Reza Arzani completed a course in Windows Server 2012 R2 Access and Information Protection on November 2nd, 2016. The document confirms Reza's achievement in this course and the date it was completed.
Het Trefpunt in Kortrijk is een unieke bistro in het historische hart van de stad. Gelegen in het Kortrijkse Ondernemerscentrum maar voor iedereen toegankelijk. Met een eigenzinnig interieur en met een verrassend en aangenaam terras in de zomermaanden, is een bezoek aan het Trefpunt meer dan de moeite waard.
De vaste huiskok serveert steeds dagverse en seizoensgebonden producten. Een verzorgde lunch, suggestiemenu of gerechten à la carte en een uitgebreid bier- en wijnassortiment zijn de troeven van deze bistro met een prachtig kader. Voor bedrijven en groepen kunnen speciale arrangementen worden samengesteld.
Shock is a common complication of severe febrile illness, and worldwide aggressive correction with intravenous bolus therapy is recommended as the initial treatment. Nevertheless, the evidence supporting this approach remains weak. The only controlled trial of fluid resuscitation, Fluid Expansion as Supportive Therapy (FEAST), involving 3141 African children with severe febrile illness, including large groups with sepsis and malaria, called into question aggressive fluid resuscitation, demonstrating excess mortality in both bolus arms (albumin and saline) compared to no-bolus control, relative risk of morality in bolus versus control was 1.45(1.13-1.86, p=0.003). Excess mortality was consistent across all subgroups, being greatest in those with the most severe forms of shock and acidosis. Remarkably, despite earlier shock reversal in those receiving fluid boluses the excess mortality in the FEAST trial was caused by subsequent cardiovascular collapse and was not secondary to fluid overload.
These observations are intriguing warranting an in-depth understanding of host responses including those of the myocardium to fluid resuscitation and at the microvasacular level since the two maybe synergistic. Current studies are underway in ovine models of sepsis (‘FEAST-in-Sheep’) in Professor John Fraser’s laboratory, Brisbane to understand the mechanism of harm, gain further insights in host responses to fluid management, and re-define the optimal fluid and supportive inotrope/vasopressor management of septic shock.
Four years have elapsed since the publication of FEAST, yet World Health Organization continues to recommend fluid boluses for children managed in resource-poor hospitals, where there is no access to intensive care. These are the precise settings where the FEAST trial was conducted in order to inform management guidelines. In Africa alone, where one in 10 febrile child admissions present with shock, we have estimated that the current guidelines, if fully implemented, will result in ~5,600 and 33,000 excess deaths each year per million hospital admissions treated for shock.
Het Trefpunt in Kortrijk is een unieke bistro in het historische hart van de stad. Gelegen in het Kortrijkse Ondernemerscentrum maar voor iedereen toegankelijk. Met een eigenzinnig interieur en met een verrassend en aangenaam terras in de zomermaanden, is een bezoek aan het Trefpunt meer dan de moeite waard.
De vaste huiskok serveert steeds dagverse en seizoensgebonden producten. Een verzorgde lunch, suggestiemenu of gerechten à la carte en een uitgebreid bier- en wijnassortiment zijn de troeven van deze bistro met een prachtig kader. Voor bedrijven en groepen kunnen speciale arrangementen worden samengesteld.
Shock is a common complication of severe febrile illness, and worldwide aggressive correction with intravenous bolus therapy is recommended as the initial treatment. Nevertheless, the evidence supporting this approach remains weak. The only controlled trial of fluid resuscitation, Fluid Expansion as Supportive Therapy (FEAST), involving 3141 African children with severe febrile illness, including large groups with sepsis and malaria, called into question aggressive fluid resuscitation, demonstrating excess mortality in both bolus arms (albumin and saline) compared to no-bolus control, relative risk of morality in bolus versus control was 1.45(1.13-1.86, p=0.003). Excess mortality was consistent across all subgroups, being greatest in those with the most severe forms of shock and acidosis. Remarkably, despite earlier shock reversal in those receiving fluid boluses the excess mortality in the FEAST trial was caused by subsequent cardiovascular collapse and was not secondary to fluid overload.
These observations are intriguing warranting an in-depth understanding of host responses including those of the myocardium to fluid resuscitation and at the microvasacular level since the two maybe synergistic. Current studies are underway in ovine models of sepsis (‘FEAST-in-Sheep’) in Professor John Fraser’s laboratory, Brisbane to understand the mechanism of harm, gain further insights in host responses to fluid management, and re-define the optimal fluid and supportive inotrope/vasopressor management of septic shock.
Four years have elapsed since the publication of FEAST, yet World Health Organization continues to recommend fluid boluses for children managed in resource-poor hospitals, where there is no access to intensive care. These are the precise settings where the FEAST trial was conducted in order to inform management guidelines. In Africa alone, where one in 10 febrile child admissions present with shock, we have estimated that the current guidelines, if fully implemented, will result in ~5,600 and 33,000 excess deaths each year per million hospital admissions treated for shock.