David Raminfard, president of Kaslen Textiles, emphasizes the importance of thread count as a measure of fabric quality, indicating the density of threads in a square inch. While a higher thread count can enhance softness and comfort, the quality of yarn and weave type also play crucial roles in defining fabric comfort. The ideal thread count for a balance of softness and breathability is often found around 400, as counts above 600-800 may hinder airflow.