The document discusses building new clinical information systems that enable intra- and inter-operability. It provides background on Paolo Ciccarese, including his experience developing ontologies and semantic technologies to improve clinical decision support, workflows, and data integration across healthcare organizations. Ciccarese advocates for knowledge-based clinical systems that leverage formal medical terminologies and ontologies to optimize processes and support continuity of care.
Semantic Web powering Enterprise and Web ApplicationsAmit Sheth
The document summarizes a presentation given by Amit Sheth at the 48th ACM Southeast Conference in Oxford, Mississippi from April 15-17, 2010. The presentation discussed several real-world applications of semantic web technologies in domains such as financial services, defense and intelligence, and clinical decision making. Specific applications highlighted included risk analysis in banking, assessing intelligence needs, and powering an active semantic electronic medical record system.
Martin Dudziak has extensive experience in biological and biomedical research and technology development. He has led multiple projects involving computational modeling of genomics data, medical research, and developing response systems for biological or chemical threats. Currently he works as the Chief Scientist of Tetrad Technologies Group and a visiting professor, applying his expertise in areas like artificial intelligence, sensors, and public health technologies.
Dr. Chute will overview progress around data normalization and high throughput clinical phenotyping (recognizing groups of patients for quality, practice, or research use-cases from electronic medical records (EMRs). These techniques were demonstrated to generate comparable and consistent information from multiple academic medical centers with heterogeneous EMR systems and record structures in the NHGRI funded eMERGE consortium (gwas.net). Tools and techniques for data normalization and phenotyping have been generalized and partially commoditized as open-source archetypes software in the ongoing SHARPn (SHARPn.org).
The document is a chapter from a story about the Four Legacies family. It introduces the twins Ruby and Gemma complaining about their new school uniforms. Their brother Henry then models the new boys' uniform for them. At a family meeting, their father David announces he will choose an heir from the three siblings. Ruby and Gemma do not want the responsibility, so Henry accepts becoming the heir to the Four Legacies. The chapter then transitions to a meeting between David, Kate, Ross, and Kaylynn to discuss contacting the supernatural residents of their town, but they have been unable to find any.
Waylon Brown passes away, leaving behind a large family. His ghost begins appearing to them. Meanwhile, Knut goes into labor and delivers twins - a girl named Eliza with dark features, and a paler girl named Felicity with lighter eyes like Knut's mother. Charlie also rediscovers her magic artifacts and powers after neglecting them for years.
The document presents schematic design plans and illustrations for a residential compound in Abu Dhabi, UAE. It includes a site plan showing 44 labeled areas, elevations of the north and south boundary walls, aerial views of the guest arrival and main villa event space, sections of the event lawn and health club/swimming pool, and perspective views of various spaces. Enlarged sections provide more detail on the main villa courtyard, parterre garden, entry garden, and sculptural mound at the entry drive.
The document discusses the electrical characteristics and testing of uni-junction transistors. It describes the original uni-junction transistor as a bar of N-type semiconductor material with a P-type diffusion. It also describes the programmable uni-junction transistor which consists of four P-N layers with an anode, cathode, and gate. Both are used as trigger devices for thyristors and in relaxation oscillators due to their negative resistance characteristic. The document provides instructions to test a programmable uni-junction transistor by measuring resistances between the emitter, base 1, and base 2 in different configurations and verifying they are approximately equal and have the expected high or low resistance values.
Semantic Web powering Enterprise and Web ApplicationsAmit Sheth
The document summarizes a presentation given by Amit Sheth at the 48th ACM Southeast Conference in Oxford, Mississippi from April 15-17, 2010. The presentation discussed several real-world applications of semantic web technologies in domains such as financial services, defense and intelligence, and clinical decision making. Specific applications highlighted included risk analysis in banking, assessing intelligence needs, and powering an active semantic electronic medical record system.
Martin Dudziak has extensive experience in biological and biomedical research and technology development. He has led multiple projects involving computational modeling of genomics data, medical research, and developing response systems for biological or chemical threats. Currently he works as the Chief Scientist of Tetrad Technologies Group and a visiting professor, applying his expertise in areas like artificial intelligence, sensors, and public health technologies.
Dr. Chute will overview progress around data normalization and high throughput clinical phenotyping (recognizing groups of patients for quality, practice, or research use-cases from electronic medical records (EMRs). These techniques were demonstrated to generate comparable and consistent information from multiple academic medical centers with heterogeneous EMR systems and record structures in the NHGRI funded eMERGE consortium (gwas.net). Tools and techniques for data normalization and phenotyping have been generalized and partially commoditized as open-source archetypes software in the ongoing SHARPn (SHARPn.org).
The document is a chapter from a story about the Four Legacies family. It introduces the twins Ruby and Gemma complaining about their new school uniforms. Their brother Henry then models the new boys' uniform for them. At a family meeting, their father David announces he will choose an heir from the three siblings. Ruby and Gemma do not want the responsibility, so Henry accepts becoming the heir to the Four Legacies. The chapter then transitions to a meeting between David, Kate, Ross, and Kaylynn to discuss contacting the supernatural residents of their town, but they have been unable to find any.
