This document discusses advanced process control techniques that can be applied in pharmaceutical manufacturing. It begins by defining basic process control concepts. Then it discusses the benefits of advanced process control, such as improved quality, increased production, and reduced costs. Several advanced control techniques are described, including model predictive control, Kalman filters, neural networks, and linear programming optimization. The document argues that techniques used successfully in other industries can be adapted for pharmaceutical applications to further improve process performance and product quality.
This document discusses advanced process control techniques that can be applied in pharmaceutical manufacturing. It begins by defining basic process control concepts. Then it discusses the benefits of advanced process control, such as improved quality, increased production, and reduced costs. Several advanced control techniques are described, including model predictive control, Kalman filters, neural networks, and linear programming optimization. The document argues that techniques used successfully in other industries can be adapted for pharmaceutical applications to further improve process performance and product quality.
This document is a resume for Stephen Oyetunji, an experienced engineer with over 20 years of experience in the oil and gas industry. He has held roles such as Assistant Chief Observer and Head of Recording, where he oversaw seismic data acquisition projects and quality control. His background includes experience operating seismic data acquisition equipment, ensuring health and safety compliance, and supervising recording crews of up to 400 people. He also has a Master's degree in Business Administration and a Bachelor's degree in Electrical and Electronics Engineering.
This document describes implementing real-time non-linear regression models in a DeltaV controller to determine chromatography elution endpoints. Three models were used - smoothing, linear regression, and a non-linear extreme value function. The non-linear model fits peak data to an extreme value function using Newton-Raphson iterative numerical solving to determine peak height, width, and retention time. This allows calculating the endpoint as a percentage of peak maximum. The model was validated against laboratory data to within acceptable error ranges and allows robust, real-time endpoint determination for chromatography processes.
This document summarizes the development of a control system for a continuous pharmaceutical tablet manufacturing process using direct compaction. It describes integrating process analytical technology (PAT) tools like NIR spectroscopy with a DeltaV control system using SynTQ and MATLAB. A prediction model is built in UnscramblerX from NIR spectra to monitor the API composition. Different control strategies like MPC, PID, and Smith predictor are implemented and evaluated in DeltaV. The performance is assessed using a gPROMS model. The developed control system enables flexible control of the continuous tablet manufacturing process.
Applying Batch Data Principles to Continuous Manufacturing AIChE FinalPaul Brodbeck
RTD models enable the application of traditional batch reporting and analysis techniques to continuous manufacturing processes. RTD models represent the relationship between input and output concentrations in a unit operation over time. By integrating individual unit operation RTD models, a full line RTD can be achieved to enable material tracing from raw materials to final product for continuous pharmaceutical manufacturing. Reporting architectures are also discussed that utilize an RTD model-driven contextualization approach for continuous process reporting.
This document is a resume for Stephen Oyetunji, an experienced engineer with over 20 years of experience in the oil and gas industry. He has held roles such as Assistant Chief Observer and Head of Recording, where he oversaw seismic data acquisition projects and quality control. His background includes experience operating seismic data acquisition equipment, ensuring health and safety compliance, and supervising recording crews of up to 400 people. He also has a Master's degree in Business Administration and a Bachelor's degree in Electrical and Electronics Engineering.
This document describes implementing real-time non-linear regression models in a DeltaV controller to determine chromatography elution endpoints. Three models were used - smoothing, linear regression, and a non-linear extreme value function. The non-linear model fits peak data to an extreme value function using Newton-Raphson iterative numerical solving to determine peak height, width, and retention time. This allows calculating the endpoint as a percentage of peak maximum. The model was validated against laboratory data to within acceptable error ranges and allows robust, real-time endpoint determination for chromatography processes.
This document summarizes the development of a control system for a continuous pharmaceutical tablet manufacturing process using direct compaction. It describes integrating process analytical technology (PAT) tools like NIR spectroscopy with a DeltaV control system using SynTQ and MATLAB. A prediction model is built in UnscramblerX from NIR spectra to monitor the API composition. Different control strategies like MPC, PID, and Smith predictor are implemented and evaluated in DeltaV. The performance is assessed using a gPROMS model. The developed control system enables flexible control of the continuous tablet manufacturing process.
