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Prostatectomia radicale ed efficacia ddeeii ddiiffffeerreennttii 
pprroottooccoollllii tteerraappeeuuttiiccii nneellllaa DDEE ppoosstt--cchhiirruurrggiiaa:: 
EEssiissttee uunn rruuoolloo rriiaabbiilliittaattiivvoo ddeeggllii II--PPDDEE55,, FFIICC oo aallttrroo?? 
FFaabbrriizziioo GGaalllloo 
SS..CC.. UUrroollooggiiaa 
OOssppeeddaallee SS.. PPaaoolloo,, SSaavvoonnaa
Il DE èè uunnaa ppoossssiibbiillee ccoommpplliiccaannzzaa sseeccoonnddaarriiaa 
aa qquuaalluunnqquuee ttiippoo ddii ttrraattttaammeennttoo ppeerr ttuummoorree 
pprroossttaattiiccoo 
IIll ttaassssoo ddii DDEE iiaattrrooggeennaa vvaarriiaa ttrraa 3300%% ee 9900%% 
↓↓ 
EE’’ uunn pprroobblleemmaa rriilleevvaannttee!!
Fisiopatologia ddeell DDEE iiaattrrooggeennoo 
Mulhall J. Et al J Sex Med 2013;10:195–203
TTrraattttaammeennttoo rriiaabbiilliittaattiivvoo 
≠≠ 
TTrraattttaammeennttoo ddeellllaa DDEE 
IIll ccoonncceettttoo ddii rriiaabbiilliittaazziioonnee vvaa oollttrree iill 
ttrraattttaammeennttoo ddeellllaa DDEE iiaattrrooggeennaa iinn qquuaannttoo 
pprreevveeddee uunnaa sseerriiaa ddii iinntteerrvveennttii aall ddii ffuuoorrii
Trattamento rriiaabbiilliittaattiivvoo ddeell DDEE iiaattrrooggeennoo 
1. Come agisce? 
2. Migliora davvero l’attività erettiva? 
3. Quale tipo di trattamento?
Trattamento rriiaabbiilliittaattiivvoo ddeell DDEE iiaattrrooggeennoo 
1. Come agisce? 
2. Migliora davvero l’attività erettiva? 
3. Quale tipo di trattamento?
Gli obiettivi ddeellllaa rriiaabbiilliittaazziioonnee ssoonnoo bbaassaattii 
ssuu ttrree aassppeettttii:: 
11.. MMiigglliioorraarree ll’’oossssiiggeennaazziioonnee ddeeii ccoorrppii ccaavveerrnnoossii 
22.. PPrreesseerrvvaarree ssttrruuttttuurraa ee ffuunnzziioonnee ddeellll’’eennddootteelliioo 
33.. PPrreevveenniirree llee mmooddiiffiiccaazziioonnee ddeellllee cceelllluullee 
mmuussccoollaarrii lliissccee ddeeii ccoorrppii ccaavveerrnnoossii
Trattamento rriiaabbiilliittaattiivvoo ddeell DDEE iiaattrrooggeennoo 
1. Come agisce? 
2. Migliora davvero l’attività erettiva? 
3. Quale tipo di trattamento?
Trattamento rriiaabbiilliittaattiivvoo ddeell DDEE iiaattrrooggeennoo 
1. Come agisce? 
2. Migliora davvero l’attività erettiva? 
3. Quale tipo di trattamento?
QQuuaallee ttiippoo ddii ttrraattttaammeennttoo?? 
1. I-PDE5 
2. F.I.C. o intraurethral alprostadil 
3. Vacuum device
II--PPDDEE55 
Sildenafil (1998): Viagra 25-50-100 mg 
Tadalafil (2003): 5-10-20 mg 
Vardenafil (2003): 2,5-5-10-20 mg 
Avanafil (2014): 50-100-200 mg
II--PPDDEE55
II--PPDDEE55 
QQuuaallee ttiippoo ddii ssoommmmiinniissttrraazziioonnee?? 
OOnnccee aa ddaayy vvss oonn ddeemmaanndd??
QQuuaallee ttiippoo ddii ssoommmmiinniissttrraazziioonnee??
QQuuaallee ttiippoo ddii ssoommmmiinniissttrraazziioonnee??
QQuuaallee ttiippoo ddii ssoommmmiinniissttrraazziioonnee??
II--PPDDEE55 
Quale ttiippoo ddii ssoommmmiinniissttrraazziioonnee??
FF..II..CC..
FF..II..CC..
TTrraannssuurreetthhrraall aallpprroossttaaddiill
VVAACCUUUUMM DDEEVVIICCEE
VVAACCUUUUMM DDEEVVIICCEE
QQuuaallee ttiippoo ddii ttrraattttaammeennttoo??
II--PPDDEE55 
Treatment I-PDE5 95% 
I.C.I. 75% 
Vacuum device 30% 
Intraurethral alprostadil 10% 
Teloken et al. J Sex Med 2009; 6: 2032-2038
Teloken et al. J Sex Med 2009; 6: 2032-2038 
IAM 2014
SScchheemmaa ppeerrssoonnaallee 
I-PDE5 on 
demand 
oppure nulla 
I-PDE5 on 
demand 
oppure nulla 
 