Waylon Brown passes away, leaving behind a large family. His ghost begins appearing to them. Meanwhile, Knut goes into labor and delivers twins - a girl named Eliza with dark features, and a paler girl named Felicity with lighter eyes like Knut's mother. Charlie also rediscovers her magic artifacts and powers after neglecting them for years.
The document presents schematic design plans and illustrations for a residential compound in Abu Dhabi, UAE. It includes a site plan showing 44 labeled areas, elevations of the north and south boundary walls, aerial views of the guest arrival and main villa event space, sections of the event lawn and health club/swimming pool, and perspective views of various spaces. Enlarged sections provide more detail on the main villa courtyard, parterre garden, entry garden, and sculptural mound at the entry drive.
The document discusses the electrical characteristics and testing of uni-junction transistors. It describes the original uni-junction transistor as a bar of N-type semiconductor material with a P-type diffusion. It also describes the programmable uni-junction transistor which consists of four P-N layers with an anode, cathode, and gate. Both are used as trigger devices for thyristors and in relaxation oscillators due to their negative resistance characteristic. The document provides instructions to test a programmable uni-junction transistor by measuring resistances between the emitter, base 1, and base 2 in different configurations and verifying they are approximately equal and have the expected high or low resistance values.
This document discusses assistive technology and its role in developing Individualized Education Plans (IEPs) for students with disabilities. It defines key terms like IEPs, assistive technology, accommodations, and modifications. It provides examples of low, medium, and high-tech assistive devices and describes how a student named Teddy uses assistive technology tools like a laptop, word prediction software, and text-to-speech programs to help with reading, writing, and learning. It also includes a sample social studies lesson plan and describes accommodations that could be made to help include students with different needs.
2010 Smalll Business Presentation for HAULErin McClarty
This document outlines various legal issues that small businesses and non-profits should be aware of, including how to choose an appropriate legal structure, labor laws, intellectual property concerns, and how to protect themselves legally. It discusses the differences between sole proprietorships, partnerships, corporations and LLCs. It also covers non-profit structures like trusts, unincorporated associations and corporations. The document provides an overview of relevant laws around topics like telephone solicitations, websites, email marketing and charitable solicitations. It emphasizes the importance of educating yourself on applicable laws and utilizing legal counsel.
Seminar for undergrads at Parsons New School.
How does one identify opportunities to create new things, services, experiences? Are all innovations good? What is the history of innovation and how are innovative ideas and practices integrated in cultural practices? This course explores classic texts on entrepreneurship and innovation while also considering the role of the artist and design as an agent of change, and the nature and promise of technology in the creation of our possible future(s).
This document provides tips for effective preaching with a focus on delivering a message that can change lives. It recommends preachers pick a single point, determine the goal of the message, create a map or structure, internalize the content, engage the audience and find their authentic voice to avoid coming across as foolish, ridiculous or uncomfortable. The overall goal of preaching should be life change, not just information sharing.
This document discusses assistive technologies and supports for students with disabilities in inclusive classrooms. It defines inclusion and least restrictive environment, and notes benefits of inclusion such as increased socialization and role models. For students with ADHD, low-to-high tech assistive technologies include voice recorders, manipulatives, and reading trackers, while additional supports do not require technology, like highlighted materials and breaks. Students with auditory disabilities may use voice-to-text software, hearing aids, real-time captioning, and FM systems. Learning disabilities can be assisted through word processors, prediction software, audio books and e-dictionaries, along with extended time and customized materials.
Este documento contém informações sobre vários projetos de arquitetura e engenharia de uma empresa chamada LACOPLANO, LDA localizada em Portugal. São apresentados detalhes como áreas de terreno, construção e pavimentos de casas individuais e apartamentos localizados em diferentes regiões do Algarve, como Portelas, Atalaia, Meia Praia e Portimão. Também é descrito um empreendimento imobiliário chamado LAGOSPARQUE com apartamentos de tipologias T2 e T3.
The document summarizes the agenda for a Toastmasters leadership institute for vice presidents of public relations. It includes an icebreaker exercise, a discussion of the district and club success plan, an overview of public relations, Toastmasters rebranding efforts, and an exercise on where leaders are made. Attendees are reminded to fill out paperwork to get credit for attending.
The human digestive system breaks down food into chemicals that the body can use for fuel. Food is broken down initially in the mouth through chewing and saliva. It then moves to the stomach where acid breaks it down further before entering the small intestine for most digestion. Digestive juices in the small intestine finish breaking down food and nutrients are absorbed. Undigested waste moves to the large intestine where water is absorbed before waste is excreted. The pancreas, liver, and gallbladder aid digestion by producing enzymes and bile needed to break down nutrients like fats.
