Mesenchymal stem cells (MSCs) are a type of adult stem cell that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells), and adipocytes (fat cells). MSCs have the potential to be used for regenerative medicine, tissue engineering, and cell therapy due to their ability to self-renew and differentiate. Several types of MSCs can be categorized based on their origin and potential for differentiation.
1: Bone Marrow-Derived MSCs
2: Adipose Tissue-Derived MSCs
3: Umbilical Cord-Derived MSCs
4: Dental Pulp-Derived MSCs
5: Synovial-Derived MSCs
The pursuit of understanding cellular processes and their intricate interplay with external stimuli lies at the heart of modern biomedical research. In this context, assay development in cell culture has emerged as an indispensable tool, allowing scientists to investigate cellular responses, signalling pathways, drug effects, and disease mechanisms in a controlled and replicable environment. This essay delves into the significance of assay development in cell culture, its methodologies, applications, and contributions to advancing scientific knowledge.
In conclusion, both cell strains and primary cells have played vital roles in advancing our understanding of cellular processes, disease mechanisms, and drug discovery. While cell strains provide a continuous and convenient supply of cells, primary cells offer a more authentic representation of human biology, enabling researchers to study specific tissues and diseases in a physiologically relevant context. The growth of cell strains and the significance of primary cells have propelled biomedical research forward, leading to breakthroughs in various fields and fostering the development of innovative therapeutic strategies. As technologies continue to evolve, primary cells will remain indispensable in further unraveling the complexities of human health and disease.
Cell culture is an essential technique used in many fields, including biotechnology, pharmaceuticals, and medical research. It involves the growth and maintenance of cells in a controlled environment, typically in a laboratory setting. Let’s explore some of the challenges and solution associated with scaling up cell culture.
Maintaining Cell Viability
Contamination
Optimization of Culture Medium
Scale-up Cost
Website:- https://kosheeka.com/
Primary human cells are cells that have been taken out of human tissues like bone marrow and blood. They are recognised as a crucial tool for developing in vivo models, such as xenograft or humanised mice, or for in vitro cell-based tests.
Cancer stem cells (CSC) are currently one of the most complex targets for cancer therapy. Cancer hierarchy has developed as a revolutionary framework over the last two decades, altering our understanding of tumour heterogeneity and cancer therapeutic administration.
KOSHEEKA is powered by Advancells: India’s premier regenerative medicine solution provider. We provide authentic, high quality, standard primary cells and stem cells required for scientific animal cell culture research and breakthrough in the field of healthcare.
Kosheeka is the premier provider of regenerative medicine solutions in India. The company
promotes the production of customized primary cells and stem cells essential for
groundbreaking scientific advancements. The company is a pioneer in stem cell research and
has established massive production of Mesenchymal Stem Cells (MSCs).
In vitro models are crucial tools in cancer research because they assist researchers to identify carcinogens, developing cancer therapies, drug discovery, and study about the molecular pathways of tumour growth and spread. Cancer cells are an essential part of any in vitro tumour model. Cancer cell lines are simple to culture, allow for quick comparisons of experiments, and are commonly employed to research tumour cell biology molecular pathways. Tumour cell biology, 3D cell culture, tissue engineering, biomaterials, microfabrication, and microfluidics advancements have facilitated the dynamic development of in vitro tumour models.
The pursuit of understanding cellular processes and their intricate interplay with external stimuli lies at the heart of modern biomedical research. In this context, assay development in cell culture has emerged as an indispensable tool, allowing scientists to investigate cellular responses, signalling pathways, drug effects, and disease mechanisms in a controlled and replicable environment. This essay delves into the significance of assay development in cell culture, its methodologies, applications, and contributions to advancing scientific knowledge.
