Malfunctions in the fuel injectors, air intake system, or ignition system can cause engine misfire in a Mercedes-Benz. Specifically, issues with the timing of fuel injection, insufficient air intake, or irregular spark generation can disrupt the air-fuel combustion process. Engine misfire due to mechanical faults should not be neglected, as it can damage the engine over time if left unrepaired. Common signs of misfire include increased fuel consumption, popping sounds, engine vibration, stalling, and poor performance.