The slides of the invited talk Maurizio Marchese from the LiquidPub team gave at the Workhop on Automated Experimentation at e-Science Institute, Edinburgh, February 24th, 2010
The document outlines objectives and tasks for creating a 3D character model for a game. The objectives include identifying the character's style, creating a 3D model, researching fabric creation methods, and rigging the final model. Various teams are tasked with 3D modeling, 2D textures, video production, and client communication. Progress has been slowed by issues perfecting the character's hands and coat simulation. Deadlines need to be adjusted and the client updated on changes. Overall, more time is needed to achieve the objectives due to underestimating the work required.
The document discusses data presentation and geospatial data. It covers experimenting with new applications of existing technology, focusing on the medium and context of use when presenting data. It also discusses issues with representing locations and polygons with single points (centroids) and the need for problem maps that show meta-level understandings rather than just algorithms. The document advocates for an iterative design process focused on the user experience.
Kate died at the age of 75 after her sixth grandchild's birthday party. Her death was unexpected. Later that week, Quinn also died at age 75. Ally and James then grew up their newborn twins Luke and Lorelai. Galahad had just finished his final exams and was relaxing at home when his housemate Tessa returned from celebrating her engagement.
Nick is a wealthy 20-year-old British man who lives in London and parties excessively, having multiple girlfriends at once. After cheating on four women who find out, his life falls apart and he realizes that true happiness comes from meaningful relationships, not money or possessions. The film is targeted at audiences aged 16 and up who enjoy clubbing and partying in London like the main character. Key locations used in filming include Westminster Abbey, Big Ben, and clubs in Mayfair to depict Nick's extravagant lifestyle before he learns his lesson.
Charlie receives a phone call that her grandmother has passed away. She returns home with her brothers where their mother Quinn informs them that one of them will need to take over the family legacy. Both Charlie and her brother Gideon decline as Charlie wants to move into her grandmother's house and Gideon is gay and doesn't want to risk not being able to marry his boyfriend. This leaves their youngest brother James as the heir to the family legacy.
La Unión Europea ha propuesto un nuevo paquete de sanciones contra Rusia que incluye un embargo al petróleo. El embargo prohibiría la importación de petróleo ruso a la UE y también prohibiría a los buques europeos transportar petróleo ruso a otros lugares. Sin embargo, Hungría se opone al embargo al petróleo, lo que podría retrasar la aprobación del paquete de sanciones de la UE.
The document discusses various free multimedia tools that can be used in the classroom, including photo editing software, photo sharing sites, audio streaming websites, and video creation tools. It provides examples of using Pixlr for photo editing, Flickr and Voicethread for sharing media, Pandora and LastFM for streaming audio, and Animoto, Flixtime, and Windows Movie Maker for creating videos from photos and adding effects, music, and voice narration. The author found the class on multimedia tools to be one of their favorites and especially enjoyed learning how to make videos and add voice to pictures through Voicethread.
The document discusses switching the format of updates for "The Four Legacies" from written chapters to picture slideshows ("picspam updates") due to the time it takes to write full chapters. It then provides the first picspam update, sharing pictures of the sims and their activities over time, including births, age progressions, holidays and more. The author asks for feedback on the new picspam format versus returning to written chapters.
Zack Blanchflower is an experienced healthcare IT professional with over 7 years of experience implementing and optimizing electronic health records systems. He has 3 years of experience with Epic OpTime/Anesthesia and was involved in full Epic implementations and upgrades. He has a background in biology and healthcare and holds Epic OpTime and Anesthesia certifications.
Open Insights Harvard DBMI - Personal Health Train - Kees van Bochove - The HyveKees van Bochove
In this talk, the Personal Health Train concept will be introduced, which enables running personalized medicine workflows as trains visiting data stations (e.g. hospital records, primary care records, clinical studies and registries, patient-held data from e.g. wearable sensors etc.) The Personal Health Train is a very powerful concept, which is however dependent on source medical data to be coded with appropriate metadata on consent, license, scope etc. of the data, and the data itself to be encoded using biomedical data standards, which is an ever growing field in biomedical informatics. In order to realize the Personal Health Train biomedical data will need to be FAIR, i.e. adopt the FAIR Guiding Principles. This talk will cover the emerging GO-FAIR international movement, and provide examples of how several European health data networks currently are adopting open standards based stacks, to enable routine health care data to be come accessible for research.
This document discusses assistive technology and its role in developing Individualized Education Plans (IEPs) for students with disabilities. It defines key terms like IEPs, assistive technology, accommodations, and modifications. It provides examples of low, medium, and high-tech assistive devices and describes how a student named Teddy uses assistive technology tools like a laptop, word prediction software, and text-to-speech programs to help with reading, writing, and learning. It also includes a sample social studies lesson plan and describes accommodations that could be made to help include students with different needs.
2010 Smalll Business Presentation for HAULErin McClarty
This document outlines various legal issues that small businesses and non-profits should be aware of, including how to choose an appropriate legal structure, labor laws, intellectual property concerns, and how to protect themselves legally. It discusses the differences between sole proprietorships, partnerships, corporations and LLCs. It also covers non-profit structures like trusts, unincorporated associations and corporations. The document provides an overview of relevant laws around topics like telephone solicitations, websites, email marketing and charitable solicitations. It emphasizes the importance of educating yourself on applicable laws and utilizing legal counsel.
