The document summarizes a study on the prevalence of metabolic syndrome in patients with acute stroke in Yemen. The study found that:
1) The prevalence of metabolic syndrome in acute stroke patients was 39.5%, with males more affected than females.
2) Hypertension was the most common metabolic comorbidity in stroke patients with metabolic syndrome, while central obesity was the least common.
3) The authors conclude that metabolic syndrome is common in stroke patients, which could be explained by metabolic syndrome itself or other metabolic comorbidities often associated with it.
CVD Egypt Clinical Diabetes Reprint Summer 2010Mahmoud IBRAHIM
This document summarizes a study on screening Egyptian patients for diabetes and cardiovascular risk factors. The study found:
- 22.9% of patients had diabetes, 30.7% had hypertension, 33.4% had dyslipidemia, and 43% were smokers.
- Cardiovascular risk factors were more prevalent in females (57.7%) and urban populations (72.2%).
- Obesity affected 29% of patients and was correlated with higher blood pressure. Family history of diabetes was associated with higher BMI, waist circumference, blood sugar, and triglycerides.
- The high prevalence of risk factors indicates a need for national prevention programs in Egypt targeting obesity, diabetes, hypertension
Abstract— Non Alcoholic Fatty Liver Disease is also becoming public health impotance nowadays. So this study was aimed to determine the association of Non Alcoholic Fatty Liver Disease with metabolic syndrome and Cardio-Vascular disease along with assessment of degree of severity of NAFLD with respect to number of components of metabolic syndrome. This study includes a total of 222 subjects were enrolled as per the inclusion/exclusion criteria, out of which 110 cases who had NAFLD with hepatic steatosis on ultrasonography and 112 subjects who did not have NAFLD were considered control. These cases and controls were interrogated and investigated further. Observations were recorded and association of Non Alcoholic Fatty Liver Disease with metabolic syndrome and Cardio-Vascular disease along with assessment of degree of severity of NAFLD with respect to number of components of metabolic syndrome. Statistical methods used were unpaired student’s t-test for continuous variables, Fischer’s and chi-sq test for categorical variables using bivariate analysis by Graph Pad Instat Version 3.10. Risk was assessed in terms of Odd's Ratio. The patients with MS and NAFLD had a higher proportion of CVD compared with those who did not have NAFLD (29.1 vs 18.1 %). This study concludes that NAFLD is significantly associated with MS; most significant with WC, followed by TG and FBS and thus can be considered as hepatic component of MS. This needs more research with large multi-centric prospective studies to evaluate NAFLD as an independent risk factor for CVD.
This document provides information about the 7th International Conference on Biotechnology, Bioinformatics, Bio Medical Sciences and Stem Cell Applications that was held from November 11-12, 2016 at the Nanyang Technological University in Singapore. It lists the conference venue and contact information. It also provides details about the plenary speaker, Yoshiko Yamaguchi, and includes the abstract of a study presented on hypertension in Sohag City, Egypt.
This study examined the prevalence of metabolic syndrome (MS) among 200 obese patients in Yemen. The overall prevalence of MS was 46%, with no significant difference between men and women. High blood pressure was the most common comorbidity, present in 68% of patients with MS. Other common comorbidities included high triglycerides (66%), low HDL cholesterol (64%), and high fasting blood glucose (41%). The results indicate a high prevalence of MS and its components among obese Yemeni patients, highlighting an urgent need for strategies to prevent and treat MS and related conditions like cardiovascular disease and diabetes.
Renal disease in diabetes from prediabetes to late vasculopathy complication...nephro mih
This document provides information about Prof Basset El Essawy's qualifications and a lecture on renal disease in diabetes. It discusses epidemiological data on diabetic kidney disease prevalence in the US, summarizes findings from large diabetes treatment trials, and defines insulin resistance and prediabetes. It also covers prediabetes and nephropathy, presents case studies, and examines insulin resistance and vascular calcification.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay
CVD Egypt Clinical Diabetes Reprint Summer 2010Mahmoud IBRAHIM
This document summarizes a study on screening Egyptian patients for diabetes and cardiovascular risk factors. The study found:
- 22.9% of patients had diabetes, 30.7% had hypertension, 33.4% had dyslipidemia, and 43% were smokers.
- Cardiovascular risk factors were more prevalent in females (57.7%) and urban populations (72.2%).
- Obesity affected 29% of patients and was correlated with higher blood pressure. Family history of diabetes was associated with higher BMI, waist circumference, blood sugar, and triglycerides.
- The high prevalence of risk factors indicates a need for national prevention programs in Egypt targeting obesity, diabetes, hypertension
Abstract— Non Alcoholic Fatty Liver Disease is also becoming public health impotance nowadays. So this study was aimed to determine the association of Non Alcoholic Fatty Liver Disease with metabolic syndrome and Cardio-Vascular disease along with assessment of degree of severity of NAFLD with respect to number of components of metabolic syndrome. This study includes a total of 222 subjects were enrolled as per the inclusion/exclusion criteria, out of which 110 cases who had NAFLD with hepatic steatosis on ultrasonography and 112 subjects who did not have NAFLD were considered control. These cases and controls were interrogated and investigated further. Observations were recorded and association of Non Alcoholic Fatty Liver Disease with metabolic syndrome and Cardio-Vascular disease along with assessment of degree of severity of NAFLD with respect to number of components of metabolic syndrome. Statistical methods used were unpaired student’s t-test for continuous variables, Fischer’s and chi-sq test for categorical variables using bivariate analysis by Graph Pad Instat Version 3.10. Risk was assessed in terms of Odd's Ratio. The patients with MS and NAFLD had a higher proportion of CVD compared with those who did not have NAFLD (29.1 vs 18.1 %). This study concludes that NAFLD is significantly associated with MS; most significant with WC, followed by TG and FBS and thus can be considered as hepatic component of MS. This needs more research with large multi-centric prospective studies to evaluate NAFLD as an independent risk factor for CVD.
