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- 1. PRESENTEDBy MinaReda HERBAL MEDICINE FOR BenignProstatic Hypertrophy Supervised by Prof.dr. Sameeh El-Dahmy
- 2. Benign prostatic hypertrophyis a Generalised disease of the prostate due to hormonal derangement which leads to enlargement of the gland (increase in the number of epithelial cells and stromal tissue) to cause compression of the urethra leading to symptoms . Introduction
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- 5. Symptoms • Lower urinarytract symptoms (LUTS) • Voiding (Obstructive) Symptoms Intermittency Hesitancy Incomplete voiding Weak urinary stream Straining to pass urine Prolonged micturition Terminal dribbling • Storage (Irritative) Symptoms Frequency of urination Nocturia Urgency (compelling need to void that can not be deferred) Urge incontinence
- 6. Treatment of BPH •Lifestyle modification • Watchful Waiting • Medical Therapy Alpha blockers 5α-Reductase inhibitors Combination Therapy • Phytotherapy (alternative) • Surgical Treatment : Conventional Surgical or Minimally Invasive Treatment
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- 8. The Palm achievesa height of 6-10 feet. Fruit are irregularly spherical to oblong, ranging in length from 1/2 to 1 inches and 1/2 inch diametre, are deep red-brown and wrinkled.
- 9. • Source --Serenoa repens Bartram. -- Native to the Southern Atlantic coast through the Gulf coast from South Carolina through Texas. • Family: Arecaceae .
- 10. • lauric acid, Palmitic and other fatty acids • Phytosterols • B-sitosterol • Polysaccharides • Manitol , galactose • Monoacylglycerides • Monolaurin • monomyristicin n-Hexane liposterolic extract, containing
- 11. • Antiandrogenic effects •Inhibition of 5-alpha reductase (in vitro) Testosterone DHT • Antagonism of DHT at androgen receptors • New studies are showing that – saw palmetto also reduces smooth muscle contraction, thereby relaxing the bladder and sphincter muscles that cause urinary urgency.
- 12. DHT Estrogen Testosterone TR Prostate cell DNA R&CD Rapid cell proliferation
- 13. • Saw Palmettois effective in the treatment of genitourinary problems, including benign prostatic hypertrophy (BPH) • Other purported uses – to increase sperm production – to increase breast size in women – to increase libido – mild diuresis Proposed Uses
- 14. Similar in efficacyrelative to finasteride Less (though not significantly) effective than alpha1 adrenergic blockade in a decoction or tea. 0.5 to 1 G dried berries 1 to 2 G fresh saw palmetto berries Herbal Usage Human clinical trials have used 320 mg p.o. in divided doses, twice daily Pregnancy Women of child- bearing age Due to actions potentially similar to those produced by finasteride
- 15. The plant grows2-3 feet high with heart-shaped, serrated leaves. Plants are gender specific, with flowers in long , branched clusters appearing June- September. The plant is hirsute, with each hair serving as a small, hollow, needle-like form of protection.
- 16. • Source Urticadioica L., a perennial of the nettle family (Urticaceæ).
- 17. • Histamine, serotonin,choline, formic acid Stems (non- therapeutic) -- • Phenylpropanes and lignans(pinoresinol- secoisolarci-resinol)Roots -- • Scopoletin, steryl derivatives, lignan glycosides, flavonol glycosides Roots and Flowers -- • B, C, and K vitamins, sitosterol and other steroid related compoundsWhole Plant --
- 18. • Antiandrogenic effects –inhibits the binding of a testosterone-related protein to its receptor site on prostate cell membranes. • evidence exists for – Use as a bladder irrigant in humans resulted in reduces postoperative blood loss, bacteriuria, and inflammation. R-prostateDHT
- 19. DHT Estrogen Testosterone TR Prostate cell DNA R&CD Rapid cell proliferation
- 20. • Benign ProstaticHypertrophy • Other purported uses – Diuresis -- hypertension, heart failure, and urinary, bladder, and kidney dysfunction – Rheumatoid arthritis, antispasmodic, expectorant, asthma, cough, tuberculosis, locally for alopecia, epistaxis, uterine bleeding, diabetes, gout, cancer, eczema, wound healing Proposed Uses
- 21. 1-2 tea- spoonfuls of driedherb in 1 cup of boiling water, up to twice daily 1/4 to 1 teaspoonful up to twice daily Herbal Usage 300 mg capsules as needed Pregnancy Children under 2 years old Contact dermatitis (especially fresh)
- 22. It is anevergreen tree native to the higher elevations of central and southern Africa.