Seminar for undergrads at Parsons New School.
How does one identify opportunities to create new things, services, experiences? Are all innovations good? What is the history of innovation and how are innovative ideas and practices integrated in cultural practices? This course explores classic texts on entrepreneurship and innovation while also considering the role of the artist and design as an agent of change, and the nature and promise of technology in the creation of our possible future(s).
This document provides tips for effective preaching with a focus on delivering a message that can change lives. It recommends preachers pick a single point, determine the goal of the message, create a map or structure, internalize the content, engage the audience and find their authentic voice to avoid coming across as foolish, ridiculous or uncomfortable. The overall goal of preaching should be life change, not just information sharing.
This document discusses assistive technologies and supports for students with disabilities in inclusive classrooms. It defines inclusion and least restrictive environment, and notes benefits of inclusion such as increased socialization and role models. For students with ADHD, low-to-high tech assistive technologies include voice recorders, manipulatives, and reading trackers, while additional supports do not require technology, like highlighted materials and breaks. Students with auditory disabilities may use voice-to-text software, hearing aids, real-time captioning, and FM systems. Learning disabilities can be assisted through word processors, prediction software, audio books and e-dictionaries, along with extended time and customized materials.
Este documento contém informações sobre vários projetos de arquitetura e engenharia de uma empresa chamada LACOPLANO, LDA localizada em Portugal. São apresentados detalhes como áreas de terreno, construção e pavimentos de casas individuais e apartamentos localizados em diferentes regiões do Algarve, como Portelas, Atalaia, Meia Praia e Portimão. Também é descrito um empreendimento imobiliário chamado LAGOSPARQUE com apartamentos de tipologias T2 e T3.
The document summarizes the agenda for a Toastmasters leadership institute for vice presidents of public relations. It includes an icebreaker exercise, a discussion of the district and club success plan, an overview of public relations, Toastmasters rebranding efforts, and an exercise on where leaders are made. Attendees are reminded to fill out paperwork to get credit for attending.
The human digestive system breaks down food into chemicals that the body can use for fuel. Food is broken down initially in the mouth through chewing and saliva. It then moves to the stomach where acid breaks it down further before entering the small intestine for most digestion. Digestive juices in the small intestine finish breaking down food and nutrients are absorbed. Undigested waste moves to the large intestine where water is absorbed before waste is excreted. The pancreas, liver, and gallbladder aid digestion by producing enzymes and bile needed to break down nutrients like fats.
The slides of the invited talk Maurizio Marchese from the LiquidPub team gave at the Workhop on Automated Experimentation at e-Science Institute, Edinburgh, February 24th, 2010
The document outlines objectives and tasks for creating a 3D character model for a game. The objectives include identifying the character's style, creating a 3D model, researching fabric creation methods, and rigging the final model. Various teams are tasked with 3D modeling, 2D textures, video production, and client communication. Progress has been slowed by issues perfecting the character's hands and coat simulation. Deadlines need to be adjusted and the client updated on changes. Overall, more time is needed to achieve the objectives due to underestimating the work required.
The document discusses data presentation and geospatial data. It covers experimenting with new applications of existing technology, focusing on the medium and context of use when presenting data. It also discusses issues with representing locations and polygons with single points (centroids) and the need for problem maps that show meta-level understandings rather than just algorithms. The document advocates for an iterative design process focused on the user experience.
Kate died at the age of 75 after her sixth grandchild's birthday party. Her death was unexpected. Later that week, Quinn also died at age 75. Ally and James then grew up their newborn twins Luke and Lorelai. Galahad had just finished his final exams and was relaxing at home when his housemate Tessa returned from celebrating her engagement.
Nick is a wealthy 20-year-old British man who lives in London and parties excessively, having multiple girlfriends at once. After cheating on four women who find out, his life falls apart and he realizes that true happiness comes from meaningful relationships, not money or possessions. The film is targeted at audiences aged 16 and up who enjoy clubbing and partying in London like the main character. Key locations used in filming include Westminster Abbey, Big Ben, and clubs in Mayfair to depict Nick's extravagant lifestyle before he learns his lesson.
Charlie receives a phone call that her grandmother has passed away. She returns home with her brothers where their mother Quinn informs them that one of them will need to take over the family legacy. Both Charlie and her brother Gideon decline as Charlie wants to move into her grandmother's house and Gideon is gay and doesn't want to risk not being able to marry his boyfriend. This leaves their youngest brother James as the heir to the family legacy.
La Unión Europea ha propuesto un nuevo paquete de sanciones contra Rusia que incluye un embargo al petróleo. El embargo prohibiría la importación de petróleo ruso a la UE y también prohibiría a los buques europeos transportar petróleo ruso a otros lugares. Sin embargo, Hungría se opone al embargo al petróleo, lo que podría retrasar la aprobación del paquete de sanciones de la UE.
