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The document discusses the importance of including information on harmful effects when conducting systematic reviews in order to properly assess the balance of benefits and harms of interventions. It notes that data on adverse effects is often incomplete and of lower quality than data on effectiveness, and provides suggestions for how to search for, analyze, and synthesize this information to provide a more comprehensive assessment of medical treatments. Gaps and weaknesses in current data on adverse effects are identified, and guidance is provided on prioritizing reviews to fill these evidence gaps.
Use of economic calculations towards fisheries management decisionsRobert Lee
This document discusses using financial calculations to inform fisheries management decisions in Thai trawl fisheries. It presents data on costs, earnings, and internal rates of return for 14-18m otter trawlers. Sensitivity analysis shows the IRR is most sensitive to changes in fuel price, trash fish price, and number of fishing days. Two scenarios are analyzed that increase prices and reduce fishing days, resulting in a higher IRR of 11.85%. Management questions are raised about reducing fishing effort by having fewer fishing days per vessel and paying processors to increase prices, which could reduce bycatch by nearly 3,000 tonnes annually across 1,500 boats.
ABSTRACT
The main objective of present research work is to formulate the of Domperidone Maleate floating tablets.
Domperidone Maleate, an antiemetic and a prokinetic agent belongs to BCS Class-II and Indicated for treatment of
upper gastrointestinal motility disorders by blocking the action of Dopamine. The Floating tablets of Domperidone
Maleate were prepared employing different concentrations of HPMCK4M and Guar Gum in different combinations
as a release rate modifiers by Direct Compression technique using 32 factorial design. The concentration of
HPMCK4M and Guar Gum was selected as independent variables, X1 and X2 respectively whereas, time required
for drug dissolution t10%, t50%,t75%,t90%were selected as dependent variables. Totally nine formulations were designed
and are evaluated for hardness, friability, thickness, Assay, Floating Lag time, In-vitro drug release. From the
Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro
dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like
intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for t10%,
t50%, t75%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations(C1,
C2). According to SUPAC guidelines the formulation (F5) containing combination of 18.75% HPMCK4M and
18.75% Guar Gum, is the most similar formulation (similarity factor f2=89.03, dissimilarity factor f1= 11.539& No
significant difference, t= 0.169) to marketed product (DOMSTAL OD). The selected formulation (F5) follows
Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.925).
Keywords: Domperidone Maleate, 32Factorial Design, Gastro retentive Floating Tablet, HPMCK100M, Sodium
bicarbonate, Floating Lag Time, SUPAC, Non-Fickian Diffusion Mechanism.
El documento describe los criterios clínicos y radiológicos para determinar la progresión de la artritis reumatoide, así como los criterios para la remisión y el estado funcional. Se dividen los estadios de progresión de 1 a 4 en función de la gravedad de la destrucción ósea y articular observada en radiografías. También se enumeran cinco criterios para definir la remisión de la artritis reumatoide y se clasifica el estado funcional en cuatro clases en función de la capacidad para realizar actividades de la vida diaria
The document discusses the importance of including information on harmful effects when conducting systematic reviews in order to properly assess the balance of benefits and harms of interventions. It notes that data on adverse effects is often incomplete and of lower quality than data on effectiveness, and provides suggestions for how to search for, analyze, and synthesize this information to provide a more comprehensive assessment of medical treatments. Gaps and weaknesses in current data on adverse effects are identified, and guidance is provided on prioritizing reviews to fill these evidence gaps.
Use of economic calculations towards fisheries management decisionsRobert Lee
This document discusses using financial calculations to inform fisheries management decisions in Thai trawl fisheries. It presents data on costs, earnings, and internal rates of return for 14-18m otter trawlers. Sensitivity analysis shows the IRR is most sensitive to changes in fuel price, trash fish price, and number of fishing days. Two scenarios are analyzed that increase prices and reduce fishing days, resulting in a higher IRR of 11.85%. Management questions are raised about reducing fishing effort by having fewer fishing days per vessel and paying processors to increase prices, which could reduce bycatch by nearly 3,000 tonnes annually across 1,500 boats.
ABSTRACT
The main objective of present research work is to formulate the of Domperidone Maleate floating tablets.
Domperidone Maleate, an antiemetic and a prokinetic agent belongs to BCS Class-II and Indicated for treatment of
upper gastrointestinal motility disorders by blocking the action of Dopamine. The Floating tablets of Domperidone
Maleate were prepared employing different concentrations of HPMCK4M and Guar Gum in different combinations
as a release rate modifiers by Direct Compression technique using 32 factorial design. The concentration of
HPMCK4M and Guar Gum was selected as independent variables, X1 and X2 respectively whereas, time required
for drug dissolution t10%, t50%,t75%,t90%were selected as dependent variables. Totally nine formulations were designed
and are evaluated for hardness, friability, thickness, Assay, Floating Lag time, In-vitro drug release. From the
Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro
dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like
intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for t10%,
t50%, t75%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations(C1,
C2). According to SUPAC guidelines the formulation (F5) containing combination of 18.75% HPMCK4M and
18.75% Guar Gum, is the most similar formulation (similarity factor f2=89.03, dissimilarity factor f1= 11.539& No
significant difference, t= 0.169) to marketed product (DOMSTAL OD). The selected formulation (F5) follows
Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.925).
Keywords: Domperidone Maleate, 32Factorial Design, Gastro retentive Floating Tablet, HPMCK100M, Sodium
bicarbonate, Floating Lag Time, SUPAC, Non-Fickian Diffusion Mechanism.