In conclusion, both cell strains and primary cells have played vital roles in advancing our understanding of cellular processes, disease mechanisms, and drug discovery. While cell strains provide a continuous and convenient supply of cells, primary cells offer a more authentic representation of human biology, enabling researchers to study specific tissues and diseases in a physiologically relevant context. The growth of cell strains and the significance of primary cells have propelled biomedical research forward, leading to breakthroughs in various fields and fostering the development of innovative therapeutic strategies. As technologies continue to evolve, primary cells will remain indispensable in further unraveling the complexities of human health and disease.
Cell culture is an essential technique used in many fields, including biotechnology, pharmaceuticals, and medical research. It involves the growth and maintenance of cells in a controlled environment, typically in a laboratory setting. Let’s explore some of the challenges and solution associated with scaling up cell culture.
Maintaining Cell Viability
Contamination
Optimization of Culture Medium
Scale-up Cost
Website:- https://kosheeka.com/
Primary human cells are cells that have been taken out of human tissues like bone marrow and blood. They are recognised as a crucial tool for developing in vivo models, such as xenograft or humanised mice, or for in vitro cell-based tests.
Cancer stem cells (CSC) are currently one of the most complex targets for cancer therapy. Cancer hierarchy has developed as a revolutionary framework over the last two decades, altering our understanding of tumour heterogeneity and cancer therapeutic administration.
KOSHEEKA is powered by Advancells: India’s premier regenerative medicine solution provider. We provide authentic, high quality, standard primary cells and stem cells required for scientific animal cell culture research and breakthrough in the field of healthcare.
Kosheeka is the premier provider of regenerative medicine solutions in India. The company
promotes the production of customized primary cells and stem cells essential for
groundbreaking scientific advancements. The company is a pioneer in stem cell research and
has established massive production of Mesenchymal Stem Cells (MSCs).
In vitro models are crucial tools in cancer research because they assist researchers to identify carcinogens, developing cancer therapies, drug discovery, and study about the molecular pathways of tumour growth and spread. Cancer cells are an essential part of any in vitro tumour model. Cancer cell lines are simple to culture, allow for quick comparisons of experiments, and are commonly employed to research tumour cell biology molecular pathways. Tumour cell biology, 3D cell culture, tissue engineering, biomaterials, microfabrication, and microfluidics advancements have facilitated the dynamic development of in vitro tumour models.
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
This article is all about what AI trends will emerge in the field of creative operations in 2024. All the marketers and brand builders should be aware of these trends for their further use and save themselves some time!
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
2024 State of Marketing Report – by HubspotMarius Sescu
https://www.hubspot.com/state-of-marketing
· Scaling relationships and proving ROI
· Social media is the place for search, sales, and service
· Authentic influencer partnerships fuel brand growth
· The strongest connections happen via call, click, chat, and camera.
· Time saved with AI leads to more creative work
· Seeking: A single source of truth
· TLDR; Get on social, try AI, and align your systems.
· More human marketing, powered by robots
ChatGPT is a revolutionary addition to the world since its introduction in 2022. A big shift in the sector of information gathering and processing happened because of this chatbot. What is the story of ChatGPT? How is the bot responding to prompts and generating contents? Swipe through these slides prepared by Expeed Software, a web development company regarding the development and technical intricacies of ChatGPT!
Product Design Trends in 2024 | Teenage EngineeringsPixeldarts
The realm of product design is a constantly changing environment where technology and style intersect. Every year introduces fresh challenges and exciting trends that mold the future of this captivating art form. In this piece, we delve into the significant trends set to influence the look and functionality of product design in the year 2024.
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying it’s good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
This article is all about what AI trends will emerge in the field of creative operations in 2024. All the marketers and brand builders should be aware of these trends for their further use and save themselves some time!
A report by thenetworkone and Kurio.
