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Skin Tumors
Benign and Malignant
By
Peter D. Hino, M.D.
Benign Tumors
Derived from
Superficial Epidermis
Seborrheic Keratosis
◼ More common in the
elderly
◼ Often pigmented
◼ Variable size
◼ “Barnacle-like”
appearance
◼ Usually asymptomatic
Stucco Seborrheic Keratosis
◼ Primarily on the
extremities, especially
distally
◼ Often small 2-3mm
white plaques that are
easily lifted off
Keratoacanthoma
◼ Rapidly evolving tumor,
often in the matter of weeks,
possibly of viral origin
◼ Composed of keratinizing
squamous cells
◼ More common in fair
skinned, elderly people
◼ May resolve spontaneously
over a period of 2 to 12
months
Epidermal Nevus
Nevus Comedonicus
Acrochordon
(Skin tags)
◼ Occur in approximately
25% of males and
females
◼ Occur in the axilla, neck
and inguinal region
◼ Increase with age
beginning the 20s up into
the 50s
◼ Few to multiple
Benign Tumors Derived
from the Epidermal
Appendages
Epidermoid Cyst
Epidermoid Cyst
◼ Common, affecting
young and middle age
adults
◼ Usually seen on the head,
neck and trunk
◼ Often can identifiy a
punctum
◼ Cyst contains keratin
Pilar Cysts
Sebaceous Hyperplasia
◼ Found on the face
◼ Singular to multiple in
number
◼ Usually 2-3mm up to
6mm with umbilication
◼ Often begin to appear in
the 30s and increase with
age
Nevus Sebaceous of Jadassohn
Hidrocystoma
Syringomas
◼ Sweat duct tumors
◼ More common in
females
◼ May first appear in
adolescence, but more
often in the third decade
◼ Found around eyelids
and are skin colored to
yellow in appearance
Eccrine Poroma
◼ Tumor arising from the
eccrine duct epithelium
◼ Often on the soles and
palms
◼ Tend to be moist, red
and exophytic
Clear Cell Acanthoma
◼ A scaly plaque or nodule
that has an accumulation
of glycogen containing
cells
◼ Most common on the
lower limbs
◼ Usually solitary and may
persists for years
Benign Melanocytic
Tumors
Nevus
A benign cluster of melanocytic cells arising
as a result of proliferation of melanocytes at
the dermo-epidermal junction. These may all
remain in contact with the basal layer (the
junctional nevus) or may become dettached
from the basal layer and lie free in the dermis
(the compound and intradermal nevus).
Halo Nevus
Spitz Nevus
◼ A compound nevus seen
most commonly in
children and with lesser
frequency in adults
◼ They appear suddenly
and the color is caused
by increased vascularity
◼ Its pathological features
can be difficult to
distinguish from
malignant melanoma
Blue Nevus
◼ An area of blue-black dermal pigmentation produced by an
aberrant collection of pigment producing melanocytes
◼ The brown pigment absorbs the longer wavelength of light and
scatters blue light (Tyndall effect)
◼ Extend into the deep dermis, often occur on extremities and the
dorsum of the hand
Benign Tumors Derived
from Mesodermal Tissue
Dermatofibroma
◼ Can occur on any part of
the body, most common
on the lower extremities,
to a lesser degree on the
upper extremities and
trunk
◼ May be single or multiple
◼ Usually pink or brown
◼ Commonly 6mm or less
◼ Hard consistency
Fibrous Papule
◼ Small facial papule with a fibrovascular content
◼ Usually seen on or next to the nose
◼ Usually singular but on occasion can be multiple
Keloid
◼ An exaggerated
reparative fibroblastic
response to injury of the
skin
◼ Genetic tendency
◼ Most commonly found
on the ears, neck and
trunk
Cherry Angioma
Pyogenic Granuloma
◼ A vasular nodule that
develops rapidly, with a
glistening moist surface
◼ Often may appear at a
site of recent trauma
◼ Composed of
proliferating capillaries in
a loose stroma
◼ Bleeds easily
Lipoma
