Gel and acrylic nails differ in their application process, appearance, drying/curing time, flexibility, and removal method. Gel nails are applied in layers and cured under UV light while acrylic nails set naturally after applying the liquid and powder. Gel nails have a glossier look while acrylic nails appear sturdier. Acrylic nails dry faster than gel nails but gel nails require UV curing. Gel nails are more flexible but acrylic nails are more durable. Gel nails must be filed off for removal while acrylic nails are soaked and buffed.