People are exposed to harmful substances at every stage of the building materials lifecycle, from extraction and manufacturing to construction, occupation, and demolition. Exposure can occur through inhalation of airborne contaminants, ingestion of contaminated water or food, and dermal contact. Substances of concern that pose health risks at various lifecycle stages include cadmium, mercury, phthalates, dioxins, and lead. These substances are linked to issues like cancer, neurological and reproductive harm, and impaired development.