The contributing experts and agencies are (in an alphabetical order): Sylwia Rytel, Social Media Supervisor, 180heartbeats + JUNG v MATT (PL), Sharlene Jenner, Vice President - Director of Engagement Strategy, Abelson Taylor (USA), Alex Casanovas, Digital Director, Atrevia (ES), Dora Beilin, Senior Social Strategist, Barrett Hoffher (USA), Min Seo, Campaign Director, Brand New Agency (KR), Deshé M. Gully, Associate Strategist, Day One Agency (USA), Francesca Trevisan, Strategist, Different (IT), Trevor Crossman, CX and Digital Transformation Director; Olivia Hussey, Strategic Planner; Simi Srinarula, Social Media Manager, The Hallway (AUS), James Hebbert, Managing Director, Hylink (CN / UK), Mundy Álvarez, Planning Director; Pedro Rojas, Social Media Manager; Pancho González, CCO, Inbrax (CH), Oana Oprea, Head of Digital Planning, Jam Session Agency (RO), Amy Bottrill, Social Account Director, Launch (UK), Gaby Arriaga, Founder, Leonardo1452 (MX), Shantesh S Row, Creative Director, Liwa (UAE), Rajesh Mehta, Chief Strategy Officer; Dhruv Gaur, Digital Planning Lead; Leonie Mergulhao, Account Supervisor - Social Media & PR, Medulla (IN), Aurelija Plioplytė, Head of Digital & Social, Not Perfect (LI), Daiana Khaidargaliyeva, Account Manager, Osaka Labs (UK / USA), Stefanie Söhnchen, Vice President Digital, PIABO Communications (DE), Elisabeth Winiartati, Managing Consultant, Head of Global Integrated Communications; Lydia Aprina, Account Manager, Integrated Marketing and Communications; Nita Prabowo, Account Manager, Integrated Marketing and Communications; Okhi, Web Developer, PNTR Group (ID), Kei Obusan, Insights Director; Daffi Ranandi, Insights Manager, Radarr (SG), Gautam Reghunath, Co-founder & CEO, Talented (IN), Donagh Humphreys, Head of Social and Digital Innovation, THINKHOUSE (IRE), Sarah Yim, Strategy Director, Zulu Alpha Kilo (CA).
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
It’s important that you’re ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
You’ll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If you’re looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
The six step guide to practical project management
If you think managing projects is too difficult, think again.
We’ve stripped back project management processes to the
basics – to make it quicker and easier, without sacrificing
the vital ingredients for success.
“If you’re looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.”
Dr Andrew Makar, Tactical Project Management
Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...
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i
v
e
dMS
C
s
:
A
d
i
p
o
s
et
i
s
s
u
e
,
a
l
s
ok
n
o
w
na
sf
a
t
t
i
s
s
u
e
,
i
sa
n
o
t
h
e
rs
o
u
r
c
eo
f
MS
C
s
.
A
d
i
p
o
s
et
i
s
s
u
e
-
d
e
r
i
v
e
dMS
C
sa
r
es
i
mi
l
a
rt
ob
o
n
ema
r
-
r
o
w
-
d
e
r
i
v
e
dMS
C
si
nt
e
r
mso
f
t
h
e
i
rp
o
t
e
n
t
i
a
l
f
o
rd
i
f
f
e
r
e
n
t
i
a
t
i
o
n
a
n
da
b
i
l
i
t
yt
os
e
l
f
-
r
e
n
e
w
.
2
.
A
d
i
p
o
s
eT
i
s
s
u
e
-
D
e
r
i
v
e
dMS
C
s
:
T
y
p
e
so
f
Me
s
e
n
c
h
y
ma
l
S
t
e
m C
e
l
l
s
2. U
mb
i
l
i
c
a
l
c
o
r
di
sar
i
c
hs
o
u
r
c
eo
f
MS
C
st
h
a
t
c
a
nb
eh
a
r
v
e
s
t
e
d
f
r
o
m t
h
e u
mb
i
l
i
c
a
lc
o
r
d b
l
o
o
d a
n
d Wh
a
r
t
o
n
'
sj
e
l
l
y
.U
mb
i
l
i
c
a
l
c
o
r
d
-
d
e
r
i
v
e
dMS
C
sh
a
v
et
h
ep
o
t
e
n
t
i
a
l
t
od
i
f
f
e
r
e
n
t
i
a
t
ei
n
t
oav
a
r
i
-
e
t
yo
f
c
e
l
l
t
y
p
e
s
,
i
n
c
l
u
d
i
n
gmu
s
c
l
e
,
b
o
n
e
,
a
n
dc
a
r
t
i
l
a
g
ec
e
l
l
s
.
