Stroke Reperfusion Injury

1. Stroke Reperfusion Injury
Ade Wijaya, MD – July 2019

2. Definition
 Initial restriction of blood supply followed by subsequent vascular
restoration and concomitant reoxygenation of downstream tissue
 Tissue injury
Bright R, Mochly-Rosen D. The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke. 2005 Dec 1;36(12):2781-90.
Khatri R, McKinney AM, Swenson B, Janardhan V. Blood–brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke. Neurology. 2012 Sep 25;79(13 Supplement 1):S52-7.

4. Venkat P, Chopp M, Chen J. Blood–brain barrier disruption, vascular impairment, and ischemia/reperfusion damage in diabetic stroke. Journal of the American Heart Association. 2017 Nov 6;6(6):e005819.

5. (Barone and Feuerstein 1999; Lipton 1999; White et al. 2000; Hertz 2008; Macrez et al. 2011)

6. Bright R, Mochly-Rosen D. The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke. 2005 Dec 1;36(12):2781-90.

7. Bright R, Mochly-Rosen D. The role of protein kinase C in cerebral ischemic and reperfusion injury. Stroke. 2005 Dec 1;36(12):2781-90.

8. Summary
 BBB changes during ischemia and reperfusion are dynamic and
complex
 As current revascularization approaches have become highly
successful and continue to improve, the concept of reperfusion injury
will become more prominent with respect to patient treatment and
supportive care