The document discusses various free multimedia tools that can be used in the classroom, including photo editing software, photo sharing sites, audio streaming websites, and video creation tools. It provides examples of using Pixlr for photo editing, Flickr and Voicethread for sharing media, Pandora and LastFM for streaming audio, and Animoto, Flixtime, and Windows Movie Maker for creating videos from photos and adding effects, music, and voice narration. The author found the class on multimedia tools to be one of their favorites and especially enjoyed learning how to make videos and add voice to pictures through Voicethread.
The document discusses switching the format of updates for "The Four Legacies" from written chapters to picture slideshows ("picspam updates") due to the time it takes to write full chapters. It then provides the first picspam update, sharing pictures of the sims and their activities over time, including births, age progressions, holidays and more. The author asks for feedback on the new picspam format versus returning to written chapters.
Zack Blanchflower is an experienced healthcare IT professional with over 7 years of experience implementing and optimizing electronic health records systems. He has 3 years of experience with Epic OpTime/Anesthesia and was involved in full Epic implementations and upgrades. He has a background in biology and healthcare and holds Epic OpTime and Anesthesia certifications.
Open Insights Harvard DBMI - Personal Health Train - Kees van Bochove - The HyveKees van Bochove
In this talk, the Personal Health Train concept will be introduced, which enables running personalized medicine workflows as trains visiting data stations (e.g. hospital records, primary care records, clinical studies and registries, patient-held data from e.g. wearable sensors etc.) The Personal Health Train is a very powerful concept, which is however dependent on source medical data to be coded with appropriate metadata on consent, license, scope etc. of the data, and the data itself to be encoded using biomedical data standards, which is an ever growing field in biomedical informatics. In order to realize the Personal Health Train biomedical data will need to be FAIR, i.e. adopt the FAIR Guiding Principles. This talk will cover the emerging GO-FAIR international movement, and provide examples of how several European health data networks currently are adopting open standards based stacks, to enable routine health care data to be come accessible for research.
Zack Blanchflower is an experienced healthcare IT professional with over 7 years of experience implementing and optimizing electronic health records systems, including 3 years working with Epic OpTime/Anesthesia. He has helped hospitals nationwide with planning, implementing, and optimizing their EHRs.
The MARC-HI EHR Project aims to build a reference implementation of Canada's national Electronic Health Record (EHR) system using open source tools. The project brings together academic researchers and industry partners to develop interoperable EHR systems based on standards. Initial demonstrations showed the ability to share patient discharge summaries and referrals between different healthcare providers. Ongoing work includes integrating laboratory data and evaluating system performance. Challenges include integrating legacy systems and developing tools to simplify working with complex EHR specifications and messages.
Jonell Agyei-Sakyi has over 10 years of experience in healthcare IT. She has worked as a senior technical analyst for the ConnectingGTA program, managing the implementation of laboratory data feeds from multiple hospitals into a central repository. She also has experience as an EHR trainer, business analyst, and billing specialist. She is proficient in areas such as HL7 data exchange, clinical workflows, healthcare standards, and databases. In her current role, she coordinates technical activities between vendors and healthcare providers. She also participates in testing and troubleshooting to ensure seamless integration.
eHealth Governance in a Local Organisation. The Experience from Pompidou Hospital. Degoulet P. eHealth week 2010 (Barcelona: CCIB Convention Centre; 2010)
Supporting a Collaborative R&D Organization with a Dynamic Big Data SolutionSaama
Nikhil Gopinath presents regarding big data solutions at the Big Data and Analytics for Healthcare and Life Sciences Summit on October 18, 2017 in San Francisco, CA.
Stephen Friend CRUK-MD Anderson Cancer Workshop 2012-02-28Sage Base
This document summarizes Stephen Friend's talk on open source pre-competitive drug discovery. It discusses moving beyond linear investigations of science and how researchers work by exploring new forms of partnering and collaboration between organizations. Examples are given of data and resources being shared between pharmaceutical companies, cancer centers, and non-profit organizations to enable more integrated approaches to classifying disease subtypes and developing combination therapies. The challenges of current disease models and pathway knowledge are noted. There is a call for more diverse and powerful use of network models to gain a deeper understanding of overlapping biological pathways and the complexity of disease. Sage Bionetworks is introduced as a non-profit working to create an open commons to accelerate disease research through data sharing and collaborative
Pistoia presentation bio it-worldexpo 21april2010Nick Lynch
The document summarizes the origins and operations of the Pistoia Alliance, a non-profit organization formed to facilitate pre-competitive collaboration in the life sciences industry. The Pistoia Alliance was formed in Pistoia, Italy by GSK, AZ, Pfizer and Novartis to address common challenges with data interchange. Its mission is to standardize data exchange to reduce costs. Current projects include developing standards for semantic enrichment of literature, sequence data services, and electronic lab notebook queries. The organization has over 30 members and operates working groups to develop open standards through a governance process.