Premalignant Tumors
Actinic Keratosis
◼ Hyperkeratotic lesions
occurring in sun exposed
adult skin
◼ May exist in a premalignant
state for years
◼ Often begin as an area of
increased vascularity with the
surface becoming rough
◼ May progress to squamous
cell carcinoma
Actinic Cheilitis
Squamous Cell Carcinoma in situ
(Bowen’s Disease)
◼ A persistent, progressive,
nonelevated, red, scaly or
crusted plaque
◼ An intraepidermal
proliferation on exposed
and nonexposed areas of
the body
◼ Often mistaken for
eczema or psoriasis
Epidermal Malignancies
Superficial Basal Cell Carcinoma
Basal Cell Carcinoma
◼ Most common form of
skin cancer
◼ Usually appears on sun
damaged skin
◼ Pearly appearance with
superficial telangiectasias
◼ Rarely metastasizes
◼ Derived from basal cell
layer of the epidermis
Pigmented Nodular Basal Cell
Carcinoma
Sclerosing Basal Cell Carcinoma
Squamous Cell Carcinoma
Squamous Cell Carcinoma
◼ Often in older fair
skinned persons
◼ Hyperkeratotic and often
ulcerates
◼ SCC is separated into
two groups based on
malignant potential
In Situ Malignant Melanoma
◼ Melanoma cells confined
to the epidermis
◼ Lack in invasion may
persist for months to
years
◼ Simple excision is often
curative
Superficial Spreading Melanoma
Superficial Spreading Melanoma
◼ Most common in middle
age
◼ Develops anywhere on
the body, back in both
sexes and legs in females
◼ Haphazard combination
on colors but may be
uniformly brown or
black
Acral Lentinginous Melanoma
◼ Most common in blacks
and orientals
◼ Appears on the palms,
soles terminal phalanges
and mucous membranes
◼ The tumor is very
aggressive and
metastasizes early
Nodular Melanoma
◼ Occurs in the fifth or sixth
decade
◼ More frequent in males with
a ratio of 2:1
◼ Found anywhere on the body
◼ Most frequently
misdiagnosed because it can
resemble a blood blister,
hemangioma, dermal nevus
or polyp
Amelanotic Melanoma
Skin Tumors.pdf

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Skin Tumors.pdf

  • 1. Skin Tumors Benign and Malignant By Peter D. Hino, M.D.
  • 3.
  • 4. Seborrheic Keratosis ◼ More common in the elderly ◼ Often pigmented ◼ Variable size ◼ “Barnacle-like” appearance ◼ Usually asymptomatic
  • 5. Stucco Seborrheic Keratosis ◼ Primarily on the extremities, especially distally ◼ Often small 2-3mm white plaques that are easily lifted off
  • 6.
  • 7. Keratoacanthoma ◼ Rapidly evolving tumor, often in the matter of weeks, possibly of viral origin ◼ Composed of keratinizing squamous cells ◼ More common in fair skinned, elderly people ◼ May resolve spontaneously over a period of 2 to 12 months
  • 10.
  • 11. Acrochordon (Skin tags) ◼ Occur in approximately 25% of males and females ◼ Occur in the axilla, neck and inguinal region ◼ Increase with age beginning the 20s up into the 50s ◼ Few to multiple
  • 12. Benign Tumors Derived from the Epidermal Appendages
  • 14. Epidermoid Cyst ◼ Common, affecting young and middle age adults ◼ Usually seen on the head, neck and trunk ◼ Often can identifiy a punctum ◼ Cyst contains keratin
  • 16.
  • 17. Sebaceous Hyperplasia ◼ Found on the face ◼ Singular to multiple in number ◼ Usually 2-3mm up to 6mm with umbilication ◼ Often begin to appear in the 30s and increase with age
  • 18. Nevus Sebaceous of Jadassohn
  • 20.
  • 21. Syringomas ◼ Sweat duct tumors ◼ More common in females ◼ May first appear in adolescence, but more often in the third decade ◼ Found around eyelids and are skin colored to yellow in appearance
  • 22. Eccrine Poroma ◼ Tumor arising from the eccrine duct epithelium ◼ Often on the soles and palms ◼ Tend to be moist, red and exophytic
  • 23.
