This study examined whether gradually increasing the intensity of tones during habituation leads to greater decrement of the eyeblink reflex response in humans compared to tones of a constant intensity. Participants were exposed to 110 tones and divided into two groups - one received tones that increased from 60-90 dB, while the other received tones at a constant 90 dB intensity. The results showed that the response in the last block of 90 dB tones was significantly lower for the incremental group, supporting the idea that gradually increasing intensity leads to stronger habituation of the eyeblink response. This study provides evidence for the "incremental stimulus intensity effect" in humans, extending previous findings from other species.
1) The study examined the effects of varying light wavelengths (red vs blue) on the physiology and behaviors of hermit crabs (Coenobita clypeatus).
2) Hermit crabs exposed to red light showed decreased feeding, and increased aggressive and exploratory behaviors compared to those exposed to blue light.
3) Hermit crabs exposed to red light also had higher numbers of serotonin-positive cells in the eyestalk compared to those exposed to blue light. The number of serotonin-positive cells correlated with the duration of behaviors observed.
The document summarizes a study that investigated whether neurodegeneration alone can cause schizophrenia-like behaviors in mice. The study ablated neural stem cells in transgenic mice using ganciclovir over 56 days. Behavioral tests revealed no significant differences between control and ablated mice in prepulse inhibition, locomotor activity after PCP/amphetamine, time spent in open arms of elevated plus maze, or floating behavior in Porsolt swim test. This suggests neurodegeneration alone may not cause schizophrenia. However, other studies that also applied stressors found ablation did produce schizophrenia-like behaviors, so stress may be a contributing factor.
Jessica Groves-Chapman has extensive education and experience in neuroscience and exercise psychology. She received her PhD in Neuroscience from the University of Georgia in 2014, with a dissertation on the neuroprotective effects of physical activity. She has held positions as an Assistant Professor and graduate research assistant, conducting research on topics like galanin modulation and exercise-induced neuroprotection. Her work has been published in peer-reviewed journals and she has presented research at numerous conferences.
Subacute dermal toxicity investigation of nanosilver on serum chemical biomar...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
Nanosilver is one of the most widely used nanomaterials due to its strong antimicrobial activity. Thus, because of increasing potential for exposure of human to nanosilver, there is an increasing concern about possible side effects of these nanoparticles. In this study, we tested the potential dermal toxicity of nanosilver bandage on serum chemical biomarkers in mice.
Materials and Methods:
In this study, 20 male BALB/c mice were randomly allocated into the treatment and control groups (n=10). After general anesthesia and shaving the back of all animals in near the vertebral column, in the nanosilver group, a volume of 50μl of 10 μg/ml of nanosilver solution (40 nm), and in the control group the same amount of distilled water was added to the sterile bandage of mice, then the bandages were fixed on the skin surface with cloth glue. After 3 and 7 days, the bandages were opened and serum levels of blood urea
nitrogen (BUN), creatinine (Cr), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured by using standard kits for two groups of mice.
Results:
In treatment group, a significant increase in ALT, AST and BUN levels were observed compared with control group during experiment periods (p<0.05),>0.05).
Conclusion:
The present results indicated that the dermal absorption of 10 μg/ml nanosilver (40 nm) can lead to hepatotoxicity and renal toxicity in mice.
Behavioural sensitisation to mk 801 is dose-dependent andjoaomarcos2013
The study investigated the effects of MK-801 dose and environmental context on the development of behavioural sensitization in male rats. In experiment 1, rats were administered varying doses of MK-801 or saline daily for 7 days and locomotor activity was measured. Only the 0.25 mg/kg dose produced robust sensitization upon challenge after withdrawal. In experiment 2, rats treated with 0.25 mg/kg MK-801 either in their home cage or a novel test cage both developed equal sensitization, indicating context did not modulate the effect. The results show MK-801 sensitization displays an inverted-U dose response and is independent of the environmental context during drug exposure.
The document summarizes research on the functions of the prefrontal cortex (PFC) and the role of long-term potentiation (LTP). It discusses how the PFC is involved in decision making, error detection, executive control, and modulation of remote spatial memories. Experiments show that transient inactivation of the PFC decreases recently acquired voluntary behaviors like wheel running in rats. Other experiments demonstrate that inhibition of the PFC reduces freezing responses to learned fears. Additional research presented finds that the PFC is necessary for retrieval of remote spatial memories in mice over 30 days. Finally, the document discusses how dopamine modulation in the PFC improves retrieval of remote spatial memories in rats.