El documento describe los criterios clínicos y radiológicos para determinar la progresión de la artritis reumatoide, así como los criterios para la remisión y el estado funcional. Se dividen los estadios de progresión de 1 a 4 en función de la gravedad de la destrucción ósea y articular observada en radiografías. También se enumeran cinco criterios para definir la remisión de la artritis reumatoide y se clasifica el estado funcional en cuatro clases en función de la capacidad para realizar actividades de la vida diaria
Jaunā pedagoģija – jaunas lomas mācību klasē, virzoties no virspusējas faktu apgūšanas uz dziļākas izpratnes veidošanu, prasmju un rakstura attīstīšanu.
Andris Gribusts, izglītības uzņēmuma "Lielvārds" Kompetences centra vadītājs
Prezentācija 2016. gada 16. martā forumā "Iespēju Tilts"
Este documento describe una serie de actividades de una semana sobre números para alumnos de jardín de niños. Las actividades utilizan materiales manipulables como corchos, manos de cartón y círculos para que los estudiantes practiquen el reconocimiento y representación de números hasta 10 mediante el conteo de objetos. El propósito es que los estudiantes mejoren su razonamiento lógico y conocimiento de los números a través del juego y práctica con estrategias de conteo.
The document appears to list animals that can be found at a zoo using their first letter, including giraffe, lions, and foxes. It also mentions wolves. However, the formatting makes it difficult to discern all of the animals mentioned.
Content Marketing World: Training with Content Marketing Jedi Masters #CMWorldJim MacLeod
For a few days in late 2016, The Content Marketing Institute brought together the world's leaders in Content Marketing. Here are a few of the pearls of wisdom that they delivered to save us from the dark side of Marketing.
digital testing of high voltage circuit breakerRenuka Verma
The document discusses digital testing of high voltage circuit breakers. Digital testing involves developing a software model of a circuit breaker using measurements from standard laboratory tests. This allows evaluation of circuit breakers' performance in different scenarios without full-scale testing. Some advantages are reducing testing costs and time, estimating interrupting limits, and accelerating circuit breaker design development. Applications include analyzing the influence of parallel capacitance and current line length. Digital testing provides precise information about circuit breakers' performance.
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حجاب شرعی در عصر پیامبر امیر حسین ترکاشوندmohamad hamidi
اگر در دسترسی به این کتاب با مشکل مواجه شدید میتوانید این کتاب و کتابهای مشابه را از این آدرس نیز دریافت کنید
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قرآن بدون حدیث هم قابل فهم است مصطفی طباطباییmohamad hamidi
اگر در دسترسی به این کتاب با مشکل مواجه شدید میتوانید این کتاب و کتابهای مشابه را از این آدرس نیز دریافت کنید
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اگر در دسترسی به این کتاب با مشکل مواجه شدید میتوانید این کتاب و کتابهای مشابه را از این آدرس نیز دریافت کنید
https://www.mediafire.com/folder/9q7ki7q8obocv
Jaunā pedagoģija – jaunas lomas mācību klasē, virzoties no virspusējas faktu apgūšanas uz dziļākas izpratnes veidošanu, prasmju un rakstura attīstīšanu.
Andris Gribusts, izglītības uzņēmuma "Lielvārds" Kompetences centra vadītājs
Prezentācija 2016. gada 16. martā forumā "Iespēju Tilts"
Este documento describe una serie de actividades de una semana sobre números para alumnos de jardín de niños. Las actividades utilizan materiales manipulables como corchos, manos de cartón y círculos para que los estudiantes practiquen el reconocimiento y representación de números hasta 10 mediante el conteo de objetos. El propósito es que los estudiantes mejoren su razonamiento lógico y conocimiento de los números a través del juego y práctica con estrategias de conteo.
The document appears to list animals that can be found at a zoo using their first letter, including giraffe, lions, and foxes. It also mentions wolves. However, the formatting makes it difficult to discern all of the animals mentioned.
Content Marketing World: Training with Content Marketing Jedi Masters #CMWorldJim MacLeod
For a few days in late 2016, The Content Marketing Institute brought together the world's leaders in Content Marketing. Here are a few of the pearls of wisdom that they delivered to save us from the dark side of Marketing.
digital testing of high voltage circuit breakerRenuka Verma
The document discusses digital testing of high voltage circuit breakers. Digital testing involves developing a software model of a circuit breaker using measurements from standard laboratory tests. This allows evaluation of circuit breakers' performance in different scenarios without full-scale testing. Some advantages are reducing testing costs and time, estimating interrupting limits, and accelerating circuit breaker design development. Applications include analyzing the influence of parallel capacitance and current line length. Digital testing provides precise information about circuit breakers' performance.
اگر در دسترسی به این کتاب با مشکل مواجه شدید میتوانید این کتاب و کتابهای مشابه را از این آدرس نیز دریافت کنید
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حجاب شرعی در عصر پیامبر امیر حسین ترکاشوندmohamad hamidi
اگر در دسترسی به این کتاب با مشکل مواجه شدید میتوانید این کتاب و کتابهای مشابه را از این آدرس نیز دریافت کنید
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قرآن بدون حدیث هم قابل فهم است مصطفی طباطباییmohamad hamidi
اگر در دسترسی به این کتاب با مشکل مواجه شدید میتوانید این کتاب و کتابهای مشابه را از این آدرس نیز دریافت کنید
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