This study evaluated the effect of silicone oil versus gas tamponade on retinal layer thickness following macula-on retinal detachment surgery using OCT imaging. The study found that silicone oil tamponade resulted in a significant decrease in total retinal thickness and thickness of inner retinal layers and outer retinal layers except the photoreceptor layer. Gas tamponade did not significantly reduce retinal thickness. Silicone oil tamponade also resulted in significantly worse visual acuity outcomes compared to gas tamponade. The decrease in thickness of the ganglion cell layer, outer plexiform layer, and outer nuclear layer showed the strongest correlation with changes in visual acuity in the silicone oil group.

1. RETINAL LAYER
SEGMENTATION AFTER
SILICONE OIL
OR
GAS TAMPONADE
FOR MACULA-ON RETINAL
DETACHMENT USING OCT
SUNG HOON LEE, MD,* JONG WOOK HAN, MD,* SUK HO BYEON, MD,* SUNG SOO KIM, MD,†
HYOUNG JUN KOH, MD,† SUNG CHUL LEE, MD,† MIN KIM, MD*
RETINA 0:1–10, 2017

2. To evaluate and compare the effect
of silicone oil and gas on the
thickness of all retinal layers in
eyes with macula-on retinal
detachment.

3. • Silicone Tamponade = 367
• Gas Tamponade = 310
• Rheg RD NOT involving Macula +
underwent Vitrectomy with R.Error
+/- 5D SE & +/-2D Astig.
RETROSPECTIVE COMPARITIVE INTERVENTIONAL CASE SERIES .
GANGMAN SEVERANCE HOSPITAL
(2011-2015)
• Thickness of all retinal layers & BCVA at
6 months and 9 months after primary
RD surgery with Spectralis OC
• Silicone Oil used of same brand i.e
Oxane 1300 (Bausch & Lomb, Inc, New
York, NY) ,removed after 101+/- 42
days
• Gas C3F8
• Xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
DR with ME , Uveitis with ME
Mac.Hole, ERM,Glaucoma & ONH
abnormalities, PFCL usage in Sx, who
required 2nd sx
STUDY DESIGN
• 33 eyes that underwent 1,000 cs silicone oil injection &
• 31 eyes with gas tamponade were finally enrolled in the
study

4. • Preoperative SD-OCT measurements were performed the day before surgery,
and postoperative measurements were performed 6 months after silicone oil
removal or 6 months after gas tamponade
• The new technique for automated retinal segmentation of SD-OCT retinal images
was applied to distinguish each retinal layer and quantify its thickness
(Segmentation Technology; Heidelberg Engineering, Inc). The inbuilt Spectralis
software, Heidelberg Eye Explorer (version 6.0.9.0), was used for segmentation.
• The Spectralis software measures the total retinal thickness as the vertical
distance between the internal limiting membrane and Bruch membrane.
• The degree of change in thickness of each retinal layer within 1 mm ETDRS
subfields was analyzed.

8. Postoperatively, eyes in the silicone oil group
had a statistically
significant decrease in total retinal thickness
of
23.61 ±17.01 mm at 6 months (P , 0.001) and
23.74 ±17.50 mm at 9 months (P , 0.001)
after primary
RD surgery

9. Comparison of Retinal Layer Segmentation
Between Silicone Oil V/S Gas Tamponade Groups

10. The change in thickness of each retinal layer within a 1 mm ETDRS subfield in the
silicone oil group was compared with that in the gas group.
• Postoperatively, there was a significant drop in BCVA in the silicone oil group
(66.57 ETDRS letters, P = 0.004 at 6 months after RD surgery, 66.35 ETDRS
letters, P = 0.003 at 9 months after RD surgery), but no significant change in the
gas group (79.81 ETDRS letters, P = 0.976).
• The postoperative BCVA in the silicone oil group was significantly worse than
that in the gas group (6 months after RD surgery: P = 0.018, 9 months after RD
surgery: P = 0.016)
• The mean duration of the silicone oil tamponade was 101 days (±42 days). After
adjusting for age, sex, and axial length, silicone oil tamponade duration was found to
have no statistically significant correlation with either postoperative final visual acuity
or the degree of retinal thinning (all P . 0.05).

11. DISCUSSION
• Silicone oil tamponade had a significant effect on the postoperative
decrease in thickness of all retinal layers, except for the photoreceptor
layer.
• Decreased thickness was noted not only in the inner retinal layer but in
the outer retinal layer as well.
• No significant reduction of retinal thickness in any of the retinal layers
after gas tamponade.
• Decrease of GCL, OPL, and ONL thickness showed the strongest
correlation with changes in visual acuity in the silicone oil group.

12. SILICONE OIL DAMAGE ACTION
• Possible causes include mechanical stress to the fovea
induced by silicone oil, and subsequent early loss of
ONL cell bodies.
• Emulsified silicone oil may induce an internal limiting
membrane defect and may be toxic to the retina by
entering theM intraretinal space and causing retinal
thinning

13. Removal of silicone oil, performed as
early as possible, may minimize
complications, such as secondary
glaucoma, cataract, and vision loss,
and may help avoid potential toxic
effects.

14. • Thank you everyone for patiently listening to this journal by DR.PUSHKAR DHIR
• For feedbacks & brickbats plz mail at
• ykush@yahoo.co.in./drdhir2014@gmail.com

16. Questions?
• 1. what was FAX? During suregeries
• 2.Any hypothesis why photoreceptor layer
didn’t get affected?
• 3. Any Cryo procedure was done along
• 4. Suregeon same or different?
5.