This document provides information about the 7th International Conference on Biotechnology, Bioinformatics, Bio Medical Sciences and Stem Cell Applications that was held from November 11-12, 2016 at the Nanyang Technological University in Singapore. It lists the conference venue and contact information. It also provides details about the plenary speaker, Yoshiko Yamaguchi, and includes the abstract of a study presented on hypertension in Sohag City, Egypt.
This study examined the prevalence of metabolic syndrome (MS) among 200 obese patients in Yemen. The overall prevalence of MS was 46%, with no significant difference between men and women. High blood pressure was the most common comorbidity, present in 68% of patients with MS. Other common comorbidities included high triglycerides (66%), low HDL cholesterol (64%), and high fasting blood glucose (41%). The results indicate a high prevalence of MS and its components among obese Yemeni patients, highlighting an urgent need for strategies to prevent and treat MS and related conditions like cardiovascular disease and diabetes.
Renal disease in diabetes from prediabetes to late vasculopathy complication...nephro mih
This document provides information about Prof Basset El Essawy's qualifications and a lecture on renal disease in diabetes. It discusses epidemiological data on diabetic kidney disease prevalence in the US, summarizes findings from large diabetes treatment trials, and defines insulin resistance and prediabetes. It also covers prediabetes and nephropathy, presents case studies, and examines insulin resistance and vascular calcification.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
All manuscripts are subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication in another journal) will be published without delay
Prospective Cohort Study for Cardiovascular Intervention Medical research- Pu...Pubrica
Cohort studies are the analytical design of observational studies that are epidemiologically used to identify and quantify the relationship between exposure and outcome
This article will provide knowledge about Designing A Prospective Cohort Study For Cardiovascular Intervention
Learn More: https://bit.ly/2NOP5ZX
Contact us:
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom : +44-1143520021
Interheart risk modifiable factors in micardio infraction 2004Medicina
This document summarizes the objectives and methods of the INTERHEART study, a large international case-control study designed to assess the importance of cardiovascular risk factors worldwide. The study aimed to enroll approximately 15,000 cases of acute myocardial infarction and a similar number of controls from 52 countries representing all inhabited continents. The study investigated the association between nine modifiable risk factors (smoking, lipids, hypertension, diabetes, obesity, diet, physical activity, alcohol consumption, psychosocial factors) and the risk of myocardial infarction. Standardized questionnaires and physical examinations were used to collect information from all participants. Blood samples were also collected to analyze lipid levels. The results of this large, global study could help determine if cardiovascular risk factors have similar or
Microalbuminuria in Saudi Adults with Type 1 Diabetes Mellitus_Crimson Publis...CrimsonPublishersIOD
Background: Diabetes mellitus is among the most common chronic non-communicable diseases. The development of microalbuminuria in type 1 diabetes increases the risk for renal and cardiovascular disease.
Methods: A cross sectional study was conducted at the Primary Health Care Clinics at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. A total of 334 Saudi with type 1 diabetes were randomly selected.
Results: Total of 334 patients with T2DM included in this study; 102 (30.5%) male and 232 (69.5%) female with mean age 25.8±3.4. MA was present in 99 (29.6%). MA was not significantly more prevalent in female (69.4%) with female predominance (sex ratio male: female) 1:2.3. HTN with MA was significantly more prevalent in 51(51.5%) of MA group with odd ratio 1.7 (1.2-2.4), p=0.001 with no siginificant difference between both gender. Patients with MA have significant higher HbA1c than patients with normal buminuria and there was a significant difference between gender (p< 0.0001) and when compared to HbA1c groups (p=0.002).
Conclusion: The frequency of microalbuminuria in patients with type 1 diabetes in this study is high. It is mandatory to have adequate diagnostic, therapeutic and educational resources in addition to competent physicians who can manage microalbuminuria in diabetic patients by using a continuing, comprehensive and coordinated approach.
This study estimated the prevalence of chronic kidney disease (CKD) among 132 patients attending a diabetes clinic in Jamaica. Approximately 86% of patients had CKD based on estimated glomerular filtration rate (eGFR) below 60 or albuminuria of 30 mg/g or higher. Over 20% had moderate albuminuria and 62% had severe albuminuria. Based on risk categories from the KDIGO guidelines, 51% were at high risk and 17% at very high risk of adverse outcomes like mortality, cardiovascular disease, and kidney failure. The high prevalence of CKD and risk of adverse outcomes shows the need for further studies on preventing CKD in diabetes patients in developing countries.
Frequency of metabolic syndrome and its’ variousSamiullah Shaikh
This study examined the frequency of metabolic syndrome and its components in 357 patients with ischemic stroke in Pakistan. The researchers found that metabolic syndrome was present in 46.2% of patients, with the three most common components being high waist circumference (34.5%), high fasting blood sugar (35.3%), and low HDL cholesterol (26.5-73.5%). Female patients accounted for 75.2% of those with metabolic syndrome. The results suggest metabolic syndrome is a frequent occurrence in patients with ischemic stroke and its components are strongly associated with increased risk of the condition.
The document summarizes a study that examined the prevalence of metabolic syndrome across 7 Latin American cities according to NCEP ATP III criteria. Key findings include:
1) Metabolic syndrome prevalence ranged from 14% to 27% across cities, highest in Mexico City and Barquisimeto, and lowest in Quito.
2) Prevalence increased with age and more number of metabolic syndrome components.
3) Participants with metabolic syndrome had higher carotid intima-media thickness and more prevalent carotid plaque than those without.
4) Over half of individuals with certain metabolic abnormalities like high triglycerides or glucose issues met criteria for full metabolic syndrome.
The document summarizes a study that examined the prevalence of metabolic syndrome across 7 Latin American cities according to NCEP ATP III criteria. Key findings include:
1) Metabolic syndrome prevalence ranged from 14% to 27% across cities, highest in Mexico City and Barquisimeto, and lowest in Quito.
2) Prevalence increased with age and more number of metabolic syndrome components.
3) Participants with metabolic syndrome had higher carotid intima-media thickness and more prevalent carotid plaque than those without.
