a Stroke or a brain attack can now be treated by NeuroAiD, a new medical treatment that has proven to help stroke patients to enhance rehabilitation and recovery. Clinical data and trials have been published to show the safety and effcacy of this stroke treatment. This stroke recovery treatment is a real hope for stroke drugs and medications.

1. Start Recovering Now
Enhances Stroke Recovery and Supports
Neurological Functions

2. Stroke has a devastating impact on million of lives
Stroke is the leading cause of adult disability worldwide
• A stroke occurs every 2 seconds
• 15 Million strokes per year (2/3 only partial recovery)
Patients are left without a treatment
• Neuroprotective agents have not (yet) delivered their promise
• Hyper acute intravenous thrombolysis available only to a minority of
patients
• Lack of pharmacological modalities to support post stroke recovery
• Patients grow desperate and frustrated
Interest to look at new sources of therapeutics

3. • Biopharmaceutical company incorporated in 2003
• By a group of renown scientists from east and west and businessmen.
• Focus on safety, quality and clinical data
• Offices in Singapore and Paris
• Important involvement & initiative of academic/key opinion leaders & clinicians.
SCIENTIFIC ADVISORY BOARD, MEDICAL EXPERTS AND INVESTIGATORS
TCM understanding, Biology and EBM expertise,
Georges Charpak
Nobel Laureate
Etienne Beaulieu
Former President,
French Academy
of Sciences
Michel Lazdunski
Director Pharmacology,
CNRS
Acad. Shi Xuemin
Tianjin First Teaching
Hospital of TCM
Acad Han Ji Sheng
Beijing
Neuroscience Inst.
Prof. Zhao Guo Ping
Shanghai Genome
Center
MG Bousser
Advisor on Stroke and
Migraine(France)
Pr Geoffrey Donnan
National Stroke
Institute, University of
Melbourne, Australia
Dr Christopher CHEN
Singapore
National University of
Singapore

4. “Moleac introduced in the
market NeuroAiD™, the first
treatment that brings faster and
fuller recovery for stroke
patients...”
“Moleac receives the Frost &
Sullivan Asia Pacific Excellence in
Healthcare Award for the success
of its stroke treatment drug
NeuroAiD™...”
Awards recognitions

5. NeuroAiD™ treatment

6. Introduction to NeuroAiD™
• NeuroAiD™ is a post stroke recovery medicine for faster and fuller neurological
recovery
• It aids in recovering your independence and reducing neurological deficits
• Effective at early and late stage of stroke as an add-on treatment
• Strong clinical data on efficacy and safety
• 0.5 million patients in 25 countries
Details
• 3 months treatment recommended . Results usually observed within one month
• Capsule form - (can be opened and diluted in water or administrated via gastric tube)
• NeuroAiD™ should be initiated as soon as possible post stroke and it has shown to be
effective up to at least 6 months post stroke.
Aimed at long term reduction of disabilities after a stroke

7. How NeuroAiD™ improves
SPEECH – case study in
European Neurology journal
reports several improvements
of vision disabilities, with
resolution of anomia and
aphasia.
MOTOR – Stroke publication
reports that patients on
NeuroAiD™ showed a 25%
higher recovery in motor
deficits after one month
treatment.
VISION – case study in
European Neurology journal
reports several improvements
of vision disabilities, with
resolution of diplopia and
hemianopia.
Clinical trials and number of case reports
demonstrated improvements in :
- Motor functions,
- Speech (anomia, aphasia)
- Vision (hemianopia, diplopia)
- Other cognitive.

8. Introduction to NeuroAiD™
Footage
• NeuroAiD™ commercialization is pursued through a network of affiliates
• In the European Union our subsidiaries in Paris prepare the registration
• We are pursuing exponential geographic expansion
2007 2008 2009 2010 2011
Singapore Malaysia Pakistan Argentina
Iran
Jordan
Lebanon
Iraq
ThailandPhilippines
Vietnam
Indonesia
Algeria
Russia
Mexico
Lebanon
Europe
Eastern Europe
CIS
USA
Middle-East
Korea…

9. NeuroAiD™ in stroke treatment
NeuroAiD™ has shown efficacy in acute and late post-stroke stage.
4 - 5 hours First day 1 week 6 months
Hyper acute
therapies
such as: rTPA
Window to start the treatment with NeuroAiD™
Acute stage Late stage
Stroke onset
24 hours
Rehabilitation

10. Publications
Medical marketing – Publications

11. Scientific publications
• 7 recent publications summarize NeuroAiD™’s efficacy data, pharmacology data and excellent
tolerability :
– Neuropharmacology in 2010 – Pharmacology data
– Cerebrovascular Diseases in 2010 - Safety data in acute stage
– Cerebrovascular Diseases TIERS in 2009 – Pilot study
– Stroke Journal in 2009 – Efficacy trial
– European Neurology in 2008 – Case report
– Cerebrovascular Diseases in 2008 – Safety trial
– The International Journal of Stroke in 2009 – The CHIMES
protocol

12. Summary of existing clinical evidence
• Pharmacological data show neuroproliferative, neuroregenerative and
neuroprotective properties
• Patients on NeuroAiD™ had 2.4 times more chances to achieve independence
after one month of treatment
• Patients on NeuroAiD™ showed a 25% higher recovery in the motor components
• Many studies and case reports (even at late stage of stroke onset) show good
recovery in motor function, balance, visual and speech functions for patients taking
NeuroAiD™
•NeuroAiD™ does not modify hematological, hemostatic, and biochemical and
ECG parameters in normal subjects and stroke patients

13. Clinical Trials

14. 14
Clinical trials
Clinical trials
CHIMES sites
R & D

15. Clinicians leading the CHIMES trial
Prof MG BOUSSER
Hôpital Lariboisière
France
Prof. Geoffrey DONNAN
National Stroke Institute –
University of Melbourne
Australia
Prof David MACHIN
CTERU
Singapore
Prof Christophe TZOURIO
Paris - France
DMSB
Dr Christopher CHEN
National University
Singapore
CTERU (academic CRO)
Dr Tan Say Beng
Clinical Trials and Epidemiology Research
Unit
4 Centres recruiting:
University of Santo Tomas, Jose
Reyes Medical Centre, Davao
Medical Center; Philippines General
Hospital
Prof Jose NAVARRO,
Dr Alejandro C. BAROQUE,
Dr Hil Gan,
Dr Annabelle Lao
Dr Carlos I Chua (PI)
Dr Cristina M San Jose
All 4 centres: NUH
SGH, TTSH, CGH
Dr N.V. RAMANI,
Dr Sherry Young,
Dr. Bernard CHAN,
Dr CHANG Hui Meng
Dr Rajinder Singh
SINGAPORE PHILIPPINES
5 Centres
Siriraj Hospital
Chiangmai University Hospital
Chulalongkorn Hospital
King Mongkutla Hospital
Thammasat Hospital
THAILAND
Prof Niphon Poungvarin
Dr Siwaporn Chankrachang
Dr Nijasri Suwanwela,
Dr Samart Nidhinandana
Dr Sombat Muengtaweepongsa
More centres in discussion in
• Pakistan
• Indonesia
• Malaysia
• Hong Kong
Chimes provides an important platform
Access to leading clinicians / further data on NeuroAiD™ when started within 72h after stroke onset
SRI LANKA
Dr Asita da Silva
University of Kelaniya

16. Thank You
Find out more
www.neuroaid.com