. Be very sure there is a PROGRAM
4. Complete tables before finalizing narrative
5. Review the review criteria
6. Explain, explain, explain. Remember reviewers
are expert faculty familiar with training
9
Institutional Training Review Criteria
~750 Electronic TG Submissions (May; Sept, Jan)
Center for Scientific Review to Institute/Center
Study Sectionā€”Initial Review Group
3-4 reviewers
Established scientists, many with training experience
Program merit
Scored Review Criteria:
1. Training Program and Environment
2. Training Program Director/Principal Investigator
3. Preceptors/Mentors
4. Trainees
5. Training Record Overall Impact Score: 1-9
Institute or Center Council
Program relevance, guidance to program staff
10
Hallmarks of Good Training Programs
Student development for biomedical team
experience, contributions, growth, project
Contemporary, mentored research education
broad and deep academic curriculum
research skills and knowledge
conceptual judgment, right questions
communication skills
Career development for multiple outcomes
as a scientist (fellowships, mtgs, papers)
teaching activity? Leadership? Mgmt?
externships? Policy? Workshops?
Responsible Conduct
11
Training Programs are Developmental, not Selection
Potential Trainees
How select for TG and why
Matriculant
UG major
Research Interest
Courses taken
Lab affiliation
PhD Program
Pilot research
Program Activities
Planned interventions
Milestone/ Outcomes
Intended changes
Mentored Research
PI, advisory comm
research design
new techniques
Planned Curriculum
knowledge
teaching
Skill building
oral communication
writing workshops
new collaborations
Contemporary science
meet new scientists
Career Exposure
know next steps
Short term
Research publications
Poster, meeting
Fellowship
Longer term
Next position
Biomedical career
Research grants
Mentoring others
12
Active Program Beyond Research in PI lab
ā€œvalue addedā€
PROGRAM IS MORE THAN WORK IN A LAB
Active nomination, selection of candidates from pool
Planned academics with flexibility
Seminars, enhancement activities
Longitudinal program beyond funding
Faculty trainer responsibilities make program strong
Intentional activities to achieve outcomes
13
1. Training Program and Environment
ā€¢ Are the research facilities and training environment
conducive to prepare trainees for successful careers as
biomedical scientists?
ā€¢ Do the objectives, design and direction of the proposed
research program ensure effective training?
ā€¢ Is the proposed program of training likely to ensure that
trainees will be prepared for successful and productive
scientific careers?
ā€¢ Do the courses, where relevant, and research training
experiences address state-of-the-art science relevant to the
aims of the program?
ā€¢ Does the program provide training in inter- or
multidisciplinary research and/or provide training in state-of-
the-art or novel methodologies and techniques?
ā€¢ Is a significant level of institutional commitment to the
program evident?
14
2. Training Program Director/Principal Investigator
Does the Training PD/PI have the scientific background, expertise, and
experience to provide strong leadership, direction, management, and
administration to the program?
His/her trainees, outcomes
Does the PD/PI plan to commit sufficient time to the program to ensure
its success?
Is sufficient administrative and research training support provided for
the program?
Is a strong justification provided that the multiple PD/PI leadership
approach will benefit the training program and the trainees?
roles and responsibilities, governance, and organizational structure
consistent with and justified by training program and with the
complementary expertise of PD/PIs?
15
3. Preceptors/Mentors
Are sufficient numbers of experienced preceptors/mentors with
appropriate expertise and funding available to support the
number and level of trainees proposed in the application?
3-4x faculty available to student, not all one labā€¦
Do the preceptors/mentors have strong records as researchers,
including successful competition for research support in areas
directly related to the proposed research training program?
How diverse are faculty?
Do the preceptors/mentors have strong records of training pre-
and/or postdoctorates?
16
4. Trainees
Is a recruitment plan proposed with strategies to attract
high quality, diverse, trainees?
Are there well-defined and justified selection criteria and
retention strategies?
Nomination, re-appointment criteria, process
Is there evidence of a competitive applicant pool in
sufficient numbers to warrant the proposed size and
levels?
TG is catalytic, supports a third(?) of relevant TGE
students
17
4. Trainees (cont)
For renewal applications, how successful has program been in
attracting and retaining individuals from diverse populations,
including populations underrepresented in science?
Report Trainees
Training Grant Eligible
Students from groups underrepresented in biomedical science
Students with disabilities, defined as physical or mental
impairment that substantially limits one or more major life
activities.
18
Once in program, students change minds
ā€¦and make choices about careers
Graduate students in basic biomedical sciences
ā€¢ Many initially have goal of academic research
ā€¢ Midway thru PhD are considering multiple careers
What does the change in attitude mean?
didnā€™t know possibilities when began grad school
perhaps worried about academic path
learned more about whatā€™s enjoyable
identified next steps for careers
Fuhrmann et al 2011 CBE Life Sci Educn 10: 239-249
19
How Assess Skills and Interests?
Individual Development Plan
To be used in training, fellowships, RPGsā€¦
20
The IDP involves
The scholar The mentor
self assessment familiarity with opportunities
Survey opportunities discuss opportunities
Write IDP review IDP, help revise
Implement plan assess new tasks, progress
in light of the plan
1.Skills assessment-strengths and weaknesses
2.Career match- do goals match skills and interest
3.Do it again next year
21
5. Training Record
How successful are the trainees in completing the program?
How productive are trainees in terms of research accomplishments
and publications?
How successful are trainees in obtaining further training
appointments, fellowships, and/or career development awards?
How successful are the trainees in achieving productive scientific
careers, as evidenced by successful competition for research
grants, receipt of honors or awards, high-impact publications,
receipt of patents, promotion to scientific leadership positions,
and/or other such measures of success?
22
5. Training Record
For programs that provide research training to health-
professional doctorates, is there a record of retaining health
professionals in research training or other research activities for
at least two years?
Does the program have a rigorous evaluation plan to assess the
quality and effectiveness of the training?
Annually assess outcomes?
Adapt to changes?
Test intervention hypothesis?
Are effective mechanisms in place for obtaining feedback from
current and former trainees and monitoring traineesā€™
subsequent career development?