4) Over half of individuals with certain metabolic abnormalities like high triglycerides or glucose issues met criteria for full metabolic syndrome.
Core Components of the Metabolic Syndrome in Nonalcohlic Fatty Liver DiseaseIOSR Journals
This study examined the association between nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) in Bangladeshi patients. The study included 67 patients diagnosed with NAFLD and 50 healthy controls matched for age and BMI. Results found that NAFLD patients had higher levels of insulin resistance, triglycerides, and central obesity compared to controls. However, no significant association was found between MetS and NAFLD when defined by common diagnostic criteria. Individual components of MetS like dyslipidemia, central obesity, and high postprandial glucose were significantly associated with NAFLD on logistic regression analysis. The study concludes that while various MetS components are linked to NAFLD in
This study compared the 7-year risk of heart attack in people with and without type 2 diabetes. It found:
1) The risk of heart attack over 7 years was much higher in people with prior heart attack (18.8% without diabetes, 45% with diabetes) compared to those without (3.5% without diabetes, 20.2% with diabetes).
2) People with diabetes but no prior heart attack had a similar risk of death from heart disease as people without diabetes but with a prior heart attack.
3) These findings suggest that people with diabetes should be treated as aggressively for cardiovascular risk factors as nondiabetic people with established heart disease.
Clinical, laboratory and histological associations in clinical, laboratory an...Dr. sreeremya S
Clinical, laboratory and histological associations in clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease
This study examined risk factors for post-transplant erythrocytosis (PTE) in 235 kidney transplant recipients. The results showed that being male significantly increased the risk of developing PTE. Patients with polycystic kidney disease or glomerulonephritis also had a higher risk. While smoking was associated with PTE, further analysis revealed this was likely due to the relationship between smoking and male sex rather than a direct effect. The study did not find significant relationships between PTE and other factors like hypertension, diabetes, transplant organ source, or immunosuppressant regimen.
Clinically inapparent adrenal masses which are incidentally detected have become a common problem in everyday practice. Approximately 5-20% of adrenal incidentalomas present subclini- cal cortisol hypersecretion which is characterized by subtle alterations of the hypothalamic- pituitary-adrenal axis due to adrenal autonomy. this disorder has been described as subclinical cushing’s syndrome, since there is no typical clinical phenotype. the diagnosis of subclinical cushing’s syndrome is based on biochemical evaluation; however, there is still no consensus for the biochemical diagnostic criteria. An abnormal 1mg dexamethasone suppression test (Dst) as initial screening test in combination with at least one other abnormal test of the hypothalamic-pituitary-adrenal axis has been advocated by most experts for the diagnosis of subclinical cushing’s syndrome. Dst is the main method of establishing the diagnosis, while there is inhomogeneity of the information that other tests provide. Arterial hypertension, diabetes mellitus type 2 or impaired glucose tolerance, central obesity, osteoporosis/vertebral fractures and dyslipidemia are considered as detrimental effects of chronic subtle cortisol excess, although there is no proven causal relationship between subclinical cortisol hyperse- cretion and these morbidities. therapeutic strategies include careful observation along with medical treatment of morbidities potentially related to subtle cortisol hypersecretion versus laparoscopic adrenalectomy. the optimal management of patients with subclinical cushing’s syndrome is not yet defined. the conservative approach is appropriate for the majority of these patients; however, the duration of follow-up and the frequency of periodical evaluation still remain open issues. surgical resection may be beneficial for patients with hypertension, diabetes mellitus type 2 or abnormal glucose tolerance and obesity.
This study evaluated the impact of diabetes mellitus and obesity on male infertility in Iraqi patients. It found that:
1) Serum levels of HbA1C, a marker of long-term blood sugar control, were higher in diabetic patients regardless of BMI compared to healthy controls. HbA1C was also higher in normo-BMI diabetic patients compared to obese diabetic patients.
2) Serum free testosterone levels, important for male fertility, were significantly lower in obese diabetic patients compared to overweight diabetic and healthy patients.
3) There was a significant negative correlation between serum free testosterone levels and HbA1C in obese diabetic patients, suggesting poorer blood sugar control is associated with lower testosterone.
Background; Myocardial Infarction (MI) is a term which is used for defining the necrosis in the heart muscle due to the lack of the oxygen need of myocardium which cannot be supplied by the coronaries. Aim: This study was carried out to determine the effects of some lifestyle and anthropometric parameters on some cardiac enzymes. Methods: A total of 146 students of sex, age bracket, (16 - 30) were recruited for this study. Enzymatic methods were used in the determination of AST, ALT, CKMB activities. Anthropometric measurements of the participants were taken. The result showed that there was significant increase in systolic blood pressure (SBP), weight and height (p<0.05), but there was no significant increase in their diastolic blood pressure (DBP) and body mass index (BMI) (p>0.05) in the serum ALT, AST, and CKMB activities. However, there was significant difference in ALT and AST activities (P<0.05) but there was no significant difference in serum CKMB activity (P>0.05). Statistically the percentage of the participants that had their serum ALT activity above the reference range were 16.6%, those within the reference range were 83.4%,. In serum AST activity, the percentage above the reference range were 19.9%, those within the reference range were 80.1%. Meanwhile, in serum CK-MB activity, those above the reference range were 25.2% while those within the reference range were 74.8%. Conclusion: This could be probably indicate that the leakage of AST and ALT activities may be of hepatic origin. . The non-significant increase in CKMB which is a specific marker of myocardial injury, could suggest that the subjects were not at risk of developing of myocardial infarction as regards their age.
This study examined the association between preoperative serum potassium levels and perioperative outcomes in 2402 patients undergoing elective cardiac surgery. The study found that serum potassium levels below 3.5 mmol/L were associated with increased risks of perioperative arrhythmias, intraoperative arrhythmias, and postoperative atrial fibrillation/flutter. Lower potassium levels were also linked to greater needs for cardiopulmonary resuscitation, though this association was not statistically significant after adjusting for confounding factors. The results suggest that screening for and correcting hypokalemia prior to cardiac surgery could help mitigate adverse perioperative events.
