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Lactoferrin (Lf) is 80 kDa iron-binding glycoprotein of transferrin family. It is made of single polypeptide chain folded into two symmetrical lobes. Lf is a basic, positively charged protein which has high iron binding affinity (Kd~10-20 M). Lf has been secreted from exocrine glands and in specific granules of Neutrophils. Lactoferrin has role in Iron transporting and various other biological functions like antibacterial, antiviral, antifungal, antiparasitic and anticarcinogenic. Recent progress in our understanding of the mechanisms of lactoferrin has led us to believe that this protein activates intracellular signaling, specifically through the modulation of cytokines, chemokines, growth factors and interleukins. The inflammatory diseases and tumour progression depends primarily on the dysfunction of these factors and the activation of immune cells such as T lymphocytes, monocytes and natural killer cells. Therefore, studying the possible influences of lactoferrin may exert on regulating these mediators is beneficial. However, lactoferrin has an immune-modulatory function that connection to immune response, disease regression and diagnosis. The important role of lactoferrin has made it attractive therapeutic agent against chronic diseases. Recent nanotechnology based strategies used to diagnosing infection, cancer, neurological and inflammatory diseases.
Lactoferrin
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Karmveer Yadav
As an essential organelle in the cell, the lysosome is responsible for digestion and recycling of intracellular components, storage of nutrients, and pH homeostasis. The lysosome is enclosed by a special membrane to maintain its integrity, and nutrients are transported across the membrane by numerous transporters. Increasing evidence suggests that the nutrient-sensitive transcription factors (TFs): transcription factors EB (TFEB), p53, and members of the FOXO family, regulate lipophagy during fasting and that the nuclear receptor and co-receptor family members: PPARa and PGC1a, link lipophagy to other pathways involved in lipid catabolism. Moreover, the signals that trigger lipophagy may start from within the lysosome. The lysosome is emerging as a sensor of cellular metabolic cues. The capacity of mTORC1 to associate to the lysosomal membrane, along with the recent observation that members of the extracellular signal regulated kinase (ERK) pathway localize to autophagosomes, are both indications that the lysosomal/ autophagy pathway is a critical regulator of cellular metabolism. This observation raises new important biological questions on the role of the lysosome in regulating energy metabolism and suggests that genetic and environmental factors affecting lysosomal homeostasis can influence whole-body metabolism. This concept may have a profound impact on the development of novel therapeutic strategies for a variety of human diseases, ranging from genetic disorders such as lysosomal storage diseases (LSDs) to the more common metabolic processes associated with aging and obesity. Using a combination of genetics, metabolomics, biochemistry, and immunocytochemistry, Folick et al. explored the molecular mechanisms by which lysosomal LIPL-4 activation regulates aging in C. elegans. They show that worms overexpressing LIPL-4 live substantially longer than normal worms and produce increased amounts of several bioactive lipids, notably the fatty acid oleoylethanolamide(OEA). In addition to OEA, other lipids or metabolites could act as diffusible signals between different organelles to orchestrate coordinated cellular responses. Unbiased metabolomic profiling is a promising discovery tool to decipher the mechanisms underlying many human metabolic diseases. This approach would also help to identify the elusive ligands for many nuclear receptors. Ultimately, modulations of bioactive lipids could be a therapeutic strategy for a wide range of human metabolic disorders and age-related diseases.
Lysosome an orchestrating, metabolic sensor during fasting
Lysosome an orchestrating, metabolic sensor during fasting
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Restaurant management system has changed current era for order management. With latest software technology once can save time and budget. It is far better than traditional methods of ordering. Various restaurants are implementing this methodology and gaining more return on investment.It is also known as restaurant software, restaurant point of sale or restaurant POS. It offers digital restaurant menu that makes easy for customers to go through available menu along with promotional offer.
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Lactoferrin (Lf) is 80 kDa iron-binding glycoprotein of transferrin family. It is made of single polypeptide chain folded into two symmetrical lobes. Lf is a basic, positively charged protein which has high iron binding affinity (Kd~10-20 M). Lf has been secreted from exocrine glands and in specific granules of Neutrophils. Lactoferrin has role in Iron transporting and various other biological functions like antibacterial, antiviral, antifungal, antiparasitic and anticarcinogenic. Recent progress in our understanding of the mechanisms of lactoferrin has led us to believe that this protein activates intracellular signaling, specifically through the modulation of cytokines, chemokines, growth factors and interleukins. The inflammatory diseases and tumour progression depends primarily on the dysfunction of these factors and the activation of immune cells such as T lymphocytes, monocytes and natural killer cells. Therefore, studying the possible influences of lactoferrin may exert on regulating these mediators is beneficial. However, lactoferrin has an immune-modulatory function that connection to immune response, disease regression and diagnosis. The important role of lactoferrin has made it attractive therapeutic agent against chronic diseases. Recent nanotechnology based strategies used to diagnosing infection, cancer, neurological and inflammatory diseases.
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As an essential organelle in the cell, the lysosome is responsible for digestion and recycling of intracellular components, storage of nutrients, and pH homeostasis. The lysosome is enclosed by a special membrane to maintain its integrity, and nutrients are transported across the membrane by numerous transporters. Increasing evidence suggests that the nutrient-sensitive transcription factors (TFs): transcription factors EB (TFEB), p53, and members of the FOXO family, regulate lipophagy during fasting and that the nuclear receptor and co-receptor family members: PPARa and PGC1a, link lipophagy to other pathways involved in lipid catabolism. Moreover, the signals that trigger lipophagy may start from within the lysosome. The lysosome is emerging as a sensor of cellular metabolic cues. The capacity of mTORC1 to associate to the lysosomal membrane, along with the recent observation that members of the extracellular signal regulated kinase (ERK) pathway localize to autophagosomes, are both indications that the lysosomal/ autophagy pathway is a critical regulator of cellular metabolism. This observation raises new important biological questions on the role of the lysosome in regulating energy metabolism and suggests that genetic and environmental factors affecting lysosomal homeostasis can influence whole-body metabolism. This concept may have a profound impact on the development of novel therapeutic strategies for a variety of human diseases, ranging from genetic disorders such as lysosomal storage diseases (LSDs) to the more common metabolic processes associated with aging and obesity. Using a combination of genetics, metabolomics, biochemistry, and immunocytochemistry, Folick et al. explored the molecular mechanisms by which lysosomal LIPL-4 activation regulates aging in C. elegans. They show that worms overexpressing LIPL-4 live substantially longer than normal worms and produce increased amounts of several bioactive lipids, notably the fatty acid oleoylethanolamide(OEA). In addition to OEA, other lipids or metabolites could act as diffusible signals between different organelles to orchestrate coordinated cellular responses. Unbiased metabolomic profiling is a promising discovery tool to decipher the mechanisms underlying many human metabolic diseases. This approach would also help to identify the elusive ligands for many nuclear receptors. Ultimately, modulations of bioactive lipids could be a therapeutic strategy for a wide range of human metabolic disorders and age-related diseases.
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