23
Institutional Training
Additional Review Criteria & Considerations
Additional Review Criteria
Protection for Human Subjects
Inclusion of Women, Minorities, and Children
Vertebrate Animals
Biohazards
Resubmission, Renewal, Revision factors
Additional Review Considerations:
Diversity Recruitment Plan
Training in Responsible Conduct of Research
Select Agent Research
Budget and Period of Support
24
Table 1. Participating Departments
24
Table 1. Membership of Participating Departments/Programs
(Alphabetically)
Participating
Department /
Program
Faculty
Members in
Department /
Program
Faculty
Members
Participating
in This
Application
Predoctoral
Trainees in
Department /
Program
(Supported
by Any NIH
Training
Grant)
Predoctoral
Trainees With
Participating
Faculty
(TGE)
A/B/C
For Renewal
Applications,
Predoctoral
Trainees
Supported by
This Training
Grant
(TGE)
A/B/C
Postdoctoral
Trainees in
Department /
Program
(Supported
by Any NIH
Training
Grant)
Postdoctoral
Trainees
With
Participating
Faculty
(TGE)
A/B/C
For Renewal
Applications,
Postdoctoral
Trainees
Supported by
This Training
Grant
(TGE)
A/B/C
Dept. of Biology 45 14 38 (15) 12 (6)
1/1/0
2 (2)
1/0/0
50 (5) 15 (7)
1/0/0
2 (2)
0/0/0
Neuroscience
Program
32 20 31 (20) 14 (7)
2/0/1
4 (4)
0/1/0
40 (7) 23 (10)
0/0/1
2(2)
1/0/0
Dept. of
Pharmacology
(Medical School)
25 5 30 (10) 5 (3)
1/0/0
3 (3)
0/0/0
28 (0) 12 (6)
0/0/1
0 (0)
0/0/0
Totals N/A N/A 99 (45)
31 (16)
4/1/1
9 (9)
1/1/0 108 (12) 50 (23)
4 (4)
1/0/0
Table 1 Instructions: Provide the total number of current faculty members, predoctoral trainees, and postdoctoral trainees in each
participating department/program. Indicate the number of faculty members participating in this training grant application, the numbers of
predoctoral and postdoctoral trainees with the participating faculty, and in parenthesis put the number of these trainees who are training
grant eligible (TGE). For renewal applications, include the number of trainees currently supported by the training grant. Faculty members
may count as part of both their primary department and an interdepartmental program(s). Predoctoral and postdoctoral trainees count only
once and should be associated with a single department or program. underrepresented minorities (Group A), who are individuals with
disabilities (Group B), or who are individuals from disadvantaged backgrounds (Group C).
Rationale: This table provides insight into the environment in which training will take place. It allows reviewers to assess whether the
program has the "critical mass" (trainees, faculty and other research personnel, and representation/distribution of scientific disciplines) to
be successful.
(Finish this table lastā€¦complicated)
25
Table 2. Participating Faculty Members
Table 2. Participating Faculty Members
(Alphabetically by Faculty Member)
Name/Degree(s) Rank Primary (& Secondary) Appointment(s) Role in Program Research Interest
Abrams-Johnson, Jane, PhD Asst. Prof. Pharmacology;
(Biochemistry-Medical School)
Mentor Regulation of Synthesis of
Biogenic Amines
Jones, Lisa S., MD Res. Asst.
Prof.
Microbiology and Immunology
(Neuroscience Program)
Mentor
Exec Com
Protein Structure, Folding,
and Immunogenicity
Sandoz, J. Miguel, MD, PhD Assoc. Prof. Neuroscience Program Mentor Developmental Genetics in
Drosophila
Thomas, C. James, III, PhD Prof. & Chr. Biochemistry and Molecular Biophysics Program Director Molecular and Genetic
Analysis of RNA Viruses
Table 2 Instructions: List each training faculty member with his/her degree(s), academic rank, primary departmental affiliation and
secondary appointments, role in the proposed training grant program, and research interests that are relevant to this program.
Rationale: This information allows reviewers to assess the distribution of junior versus senior faculty and clinical versus basic scientists
participating in the training program, as well as their distribution by department. The data concisely summarize the scientific areas of the
training faculty.
(Easy, easy to modify as program shapes up. Start here)
26
Table 3. Existing Institutional Training Grants
Table 3. Institutional Training Grant Support Available to Participating Faculty Members, Department(s), or Program(s)
Title of Training Grant
Funding Source
Including
Identifying
Number
Active or
Pending
Project
Period
Program
Director
(Department)
Predoctoral
Trainees
Supported
This Year
Postdoctoral
Trainees
Supported
This Year
Short-
Term
Trainees
Supported
This Year
Total No. of
Participating
Faculty
Names of
Overlapping
Faculty
Bioimmunotherapy
Training Grant
T32 CA05964-11 06/02-07/07 Baker, A.
(Pathology)
12 25 Abelson
Brown
Fields
Johnson
Sung
Watson
Pharmacological
Sciences
T32 GM04823-01 Pending James, C.
(Pharmacology)
10 19 Jones
Jenson
Watson
Genetic Basis of Mental
Illness
T32 MH02708-07 06/03-07/08 Johnson, A.
(Psychiatry)
4 4 7 Johnson
Watson
Totals N/A N/A N/A 26 4 0 51 N/A
Table 3 Instructions: List all current and pending training support available to the participating faculty members, department(s) or
programs(s). For each grant, include the title of the training grant; funding source and complete identifying number; status (active or
pending) and dates of the entire project period; name of the program director and department; number(s) of training positions (predoctoral,
postdoctoral, and short term), number of participating faculty members; and list overlapping participating faculty members, who are also
named in this application.
Rationale: This table will permit an evaluation of the level of support for training available to each of the participating
departments/programs and the extent to which the proposed training grant overlaps with or duplicates available training grant support. It is
useful in determining the number of training positions to be awarded.
Explain overlapping faculty!
27
Table 4. Grant Support of Faculty
Table 4. Grant and Contract Support of the Participating Faculty Members
(Alphabetically by Faculty Member)
Faculty
Member
Source of Support, Grant
Number and Status Faculty Member Role on Project and Grant Title
Project Period
Active
Current Year Direct
Costs Awarded
(Total Direct Costs for
Awards With Substantial
Future Changes)
Jones, J. NIH 1 R01 CA76259-01 * PI - Structure and Function of Acetylcholine Receptors 05/09-05/014 * $190,000
Jones, J. NIH 5 K08 AI00091-03 PI - Purification & Identification of Receptors 11/03-11/08 $140,000
Mack, T. American Heart Assoc. PI - Control of Angiogenesis 03/05-03/08 $185,000
Mack, T. NSF PCM 80-12935
(D. Stockton, PD/PI)
Co-PI - Cell Culture Center 12/06-12/09 $180,000
Mack, T. NIH 1 P01 CA71802-02
(D. Stockton, PD/PI)
Project Leader of Subproject 4: "Genetic Control of
Cell Division"
10/05-10/09 $165,000
Smith, J. None
Zachary, A. NIH 1 U01 AI-28507-01 * PI ā€“ Human Monoclonal Antibodies as a Therapy for
Staphyloccal Enterotoxin
07/09-07/14 * $200,000
($3 million)
Table 4 Instructions: For each participating faculty member, list active and pending research grant and contract support from all sources
(including Federal, non-Federal, and institutional research grant and contract support) that will provide the context for research training
experiences, but excluding research training grants. If none, state "None." Include the source of support and grant number; role of the
participating faculty member (PD/PI, co-PD/PI, etc.) in the grant; title, status (use an asterisk (*) to indicate pending sources of support)
and dates of the entire project period; and the current year annual direct costs. If the source of support is part of a multiple project grant (for
example, a P01), additionally identify the PD/PI of the overall project, and provide the above information for that component of the grant
with which the faculty member is associated. For grants with major budget changes in future years such as clinical trials, include the total
direct costs of the award in parentheses.
Rationale: This table provides evidence of the strength of the research environment, the availability of funds to support research
conducted by the trainees, and the appropriateness of the participating faculty members in terms of their active research support.
