The T cell receptor (TCR), found on the surface of T cells, is responsible for antigen recognition. It consists of two chains: the alpha (α) and beta (β) chains. Both chains have a constant region (c) and a variable region (v), and it is the variable region that determines antigen specificity. The TCR is associated with the CD3 complex, which comprises three transmembrane signalling molecules (CD3ζζ, CD3δε and CD3γε).

1. TCR T development
www.creative-biolabs.com/car-t

2. The T cell receptor (TCR), found on the surface of T
cells, is responsible for antigen recognition. It
consists of two chains: the alpha (α) and beta (β)
chains. Both chains have a constant region (c) and a
variable region (v), and it is the variable region that
determines antigen specificity. The TCR is
associated with the CD3 complex, which comprises
three transmembrane signalling molecules (CD3ζζ,
CD3δε and CD3γε).
TCR

3. Altering the specificity of T cell receptor (TCR) is
one of the popular strategies to genetically modify T
cells to enhance the tumor-killing activity of T cells.
With high-affinity TCR technology, Creative
Biolabs is capable of identifying the candidate target
tumor antigen and the sequence of tumor-specific
TCR to create tumor-specific T cells.
TCR Engineering

4. A TCR will interact with an antigen on a target cell
when the target peptide sequence is presented by the
appropriate major histocompatibility complex
(MHC-1 for cytotoxic T cells). Efficient T-cell
activation also requires the simultaneous binding of
the T cell co-receptor (CD8 for cytotoxic T cells).
ss, disulphide bridge.
TCR technology

5. Creative Biolabs
As a global company, we have more than 200
talented and well-trained scientists located in
different continents working closely with
partners from the entire world to develop and
produce medicines of tomorrow. Specifically,
we are the established leading expert in TCR
and CAR T&NK cell immune therapy
development, as we offer the one-stop custom
services that cover the entire new drug
development pipeline.

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