The document describes a conference on biotechnology, bioinformatics, biomedical sciences and stem cell applications taking place from November 11-12, 2016 in Singapore. It provides the conference schedule, list of speakers, and abstracts of papers being presented on topics related to diabetes, hypertension, cardiovascular disease, cognitive functions and thrombogenesis. The conference will bring together researchers from various universities and institutions in Asia to present and discuss their work in healthcare, life sciences and stem cell applications.
Microalbuminuria is an established risk marker for cardiovascular disease. It is defined as a urinary albumin excretion of 30-300 mg per 24 hours or an albumin-to-creatinine ratio of 30-300 mg/g. Studies have shown microalbuminuria to be associated with increased risk of cardiovascular events and mortality in the general population as well as in patients with diabetes, hypertension, and other risk factors. Even microalbuminuria levels within the normal range have been linked to early signs of atherosclerosis. Microalbuminuria reflects widespread vascular damage and is likely caused by endothelial dysfunction and activation of mediators like the renin-angiotensin-aldosterone system.
Relative risk of cardiovascular morbidity is increased in Chronic Kidney Disease (CKD). According to current KDIGO guideline
cardiovascular risk can be estimated from Glomerular Filtration Rate (GFR) and proteinuria.
Metabolic syndrome (MetS) predicts cardiovascular and cerebrovascular events over 20 years of follow-up. A study of 529 asymptomatic patients with MetS at baseline found they experienced 199 cardiovascular adverse events, compared to 120 events for 278 healthy controls, with an odds ratio of 2.3. Multivariate analysis identified MetS, BMI, C-reactive protein levels, and preclinical atherosclerosis as independent predictors of cardiovascular events over the 20 year period. Subclinical atherosclerosis was more prevalent in patients with MetS compared to controls. MetS significantly increased the risk of total cardiovascular, cerebrovascular, myocardial infarction and angina events over the long term follow-up period.
Prospective Cohort Study for Cardiovascular Intervention Medical research- Pu...Pubrica
Cohort studies are the analytical design of observational studies that are epidemiologically used to identify and quantify the relationship between exposure and outcome
This article will provide knowledge about Designing A Prospective Cohort Study For Cardiovascular Intervention
Learn More: https://bit.ly/2NOP5ZX
Contact us:
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom : +44-1143520021
Interheart risk modifiable factors in micardio infraction 2004Medicina
This document summarizes the objectives and methods of the INTERHEART study, a large international case-control study designed to assess the importance of cardiovascular risk factors worldwide. The study aimed to enroll approximately 15,000 cases of acute myocardial infarction and a similar number of controls from 52 countries representing all inhabited continents. The study investigated the association between nine modifiable risk factors (smoking, lipids, hypertension, diabetes, obesity, diet, physical activity, alcohol consumption, psychosocial factors) and the risk of myocardial infarction. Standardized questionnaires and physical examinations were used to collect information from all participants. Blood samples were also collected to analyze lipid levels. The results of this large, global study could help determine if cardiovascular risk factors have similar or
Microalbuminuria in Saudi Adults with Type 1 Diabetes Mellitus_Crimson Publis...CrimsonPublishersIOD
Background: Diabetes mellitus is among the most common chronic non-communicable diseases. The development of microalbuminuria in type 1 diabetes increases the risk for renal and cardiovascular disease.
Methods: A cross sectional study was conducted at the Primary Health Care Clinics at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. A total of 334 Saudi with type 1 diabetes were randomly selected.
Results: Total of 334 patients with T2DM included in this study; 102 (30.5%) male and 232 (69.5%) female with mean age 25.8±3.4. MA was present in 99 (29.6%). MA was not significantly more prevalent in female (69.4%) with female predominance (sex ratio male: female) 1:2.3. HTN with MA was significantly more prevalent in 51(51.5%) of MA group with odd ratio 1.7 (1.2-2.4), p=0.001 with no siginificant difference between both gender. Patients with MA have significant higher HbA1c than patients with normal buminuria and there was a significant difference between gender (p< 0.0001) and when compared to HbA1c groups (p=0.002).
Conclusion: The frequency of microalbuminuria in patients with type 1 diabetes in this study is high. It is mandatory to have adequate diagnostic, therapeutic and educational resources in addition to competent physicians who can manage microalbuminuria in diabetic patients by using a continuing, comprehensive and coordinated approach.
This study estimated the prevalence of chronic kidney disease (CKD) among 132 patients attending a diabetes clinic in Jamaica. Approximately 86% of patients had CKD based on estimated glomerular filtration rate (eGFR) below 60 or albuminuria of 30 mg/g or higher. Over 20% had moderate albuminuria and 62% had severe albuminuria. Based on risk categories from the KDIGO guidelines, 51% were at high risk and 17% at very high risk of adverse outcomes like mortality, cardiovascular disease, and kidney failure. The high prevalence of CKD and risk of adverse outcomes shows the need for further studies on preventing CKD in diabetes patients in developing countries.
Frequency of metabolic syndrome and its’ variousSamiullah Shaikh
This study examined the frequency of metabolic syndrome and its components in 357 patients with ischemic stroke in Pakistan. The researchers found that metabolic syndrome was present in 46.2% of patients, with the three most common components being high waist circumference (34.5%), high fasting blood sugar (35.3%), and low HDL cholesterol (26.5-73.5%). Female patients accounted for 75.2% of those with metabolic syndrome. The results suggest metabolic syndrome is a frequent occurrence in patients with ischemic stroke and its components are strongly associated with increased risk of the condition.
The document summarizes a study that examined the prevalence of metabolic syndrome across 7 Latin American cities according to NCEP ATP III criteria. Key findings include:
1) Metabolic syndrome prevalence ranged from 14% to 27% across cities, highest in Mexico City and Barquisimeto, and lowest in Quito.
2) Prevalence increased with age and more number of metabolic syndrome components.