Douglas Kingsford is a practicing GP and CEO who is interested in artificial intelligence, workflow, and electronic health records (EHRs). He discusses that EHRs are about interoperability, sharing data, and collaborating in patient care. However, achieving true interoperability is challenging and requires open standards, clinician input, and good governance. Simply putting data in centralized repositories or expecting everyone to use the same system will not work due to the proprietary needs of various stakeholders and desire for clinicians and patients to control personal data. True interoperability will require new types of cooperation and business models between all involved parties in a distributed system with no central control.
Stephen Friend Dana Farber Cancer Institute 2011-10-24Sage Base
The document discusses building disease models using data intensive science and open medical information systems, with the goal of better understanding disease biology before testing drugs. It describes the Sage Bionetworks non-profit organization, which aims to create a commons for shared disease maps and models through several pilot projects including clinical trial data sharing and identifying cancer patients who do not respond to approved drug regimens.
This document discusses knowledge engineering for health and big data. It notes that the rate of data generation is changing but complexity, requirement to use data, and mass of useless data are stable. Knowledge engineering was first defined in 1983 as integrating knowledge into computer systems to solve complex problems. The document discusses building a knowledge engineering community and notes a need for standards around semantics, syntax, technology, and quality. It advocates for a knowledge extraction approach rather than data warehouses and discusses architectural concepts, policy and strategy considerations, and acknowledges GEN2PHEN partners and funding sources.
Talk entitled "from the Virtual Human to a Digital Me" presented at the Virtual Physiological Human 2012 Conference held at IET Savoy, Savoy Place, London, 18-20 September 2012.
This document discusses plans to develop an electronic health record (eHR) system in Hong Kong called CMS III & eHR. The goals are to improve integrated care, support evidence-based practice, and facilitate information sharing across public and private healthcare settings. Challenges include high patient volumes, an aging population, and currently using paper records. Opportunities include increasing public awareness and more capabilities in the existing CMS system. CMS III will improve quality, efficiency and management. The vision is for a system that supports care delivery, improves outcomes, and facilitates community-wide data sharing. Development will be government-led through a multi-phase process with public-private partnerships.
What Data Science Will Mean to You - One Person's ViewPhilip Bourne
This document provides an overview of data science from the perspective of Philip Bourne. Some key points:
- Data science is disruptive to higher education and all disciplines are being impacted by large amounts of digital data.
- Data science can be defined using a 4+1 model focusing on value, design, systems, analytics, and practice.
- Principles of excellence, inclusivity, openness, and fairness should guide data science work.
- Lessons from advances in computational biology and AlphaFold2 show the importance of open data, collaboration, and engineering challenges.
- A data science school should focus on responsible data practices while balancing open research that benefits patients.
The document discusses Lundbeck's use of open source software in pharmaceutical research and informatics. It describes how Lundbeck uses open source tools like Linux, Ruby on Rails, and GNU Scientific Library to build its in-house research platform LSP. It also discusses Lundbeck's involvement in pre-competitive collaborations through initiatives like Pistoia Alliance and IMI, which aim to improve data sharing and interoperability through open source solutions. The document advocates for more use of open standards and semantic technologies to better integrate diverse data sources and enable collaborative research.
This document summarizes a panel discussion on strategies for achieving excellence in healthcare IT. The panelists were the CIOs of Main Line Health, UKE Hamburg, and St. Michael's Hospital. They discussed their experiences implementing electronic medical record systems and overcoming challenges such as change management, clinical engagement, and balancing privacy with mobility. Key lessons included developing standardized processes, taking a top-down approach with hospital-wide responsibility, and moving quickly during implementation.
Integrating OPEN ANNOTATION with any DOMAIN ONTOLOGY Paolo Ciccarese
This document discusses integrating annotations with domain ontologies using the Open Annotation model. It begins by introducing the speaker, Paolo Ciccarese, and his background working on knowledge representation and annotation. It then provides an overview of annotation and the Open Annotation model. Key points include that annotation allows relating digital resources, is important for search and discovery, and the Open Annotation model supports annotating any type of body and target. The document discusses using semantic tags from ontologies to annotate resources and provides examples of annotating images and text. It also introduces tools like Domeo that facilitate semantic annotation using ontologies and text mining. Finally, it discusses additional applications of annotation like annotating antibodies and scientific hypotheses.
(Live) Annotopia Overview by Paolo Ciccarese (Architect and principal developer)Paolo Ciccarese
Annotopia is a Universal Annotation Hub that provides you with back-end technology so that you can focus on the user interface and the knowledge creation process. Annotopia talk at 'I Annotate 2014': https://www.youtube.com/watch?v=UGvUbFv0Zl8
The document discusses Annotopia, an open annotation server that aims to support the creation, persistence, and management of annotations on any identifiable documents, multimedia, and data. It provides services and APIs for storage, search, reporting, text mining, image analysis, and integrating with controlled vocabularies and other systems. Annotopia seeks to make annotation easier by allowing the use of multiple annotation tools and clients without being tied to a specific one.
1) Annotation can help provide the best up-to-date knowledge to end users while preserving the historical record by involving experts in the knowledge creation and extraction process through crowd-sourcing annotation and semantic annotation.