28
Table 5. Training Record of Faculty
29
Table 5B. Training Record of Faculty
30
Table 6. Publications of Trainees
31
Table 7A. Admissions and Completion Records for
Participating Departments and Programs
Table 7A. Admissions and Completion Records for the Participating Departments and Programs During the Past Five Years
(Predoctoral Applicants)
Department /
Program
Entering
Year
Applicants
Applied
(TGE)
A
Applicants
Accepted
(TGE)
A
Applicants
Enrolled
(TGE)
A/B/C
Trainees
Still in
Program
(TGE)
A/B/C
Trainees
Completed
Program
Earned PhD or
MD/PhD
(TGE)
A/B/C
Trainees
Completed
Program
Earned Other
Degree
(TGE)
A/B/C
Trainees
Left
Program
(TGE)
A/B/C
Reason for Leaving
Program
(if training was not
completed)
Department of
Biochemistry
2003 8 (5)
0
6 (4)
0
4 (3)
0/3/1
2 (1)
0/0/0
1 (1)
0/0/0
0 (0)
0/0/0
1 (1)
0/0/0
Changed career
interests
Department of
Biochemistry
2004 9 (7)
1
6 (4)
10
5 (3)
0/0/0
4 (3)
0/0/0
1 (1)
0/0/0
0(0)
0/0/0
0 (0)
0/0/0
Department of
Biochemistry
2005 10 (6)
2
8 (5)
1
5 (3)
1/0/0
4 (3)
0/0/0
0 (0)
0/0/0
MS 1
1/0/0
0 (0)
0/0/0
Went to medical
school
Department of
Biochemistry
2006 12 (9)
3
10 (6)
1
8 (5)
1/0/0
6 (4)
0/0/0
0 (0)
0/0/0
0 (0)
0/0/0
2 (1)
0/0/0
1 left for a job in
industry;
1 left for reasons
unknown
Department of
Biochemistry
2007 15 (12)
4
10 (8)
2
8 (6)
2/1/0
8 (6)
2/1/0
0 (0)
0/0/0
0 (0)
0/0/0
0 (0)
0/0/0
Interdepartmental
Graduate Program in
Genetics
2003 125 (9)
5
24 (18)
0
18 (15)
0/0/0
5 (4)
00/0
12 (11)
0/0/0
0 (0)
0/0/0
1 (0)
0/0/0
Transferred to
Bioengineering PhD
program
Interdepartmental
Graduate Program in
Genetics
2004 123 (91)
3
22 (17
1
16 (16)
1/0/0
10 (10)
0/0/0
4 (4)
0/0/0
0 (0)
0/0/0
2 (2)
1/0/0
1 transferred to
another institution; 1
enrolled in medical
school
Interdepartmental
Graduate Program in
Genetics
2005 122 (85)
5
21 (19)
0
17 (16)
0/0/0
14 (14)
0/0/0
0 (0)
0/0/0
MS 1
0/0/0
2 (1)
0/0/0
1 left for job in
industry;
1 enrolled in dental
school
Interdepartmental
Graduate Program in
Genetics
2006 130 (83)
5
35 (22)
4
20 (19)
3/0/0
18 (17)
2/0/0
0 (0)
0/0/0
0 (0)
0/0/0
2 (2)
1/0/0
1 transferred to
neuroscience training
program; 1 teaching
science in high school
32
Table 8A.
Qualifications of Recent Predoctoral Applicants
Table 8A. Qualifications of Recent Predoctoral Applicants
Year
Department /
Program
Applicant
(List by
Number)
Previous
Institution(s)
Degree(s)
& Year(s)
GRE Scores
V, Q, Adv
(Percentiles)
and/or MCAT
Scores
Undergrad
GPA
Interviewed
(Y/N)
Accepted
(Y/N)
Enrolled
(Y/N)
Support
from this
Grant
(Y/N)
2007 Medical Scientist
Training Program
1* U. of WI BSN '06 12, 11, Q, 10 3.63 Y Y Y Y
2007 Medical Scientist
Training Program
2* Stanford BS '06 11, 13, N, 11 3.72 Y Y N
JHU
N
2007 Medical Scientist
Training Program
3 Yale U.
Wash. U.
BA '05
MS '06
10, 9, O, 11
660 680 740
3.78 Y N N N
2007 Molecular Biophysics
Program
1* U. of IL BS '06 700 730 720 4.0 Y Y Y Y
2007 Molecular Biophysics
Program
2* Rutgers BS '07 710 690 680 3.36 Y Y Y Y
2007 Molecular Biophysics
Program
3 Berkeley BS '07 680 710 720 3.68 Y Y N
UCSF
N
2007 Molecular Biophysics
Program
4* U. of TX BS '07 720 690 750
(97%) (79%)
(85%)
3.73 Y Y N
JHU
N
2007 Molecular Biophysics
Program
5* Tufts U. BS '06 650 670 630 3.32 N N N N
2007 Molecular Biophysics
Program
6 U. of Kyoto BS '05 480 710 720 N/A N N N N
Program Statistics
Total Number
of Applicants
Number of TGE
Applicants
Applicants
Interviewed
Applicants
Accepted
Applicants
Enrolled
Applicants
Supported By
This Grant
Average GRE /
MCAT Scores Average GPA
9 6 7 6 3 3
11, 11,11
702 705 718
3.65
33
Table 9A. Qualifications of Current
Predoctoral Trainees
Table 9A. Qualifications of the Current Predoctoral Trainees Clearly Associated with the Training Program
Department /
Program
Trainee
(List by Number)
Previous
Institution(s)
Degree(s) &
Year(s)
GRE Scores /
(Percentiles)
V, Q, Adv
and/or
MCAT Scores
Undergraduate
GPA
Current
Research
Mentor
Years in
Program
Calendar
Years
Appointed
to This
Grant
Biochem 1* U. of WI BSN '06 680 720 750 3.63 Jones, J. '07-present None
Genetics 2* MIT BS '06 12, 12, R, 14 3.72 Huerta, X. '05-present '06-'07
Genetics 3* U. Penn.
Wash. U.
