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The Skinny on Fat
The document discusses the effects of excess energy on fat cells, including hyperplasia and hypertrophy, and their implications for obesity and metabolic health. It highlights issues like heart cell death, glucose production, and insulin secretion associated with excess energy. The author emphasizes the importance of understanding these factors in relation to obesity-related metabolic risks.
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The Skinny on Fat
- 1. The Skinny onFatPeter Janiszewski, PhD Candidate, MSc
- 17. Energy SurplusFat CellHyperplasiaFat Cell HypertrophySafe ObesityDangerous ObesityExcess energy bufferedExcess energy spillover↑ heart cell death↑ Glucose production↓ Insulin Secretion↑ Lipolysis↓ Glucose Uptake↑ ‘Bad’ adipokines↑ β-cell death↑ VLDL↓ Insulin ClearanceHealthy Metabolic ProfileMetabolic Risk
- 18.