2) While annotation is a useful tool, the answer to effectively sharing knowledge is not simple, as there are still many open issues around representation of knowledge and integration of data from different sources.
3) The presenter's past work with clinical practice guidelines and knowledge representation highlighted the importance of interaction between domain experts and knowledge engineers in developing structured knowledge representations, as well as the need for more explicit semantics through use of ontologies and linked data.
Open Annotation, Specifiers and Specific Resources tutorialPaolo Ciccarese
2nd part of the west coast Open Annotation rollout:
- Open Annotation Core Model http://www.slideshare.net/azaroth42/open-annotation-core-data-model-tutorial
The document discusses the W3C Open Annotation Data Model group and their work developing an interoperable data model for annotations. It aims to allow annotations of digital resources to be portable, aggregated, and shared across different applications and platforms. The group brings together the Annotation Ontology and Open Annotation Collaboration efforts to define a common model. The model defines the basic components of an annotation - body and target - and provides examples of use cases like bookmarking, commenting, and annotating text fragments and media.
Paolo Ciccarese and Tommaso Teofili
These slides present
- current facilities and future plans for the Domeo Annotation Toolkit relating specifically to textmining use cases.
- and details of the integration of the Domeo Annotation Toolkit with Apache UIMA through Apache Clerezza.
This document discusses the Annotation Ontology (AO) and the SWAN Annotation Tool. AO is an OWL vocabulary for annotating and sharing annotations of digital resources and fragments. The SWAN Annotation Tool allows users to visually annotate documents and share annotations privately or publicly. It integrates with databases and ontologies and can run text mining algorithms on documents to assist in annotation. The tool aims to facilitate collaborative curation and knowledge sharing within scientific communities.
Claim #1: Intramembranous Aβ behaves as chaperones of other membrane proteins
An example of application of the nanopublications approach to represent AlzSWAN content.
The document describes the process of running text mining services on a news article using the SWAN Annotation Framework. It involves loading a news article, selecting text mining services to run, running the services, displaying the results, listing results in a summary panel, displaying annotations in the text, setting a summary panel, curating annotations, and extending annotations generated by the services.
AO: Annotation Ontology for science on the webPaolo Ciccarese
The document introduces the Annotation Ontology (AO), which aims to serve scientific online communities by allowing the annotation of documents on the web. AO builds upon existing annotation frameworks like Annotea and incorporates existing ontologies. It allows annotating any part of a document and different types of annotations. AO also handles annotation curation and organization into sets and perspectives for publication. Overall, AO provides a standardized way to annotate and organize annotations of documents online for scientific collaboration and discourse.
The document describes the Annotation Ontology (AO) which was developed based on Annotea for annotating different types of documents like text, images, audio, and video. AO defines different types of selectors to specify the context within documents being annotated. It also defines annotation types that are subclasses of the main Annotation type like Comment, Erratum, Question, and Explanation. AO supports grouping annotations into sets and combining annotation sets for specific documents. It aims to integrate with Annotea and SIOC standards for annotations.
1. Seman/cs is not a luxury
Building the new genera/on of Clinical Informa/on Systems
“Intra‐ and Inter‐operability”
Paolo Ciccarese*, PhD
Co‐founder and knowledge architect
*Assistant in Neurology @MassachuseHs General Hospital, Instructor in Bioinforma/cs @Harvard Medical School,
Health Care Life Science Interest Group @W3C, Consultant in SoOware innova/on
2. Timeline
Mass General/Harvard Medical School
Visitor at Stanford Univ.*
* Decision Support/ Workflow and Ontology
Based SoOware Dev. (Constant innova/on)
Online Scien/fic Communi/es
(Ontologies and Interoperability)
HCLS IG W3C
(Seman/c Web Technologies)
Simile Project – MIT**
HMS Faculty
(Seman/c Interoperability)
University of Pavia and Consultant
Clinical Workflow, Decision Support and Knowledge Management (Guide Project)
Temporal Abstrac/ons in Medicine
Regional and Na/onal Networks
2000 2004 2005 2006 2007 2008 2009
*Visi/ng Samson Tu (SAGE author) **Volunteer (coding)
4. Medicognos Research background
P.Ciccarese Phd ( Medicognos architect)
Mass General/Harvard Medical School
Online Scien/fic Communi/es
(Ontologies and Interoperability)
HCLS IG W3C
(Seman<c Web Technologies)
Simile Project – MIT**
HMS Faculty
(Seman<c Interoperability)
University of Pavia and Consultant
Clinical Workflow, Decision Support and Knowledge Management (Guide Project)
Temporal Abstrac<ons in Medicine
Regional and Na<onal Networks
New Genera/on Knowledge & Process Based EHR
2000 2004 2005 2006 2007 2008 2009
Decision Support/ Workflow and Ontology Based So:ware Dev.