BA '05
MS '07
700 710 640
(96% 82% 84%)
3.75 Felman, R. '07-present '06-present
Genetics 4 U. Mich. BA '07 650 710 630
(80% 92% 83%)
3.34 TBN '07-present None
Program Statistics
Total Number
of Trainees
Number of TGE
Trainees
Average GRE /
MCAT Scores Average GPA
4 3
690, 705, 695
12, 12, R, 14
3.61
34
Table 10. Admissions and Completion
Records of Underrepresented Individuals
Table 10: Admissions and Completion Records for Underrepresented Minority (URM) Trainees, Trainees with Disabilities, and
Trainees from Disadvantaged Backgrounds Clearly Associated With the Training Program
Diversity
Recruitment
Group
Trainee
(List by
Number)
Entering
Year
(Pre/Post)
Department /
Program
Source of Support
and if Support by
NRSA Grant
In
Training
Completed
Training
Left Without
Completing
Training
Current Status
Career or
Employment
URM Trainees 1* 2006
(Pre)
Genetics T32 GM001122
F31
Y Postdoctoral Trainee
UCSF
URM Trainees 1* 2007
(Post)
Cell Biology University Fellowship
Research
Y Mentor and student
both moved to another
institution
URM Trainees 1* 2007
(Post)
Chemistry Lectureship Y
Trainees With
Disabilities
1* 2004
(Pre)
Pharmacology T32 GM001144
F31
Y Postdoctoral Trainee
NYU
Trainees With
Disabilities
2* 2006
(Post)
Cell Biology R01 Y Career Change
Trainees With
Disabilities
3 2007
(Post)
Medicine Research Associate Y
Trainees From
Disadvantaged
Backgrounds
1* 2005
(Pre)
Genetics T32 GM001155
F31
Y Postdoctoral Trainee
U. Chicago
35
Table 11. Appointments to the Training Grant
for each Year of Past Award
Table 11. Appointments to the Training Grant For Each Year of the Past Award (Renewal Applications Only)
Grant Year 2003-2004 2004-2005 2005-2006 2006-2007 2007-2008
Predoctoral Positions Awarded (Months of Support) 10 (120) 12 (144) 14 (168) 14 (168) 14 (168)
Predoctoral Trainees Appointed (Months of Support Used) 10 (120) 131 (144) 14 (168) 132 (156) 14 (168)
Predoctoral URM Trainees Appointed (Months of Support) 1 (12) 2 (24) (0) 1 (12) 1 (12)
Predoctoral Trainees with Disabilities Appointed (Months of Support) 1 (12) 0 (0) 1 (12) 2 (12) 0 (0)
Predoctoral Trainees from Disadvantaged Background Appointed
(Months of Support)
0 (0) 0 (0) 0 (0) 0 (0) 1 (12)
Postdoctoral Positions Awarded (Months of Support) 4 (48) 4 (48) 4 (48) 4 (48) 4 (48)
Postdoctoral Trainees With MD Appointed 1 1 2 1 2
Postdoctoral Trainees With MD/PhD Appointed 2 1 1 0 0
Postdoctoral Trainees With PhD Appointed 1 1 0 1 2
Postdoctoral Trainees With Other Degree Appointed 0 DrPH DrPH PharmD 0
Postdoctoral Trainees Appointed (Months of Support Used) 4 (48) 4 (48) 4 (48) 3 (38)3 4 (48)
Postdoctoral URM Trainees Appointed (Months of Support) 1 (12) 2 (24) 0 (0) 1 (12) 1 (12)
Postdoctoral Trainees with Disabilities Appointed (Months of Support) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
Postdoctoral Trainees from Disadvantaged Background Appointed
(Months of Support)
0 (0) 0 (0 0 (0) 0 (0) 1 (12)
1
One trainee left after 6 months and a second trainee was appointed for the remainder of the year.
2
One position was not filled.
3
A fourth trainee was appointed, but fell ill and dropped out after 2 months. It was then too late to recruit a replacement trainee.
36
Table 12A. Predoctoral Trainees Supported
by this Training Grant
Table 12A. Predoctoral Trainees Supported by This Training Grant (Renewal Applications Only)
Predoctoral (and MSTP) Trainees (Listed Sequentially by Entering Class)
Enter Source(s) of Support and Academic Year for Each Grant Year
Trainee, Year of
Entry Prior Degree &
Institution (Mentor ā€“
Department /
Program)
Grant
Year
-01
95-99
Grant
Year
-02
99-00
Grant
Year
-03
00-01
Grant
Year
-04
01-02
Grant
Year
-05
02-03
Grant
Year
-06
03-04
Grant
Year
-07
04-05
Grant
Year
-08
05-06
Grant
Year
-09
06-07
Grant
Year
-10
07-08
Title of
Research
Project or
Research
Topic
Degree(s)
Received
(Year)
Current
Position and
Institution
(Grant Support
Obtained)
Cox, C., 1994 BA,
Cornell Univ.
(Jones-Biochem.)
TG TG RG RG/
TG3
Cloning of
Human Globin
Genes
MD, PhD
(2002)
Asst. Prof.
Hematology,
Rutgers (50%
clinical, 50%
research, NIH
K11)
Smith, J. G., 1995 BS,
Iowa State U.
(Gordon-MCB)
TG TG RG Structural
Studies of
Membrane-
Bound Proteins
M.S.
(2001)
Parke-Davis
(Lab.
Technician)
Johnson, J., 2002
BPharm, Duquesne
(Jacobs-Virology)
TG2 TG TG RG RG Regulation of
EBV Gene
Expression
PhD
(2007)
Postdoctoral
Trainee w/C.
Chen, Univ. of
CA, Davis
Smolock, Y., 2005 BS,
UCLA
(Rifkind-Genetics)
UF UF TG Purine
Synthesis
Mutants in
Mammalian
Cells
In Training
Thomas, G., 2007
DVM,
U. Penn
(unassigned)
TG In Training
TG1, TG2...Early, lateā€¦Explain use of slots!
37
Table 12A. Predoctoral Trainees Supported
by this Training Grant (cont)
Program Statistics
Percentage of Trainees Entering 10 Years Ago
That Completed Ph.D.s
Average Time to Ph.D. for Students in the Last 10 Years
(not including leaves of absence)
50% 6.5 years
38
The Narrative
Background
Describe data in Tables 1, 2, 3:
Departmental Membership, Participating
Faculty Members, Other TG Support
Program Plan
What students will do & why
timeline? Course structure? Expectations?
ā€¢Program Faculty
Describe data in Tables 4, 5, 6:
Faculty Grant Support, Trainees, Publication
of Trainees
39
The Narrative (cont)
ā€¢ Proposed Training
ā€¢ Training Program Evaluation
ā€¢ Trainee Candidates-Recruitment
ā€¢ Institutional Environment and Commitment
ā€¢ Admissions and Completion Records of Trainees
(Tables 7A and/or 7B)
ā€¢ Qualifications of Applicants (Tables 8A and/or
8B)
40
The Narrative (cont)
ā€¢ Current Trainee Qualifications (Tables 9A
and/or 9B)
ā€¢ Recruitment and Retention Plan to Enhance
Diversity (Tables 1, 7 A/B, Renewal Apps
Table 10)
ā€¢ Plan for Instruction in Responsible Conduct
of Research
ā€¢ For Renewal Applicationsā€”Progress
Report (Tables 11, 12 A and/orB)
41
Narrative (cont)
Human Subjects
Vertebrate Animals
Select Reagent Research
Multiple PD/PI leadership plan
Consortium/Contractural Agreements
Faculty biosketches
Appendix
42
The Narrative (cont)
Human Subjects
Vertebrate Animals
Select Reagent Research
Multiple PD/PI Leadership Plan
Consortium/Contractual Agreements
FACULTY BIOSKETCHES
Appendix
Thank You
For more info contact:
Alison Hall PhD alison.hall@nih.gov

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Writing_a_Successful_T32_Application.pptx

  • 1. NIH Institutional Training Programs: Preparing a Successful T32 Application Alison K. Hall, Ph.D. Deputy Director Division of Training, Workforce Development and Diversity National Institute of General Medical Sciences National Institutes of Health June 28, 2013
  • 2. PhD Training Continues to Evolve 2 NIH Regional Seminar June 28, 2013 NIH has supported research training since 1930s fellowships thru the 1950s National Research Service Award 1975 (i.e. T32, F30/31, F32; MARC) Ruth L. Kirschstein -funding to scientists, not health professionals -to enhance research training -in scientific areas with need for researchers -good curricula, facilities, program in addā€™n to research -dedication to developing talent
  • 3. 3 PhD support is largely on research grants Consider differences in apprenticeship vs a program Source: Graduate Student Survey, NSF
  • 4. 4 Training In light of Multiple Career Outcomes Employment of Biomedical Science PhDs by Sector - 20,000 40,000 60,000 80,000 100,000 120,000 140,000 1973 1977 1981 1985 1989 1991 1993 1993 NEW 1995 1997 1999 2001 2003 2006 2008 Number Other Government Industrial All Academic Source: http://sestat.nsf.gov/
  • 5. 5 Training in light of limited diversity in workforce Source: US Census; NSF, 2007 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Temp. Res. non-URM URM 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% 2008 2050 US Population Biomedical Workforce