D
e
n
t
a
l
p
u
l
pi
st
h
es
o
f
t
t
i
s
s
u
el
o
c
a
t
e
da
t
t
h
ec
e
n
t
r
eo
f
t
e
e
t
ha
n
d
i
sas
o
u
r
c
eo
f
MS
C
s
.
D
e
n
t
a
l
p
u
l
p
-
d
e
r
i
v
e
dMS
C
sh
a
v
et
h
ep
o
t
e
n
-
t
i
a
l
t
od
i
f
f
e
r
e
n
t
i
a
t
ei
n
t
oav
a
r
i
e
t
yo
f
c
e
l
l
t
y
p
e
s
,
i
n
c
l
u
d
i
n
gb
o
n
e
,
c
a
r
t
i
l
a
g
e
,
a
n
dn
e
r
v
ec
e
l
l
s
.
S
y
n
o
v
i
u
m i
st
h
el
i
n
i
n
go
f
j
o
i
n
t
sa
n
di
sas
o
u
r
c
eo
f
MS
C
s
.
S
y
n
o
v
i
-
a
l
-
d
e
r
i
v
e
dMS
C
sh
a
v
et
h
ep
o
t
e
n
t
i
a
l
t
od
i
f
f
e
r
e
n
t
i
a
t
ei
n
t
oav
a
r
i
e
t
y
o
f
c
e
l
l
t
y
p
e
s
,
i
n
c
l
u
d
i
n
gc
a
r
t
i
l
a
g
ea
n
dmu
s
c
l
ec
e
l
l
s
.
3
.
U
mb
i
l
i
c
a
l
C
o
r
d
-
D
e
r
i
v
e
dMS
C
s
:
4
.
D
e
n
t
a
l
P
u
l
p
-
D
e
r
i
v
e
dMS
C
s
:
5
.
S
y
n
o
v
i
a
l
-
D
e
r
i
v
e
dMS
C
s
:
I
nc
o
n
c
l
u
s
i
o
n
,
MS
C
sa
r
eat
y
p
eo
f
a
d
u
l
t
s
t
e
m c
e
l
l
w
i
t
ht
h
ep
o
t
e
n
t
i
a
l
f
o
r
d
i
f
f
e
r
e
n
t
i
a
-
t
i
o
ni
n
t
oav
a
r
i
e
t
yo
f
c
e
l
l
t
y
p
e
s
.
T
h
e
r
ea
r
es
e
v
e
r
a
l
t
y
p
e
so
f
MS
C
s
,
w
h
i
c
hc
a
nb
ec
a
t
-
e
g
o
r
i
z
e
db
a
s
e
do
nt
h
e
i
r
o
r
i
g
i
na
n
dp
o
t
e
n
t
i
a
l
f
o
r
d
i
f
f
e
r
e
n
t
i
a
t
i
o
n
.
T
h
eu
s
eo
f
MS
C
s
f
o
r
r
e
g
e
n
e
r
a
t
i
v
eme
d
i
c
i
n
ea
n
dc
e
l
l
t
h
e
r
a
p
yh
o
l
d
sg
r
e
a
t
p
r
o
mi
s
ef
o
r
t
h
et
r
e
a
t
me
n
t
o
f
av
a
r
i
e
t
yo
f
d
i
s
e
a
s
e
sa
n
di
n
j
u
r
i
e
s
.