3) Participants with metabolic syndrome had higher carotid intima-media thickness and more prevalent carotid plaque than those without.
4) Over half of individuals with certain metabolic abnormalities like high triglycerides or glucose issues met criteria for full metabolic syndrome.
The document summarizes a study that examined the prevalence of metabolic syndrome across 7 Latin American cities according to NCEP ATP III criteria. Key findings include:
1) Metabolic syndrome prevalence ranged from 14% to 27% across cities, highest in Mexico City and Barquisimeto, and lowest in Quito.
2) Prevalence increased with age and more number of metabolic syndrome components.
3) Participants with metabolic syndrome had higher carotid intima-media thickness and more prevalent carotid plaque than those without.
4) Over half of individuals with certain metabolic abnormalities like high triglycerides or glucose issues met criteria for full metabolic syndrome.
Core Components of the Metabolic Syndrome in Nonalcohlic Fatty Liver DiseaseIOSR Journals
This study examined the association between nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) in Bangladeshi patients. The study included 67 patients diagnosed with NAFLD and 50 healthy controls matched for age and BMI. Results found that NAFLD patients had higher levels of insulin resistance, triglycerides, and central obesity compared to controls. However, no significant association was found between MetS and NAFLD when defined by common diagnostic criteria. Individual components of MetS like dyslipidemia, central obesity, and high postprandial glucose were significantly associated with NAFLD on logistic regression analysis. The study concludes that while various MetS components are linked to NAFLD in
This study compared the 7-year risk of heart attack in people with and without type 2 diabetes. It found:
1) The risk of heart attack over 7 years was much higher in people with prior heart attack (18.8% without diabetes, 45% with diabetes) compared to those without (3.5% without diabetes, 20.2% with diabetes).
2) People with diabetes but no prior heart attack had a similar risk of death from heart disease as people without diabetes but with a prior heart attack.
3) These findings suggest that people with diabetes should be treated as aggressively for cardiovascular risk factors as nondiabetic people with established heart disease.
Clinical, laboratory and histological associations in clinical, laboratory an...Dr. sreeremya S
Clinical, laboratory and histological associations in clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease
This study examined risk factors for post-transplant erythrocytosis (PTE) in 235 kidney transplant recipients. The results showed that being male significantly increased the risk of developing PTE. Patients with polycystic kidney disease or glomerulonephritis also had a higher risk. While smoking was associated with PTE, further analysis revealed this was likely due to the relationship between smoking and male sex rather than a direct effect. The study did not find significant relationships between PTE and other factors like hypertension, diabetes, transplant organ source, or immunosuppressant regimen.
Clinically inapparent adrenal masses which are incidentally detected have become a common problem in everyday practice. Approximately 5-20% of adrenal incidentalomas present subclini- cal cortisol hypersecretion which is characterized by subtle alterations of the hypothalamic- pituitary-adrenal axis due to adrenal autonomy. this disorder has been described as subclinical cushing’s syndrome, since there is no typical clinical phenotype. the diagnosis of subclinical cushing’s syndrome is based on biochemical evaluation; however, there is still no consensus for the biochemical diagnostic criteria. An abnormal 1mg dexamethasone suppression test (Dst) as initial screening test in combination with at least one other abnormal test of the hypothalamic-pituitary-adrenal axis has been advocated by most experts for the diagnosis of subclinical cushing’s syndrome. Dst is the main method of establishing the diagnosis, while there is inhomogeneity of the information that other tests provide. Arterial hypertension, diabetes mellitus type 2 or impaired glucose tolerance, central obesity, osteoporosis/vertebral fractures and dyslipidemia are considered as detrimental effects of chronic subtle cortisol excess, although there is no proven causal relationship between subclinical cortisol hyperse- cretion and these morbidities. therapeutic strategies include careful observation along with medical treatment of morbidities potentially related to subtle cortisol hypersecretion versus laparoscopic adrenalectomy. the optimal management of patients with subclinical cushing’s syndrome is not yet defined. the conservative approach is appropriate for the majority of these patients; however, the duration of follow-up and the frequency of periodical evaluation still remain open issues. surgical resection may be beneficial for patients with hypertension, diabetes mellitus type 2 or abnormal glucose tolerance and obesity.
This study evaluated the impact of diabetes mellitus and obesity on male infertility in Iraqi patients. It found that:
1) Serum levels of HbA1C, a marker of long-term blood sugar control, were higher in diabetic patients regardless of BMI compared to healthy controls. HbA1C was also higher in normo-BMI diabetic patients compared to obese diabetic patients.
2) Serum free testosterone levels, important for male fertility, were significantly lower in obese diabetic patients compared to overweight diabetic and healthy patients.
3) There was a significant negative correlation between serum free testosterone levels and HbA1C in obese diabetic patients, suggesting poorer blood sugar control is associated with lower testosterone.
Background; Myocardial Infarction (MI) is a term which is used for defining the necrosis in the heart muscle due to the lack of the oxygen need of myocardium which cannot be supplied by the coronaries. Aim: This study was carried out to determine the effects of some lifestyle and anthropometric parameters on some cardiac enzymes. Methods: A total of 146 students of sex, age bracket, (16 - 30) were recruited for this study. Enzymatic methods were used in the determination of AST, ALT, CKMB activities. Anthropometric measurements of the participants were taken. The result showed that there was significant increase in systolic blood pressure (SBP), weight and height (p<0.05), but there was no significant increase in their diastolic blood pressure (DBP) and body mass index (BMI) (p>0.05) in the serum ALT, AST, and CKMB activities. However, there was significant difference in ALT and AST activities (P<0.05) but there was no significant difference in serum CKMB activity (P>0.05). Statistically the percentage of the participants that had their serum ALT activity above the reference range were 16.6%, those within the reference range were 83.4%,. In serum AST activity, the percentage above the reference range were 19.9%, those within the reference range were 80.1%. Meanwhile, in serum CK-MB activity, those above the reference range were 25.2% while those within the reference range were 74.8%. Conclusion: This could be probably indicate that the leakage of AST and ALT activities may be of hepatic origin. . The non-significant increase in CKMB which is a specific marker of myocardial injury, could suggest that the subjects were not at risk of developing of myocardial infarction as regards their age.