  • 6. 6 http://acd.od.nih.gov/Biomedical_research_wgreport.pdf ļ‚§Total of ~150,000 Biomedical US-trained PhDā€™s Postdoctoral Training 2009 Total: 37,000 to 68,000 Median Length: 4 years International Post-Training Workforce College Graduates 8% of graduates leave the US Of graduates who stay in the US skip a postdoc do a postdoc 1,900 to 3,900 in 2009 4,000 in 2009 Graduate Education & Training 2009 Total: 83,000 Time to Degree :5.5-7yrs 2009 Graduates: 9,000 16,000 in 2009 5,800 in 2009 18% Biomedical US- trained PhD 2008 ~22,500 Industrial Research 43% (23% tenured) Biomedical US- trained PhD 2008 ~55,000 Academic Research or Teaching 6% Biomedical US- trained PhD 2008 ~7,000 Governmen t Research 18% Biomedical US- trained PhD 2008 ~24,000 Science Related Non- Research 13% Biomedical US- trained PhD 2008 ~17,000 Non- Science Related 2% Biomedical US- trained PhD 2008 ~2,500 Unemployed (128,000 Biomedical US-trained PhDs) NOTE: The color of the numbers reflects the confidence in the accuracy of the data. Snapshot of the PhD Biomedical Workforce
  • 7. 7 Institutional Training Programs ā€¢ Enhance research training through a coordinated programmatic approach ā€¢ Involve many faculty, multiple departments ā€¢ Trainees are selected by the institution ā€¢ Parent Announcement Update T32 FOA updates expected July ļƒ appl due January 2014
  • 8. 8 Strategies to Develop a Strong Proposal 1. Start Early 2. Consider why a TG is important for your program 3. Be very sure there is a PROGRAM 4. Complete tables before finalizing narrative 5. Review the review criteria 6. Explain, explain, explain. Remember reviewers are expert faculty familiar with training
  • 9. 9 Institutional Training Review Criteria ~750 Electronic TG Submissions (May; Sept, Jan) Center for Scientific Review to Institute/Center Study Sectionā€”Initial Review Group 3-4 reviewers Established scientists, many with training experience Program merit Scored Review Criteria: 1. Training Program and Environment 2. Training Program Director/Principal Investigator 3. Preceptors/Mentors 4. Trainees 5. Training Record Overall Impact Score: 1-9 Institute or Center Council Program relevance, guidance to program staff
  • 10. 10 Hallmarks of Good Training Programs Student development for biomedical team experience, contributions, growth, project Contemporary, mentored research education broad and deep academic curriculum research skills and knowledge conceptual judgment, right questions communication skills Career development for multiple outcomes as a scientist (fellowships, mtgs, papers) teaching activity? Leadership? Mgmt? externships? Policy? Workshops? Responsible Conduct
  • 11. 11 Training Programs are Developmental, not Selection Potential Trainees How select for TG and why Matriculant UG major Research Interest Courses taken Lab affiliation PhD Program Pilot research Program Activities Planned interventions Milestone/ Outcomes Intended changes Mentored Research PI, advisory comm research design new techniques Planned Curriculum knowledge teaching Skill building oral communication writing workshops new collaborations Contemporary science meet new scientists Career Exposure know next steps Short term Research publications Poster, meeting Fellowship Longer term Next position Biomedical career Research grants Mentoring others
  • 12. 12 Active Program Beyond Research in PI lab ā€œvalue addedā€ PROGRAM IS MORE THAN WORK IN A LAB Active nomination, selection of candidates from pool Planned academics with flexibility Seminars, enhancement activities Longitudinal program beyond funding Faculty trainer responsibilities make program strong Intentional activities to achieve outcomes
  • 13. 13 1. Training Program and Environment ā€¢ Are the research facilities and training environment conducive to prepare trainees for successful careers as biomedical scientists? ā€¢ Do the objectives, design and direction of the proposed research program ensure effective training? ā€¢ Is the proposed program of training likely to ensure that trainees will be prepared for successful and productive scientific careers? ā€¢ Do the courses, where relevant, and research training experiences address state-of-the-art science relevant to the aims of the program? ā€¢ Does the program provide training in inter- or multidisciplinary research and/or provide training in state-of- the-art or novel methodologies and techniques? ā€¢ Is a significant level of institutional commitment to the program evident?
  • 14. 14 2. Training Program Director/Principal Investigator Does the Training PD/PI have the scientific background, expertise, and experience to provide strong leadership, direction, management, and administration to the program? His/her trainees, outcomes Does the PD/PI plan to commit sufficient time to the program to ensure its success? Is sufficient administrative and research training support provided for the program? Is a strong justification provided that the multiple PD/PI leadership approach will benefit the training program and the trainees? roles and responsibilities, governance, and organizational structure consistent with and justified by training program and with the complementary expertise of PD/PIs?
  • 15. 15 3. Preceptors/Mentors Are sufficient numbers of experienced preceptors/mentors with appropriate expertise and funding available to support the number and level of trainees proposed in the application? 3-4x faculty available to student, not all one labā€¦ Do the preceptors/mentors have strong records as researchers, including successful competition for research support in areas directly related to the proposed research training program? How diverse are faculty? Do the preceptors/mentors have strong records of training pre- and/or postdoctorates?
  • 16. 16 4. Trainees Is a recruitment plan proposed with strategies to attract high quality, diverse, trainees? Are there well-defined and justified selection criteria and retention strategies? Nomination, re-appointment criteria, process Is there evidence of a competitive applicant pool in sufficient numbers to warrant the proposed size and levels? TG is catalytic, supports a third(?) of relevant TGE students
  • 17. 17 4. Trainees (cont) For renewal applications, how successful has program been in attracting and retaining individuals from diverse populations, including populations underrepresented in science? Report Trainees Training Grant Eligible Students from groups underrepresented in biomedical science Students with disabilities, defined as physical or mental impairment that substantially limits one or more major life activities.
  • 18. 18 Once in program, students change minds ā€¦and make choices about careers Graduate students in basic biomedical sciences ā€¢ Many initially have goal of academic research ā€¢ Midway thru PhD are considering multiple careers What does the change in attitude mean? didnā€™t know possibilities when began grad school perhaps worried about academic path learned more about whatā€™s enjoyable identified next steps for careers Fuhrmann et al 2011 CBE Life Sci Educn 10: 239-249
  • 19. 19 How Assess Skills and Interests? Individual Development Plan To be used in training, fellowships, RPGsā€¦
  • 20. 20 The IDP involves The scholar The mentor self assessment familiarity with opportunities Survey opportunities discuss opportunities Write IDP review IDP, help revise Implement plan assess new tasks, progress in light of the plan 1.Skills assessment-strengths and weaknesses 2.Career match- do goals match skills and interest 3.Do it again next year
  • 21. 21 5. Training Record How successful are the trainees in completing the program? How productive are trainees in terms of research accomplishments and publications? How successful are trainees in obtaining further training appointments, fellowships, and/or career development awards? How successful are the trainees in achieving productive scientific careers, as evidenced by successful competition for research grants, receipt of honors or awards, high-impact publications, receipt of patents, promotion to scientific leadership positions, and/or other such measures of success?