 

CCoonncclluussiioonnii 
1. La riabilitazione è più efficace dell’osservazione 
2. Dovrebbe iniziare al più presto possibile 
3. I-PDE5 possono essere usati con successo nei pazienti sottoposti a RP NS 
4. Altri trattamenti (FIC, Vacuum…) possono essere associati o utilizzati, 
soprattutto in caso di inefficacia degli I-PDE5
CCoonncclluussiioonnii 
1. Scarsa evidenza per supportare veri e propri protocolli riabilitativi 
2. Specifici trattamenti non possono essere raccomandati 
3. La riabilitazione dovrebbe essere pianificata in dosi e combinazioni variabili, 
considerando i desideri e le aspettative del paziente 
4. Questi trattamenti dovrebbero essere somministrati al più presto 
5. Attenzione a non enfatizzare troppo il ruolo della riabilitazione nel recupero 
dell’attività erettiva
Questa presentazione è disponibile sul sito I AM - Interact around Man - la 
community degli specialisti della salute dell’uomo: www.esanum.it/iam. 
powered by
Tu sei libero di: 
 condividere — riprodurre, distribuire, comunicare al pubblico, esporre in pubblico, rappresentare, 
eseguire e recitare questo materiale con qualsiasi mezzo e formato; 
 modificare — remixare, trasformare il materiale e basarti su di esso per le tue opere. 
Ai seguenti termini: 
1)Attribution — Devi attribuire adeguatamente la paternità sul materiale, fornire un link alla licenza e 
indicare se sono state effettuate modifiche. Puoi realizzare questi termini in qualsiasi maniera 
ragionevolmente possibile, ma non in modo tale da suggerire che il licenziante avalli te o il modo in cui usi 
il materiale; 
2)NonCommercial — Non puoi usare il materiale per scopi commerciali; 
3)ShareAlike — Se remixi, trasformi il materiale o ti basi su di esso, devi distribuire i tuoi contributi con la 
stessa licenza del materiale originario. 
I termini completi della licenza sono disponibili qui: http://creativecommons.org/licenses/by-nc-sa/4.0/deed.it

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Prostatectomia radicale ed efficacia dei differenti protocolli terapeutici nella DE post-chirurgia