This study examined the association between preoperative serum potassium levels and perioperative outcomes in 2402 patients undergoing elective cardiac surgery. The study found that serum potassium levels below 3.5 mmol/L were associated with increased risks of perioperative arrhythmias, intraoperative arrhythmias, and postoperative atrial fibrillation/flutter. Lower potassium levels were also linked to greater needs for cardiopulmonary resuscitation, though this association was not statistically significant after adjusting for confounding factors. The results suggest that screening for and correcting hypokalemia prior to cardiac surgery could help mitigate adverse perioperative events.
The document describes a conference on biotechnology, bioinformatics, biomedical sciences and stem cell applications taking place from November 11-12, 2016 in Singapore. It provides the conference schedule, list of speakers, and abstracts of papers being presented on topics related to diabetes, hypertension, cardiovascular disease, cognitive functions and thrombogenesis. The conference will bring together researchers from various universities and institutions in Asia to present and discuss their work in healthcare, life sciences and stem cell applications.
Microalbuminuria is an established risk marker for cardiovascular disease. It is defined as a urinary albumin excretion of 30-300 mg per 24 hours or an albumin-to-creatinine ratio of 30-300 mg/g. Studies have shown microalbuminuria to be associated with increased risk of cardiovascular events and mortality in the general population as well as in patients with diabetes, hypertension, and other risk factors. Even microalbuminuria levels within the normal range have been linked to early signs of atherosclerosis. Microalbuminuria reflects widespread vascular damage and is likely caused by endothelial dysfunction and activation of mediators like the renin-angiotensin-aldosterone system.
Relative risk of cardiovascular morbidity is increased in Chronic Kidney Disease (CKD). According to current KDIGO guideline
cardiovascular risk can be estimated from Glomerular Filtration Rate (GFR) and proteinuria.
Metabolic syndrome (MetS) predicts cardiovascular and cerebrovascular events over 20 years of follow-up. A study of 529 asymptomatic patients with MetS at baseline found they experienced 199 cardiovascular adverse events, compared to 120 events for 278 healthy controls, with an odds ratio of 2.3. Multivariate analysis identified MetS, BMI, C-reactive protein levels, and preclinical atherosclerosis as independent predictors of cardiovascular events over the 20 year period. Subclinical atherosclerosis was more prevalent in patients with MetS compared to controls. MetS significantly increased the risk of total cardiovascular, cerebrovascular, myocardial infarction and angina events over the long term follow-up period.
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Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
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1. 28
Journal of the Arab Board of Health Specializations Vol.11, No 4, 2010
Original Article أصيل مقال
ABStRACt
Objective:Theobjectiveofthestudyweretodetermine
theprevalenceandidentifytheassociatedandprognostic
factors that influence the risk of metabolic syndrome
among patients with acute stroke admitted to medical
department in AL-kuwait University Hospital(KUH) in
Sanaa city, Yemen.
Methods: The study population of this cross sectional
survey consisted of 331 patients recently diagnosed
with acute stroke in the period between (2009-2010).
Metabolic syndrome was defined according to the
National Cholesterol Education Program–Adult
Treatment Panel III (NCEP –ATP III) criteria
Results: The prevalence of metabolic syndrome in
our study was 39.5% males was more frequently affected
than females. Hypertension was the most metabolic
comorbiditiesinstrokepatientswithmetabolicsyndrome
while central obesity is the least.
Conclusions: We conclude that metabolic syndrome
was common in stroke patients which could be explained
by metabolic syndrome perse or due to different
metabolic co morbidities that are associated with it.
IntRoDuCtIon
Several studies showed high prevalence of the
metabolic syndrome in different high risk populations,1,2
but the magnitude of the metabolic syndrome MS
becomes apparent when in an apparently healthy
population prevalence of nearly 24% is found.3
In our
country there is no study dealing with the prevalence of
metabolic syndrome in acute stroke patients, therefore
we decided to start this study in Al-Kuwait University
Hospital (KUH) in Sanaa City aiming to provide more
information about the prevalence of MS and other
associated risk factors in patients with acute stroke.
THE PREVALENCE OF METABOLIC SYNDROME IN PATIENTS WITH STROKE
الدماغية السكتة مرضى لدى األيضية المتالزمة انتشار
Mohammed Bamashmoos, MD; Kalid Alagbary, MD; Faizaa Asker, MD
عسكر فايزة .د ،األغبري خالد .د ،بامشموس محمد .د
البحث ملخص
المقبولين الحادة الدماغية السكتة مرضى عند لها افقة
رالم يةراإلنذا املوالعو األيضية المتالزمة انتشار تحديد إلى اسة
رالد هذه تهدف :البحث هدف
.اليمن في صنعاء مدينة في الجامعي الكويت مشفى في
تم .)2010-2009( عامي بين ة
رالفت خالل الحادة الدماغية بالسكتة ًاحديث المشخصين من ًايضرم 331 المقطعية اسة
رالد هذه شملت :البحث طرق
.)NCEP-ATPIII( الثالث البالغين معالجة سلم معايير -التثقيفي الوطني الكولسترول نامجرلب ًاتبع األيضية المتالزمة يفرتع اعتماد
تفاعرا شكل .باإلناث ً
ةنرمقا المتالزمة بهذه للذكور أكبر تأثر لوحظ كما ،%39.5 اسة
رالد هذه في األيضية المتالزمة انتشار نسبة بلغت :النتائج
ة
راألخي تبةرالم يةزالمرك البدانة احتلت بينما ،األيضية بالمتالزمة المصابين الدماغية السكتة مرضى عند افقة
رالم اضية
راإلم املوالع أكثر يانيرالش التوتر
.افق
رم كعامل
إلى أو ،ذاتها بحد األيضية المتالزمة دور إلى ى
يعز ما وهو الدماغية السكتة مرضى عند األيضية المتالزمة ع
شيو اسة
رالد هذه تظهر :االستنتاجات
.لها افقة
رالم ى
األخر اضية
راإلم املوالع
*Mohammed Bamashmoos, MD, Assistant Professor of Internal Medicine, Sana'a University, Sana'a, Yemen. E-mail: mabamashmoos@yahoo.com.