  • 22. 22 5. Training Record For programs that provide research training to health- professional doctorates, is there a record of retaining health professionals in research training or other research activities for at least two years? Does the program have a rigorous evaluation plan to assess the quality and effectiveness of the training? Annually assess outcomes? Adapt to changes? Test intervention hypothesis? Are effective mechanisms in place for obtaining feedback from current and former trainees and monitoring traineesā€™ subsequent career development?
  • 23. 23 Institutional Training Additional Review Criteria & Considerations Additional Review Criteria Protection for Human Subjects Inclusion of Women, Minorities, and Children Vertebrate Animals Biohazards Resubmission, Renewal, Revision factors Additional Review Considerations: Diversity Recruitment Plan Training in Responsible Conduct of Research Select Agent Research Budget and Period of Support
  • 24. 24 Table 1. Participating Departments 24 Table 1. Membership of Participating Departments/Programs (Alphabetically) Participating Department / Program Faculty Members in Department / Program Faculty Members Participating in This Application Predoctoral Trainees in Department / Program (Supported by Any NIH Training Grant) Predoctoral Trainees With Participating Faculty (TGE) A/B/C For Renewal Applications, Predoctoral Trainees Supported by This Training Grant (TGE) A/B/C Postdoctoral Trainees in Department / Program (Supported by Any NIH Training Grant) Postdoctoral Trainees With Participating Faculty (TGE) A/B/C For Renewal Applications, Postdoctoral Trainees Supported by This Training Grant (TGE) A/B/C Dept. of Biology 45 14 38 (15) 12 (6) 1/1/0 2 (2) 1/0/0 50 (5) 15 (7) 1/0/0 2 (2) 0/0/0 Neuroscience Program 32 20 31 (20) 14 (7) 2/0/1 4 (4) 0/1/0 40 (7) 23 (10) 0/0/1 2(2) 1/0/0 Dept. of Pharmacology (Medical School) 25 5 30 (10) 5 (3) 1/0/0 3 (3) 0/0/0 28 (0) 12 (6) 0/0/1 0 (0) 0/0/0 Totals N/A N/A 99 (45) 31 (16) 4/1/1 9 (9) 1/1/0 108 (12) 50 (23) 4 (4) 1/0/0 Table 1 Instructions: Provide the total number of current faculty members, predoctoral trainees, and postdoctoral trainees in each participating department/program. Indicate the number of faculty members participating in this training grant application, the numbers of predoctoral and postdoctoral trainees with the participating faculty, and in parenthesis put the number of these trainees who are training grant eligible (TGE). For renewal applications, include the number of trainees currently supported by the training grant. Faculty members may count as part of both their primary department and an interdepartmental program(s). Predoctoral and postdoctoral trainees count only once and should be associated with a single department or program. underrepresented minorities (Group A), who are individuals with disabilities (Group B), or who are individuals from disadvantaged backgrounds (Group C). Rationale: This table provides insight into the environment in which training will take place. It allows reviewers to assess whether the program has the "critical mass" (trainees, faculty and other research personnel, and representation/distribution of scientific disciplines) to be successful. (Finish this table lastā€¦complicated)
  • 25. 25 Table 2. Participating Faculty Members Table 2. Participating Faculty Members (Alphabetically by Faculty Member) Name/Degree(s) Rank Primary (& Secondary) Appointment(s) Role in Program Research Interest Abrams-Johnson, Jane, PhD Asst. Prof. Pharmacology; (Biochemistry-Medical School) Mentor Regulation of Synthesis of Biogenic Amines Jones, Lisa S., MD Res. Asst. Prof. Microbiology and Immunology (Neuroscience Program) Mentor Exec Com Protein Structure, Folding, and Immunogenicity Sandoz, J. Miguel, MD, PhD Assoc. Prof. Neuroscience Program Mentor Developmental Genetics in Drosophila Thomas, C. James, III, PhD Prof. & Chr. Biochemistry and Molecular Biophysics Program Director Molecular and Genetic Analysis of RNA Viruses Table 2 Instructions: List each training faculty member with his/her degree(s), academic rank, primary departmental affiliation and secondary appointments, role in the proposed training grant program, and research interests that are relevant to this program. Rationale: This information allows reviewers to assess the distribution of junior versus senior faculty and clinical versus basic scientists participating in the training program, as well as their distribution by department. The data concisely summarize the scientific areas of the training faculty. (Easy, easy to modify as program shapes up. Start here)
  • 26. 26 Table 3. Existing Institutional Training Grants Table 3. Institutional Training Grant Support Available to Participating Faculty Members, Department(s), or Program(s) Title of Training Grant Funding Source Including Identifying Number Active or Pending Project Period Program Director (Department) Predoctoral Trainees Supported This Year Postdoctoral Trainees Supported This Year Short- Term Trainees Supported This Year Total No. of Participating Faculty Names of Overlapping Faculty Bioimmunotherapy Training Grant T32 CA05964-11 06/02-07/07 Baker, A. (Pathology) 12 25 Abelson Brown Fields Johnson Sung Watson Pharmacological Sciences T32 GM04823-01 Pending James, C. (Pharmacology) 10 19 Jones Jenson Watson Genetic Basis of Mental Illness T32 MH02708-07 06/03-07/08 Johnson, A. (Psychiatry) 4 4 7 Johnson Watson Totals N/A N/A N/A 26 4 0 51 N/A Table 3 Instructions: List all current and pending training support available to the participating faculty members, department(s) or programs(s). For each grant, include the title of the training grant; funding source and complete identifying number; status (active or pending) and dates of the entire project period; name of the program director and department; number(s) of training positions (predoctoral, postdoctoral, and short term), number of participating faculty members; and list overlapping participating faculty members, who are also named in this application. Rationale: This table will permit an evaluation of the level of support for training available to each of the participating departments/programs and the extent to which the proposed training grant overlaps with or duplicates available training grant support. It is useful in determining the number of training positions to be awarded. Explain overlapping faculty!