- 23. • Source –Africa • Family: Rosaceae.
- 24. Phytosterols • beta-sitosterol • Soygenistein pentacyclic terpenes • Oleanic and Ursolic acid the ferulic esters
- 25. • Reduce prostateswelling (edema) • Antiandrogenic effects – block dihydrotestosterone binding to prostate cells. • New studies show that – pygeum also interferes with protein kinase C activity to inhibit the proliferation of prostate cells. R-prostateDHT
- 26. DHT Estrogen Testosterone TR Prostate cell DNA R&CD Rapid cell proliferation Protein kinase c
- 27. • Benign ProstaticHypertrophy • Other purported uses – improve urinary symptoms associated with enlargement of the prostate gland – Reduces, urinary frequency, the number of times patients need to wake up at night to urinate. Proposed Uses
- 28. Saw Palmetto, Pygeum,Stinging Nettle, Quercetin, is carefully formulated with important herbs and nutrients to provide optimal prostate health: 100 mg once daily 50 mg twice daily Herbal Usage The recommended dose is 50 to 150 mg daily Pregnancy Women of child- bearing age Due to actions potentially similar to those produced by finasteride
- 29. Source -- Cucurbitapepo L., Cucurbitaceæ family widely cultivated in North America and Australia. Active Parts -- Seeds
- 30. Cucurbitin ((-)-3- amino-3- carboxypyrrolidine) a water soluble aminoacid. Pumpkin fixed Seed Oil Unsaturated fatty acids • c. 25% oleic • 55% linoleic acids phytosterols • B- sitosterol • Spinasterol
- 31. • Testosterone DHT •Antiandrogenic effects – block dihydrotestosterone binding to prostate cells. • Anti-inflamatory due to B-Sitosterole R-prostateDHT
- 32. DHT Estrogen Testosterone TR Prostate cell DNA R&CD Rapid cell proliferation Protein kinase c
- 33. • Benign ProstaticHypertrophy • Other uses – Cucurbitin exhibits • anthelminthic activity against • pinworms • tapeworms in mice. • It has also been shown to inhibit the growth of immature Schistosoma Proposed Uses
- 34. Dosage Forms seeds (wholeor crushed), seed extract or oil, tablets, tea Pepon:Trade Names 100 mg once daily 50 mg twice daily Herbal Usage ingestion of a handful of seeds daily Pregnancy Women of child- bearing age Electrolyte Imbalance (from the mild diuretic actions)
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- 36. High amounts intomatoes &tomato products One cup (240 mL) of tomato juice = 23 mg of lycopene. A powerful antioxidant that may help protect cells from damage. 4 mg of lycopene supplements twice daily might delay
- 37. a comprehensive, natural formula designedto support a healthy prostate.
- 38. Saw Palmetto Extract320 mg Nettle Leaf Extract 240 mg Proprietary Blend 50 mg .”pygeum africanum powder ”. Pumpkin Seed Oil 50 mg Lycopene (Lyc-O-Mato®) 5 mg Zinc Selenium Vitamin E Iodine
- 39. • Benign prostatichyperplasia is a common finding in most of the aged males and does not signify any risk of developing cancer. • Treatment becomes necessary if the affected individuals begin developing any symptoms. • An annual checkup for monitoring the growth of prostate may be beneficial in individuals aged above 40 years. • The herbal preparation was shown to be well tolerated and have a significant positive effect on physical symptoms of BPH when taken over 3 months, a clinically significant outcome in otherwise healthy men. • A significant limiting factor to our understanding of the use and effectiveness of phytotherapy is the lack of standardization of these products . Conclusion