5. Original GPs requirements 2005
1. Usability
2. Process Management/Op/miza/on/Improvement
3. Collabora/on ‐ care networks
4. Medical Knowledge Management ‐ formal mul/lingual
terminologies, evidence‐based recommenda/ons
5. Communica/on ‐ interoperability with labs and hospitals
Transform the problem oriented EPR in a distributed clinical process
management system with embedded clinical decision support
Con/nuity of Care and Disease Management
7. Why it is so hard?
Diminishing the seman/c impedance
physician mental model soOware
Usability
Evidence‐based
Workflow op/miza/on
medicine
Cost Containment Economies by Outcome
(Disease Management) Improvement
Interoperability
Quality of data informa/on knowledge
encoded in the plaporm and
exchanged with the external world
9. eHealth for Safety 2007*
New genera/on of advanced, user‐friendly and
ubiquitous tools for:
• Integra/on of decision support and workflow
support systems with pa/ent record
• Knowledge representa/on
• Advanced terminology‐driven eHealth tools for data
entry and retrieval
• Clinical informa/on systems integra/on of pa/ent
data across the con/nuum of care
* eHealth for Safety – Impact of ICT on Pa/ent Safety and Risk Management,
October 2007 European commission, Informa/on Society and Media
11. New organiza/onal architecture
Health Insurance
Data 2x anonym
P4P Quality Indicators
Primes
(global)
Feedback
GP Data
anonymized
P4P Primes
Cl Experts
QI PH Experts SP
Coaches MD
Pharmacy
Pa/ent
Nurse Hospital
12. New informa/on architecture
Knowledge based Clinical Workflow Management with Decision Support
Patient Status Patient Status Patient Status
Data Data Data
Data Data Data
KPI KPI KPI
Clinical Guideline
CDS Operational Process Management
ex: lab tests
Care flow execution Alerts
Agreed Care Plan
Quality /Safety /Efficiency
Indicators Ac/vity 1 D Ac/vity 2 Ac/vity n
Process Reenginering Process Mining
Strategic Process Management
CDS :clinical decision support
13. The key role of clinical decision support
• All currently known large studies concluded that: EPR/
EHR are not enough for quality improvement!
• As EHR use broadens, one should not assume an
automa/c diffusion of improved quality of care
• In selec/ng an EHR, physician prac/ces should carefully
consider the inclusion of: clinical decision support to
facilitate quality care
1.EMR SophisBcaBon Correlates to Hospital Quality Data, Comparing EMR AdopBon to Care Outcomes, HIMSS 2007
2.Electronic Medical Records and Diabetes Quality of Care: Results From a Sample of Family Medicine PracBces Jesse C. Crosson, PhD ANNALS OF FAMILY
MEDICINE MAY/JUNE 2007
3.Electronic Health Record Use and the Quality of Ambulatory Care in the United States, Jeffrey A. Linder ARCH INTERN MED JULY 2007
4.The Value of InformaBon Technology‐Enabled Diabetes Management Davis Bu,Center for InformaBon Technology Leadership. 2007
17. Ontology‐based plaporm
• Every aspect in the system is built on ontologies
defined using a subset of OWL (proprietary
solu/on at run/me)*
• More expressive OWL for analysts (knowledge
modeling, model checking, maintenance, mining)
with enterprise tools
• Referent tracking** (unique IDs)
* Ontology‐Based Integra/on of Medical Coding Systems and Electronic Pa/ent Records
Ceusters W, Smith B, De Moor G
** Strategies for referent tracking in electronic health records. Ceusters W,
Smith B. J Biomed Inform. 2006 Jun;39(3):362‐78. Epub 2005 Sep 9.
21. Unified Seman/c Model
Occurrence
How it occurred
When?
Who reported it?
What were circumstances?
…
Process (Workflow)
How it was acquired
Who?
Biomedical
Disease
When? Sign
What
Data
Within which Symptom
careplan task? …
…
Classifiers
‐ Ac/ve problems/cau/ons/…
Journal
‐ Encounter/sub‐encounter Medicognos
‐ Observa/on/Query templates Onthotypes®
How it organized for the users
Clinical Info Management
22. Medicognos onthotypes®
• Defined through expressions
• Decoupling meaning from presenta/on
• Extensive usage of classifica/on
• Mul/ple presenta/on forms can have the same
meaning
29. Medicognos architecture
20%
80%
Onto‐Terminology Info. Models Executable Drug Wf Executable CDS logic
“ontotypes” KB Templates KB Drug Therapy Wf KB Rules KB
Concept Template Workflow Drug KB Queries &Rules Builder
Builder Builder Builder Builder Clinical Domain Language
Clinical Knowledge Management Studio
Domain Clinical SituaBon Care OrganisaBon
Biomedical
Ontologies Care Plan
OBO?
BFO? OrganisaBon
Time/Space Process
FoundaBonal layer
30. 2 cents on interoperability
• Need for formally defined seman/cs
• Intra‐operability and Inter‐operability go together
• Being able to communicate with other systems
depends on the expressiveness of the “internals” first
and of the communica/on protocols later on
• The seman/c models have to be produced
incrementally and tested con/nuously in seman/cally
oriented soOware (full stack)
• The seman/c is not limited to pa/ent data but is a
mix‐up of several clinical aspects
• All the aspects have to evolve in lockstep