3. • Basal cell carcinoma is the most common
human malignancy worldwide.
• It accounts for more than 75% of skin
cancers
4.
5. • Primary Tumor (T)TXPrimary tumor cannot be assessedT0No
evidence of primary tumorTisCarcinoma in situ
• T1Tumor ≤2 cm in greatest dimension
• T2Tumor >2 cm, but not >5 cm, in greatest dimension
• T3Tumor >5 cm in greatest dimension
• T4Tumor invades deep extradermal structures (i.e., cartilage,
skeletal muscle, or bone)
• Regional Lymph Nodes (N)NXRegional lymph nodes cannot be
assessedN0No regional lymph node metastasis
• N1Regional lymph node metastasis
• Distant Metastasis (M)MXDistant metastasis cannot be
assessedM0No distant metastasisM1Distant metastasis
6. • Chronic exposure to sunlight is the
principal cause of basal cell carcinomas,
and thus lesions characteristically occur on
exposed parts of the body—the face, ears,
neck, scalp, shoulders, and back
7. • Superficial
• Nodular ulcerative the most common
• Sclerosing the most aggresive
• Pigmented
• Cystic
8.
9.
10.
11.
12. Option of managements
• Curettage and electro desiccation
• cryosurgery
• Topical 5-fluorouracil
• topical imiquimod, intralesional interfron
• , radiotherapy, or surgical excision.
• The same limitations of radiotherapy in
treatment of basal cell carcinoma are
applicable
13. • Mohs' micro surgery is the most definitive
modality and treatment of choice in high-
risk BCC of anatomically complex areas on
the face
14. SQUAMOUS CELL CARCINOMA
• Squamous cell carcinomas account for
20% of skin cancers
• Precipitating factor :sunlight, susceptible
phenotype, and compromised immunity, in
addition to environmental conditions and
diseases
15. • A Marjolin ulcer is a squamous cell
carcinoma that has developed in an
area of chronic inflammation and
scarring, which carries a risk of
metastasis of nearly 50%.
31. Background
Definition: Malignant transformation of the melanocyte
It is the 4% all skin cancer It occurs most commonly on
the extremities in female and on trunk in male
But it can occur in eye ,GI tract mucosa ,sinus ,anus and
vagina that beyond our scope
Incidence, 15:100000
• 70% of death
• Common in Caucasian population
• it is the most common ca female age of 25-29year
32. Etiology and risk factor
• UV radiation
• Skin ,eye and hair color
• Actinic keratosis nonmelanoma skin ca
• History of sun burn
• Immunosuppression
• Family and personal history
• Mutation
• Xeroderma pigmentosis
• Atypical nevus
• Nevus more than 50-100
• Giant melanocytic nevus Size greater than 20cm
33.
34. Clinical manifestation
• ABCDE rule
Warning sign
A asymmetry
B border irregularity
C color change
D diameter 6mm and above
E
35. • Ugly duckling sign
• ABCD rule fail in nodular melanoma
• Early Itching sensation
• Bleeding
• Change is key for diagnosis
• Different nevus from adjacent is suspicious
(difference)
• Photography
• Dermoscopy
• Early detection
37. Staging
Clinical staging based on clincal
and radilogical
CLINICAL STAGE GROUPING
Stage 0 Tis N0 M0
Stage IA T1a N0 M0
Stage IB T1b N0 M0
T2a N0 M0
Stage IIA T2b N0 M0
T3a N0 M0
Stage IIB T3b N0 M0
T4a N0 M0
Stage IIC T4b N0 M0
Stage III Any T N1 M0
Any T N2 M0
Any T N3 M0
Stage IV Any T Any N M1
