Enhance your screening ability and advance your research by using the gold standard reagent for the study of histone and DNA methylation – Adenosyl- L-Methionine, S-[methyl-3H]; (3H-SAM)

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H-SAM FOR
EPIGENETICS
RESEARCH
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H-SAM Enhance your screening ability and advance your research by using the gold
Methylation Assay standard reagent for the study of histone and DNA methylation – Adenosyl-
L-Methionine, S-[methyl-3H]; (3H-SAM). This reagent enables both quantitative
kinetic measure of substrate methylation rates and the measure of methyltransferases with low
activity. By using 3H-SAM, the labeled methyl group is directly incorporated without disrupting the
biology of the reaction you’re studying. Save time and money – there is no need for detection
antibodies or signal amplification reagents.
Gold standard detection Target areas of study
• High sensitivity to detect low • Cancer
levels of enzyme activity • Stem cells
• Direct methylation • Immunology
measurement
• Neurodegenerative diseases
• No antibodies
• And many others
• Reliable screening method
for over 50 years
www.perkinelmer.com/3H-SAM

2. ORdERING INFORMATION
To choose the right product for your methylation assays, PerkinElmer offers several Adenosyl-L-Methionine, S-[methyl-3H]
products varying in solvent, specific activity, concentration and package size.
Product Specific Activity Concentration Size Part Number
Adenosyl-L-Methionine, S-[methyl- H] 3
5-15 Ci (185-555 GBq)/mmol 0.55 mCi (20.35 MBq)/mL 50 uCi (1.85 MBq) NET155050UC
5-15 Ci (185-555 GBq)/mmol 0.55 mCi (20.35 MBq)/mL 250 uCi (9.25 MBq) NET155250UC
5-15 Ci (185-555 GBq)/mmol 0.55 mCi (20.35 MBq)/mL 1.0 mCi (37 MBq) NET155001MC
Packaged in 10 mM sulfuric acid: ethanol (9:1).
Shipped in dry ice.
Adenosyl-L-Methionine, S-[methyl-3H] 55-85 Ci (2.03-3.15 TBq)/mmol 0.55 mCi (20.35 MBq)/mL 250 uCi (9.25 MBq) NET155H250UC
55-85 Ci (2.03-3.15 TBq)/mmol 0.55 mCi (20.35 MBq)/mL 1.0 mCi (37 MBq) NET155H001MC
Packaged in 10 mM sulfuric acid: ethanol (9:1)
under argon. Shipped in dry ice.
Adenosyl-L-Methionine, S-[methyl-3H] 12-18 Ci (444-666 GBq)/mmol 1.0 mCi (37 MBq)/mL 250 uCi (9.25 MBq) NET155V250UC
12-18 Ci (444-666 GBq)/mmol 1.0 mCi (37 MBq)/mL 1.0 mCi (37 MBq) NET155V001MC
Packaged in hydrochloric acid, pH 2.0-2.5,
under argon. Shipped in dry ice.
Complete Radiometric Solutions
From quality microplates, vials, scintillation cocktails, scintillation proximity assay (SPA) technologies and instruments.
PerkinElmer offers complementary products for your radioactive assays.
• SPA Beads and FlashPlates®
• Liquid scintillation analyzers
• Liquid scintillation and luminescence counters
• Gamma counters
• Radiomatic flow scintillation analyzers
• Microplates and vials MicroBeta2TM
• Liquid scintillation cocktails
• Radiation safety equipment
Tri-Carb®
• Cytostar-T® and scintillation microplates
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H-SAM is part of PerkinElmer’s comprehensive solution for understanding cellular signaling and morphology in
context. Only PerkinElmer provides multidirectional biochemical and cellular approaches, which enable researchers
to locate, detect and quantitate complex cellular events in the areas of cancer and epigenetic research.
PerkinElmer, Inc.
940 Winter Street
Waltham, MA 02451 USA
P: (800) 762-4000 or
(+1) 203-925-4602
www.perkinelmer.com
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009197_01 Printed in USA Jun. 2010