This presentation provides a complete and exam-oriented overview of Syphilis (उपदंश), a chronic sexually transmitted bacterial disease caused by Treponema pallidum. The slides cover definition, etiology, transmission, incubation period, stages of syphilis (primary, secondary, latent, tertiary), congenital syphilis, clinical features, diagnosis, treatment, and prevention in a simple and systematic manner. The content is specially designed for D.Pharm, B.Pharm, Nursing, Paramedical, and Medical students, useful for exams, viva, practicals, and clinical understanding. Key highlights: Stages of Syphilis with clinical features Difference between primary, secondary, and tertiary syphilis Diagnostic tests (VDRL, RPR, TPHA) Drug of choice and treatment guidelines Exam-friendly tables and mnemonics Useful for: Pharmacology | Pharmacotherapeutics | Community Pharmacy | Clinical Pharmacy #PHARMACY WITH SHUBHAM

1. SYPHILIS / सिफिलिस

2. INTRODUCTION / परिचय
• SYPHILIS IS A SEXUALLY TRANSMITTED INFECTION CAUSED BY
TREPONEMA PALLIDUM. सिफिलिस एक यौन संचारित संक्रमण है जो ट्रेपोनिमा
पैलिडम बैक्टीरिया के कारण होता है।
• SYPHILIS IS A CHRONIC SEXUALLY TRANSMITTED DISEASE
CHARACTERIZED BY STAGES OF INFECTION AFFECTING SKIN, MUCOUS
MEMBRANES, AND INTERNAL ORGANS.
सिफिलिस एक दीर्घकालिक यौन संचारित रोग है, जिसमें संक्रमण कई चरणों में त्वचा, श्लेष्म
झिल्ली और आंतरिक अंगों को प्रभावित करता है।

3. CAUSES / कारण
• • TREPONEMA PALLIDUM BACTERIA
• • SEXUAL CONTACT WITH INFECTED PERSON
• • MOTHER-TO-CHILD TRANSMISSION
• • ट्रेपोनिमा पैलिडम बैक्टीरिया
• • संक्रमित व्यक्ति से यौन संपर्क
• • मां से बच्चे तक संक्रमण

4. SYMPTOMS / लक्षण
• • PAINLESS SORES (CHANCRES)
• • SKIN RASH
• • FEVER, FATIGUE
• • बिना दर्द वाले घाव
• • त्वचा पर चकत्ते
• • बुखार, थकान

5. STAGES / चरण
• PRIMARY: Chancre
Features:
•Single, painless ulcer
•Hard indurated edges
•Clean base
Sites: Genitals, anus, mouth
• SECONDARY: OCCURS 6–8 WEEKS AFTER PRIMARY STAGE
CLINICAL FEATURES: GENERALIZED MACULOPAPULAR RASH, INCLUDES
PALMS AND SOLES, MUCOUS PATCHES IN ORAL CAVITY, FEVER, MALAISE,
PATCHY HAIR LOSS (MOTH-EATEN ALOPECIA)
• LATENT
• TERTIARY: OCCURS 10–30 YEARS AFTER UNTREATED INFECTION

6. DIAGNOSIS / निदान
• • BLOOD TESTS
• • PHYSICAL EXAMINATION
• • SEROLOGICAL TESTS
• • रक्त परीक्षण
• • शारीरिक परीक्षण
• • सीरोलॉजिकल टेस्ट

7. TREATMENT / उपचार
• PENICILLIN G IS THE DRUG OF CHOICE
• FOLLOW UP TESTING REQUIRED
‑
• ANTIBIOTICS: BENZATHINE PENICILLIN G, DOXYCYCLIN,
AZITHROMYCIN, ERTHROMYCIN
• पेनिसिलिन G मुख्य उपचार है
• • नियमित फॉलो‑अप आवश्यक

8. PREVENTION / रोकथाम
• SAFE SEX PRACTICES (सुरक्षित यौन व्यवहार)
• ROUTINE SCREENING (नियमित स्क्रीनिंग)
• TREATING INFECTED PARTNERS (संक्रमित साथियों का
इलाज)
Pregnant women should be screened
Avoid multiple partners (एक से अधिक पार्टनर से बचें)

9. SYPHILIS VS GONORRHEA
Point Syphilis (सिफिलिस) Gonorrhea (गोनोरिया)
Cause (कारण) Treponema pallidum
Neisseria
gonorrhoeae
Main Symptom (मुख्य
लक्षण)
Painless sore (बिना दर्द
का घाव)
Yellow discharge +
burning (पीला स्त्राव +
जलन)
Incubation (ऊष्मायन
काल)
3–4 weeks 2–7 days
Spread (फैलाव)
Sexual & mother-to-
child
Sexual contact
Complications
(जटिलताएँ)
Brain, heart damage Infertility, PID
Treatment (उपचार) Penicillin G Ceftriaxone