Python supports several numeric and non-numeric data types including integers, floats, complex numbers, strings, lists, and tuples. Numbers can be integers, floats, or complex, and support common operations. Strings are immutable sequences of characters that can be indexed, sliced, formatted, and concatenated. Lists are mutable sequences that can contain mixed data types, and support common operations like indexing, slicing, sorting, and joining. Tuples are similar to lists but are immutable.