  • 27. 27 Table 4. Grant Support of Faculty Table 4. Grant and Contract Support of the Participating Faculty Members (Alphabetically by Faculty Member) Faculty Member Source of Support, Grant Number and Status Faculty Member Role on Project and Grant Title Project Period Active Current Year Direct Costs Awarded (Total Direct Costs for Awards With Substantial Future Changes) Jones, J. NIH 1 R01 CA76259-01 * PI - Structure and Function of Acetylcholine Receptors 05/09-05/014 * $190,000 Jones, J. NIH 5 K08 AI00091-03 PI - Purification & Identification of Receptors 11/03-11/08 $140,000 Mack, T. American Heart Assoc. PI - Control of Angiogenesis 03/05-03/08 $185,000 Mack, T. NSF PCM 80-12935 (D. Stockton, PD/PI) Co-PI - Cell Culture Center 12/06-12/09 $180,000 Mack, T. NIH 1 P01 CA71802-02 (D. Stockton, PD/PI) Project Leader of Subproject 4: "Genetic Control of Cell Division" 10/05-10/09 $165,000 Smith, J. None Zachary, A. NIH 1 U01 AI-28507-01 * PI ā€“ Human Monoclonal Antibodies as a Therapy for Staphyloccal Enterotoxin 07/09-07/14 * $200,000 ($3 million) Table 4 Instructions: For each participating faculty member, list active and pending research grant and contract support from all sources (including Federal, non-Federal, and institutional research grant and contract support) that will provide the context for research training experiences, but excluding research training grants. If none, state "None." Include the source of support and grant number; role of the participating faculty member (PD/PI, co-PD/PI, etc.) in the grant; title, status (use an asterisk (*) to indicate pending sources of support) and dates of the entire project period; and the current year annual direct costs. If the source of support is part of a multiple project grant (for example, a P01), additionally identify the PD/PI of the overall project, and provide the above information for that component of the grant with which the faculty member is associated. For grants with major budget changes in future years such as clinical trials, include the total direct costs of the award in parentheses. Rationale: This table provides evidence of the strength of the research environment, the availability of funds to support research conducted by the trainees, and the appropriateness of the participating faculty members in terms of their active research support.
  • 28. 28 Table 5. Training Record of Faculty
  • 29. 29 Table 5B. Training Record of Faculty
  • 31. 31 Table 7A. Admissions and Completion Records for Participating Departments and Programs Table 7A. Admissions and Completion Records for the Participating Departments and Programs During the Past Five Years (Predoctoral Applicants) Department / Program Entering Year Applicants Applied (TGE) A Applicants Accepted (TGE) A Applicants Enrolled (TGE) A/B/C Trainees Still in Program (TGE) A/B/C Trainees Completed Program Earned PhD or MD/PhD (TGE) A/B/C Trainees Completed Program Earned Other Degree (TGE) A/B/C Trainees Left Program (TGE) A/B/C Reason for Leaving Program (if training was not completed) Department of Biochemistry 2003 8 (5) 0 6 (4) 0 4 (3) 0/3/1 2 (1) 0/0/0 1 (1) 0/0/0 0 (0) 0/0/0 1 (1) 0/0/0 Changed career interests Department of Biochemistry 2004 9 (7) 1 6 (4) 10 5 (3) 0/0/0 4 (3) 0/0/0 1 (1) 0/0/0 0(0) 0/0/0 0 (0) 0/0/0 Department of Biochemistry 2005 10 (6) 2 8 (5) 1 5 (3) 1/0/0 4 (3) 0/0/0 0 (0) 0/0/0 MS 1 1/0/0 0 (0) 0/0/0 Went to medical school Department of Biochemistry 2006 12 (9) 3 10 (6) 1 8 (5) 1/0/0 6 (4) 0/0/0 0 (0) 0/0/0 0 (0) 0/0/0 2 (1) 0/0/0 1 left for a job in industry; 1 left for reasons unknown Department of Biochemistry 2007 15 (12) 4 10 (8) 2 8 (6) 2/1/0 8 (6) 2/1/0 0 (0) 0/0/0 0 (0) 0/0/0 0 (0) 0/0/0 Interdepartmental Graduate Program in Genetics 2003 125 (9) 5 24 (18) 0 18 (15) 0/0/0 5 (4) 00/0 12 (11) 0/0/0 0 (0) 0/0/0 1 (0) 0/0/0 Transferred to Bioengineering PhD program Interdepartmental Graduate Program in Genetics 2004 123 (91) 3 22 (17 1 16 (16) 1/0/0 10 (10) 0/0/0 4 (4) 0/0/0 0 (0) 0/0/0 2 (2) 1/0/0 1 transferred to another institution; 1 enrolled in medical school Interdepartmental Graduate Program in Genetics 2005 122 (85) 5 21 (19) 0 17 (16) 0/0/0 14 (14) 0/0/0 0 (0) 0/0/0 MS 1 0/0/0 2 (1) 0/0/0 1 left for job in industry; 1 enrolled in dental school Interdepartmental Graduate Program in Genetics 2006 130 (83) 5 35 (22) 4 20 (19) 3/0/0 18 (17) 2/0/0 0 (0) 0/0/0 0 (0) 0/0/0 2 (2) 1/0/0 1 transferred to neuroscience training program; 1 teaching science in high school
  • 32. 32 Table 8A. Qualifications of Recent Predoctoral Applicants Table 8A. Qualifications of Recent Predoctoral Applicants Year Department / Program Applicant (List by Number) Previous Institution(s) Degree(s) & Year(s) GRE Scores V, Q, Adv (Percentiles) and/or MCAT Scores Undergrad GPA Interviewed (Y/N) Accepted (Y/N) Enrolled (Y/N) Support from this Grant (Y/N) 2007 Medical Scientist Training Program 1* U. of WI BSN '06 12, 11, Q, 10 3.63 Y Y Y Y 2007 Medical Scientist Training Program 2* Stanford BS '06 11, 13, N, 11 3.72 Y Y N JHU N 2007 Medical Scientist Training Program 3 Yale U. Wash. U. BA '05 MS '06 10, 9, O, 11 660 680 740 3.78 Y N N N 2007 Molecular Biophysics Program 1* U. of IL BS '06 700 730 720 4.0 Y Y Y Y 2007 Molecular Biophysics Program 2* Rutgers BS '07 710 690 680 3.36 Y Y Y Y 2007 Molecular Biophysics Program 3 Berkeley BS '07 680 710 720 3.68 Y Y N UCSF N 2007 Molecular Biophysics Program 4* U. of TX BS '07 720 690 750 (97%) (79%) (85%) 3.73 Y Y N JHU N 2007 Molecular Biophysics Program 5* Tufts U. BS '06 650 670 630 3.32 N N N N 2007 Molecular Biophysics Program 6 U. of Kyoto BS '05 480 710 720 N/A N N N N Program Statistics Total Number of Applicants Number of TGE Applicants Applicants Interviewed Applicants Accepted Applicants Enrolled Applicants Supported By This Grant Average GRE / MCAT Scores Average GPA 9 6 7 6 3 3 11, 11,11 702 705 718 3.65
  • 33. 33 Table 9A. Qualifications of Current Predoctoral Trainees Table 9A. Qualifications of the Current Predoctoral Trainees Clearly Associated with the Training Program Department / Program Trainee (List by Number) Previous Institution(s) Degree(s) & Year(s) GRE Scores / (Percentiles) V, Q, Adv and/or MCAT Scores Undergraduate GPA Current Research Mentor Years in Program Calendar Years Appointed to This Grant Biochem 1* U. of WI BSN '06 680 720 750 3.63 Jones, J. '07-present None Genetics 2* MIT BS '06 12, 12, R, 14 3.72 Huerta, X. '05-present '06-'07 Genetics 3* U. Penn. Wash. U. BA '05 MS '07 700 710 640 (96% 82% 84%) 3.75 Felman, R. '07-present '06-present Genetics 4 U. Mich. BA '07 650 710 630 (80% 92% 83%) 3.34 TBN '07-present None Program Statistics Total Number of Trainees Number of TGE Trainees Average GRE / MCAT Scores Average GPA 4 3 690, 705, 695 12, 12, R, 14 3.61
