Table of papers on ultrasound ONSD vs CT in traumatic brain injuries

1. SHWETA
GIDWANI
19
OCULAR
ULTRASOUND
Karakitsos
10/14
Case-­‐control
n=
54
Mean
of
3
ONSD
Cases
had
brain
injury
5.9mm
Sensitivity
=
74%
et
al,
Cases=GCS< measurements
but
controls
did
not
so
Specificity
=
65%
2006,
ICU
8
per
patient
there
were
not
truly
Greece
n=53
comparable.
95%
confidence
controls
CT
criteria
for
intervals
were
not
raised
ICP
22/54
cases
progressed
mentioned.
Marshall
Brain
to
brain
death
suggesting
Injury
Scale
a
very
sick
population.
Author, QUADAS
Study
Design
Population
Intervention
Limitations
ONSD
Conclusion
Date, Score
and
Value
Country Interval
between
ICP
and
ONSD
measurement
Blavis
et
14/14
Prospective
n=
35
Mean
binocular
Small
study
5mm
Sensitivity
100%
al,
2003,
Observational
All
ED
ONSD
measured
Convenience
sampling
Specificity
95%
USA
Blinded
patients
with
introducing
potential
for
suspected
CT
criteria
for
selection
bias
95%
confidence
ED
raised
ICP
raised
ICP:
intervals
were
not
Brain
Injury
mentioned.
Foundation
PPV
93%
NPV
100%

2. SHWETA
GIDWANI
18
OCULAR
ULTRASOUND
Author, QUADAS
Study
Design
Population
Intervention
Limitations
ONSD
Conclusion
Date, Score
and
Value
Country Interval
between
ICP
and
ONSD
measurement
Tayal
et
13/14
Prospective
n=
59
Mean
binocular
Single
measurement
in
5.0mm
Sensitivity
100%(68%-­‐
al,
2007,
Observational
All
head
ONSD
measured
each
eye
in
axial
plane
100%)
USA
Blinded
injury
Specificity
63%(50%
to
suspected
to
CT
criteria
for
Convenience
sampling.
76%)
ED
have
raised
raised
ICP:
False
positives
not
PPV
30%
ICP
by
the
Brain
Injury
discussed.
NPV
100%
clinical
Foundation
Single
radiologist
reviewing
CT
scans
Girisgin
et
10/14
Case-­‐control
n=
54
Mean
of
2
ONSD
No
blinding
6.4mm
Could
not
be
calculated
al,
2007,
All
causes
of
measurements
mean
Turkey
ED
raised
ICP
in
2
planes
in
Selection
bias
ONSD
both
eyes
n=28
cases
Patients
with
wide
ONSD
with
raised
CT
criteria
for
measurement
but
normal
ICP
in
CT
raised
ICP:
CT
were
excluded
Brain
Injury
n=26
Foundation
controls

3. SHWETA
GIDWANI
17
OCULAR
ULTRASOUND
TABLE
2:
ONSD
compared
with
CT
findings
of
raised
ICP
Author,
QUADAS
Study
Design
Population
Intervention
Limitations
ONSD
Conclusion
Date,
Score
and
Setting
cut
off
Sensitivity
and
Country
value
Specificity
95%
Confidence
Intervals
Major
et
13/14
Prospective
n=26
Mean
binocular
Convenience
sampling
as
5.0
mm
Sensitivity
86%(42%
to
al,
2010,
Observational
patients
ONSD
measured
patients
were
enrolled
99%)
UK
Blinded
needing
CT
only
when
a
trained
Specificity
(79%
to
as
part
of
CT
reviewed
by
operator
was
available.
100%)
ED
routine
care.
2
independent
radiologist
Goel
et
al,
14/14
Prospective
n=100
Mean
binocular
Method
of
sampling
was
5.0mm
Sensitivity
98.6%
2008,
Observational
All
patients
ONSD
measured
not
clear
and
the
criteria
Specificity
92.8%
India
Blinded
with
head
for
those
requiring
CT
injury
CT
criteria
for
scans
was
not
clear
95%
confidence
ED
needing
CT
raised
ICP:
intervals
were
not
Brain
Injury
Level
of
experience
and
mentioned.
Foundation
number
of
operators
doing
ONSD
PPV
97.2%
Single
measurement
not
stated
NPV
96.3%
radiologist
reviewing
all
CT
scans