Applying Batch Data Principles to Continuous Manufacturing AIChE FinalPaul Brodbeck
RTD models enable the application of traditional batch reporting and analysis techniques to continuous manufacturing processes. RTD models represent the relationship between input and output concentrations in a unit operation over time. By integrating individual unit operation RTD models, a full line RTD can be achieved to enable material tracing from raw materials to final product for continuous pharmaceutical manufacturing. Reporting architectures are also discussed that utilize an RTD model-driven contextualization approach for continuous process reporting.
Applying Batch Data Principles to Continuous Manufacturing AIChE Final
Taking Great Care Of Your Hair Today
1. Taking Great Care Of Your Hair Today
Knowing how and when to clean and style your hair can make all the difference between a
nightmare scenario and a pleasant dream. You can choose a routine for your hairdressing when you
keep your hair length and texture in mind. Read on for hair care tips designed to change your life!
If you like to style your hair in a ponytail, avoid placing the ponytail in the same spot on your head
every time. Even soft, fabric hair scrunchies can cause hair breakage if they are placed in the same
part of your hair day after day. If you have to pull all of your hair back because of work, or for other
reasons, try to pull it down for a little while every day.
If you have dull or lifeless hair, consider changing your diet. Ingredients such as vitamin E, omega 3
fats and iron play an important role in hair health. If you cannot consume enough of these nutrients
in your diet, use a well-rounded multivitamin to make up the difference.
Try to dry your hair without a hair dryer. Styling your hair with heat can often damage your hair and
cause it to become frizzy. What you should do instead is keep your hair wrapped up in a towel for a
little while. This will make your hair dry naturally, leaving you with minimal frizz.
Always find hairdressing products that are made of natural ingredients. You should also look for a
shampoo and a conditioner that corresponds to your hair type. Buy smaller sizes and try a variety of
products until you locate ones that maximize your hair's true potential.
Alcohol in hair care products will dry your hair out, so avoid them. This can really make your hair
unhealthy and that's why you have to be careful when choosing products. Read the labels, and make
sure the products that you purchase are good for the health of your hair.
Constant use of curling irons and blow dryers could damage your hair. So, before using any heated
appliance, be sure to apply some kind of a styling product to help protect your hair follicles. This will
ensure your hair get the protection it needs.
2. When you brush your locks, always start
from the bottom, working your way
back up. Work through knots in a slow
and careful fashion so as to not damage
your hair. As you do this, you can then
carefully brush from root to tip.
Adding texture to your hair is a great
idea. Properly-textured hair can be
styled in less time than untextured hair.
Texture can be added through the cut
or style, or, alternatively, through a
perm. Follow this tip and you will
increase the body that your hair has, as
well as give yourself more choice when
it comes to how you style your locks.
When shampooing, you should avoid
stripping the natural oils from your hair.
Even if your hair is oily, a harsh
shampoo which gets rid of all oil can
create a rebound effect where your hair
produces too much oil. Try using gentle
shampoos. Some people can even get
away with only washing their hair a
couple times a week.
Alcohol in hair products is a no-no for
your hair. This is a sure way to increase
the dryness of your hair. Also, do not
apply products directly to your scalp, to avoid irritation or clogged pores. Clogged pores can cause
your hair to look less healthy.
3. You might want to shower with cooler water if
you're having issues with dry hair. Your scalp and
hair can become dry if you use hot water. Warm
water is much better for your hair and your body.
You should use cool water towards the end of a
shower for shinier hair.
Brushing your hair excessively is not something that
you should do. You might think that all that
brushing is good for your hair, but that isn't the
case. Brushing damages hair and option pulls hair
out from the root, so only brush as much as
absolutely necessary.
Whether you hair styling takes an hour or five
minutes, you will be able to find something that
works for you. Educate yourself on hair color and
hair styles. Keep these tips in mind, so that you may
have hair you'll love showing off.