  • 1. Prostatectomia radicale ed efficacia ddeeii ddiiffffeerreennttii pprroottooccoollllii tteerraappeeuuttiiccii nneellllaa DDEE ppoosstt--cchhiirruurrggiiaa:: EEssiissttee uunn rruuoolloo rriiaabbiilliittaattiivvoo ddeeggllii II--PPDDEE55,, FFIICC oo aallttrroo?? FFaabbrriizziioo GGaalllloo SS..CC.. UUrroollooggiiaa OOssppeeddaallee SS.. PPaaoolloo,, SSaavvoonnaa
  • 2. Il DE èè uunnaa ppoossssiibbiillee ccoommpplliiccaannzzaa sseeccoonnddaarriiaa aa qquuaalluunnqquuee ttiippoo ddii ttrraattttaammeennttoo ppeerr ttuummoorree pprroossttaattiiccoo IIll ttaassssoo ddii DDEE iiaattrrooggeennaa vvaarriiaa ttrraa 3300%% ee 9900%% ↓↓ EE’’ uunn pprroobblleemmaa rriilleevvaannttee!!
  • 3. Fisiopatologia ddeell DDEE iiaattrrooggeennoo Mulhall J. Et al J Sex Med 2013;10:195–203
  • 4. TTrraattttaammeennttoo rriiaabbiilliittaattiivvoo ≠≠ TTrraattttaammeennttoo ddeellllaa DDEE IIll ccoonncceettttoo ddii rriiaabbiilliittaazziioonnee vvaa oollttrree iill ttrraattttaammeennttoo ddeellllaa DDEE iiaattrrooggeennaa iinn qquuaannttoo pprreevveeddee uunnaa sseerriiaa ddii iinntteerrvveennttii aall ddii ffuuoorrii
  • 5. Trattamento rriiaabbiilliittaattiivvoo ddeell DDEE iiaattrrooggeennoo 1. Come agisce? 2. Migliora davvero l’attività erettiva? 3. Quale tipo di trattamento?
  • 6. Trattamento rriiaabbiilliittaattiivvoo ddeell DDEE iiaattrrooggeennoo 1. Come agisce? 2. Migliora davvero l’attività erettiva? 3. Quale tipo di trattamento?
  • 7. Gli obiettivi ddeellllaa rriiaabbiilliittaazziioonnee ssoonnoo bbaassaattii ssuu ttrree aassppeettttii:: 11.. MMiigglliioorraarree ll’’oossssiiggeennaazziioonnee ddeeii ccoorrppii ccaavveerrnnoossii 22.. PPrreesseerrvvaarree ssttrruuttttuurraa ee ffuunnzziioonnee ddeellll’’eennddootteelliioo 33.. PPrreevveenniirree llee mmooddiiffiiccaazziioonnee ddeellllee cceelllluullee mmuussccoollaarrii lliissccee ddeeii ccoorrppii ccaavveerrnnoossii
  • 8. Trattamento rriiaabbiilliittaattiivvoo ddeell DDEE iiaattrrooggeennoo 1. Come agisce? 2. Migliora davvero l’attività erettiva? 3. Quale tipo di trattamento?
  • 9.
  • 10.
  • 11.
  • 12.
  • 13.
  • 14.
  • 15. Trattamento rriiaabbiilliittaattiivvoo ddeell DDEE iiaattrrooggeennoo 1. Come agisce? 2. Migliora davvero l’attività erettiva? 3. Quale tipo di trattamento?
  • 16. QQuuaallee ttiippoo ddii ttrraattttaammeennttoo?? 1. I-PDE5 2. F.I.C. o intraurethral alprostadil 3. Vacuum device
  • 17. II--PPDDEE55 Sildenafil (1998): Viagra 25-50-100 mg Tadalafil (2003): 5-10-20 mg Vardenafil (2003): 2,5-5-10-20 mg Avanafil (2014): 50-100-200 mg
  • 18.
  • 19.
  • 20.
  • 22. II--PPDDEE55 QQuuaallee ttiippoo ddii ssoommmmiinniissttrraazziioonnee?? OOnnccee aa ddaayy vvss oonn ddeemmaanndd??
  • 23. QQuuaallee ttiippoo ddii ssoommmmiinniissttrraazziioonnee??
  • 24. QQuuaallee ttiippoo ddii ssoommmmiinniissttrraazziioonnee??
  • 25. QQuuaallee ttiippoo ddii ssoommmmiinniissttrraazziioonnee??
  • 26. II--PPDDEE55 Quale ttiippoo ddii ssoommmmiinniissttrraazziioonnee??
  • 27.
  • 33. QQuuaallee ttiippoo ddii ttrraattttaammeennttoo??
  • 34. II--PPDDEE55 Treatment I-PDE5 95% I.C.I. 75% Vacuum device 30% Intraurethral alprostadil 10% Teloken et al. J Sex Med 2009; 6: 2032-2038
  • 35. Teloken et al. J Sex Med 2009; 6: 2032-2038 IAM 2014
  • 36. SScchheemmaa ppeerrssoonnaallee I-PDE5 on demand oppure nulla I-PDE5 on demand oppure nulla   
  • 37. CCoonncclluussiioonnii 1. La riabilitazione è più efficace dell’osservazione 2. Dovrebbe iniziare al più presto possibile 3. I-PDE5 possono essere usati con successo nei pazienti sottoposti a RP NS 4. Altri trattamenti (FIC, Vacuum…) possono essere associati o utilizzati, soprattutto in caso di inefficacia degli I-PDE5
  • 38. CCoonncclluussiioonnii 1. Scarsa evidenza per supportare veri e propri protocolli riabilitativi 2. Specifici trattamenti non possono essere raccomandati 3. La riabilitazione dovrebbe essere pianificata in dosi e combinazioni variabili, considerando i desideri e le aspettative del paziente 4. Questi trattamenti dovrebbero essere somministrati al più presto 5. Attenzione a non enfatizzare troppo il ruolo della riabilitazione nel recupero dell’attività erettiva
  • 39. Questa presentazione è disponibile sul sito I AM - Interact around Man - la community degli specialisti della salute dell’uomo: www.esanum.it/iam. powered by
  • 40. Tu sei libero di:  condividere — riprodurre, distribuire, comunicare al pubblico, esporre in pubblico, rappresentare, eseguire e recitare questo materiale con qualsiasi mezzo e formato;  modificare — remixare, trasformare il materiale e basarti su di esso per le tue opere. Ai seguenti termini: 1)Attribution — Devi attribuire adeguatamente la paternità sul materiale, fornire un link alla licenza e indicare se sono state effettuate modifiche. Puoi realizzare questi termini in qualsiasi maniera ragionevolmente possibile, ma non in modo tale da suggerire che il licenziante avalli te o il modo in cui usi il materiale; 2)NonCommercial — Non puoi usare il materiale per scopi commerciali; 3)ShareAlike — Se remixi, trasformi il materiale o ti basi su di esso, devi distribuire i tuoi contributi con la stessa licenza del materiale originario. I termini completi della licenza sono disponibili qui: http://creativecommons.org/licenses/by-nc-sa/4.0/deed.it

Editor's Notes

  1. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  2. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  3. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  4. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  5. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  6. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  7. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  8. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  9. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  10. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  11. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  12. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  13. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  14. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  15. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  16. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  17. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  18. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.
  19. Permixon is one of the medical treatment of uncomplicated, symptomatic BPH most widely used. It is an hexane lipido-sterolic extract of Serenoa repens. This part of the presentation will detail the outcomes of the investigation on this drug.