  • 24. Clear Cell Acanthoma ◼ A scaly plaque or nodule that has an accumulation of glycogen containing cells ◼ Most common on the lower limbs ◼ Usually solitary and may persists for years
  • 26. Nevus A benign cluster of melanocytic cells arising as a result of proliferation of melanocytes at the dermo-epidermal junction. These may all remain in contact with the basal layer (the junctional nevus) or may become dettached from the basal layer and lie free in the dermis (the compound and intradermal nevus).
  • 27.
  • 28.
  • 29.
  • 31. Spitz Nevus ◼ A compound nevus seen most commonly in children and with lesser frequency in adults ◼ They appear suddenly and the color is caused by increased vascularity ◼ Its pathological features can be difficult to distinguish from malignant melanoma
  • 32. Blue Nevus ◼ An area of blue-black dermal pigmentation produced by an aberrant collection of pigment producing melanocytes ◼ The brown pigment absorbs the longer wavelength of light and scatters blue light (Tyndall effect) ◼ Extend into the deep dermis, often occur on extremities and the dorsum of the hand
  • 33. Benign Tumors Derived from Mesodermal Tissue
  • 34.
  • 35. Dermatofibroma ◼ Can occur on any part of the body, most common on the lower extremities, to a lesser degree on the upper extremities and trunk ◼ May be single or multiple ◼ Usually pink or brown ◼ Commonly 6mm or less ◼ Hard consistency
  • 36. Fibrous Papule ◼ Small facial papule with a fibrovascular content ◼ Usually seen on or next to the nose ◼ Usually singular but on occasion can be multiple
  • 37.
  • 38. Keloid ◼ An exaggerated reparative fibroblastic response to injury of the skin ◼ Genetic tendency ◼ Most commonly found on the ears, neck and trunk
  • 40.
  • 41. Pyogenic Granuloma ◼ A vasular nodule that develops rapidly, with a glistening moist surface ◼ Often may appear at a site of recent trauma ◼ Composed of proliferating capillaries in a loose stroma ◼ Bleeds easily
  • 44.
  • 45. Actinic Keratosis ◼ Hyperkeratotic lesions occurring in sun exposed adult skin ◼ May exist in a premalignant state for years ◼ Often begin as an area of increased vascularity with the surface becoming rough ◼ May progress to squamous cell carcinoma
  • 47.
  • 48. Squamous Cell Carcinoma in situ (Bowen’s Disease) ◼ A persistent, progressive, nonelevated, red, scaly or crusted plaque ◼ An intraepidermal proliferation on exposed and nonexposed areas of the body ◼ Often mistaken for eczema or psoriasis
  • 51. Basal Cell Carcinoma ◼ Most common form of skin cancer ◼ Usually appears on sun damaged skin ◼ Pearly appearance with superficial telangiectasias ◼ Rarely metastasizes ◼ Derived from basal cell layer of the epidermis
  • 52. Pigmented Nodular Basal Cell Carcinoma
  • 54.
  • 55.
  • 57. Squamous Cell Carcinoma ◼ Often in older fair skinned persons ◼ Hyperkeratotic and often ulcerates ◼ SCC is separated into two groups based on malignant potential
  • 58.
  • 59. In Situ Malignant Melanoma ◼ Melanoma cells confined to the epidermis ◼ Lack in invasion may persist for months to years ◼ Simple excision is often curative
  • 61. Superficial Spreading Melanoma ◼ Most common in middle age ◼ Develops anywhere on the body, back in both sexes and legs in females ◼ Haphazard combination on colors but may be uniformly brown or black
  • 62. Acral Lentinginous Melanoma ◼ Most common in blacks and orientals ◼ Appears on the palms, soles terminal phalanges and mucous membranes ◼ The tumor is very aggressive and metastasizes early
  • 63. Nodular Melanoma ◼ Occurs in the fifth or sixth decade ◼ More frequent in males with a ratio of 2:1 ◼ Found anywhere on the body ◼ Most frequently misdiagnosed because it can resemble a blood blister, hemangioma, dermal nevus or polyp