El documento describe un proyecto de práctica pedagógico-investigativa para docentes en formación. Propone implementar acciones que ofrezcan una verdadera práctica investigativa, incluyendo etapas de sensibilización, exploración, vocacional y profesional con actividades de microenseñanza, trabajo de campo e investigación para formar docentes reflexivos.
1) The study examined the effects of varying light wavelengths (red vs blue) on the physiology and behaviors of hermit crabs (Coenobita clypeatus).
2) Hermit crabs exposed to red light showed decreased feeding, and increased aggressive and exploratory behaviors compared to those exposed to blue light.
3) Hermit crabs exposed to red light also had higher numbers of serotonin-positive cells in the eyestalk compared to those exposed to blue light. The number of serotonin-positive cells correlated with the duration of behaviors observed.
The document summarizes a study that investigated whether neurodegeneration alone can cause schizophrenia-like behaviors in mice. The study ablated neural stem cells in transgenic mice using ganciclovir over 56 days. Behavioral tests revealed no significant differences between control and ablated mice in prepulse inhibition, locomotor activity after PCP/amphetamine, time spent in open arms of elevated plus maze, or floating behavior in Porsolt swim test. This suggests neurodegeneration alone may not cause schizophrenia. However, other studies that also applied stressors found ablation did produce schizophrenia-like behaviors, so stress may be a contributing factor.
Jessica Groves-Chapman has extensive education and experience in neuroscience and exercise psychology. She received her PhD in Neuroscience from the University of Georgia in 2014, with a dissertation on the neuroprotective effects of physical activity. She has held positions as an Assistant Professor and graduate research assistant, conducting research on topics like galanin modulation and exercise-induced neuroprotection. Her work has been published in peer-reviewed journals and she has presented research at numerous conferences.
Subacute dermal toxicity investigation of nanosilver on serum chemical biomar...Nanomedicine Journal (NMJ)
Abstract
Objective(s):
Nanosilver is one of the most widely used nanomaterials due to its strong antimicrobial activity. Thus, because of increasing potential for exposure of human to nanosilver, there is an increasing concern about possible side effects of these nanoparticles. In this study, we tested the potential dermal toxicity of nanosilver bandage on serum chemical biomarkers in mice.
Materials and Methods:
In this study, 20 male BALB/c mice were randomly allocated into the treatment and control groups (n=10). After general anesthesia and shaving the back of all animals in near the vertebral column, in the nanosilver group, a volume of 50μl of 10 μg/ml of nanosilver solution (40 nm), and in the control group the same amount of distilled water was added to the sterile bandage of mice, then the bandages were fixed on the skin surface with cloth glue. After 3 and 7 days, the bandages were opened and serum levels of blood urea
nitrogen (BUN), creatinine (Cr), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured by using standard kits for two groups of mice.
Results:
In treatment group, a significant increase in ALT, AST and BUN levels were observed compared with control group during experiment periods (p<0.05),>0.05).
Conclusion:
The present results indicated that the dermal absorption of 10 μg/ml nanosilver (40 nm) can lead to hepatotoxicity and renal toxicity in mice.
Behavioural sensitisation to mk 801 is dose-dependent andjoaomarcos2013
The study investigated the effects of MK-801 dose and environmental context on the development of behavioural sensitization in male rats. In experiment 1, rats were administered varying doses of MK-801 or saline daily for 7 days and locomotor activity was measured. Only the 0.25 mg/kg dose produced robust sensitization upon challenge after withdrawal. In experiment 2, rats treated with 0.25 mg/kg MK-801 either in their home cage or a novel test cage both developed equal sensitization, indicating context did not modulate the effect. The results show MK-801 sensitization displays an inverted-U dose response and is independent of the environmental context during drug exposure.
The document summarizes research on the functions of the prefrontal cortex (PFC) and the role of long-term potentiation (LTP). It discusses how the PFC is involved in decision making, error detection, executive control, and modulation of remote spatial memories. Experiments show that transient inactivation of the PFC decreases recently acquired voluntary behaviors like wheel running in rats. Other experiments demonstrate that inhibition of the PFC reduces freezing responses to learned fears. Additional research presented finds that the PFC is necessary for retrieval of remote spatial memories in mice over 30 days. Finally, the document discusses how dopamine modulation in the PFC improves retrieval of remote spatial memories in rats.
