This document establishes a strategic plan for federally-funded artificial intelligence (AI) research and development in the United States. It identifies seven priority strategies for AI R&D investments: 1) making long-term investments in basic AI research, 2) developing methods for human-AI collaboration, 3) understanding ethical and societal implications of AI, 4) ensuring safety and security of AI systems, 5) developing shared public datasets for AI training, 6) establishing standards and benchmarks for measuring AI, and 7) understanding national workforce needs for AI R&D. The plan aims to advance national priorities through AI while minimizing potential negative impacts.