Lymph nodes showed clearance via drainage and increased severity with dose response, though this may be non-adverse and a recovery study could help determine if it is adverse. Adrenal glands showed cortical necrosis in 2 out of 10 rats at the medium exposure, which is considered a severe response, so the no observed adverse effect level is the low exposure.

1. Lymph Node
• Clearance via lymph node drainage is a part of
normal lymph node physiology
• Not adverse unless severe and associated with
necrosis
Although there is a dose response and increased severity, this change
may be non-adverse. A recovery study would help resolve this issue.

2. Adrenal
• Adrenal cortical necrosis is adverse
• The 2/10 incidence at the medium
exposure is a severe response
• The NOAEL is the low exposure