  • 34. 34 Table 10. Admissions and Completion Records of Underrepresented Individuals Table 10: Admissions and Completion Records for Underrepresented Minority (URM) Trainees, Trainees with Disabilities, and Trainees from Disadvantaged Backgrounds Clearly Associated With the Training Program Diversity Recruitment Group Trainee (List by Number) Entering Year (Pre/Post) Department / Program Source of Support and if Support by NRSA Grant In Training Completed Training Left Without Completing Training Current Status Career or Employment URM Trainees 1* 2006 (Pre) Genetics T32 GM001122 F31 Y Postdoctoral Trainee UCSF URM Trainees 1* 2007 (Post) Cell Biology University Fellowship Research Y Mentor and student both moved to another institution URM Trainees 1* 2007 (Post) Chemistry Lectureship Y Trainees With Disabilities 1* 2004 (Pre) Pharmacology T32 GM001144 F31 Y Postdoctoral Trainee NYU Trainees With Disabilities 2* 2006 (Post) Cell Biology R01 Y Career Change Trainees With Disabilities 3 2007 (Post) Medicine Research Associate Y Trainees From Disadvantaged Backgrounds 1* 2005 (Pre) Genetics T32 GM001155 F31 Y Postdoctoral Trainee U. Chicago
  • 35. 35 Table 11. Appointments to the Training Grant for each Year of Past Award Table 11. Appointments to the Training Grant For Each Year of the Past Award (Renewal Applications Only) Grant Year 2003-2004 2004-2005 2005-2006 2006-2007 2007-2008 Predoctoral Positions Awarded (Months of Support) 10 (120) 12 (144) 14 (168) 14 (168) 14 (168) Predoctoral Trainees Appointed (Months of Support Used) 10 (120) 131 (144) 14 (168) 132 (156) 14 (168) Predoctoral URM Trainees Appointed (Months of Support) 1 (12) 2 (24) (0) 1 (12) 1 (12) Predoctoral Trainees with Disabilities Appointed (Months of Support) 1 (12) 0 (0) 1 (12) 2 (12) 0 (0) Predoctoral Trainees from Disadvantaged Background Appointed (Months of Support) 0 (0) 0 (0) 0 (0) 0 (0) 1 (12) Postdoctoral Positions Awarded (Months of Support) 4 (48) 4 (48) 4 (48) 4 (48) 4 (48) Postdoctoral Trainees With MD Appointed 1 1 2 1 2 Postdoctoral Trainees With MD/PhD Appointed 2 1 1 0 0 Postdoctoral Trainees With PhD Appointed 1 1 0 1 2 Postdoctoral Trainees With Other Degree Appointed 0 DrPH DrPH PharmD 0 Postdoctoral Trainees Appointed (Months of Support Used) 4 (48) 4 (48) 4 (48) 3 (38)3 4 (48) Postdoctoral URM Trainees Appointed (Months of Support) 1 (12) 2 (24) 0 (0) 1 (12) 1 (12) Postdoctoral Trainees with Disabilities Appointed (Months of Support) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) Postdoctoral Trainees from Disadvantaged Background Appointed (Months of Support) 0 (0) 0 (0 0 (0) 0 (0) 1 (12) 1 One trainee left after 6 months and a second trainee was appointed for the remainder of the year. 2 One position was not filled. 3 A fourth trainee was appointed, but fell ill and dropped out after 2 months. It was then too late to recruit a replacement trainee.
  • 36. 36 Table 12A. Predoctoral Trainees Supported by this Training Grant Table 12A. Predoctoral Trainees Supported by This Training Grant (Renewal Applications Only) Predoctoral (and MSTP) Trainees (Listed Sequentially by Entering Class) Enter Source(s) of Support and Academic Year for Each Grant Year Trainee, Year of Entry Prior Degree & Institution (Mentor ā€“ Department / Program) Grant Year -01 95-99 Grant Year -02 99-00 Grant Year -03 00-01 Grant Year -04 01-02 Grant Year -05 02-03 Grant Year -06 03-04 Grant Year -07 04-05 Grant Year -08 05-06 Grant Year -09 06-07 Grant Year -10 07-08 Title of Research Project or Research Topic Degree(s) Received (Year) Current Position and Institution (Grant Support Obtained) Cox, C., 1994 BA, Cornell Univ. (Jones-Biochem.) TG TG RG RG/ TG3 Cloning of Human Globin Genes MD, PhD (2002) Asst. Prof. Hematology, Rutgers (50% clinical, 50% research, NIH K11) Smith, J. G., 1995 BS, Iowa State U. (Gordon-MCB) TG TG RG Structural Studies of Membrane- Bound Proteins M.S. (2001) Parke-Davis (Lab. Technician) Johnson, J., 2002 BPharm, Duquesne (Jacobs-Virology) TG2 TG TG RG RG Regulation of EBV Gene Expression PhD (2007) Postdoctoral Trainee w/C. Chen, Univ. of CA, Davis Smolock, Y., 2005 BS, UCLA (Rifkind-Genetics) UF UF TG Purine Synthesis Mutants in Mammalian Cells In Training Thomas, G., 2007 DVM, U. Penn (unassigned) TG In Training TG1, TG2...Early, lateā€¦Explain use of slots!
  • 37. 37 Table 12A. Predoctoral Trainees Supported by this Training Grant (cont) Program Statistics Percentage of Trainees Entering 10 Years Ago That Completed Ph.D.s Average Time to Ph.D. for Students in the Last 10 Years (not including leaves of absence) 50% 6.5 years
  • 38. 38 The Narrative Background Describe data in Tables 1, 2, 3: Departmental Membership, Participating Faculty Members, Other TG Support Program Plan What students will do & why timeline? Course structure? Expectations? ā€¢Program Faculty Describe data in Tables 4, 5, 6: Faculty Grant Support, Trainees, Publication of Trainees
  • 39. 39 The Narrative (cont) ā€¢ Proposed Training ā€¢ Training Program Evaluation ā€¢ Trainee Candidates-Recruitment ā€¢ Institutional Environment and Commitment ā€¢ Admissions and Completion Records of Trainees (Tables 7A and/or 7B) ā€¢ Qualifications of Applicants (Tables 8A and/or 8B)
  • 40. 40 The Narrative (cont) ā€¢ Current Trainee Qualifications (Tables 9A and/or 9B) ā€¢ Recruitment and Retention Plan to Enhance Diversity (Tables 1, 7 A/B, Renewal Apps Table 10) ā€¢ Plan for Instruction in Responsible Conduct of Research ā€¢ For Renewal Applicationsā€”Progress Report (Tables 11, 12 A and/orB)
  • 41. 41 Narrative (cont) Human Subjects Vertebrate Animals Select Reagent Research Multiple PD/PI leadership plan Consortium/Contractural Agreements Faculty biosketches Appendix
  • 42. 42 The Narrative (cont) Human Subjects Vertebrate Animals Select Reagent Research Multiple PD/PI Leadership Plan Consortium/Contractual Agreements FACULTY BIOSKETCHES Appendix
  • 43. Thank You For more info contact: Alison Hall PhD alison.hall@nih.gov