*Kalid Alagbary, MD, Assistant Professor of Internal Medicine, Sana'a University, Sana'a, Yemen.
*Faizaa Asker, MD, Arab Board.
2. 29
Journal of the Arab Board of Health Specializations Vol.11, No 4, 2010
The presence of metabolic syndrome has been asso-
ciated with an increased risk of prevalent stroke in the
existing literature. In the National Health and Nutrition
Examination survey among 10357 subjects,4
the preva-
lence of metabolic syndrome was significantly higher
in persons with self reported history of stroke (43.5%)
than in subjects with no history of vascular disease
(22.8%).
Metabolic syndrome was independently associated
with stroke history in all ethnic groups and in both sexes
(OR, 2.16 ;95% CI, 1.48 to 3.160).5
The association
between metabolic syndrome and stroke has been
confirmed in other populations integrated by elderly
subjects, and the frequency of metabolic syndrome has
been reported to be significantly higher in patients with
a history of atherothrombotic or non embolic ischemic
stroke.5-6
MEtHoDS
Thesamplingframeofthisstudyincludedallnationals
and non-national patients who were admitted with acute
stroke toAl-Kuwait University Hospital (KUH) medical
departments in Sana'a city. The diagnosis of acute
stroke was defined as rapidly developing clinical signs
of focal or global disturbance of cerebral function of
presumed vascular origin lasting more than 24 hours.
In total, 400 patients were approached by the authors
out of which 331 (82.7%) patients agreed to enroll. The
study was approved by the Joint Ethics Committee of
the Faculty of Medicine and Health Sciences of Sanaa
University. The data were collected between May 2009
and May 2010.
Data collection
After receiving a prior informed consent (a written
one from literate patients and a verbally informed one
from illiterate patients), a standardised data sheet was
used to record the demographic variables including age,
sex and presence of DM. DM was defined as a fasting
plasma glucose level of > 7.8 mmol/l, random plasma
glucose of > 11.1 mmol/l, or the requirement of regular
hypoglycaemic drug(s). History of hypertension,
hyperlipedemia (high TG, low HDL, high LDL),
smoking and ischaemic heart disease was also recorded.
Hypertension was defined as a previous record of at
least two blood pressure reading of ≥130/85mmHg.
Hyperlipedemia was defined as serum TG ≥150 mg/
dl, Low HDL ≤40 mg/dl in males and ≤50 mg/dl in
females.
Waistcircumferencewasmeasuredwithatapmeasure
mid way between lower rib margin and the iliac crest.
Blood pressure was measured in the right arm of
seated subjects using mercury sphygmomanometer
after 10-15 minutes of rest. Each subject had two
measurements of blood pressure at 5-minutes. interval.
Venous blood sampling was performed in the morning
afteranovernightfastfordeterminationoffastingplasma
glucose, triglyceride, and high density lipoprotein.
Metabolic syndrome was diagnosed according to the
NCEP-ATP 111(4) as the presence of three or more of
the following five criteria:
- Waist circumference ≥103 cm in males, or ≥88 in
females.
- Blood pressure ≥130/85 mmHg.
- Triglycerides ≥150 mg/dl.
- High density lipoprotein ≤40 mg/dl in males or ≤50
mg/dl in females.
- Fasting blood sugar ≥110 mg/dl.
The results were expressed a s mean±SD. Statistical
analysis were performed using the statistical package
for the social sciences (window version 11.0; SPSS inc,
Chicago IL USA). Differences between groups were
tested statistically using the Chi square test. Data were
considered statistically significant when the p-value
was ≤0.05.
RESultS
We studied 331 consecutive acute stroke patients, 211
(63.7%) were males and 120 (36.2%) were females.
There age ranges were between 35-78 years, mean
(55±32), males being older than females. Of all studied
3. 30
Journal of the Arab Board of Health Specializations Vol.11, No 4, 2010
patients, 266 (80.3%) had ischemic stroke and 64
(19.6%) had hemorrhagic stroke.
Total (331)
Female (120)
Male (211)
Factors
35-70
40-78
Age, (years)
120 (36%)
35 (10%)
85 (25%)
Smoking habit
266 (80.3%)
95 (28.7%)
171 (51.6%)
ischemic
Stroke
type 65 (19.6%)
25 (7.5%)
40 (12%)
hemorrhagic
108 (32.6%)
43 (12.9%)
65 (19.6%)
Type-2 DM
25 (7.5%)
10 (3%)
15 (4.5%)
IFG
70 (21.1%)
39 (11.7%)
31 (9.%)
Waist circumference
184 (55.5%)
59 (17.8%)
125 (37.7%)
HTN
103 (31.1%)
37 (11%)
66 (19.9%)
TG mg/dI
88 (26.5%)
45 (13.5%)
43 (12.9%)
HDL mg/dI
131 (39.5%)
59 (17.8%)
72 (21.7%)
Metabolic syndrom
Table 1. Baseline characteristics of patients
with stroke.
The base line characteristics of patients with stroke is
shown in Table 1.
It shows that the most important risks factor in most
patients was hypertension (55.5%) and metabolic
syndrome (39.5%).
Other traditional risk factors like smoking, type-2
diabetes, obesity and dyslipidaemia (high TG, low
HDL) was seen in a less proportion of patients.
The overall prevalence of the metabolic syndrome
was 39.5%, with prevalence of 54.9% in males and 45%
in females. However, there is no significant difference
in the prevalence of metabolic syndrome between males
and females.
The physical and metabolic characteristics of stroke
patients with and without metabolic syndrome are
shown in Table 2.
The main age for patients with metabolic syndrome
was (58.5±43) versus (55.3±21) for patients without
metabolic syndrome p=0.001,Also metabolic syndrome
with stroke was more prevalent in males.
64.8% of patients with metabolic syndrome are
smokers versus 17.5% without metabolic syndrome
(p=0.0001).
There is no significant difference regarding the
prevalence of metabolic syndrome in patients with
either ischemic or hemorrhagic stroke (p=0.44).
Seventy seven percent (77%) of the stroke patients
with metabolic syndrome had raised blood pressure
versus 41.5% of patients without metabolic syndrome
(p-value=0.00001), while 74% of them had high
FBS or type 2 DM versus 18% had normal FBS
(p-value=0.00001), 53.4% had high serum TG versus
p-value
Without MS (200)
With MS (131)
All patients (331)
Factors
0.001
55.3±21
58.5±43
54±31
Age (years)
0.0071
139 (69.5%)
72 (54.9%)
211 (63.7%)
Male sex
35 (17.5%)
58 (64.8%)
120 (36.2)
Smoking
0.44
158 (79%)
108 (82.4%)
266 (80.3%)
ischemic
Type of
stroke 0.44
42 (21%)
23 (17.5%)
65 (19.6)
hemorrhagic
0.00001
36 (18%)
82 (62.5%)
108 (32.6%)
Type-2 DM
0.02
17 (8.5%)
8 (6%)
25 (7.5%)
IFG
0.0001
18 (9%)
52 (39.6%)
70 (21%)
Obesity
0.00001
83 (41.5%)
101 (77%)
184 (55.5%)
HTN
0.0001
33 (16.5%)
70 (53.4%)
103 (31.1%)
TG mg/dl
0.0001
22 (11%)
66 (50.3%)
88 (26.5%)
HDL mg/dl
Table 2. Physical and metabolic characteristics of stroke patients with and without metabolic syndrome.
4. 31
Journal of the Arab Board of Health Specializations Vol.11, No 4, 2010
16.5% had normal TG level (p-value=0.00001) 50.3%
had low HDL cholesterol versus 11% had normal HDL
cholesterol (p-value=0.0001).
The lowest prevalence of comorbidity in patients
with metabolic syndrome was obesity (39.6% VS 9%)
(p-value=0.0001).
DISCuSSIon
This study analyzes the prevalence of the metabolic
syndrome in stroke patients who attended the medical
department in (KUH) using the NCPE panel III criteria
for definition of the metabolic syndrome.
The result of this study provide valuable information
about the metabolic syndrome in patients with stroke.
The overall prevalence of the metabolic syndrome
among patients with stroke in the present study is 39.5%
which is equal to that in other comparable studies in
stroke patients conducted in Italy 40% and 40% in
Netherland.7,8
The similarity in the prevalence might
be due to the same definition used for the criteria of
metabolic syndrome in the different study population.
The increased prevalence of the metabolic syndrome
in patients with stroke may be explained by individual
risk factors of the metabolic syndrome in association
with other not routinely measured aspects of the
metabolic syndrome as impaired fibrinolysis oxidative
stress, increased small dense LDL, hypercoagulability,
inflammation and hyperinsulinemia.9
Patients with stroke and metabolic syndrome were
older than those without metabolic syndrome (mean
58.5±43 years).
The prevalence of individual metabolic comorbidities
of the metabolic syndrome in our study was high.
Hypertension (77%) was the most common finding in
our study. this was followed by the prevalence of type-2
diabetes and IFG (74%), high TG (53.4), low HDL
50.3% and obesity 39.6%.
Similar finding was observed in the study by Chen
et al in Taiwan,9
and by Arenilly et al in Spain10
where
elevated blood pressure or previously diagnosed
hypertension has high prevalence in patients with stroke
(68.9% and 68%) respectively.
Rodriguez, et al11
found that all metabolic syndrome
components contributed to stroke risk, they found that
groups with elevated blood pressure or elevated blood
sugar were at greatest risk for stroke.
Hypertension remain the most common modifiable
risk factors for stroke in population including the
elderly.12,13,14
Presence of hypertension as apart of metabolic
syndrome was associated with increased risk of acute
stroke. This association was high statistically significant
in our study between stroke patients with and without
metabolic syndrome (p-value=0.00001).
Many researchers believe that insulin resistance is the
patho physiological process underlining the clustering
of vascular risk factors in the metabolic syndrome.15
Indices of insulin resistance predict atherosclerosis
and vascular events independently of other risk factors
including fasting glucose and lipid levels.16
Current NCEP/ATP III guidelines used impaired
fasting glucose (>110 mg/dl or previously diagnosed
type-2 diabetes as one of criterion for identifying
subjects with metabolic syndrome, insulin resistance
with normal, impaired glucose tolerance or diabetes
may play a role as risk factors for stroke.
Dyslipidaemia is the hall mark of the metabolic
syndrome. Its characterized by elevated TG and low
HDL cholesterol levels.17,18
In our analysis there is a
significant correlation between high TG and low HDL
in stroke patients with and without metabolic syndrome.
There is controversy regarding the association between
serum TG levels and stroke.19
It has been shown that
postprandial hypertriglyceridemia is associated with
carotid artery atherosclerosis.20
Nonetheless, in the Copenhagen city heart study, a
long linear association between serumTG levels and non
5. 32
Journal of the Arab Board of Health Specializations Vol.11, No 4, 2010
hemorrhagic stroke was found, which was independent
of age and sex.21
Inthemajorityofstudies,therewasinverseassociation
between HDL–C and stroke.22,23
There is evidence that excess body weight is a
predictor of stroke (total, ischemic, hemorrhagic) in
men.23
Even though obesity is regarded as modifiable
risk factor for vascular disease, high value of waist
circumference increases the risk for stroke in 20 years
old men but not in women.
ConCluSIonS
We conclude that metabolic syndrome was common
in stroke patients which could be explained by the
metabolic syndrome perse or due to different metabolic
co morbidities that are associated with it.
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