El documento describe un proyecto de práctica pedagógico-investigativa para docentes en formación. Propone implementar acciones que ofrezcan una verdadera práctica investigativa, incluyendo etapas de sensibilización, exploración, vocacional y profesional con actividades de microenseñanza, trabajo de campo e investigación para formar docentes reflexivos.
Environmental enrichment reduces seizure frequency in a rodent model of reflex epilepsy. Long Evans rats were primed to develop audiogenic seizures through repeated exposure to loud tones. One group then received environmental enrichment through interaction with objects and other rats, while a control group did not. Rats receiving enrichment showed less severe seizures, with increased latency to seizures, shorter seizure durations, and a reduced occurrence of seizures, showing that environmental enrichment can counteract the progression of seizure disorders in this model.
1) The study examined the effects of light exposure at night on cognitive function in fruit flies. Flies were exposed to either dark nights or light at night for one week and then tested in a T-maze to assess learning.
2) Flies exposed to dark nights learned to suppress their natural attraction to light in the T-maze better than flies exposed to light at night, indicating light at night disrupted cognitive function.
3) No differences were found between the groups in basic locomotion or initial light attraction, suggesting the effect was on learning and memory rather than other behaviors.
Adaptationism And Molecular Biology An Example Based On ADHDFaith Brown
This document discusses issues with the adaptationist approach taken in evolutionary psychology research. It summarizes an alternative approach proposed by the authors that begins with identifying candidate genes associated with traits, then testing for patterns of selection at the DNA level before speculating about adaptations. As an example, the authors discuss research on the dopamine receptor D4 (DRD4) gene and its association with Attention Deficit Hyperactivity Disorder (ADHD). They found evidence that a specific allele of this gene (7R) may confer advantages in conflict resolution and is more prevalent in ADHD samples. The authors argue this molecular genetic approach can help limit the number of hypotheses about adaptations that need to be considered and avoid issues with relying solely on complex clinical literature.
This experiment investigated the effects of qualitative and quantitative changes to the unconditioned stimulus (US) on associative learning. 35 participants completed a computer task where they rated the safety of different foods for fictional patients. In stage one, foods were paired with specific reactions (vomiting, diarrhea, or no reaction). In stage two, new food pairings were introduced, and the US was either changed qualitatively, quantitatively, or not at all between stages. Ratings of food safety were analyzed to assess evidence of blocking and trans-reinforcer blocking. The experiment aimed to replicate previous research while also testing the impact of qualitative US changes.
B.F. Skinner developed the theory of operant conditioning which examines how behaviors are influenced by consequences. Operant conditioners use reinforcement schedules to shape behaviors by rewarding desired responses. They can train animals to perform tasks and detect sensory stimuli. Schedules of intermittent reinforcement produce stable, schedule-controlled behaviors useful for studying mechanisms of action. Skinner argued operant conditioning could improve education by emphasizing positive reinforcement over punishment, though his views on human nature were controversial.
Mechanical Stimulation of Tibial Companiform Sensilla of a Periplaneta americ...omarhallouda
A lab report written for BIO409(Laboratory Physiology) by Omar Hallouda on the varied electrical responses of mechanically stimulated companiform sensilla on American cockroaches (Before final edit).
Females acquired auditory fear conditioning faster than males when exposed to 5 tone-shock pairings, freezing more during tones 3 and 5. Females also showed a preference for exploring a novel object compared to males. In the Morris water maze, females outperformed males in spatial learning when a prominent landmark cue was present, relying more on landmarks while males relied more on geometric cues. The results indicate sex differences in hippocampus-dependent tasks, with females dominating in some contexts. These findings should influence experimental designs and clinical treatments by considering potential sex-based differences.
1) The document discusses an experiment that examines the effects of extinction and temporal variability in context conditioning. It uses a 2x2 factorial design where participants are conditioned to a cue in one context and then receive extinction training or no extinction in a different context along with fixed or variable intervals of unsignaled outcomes.
2) The expectation is that extinction training will lead to faster context conditioning compared to no extinction. Participants in fixed interval conditions are also expected to show predictive timing abilities during a probe trial compared to variable interval conditions.
3) The group that receives extinction training with fixed intervals is predicted to show the least suppression during the probe trial due to attention to contexts and temporal cues learned during the experiment.
Repeated nicotine exposure and withdrawal in mice increased acoustic startle response, a measure of stress. Acoustic startle amplitudes increased during the third trial of nicotine exposure and at 24 hours and 120 hours of withdrawal. Administration of the CRF receptor antagonist antalarmin showed a trend of decreasing startle response at 95dB, suggesting CRF mediates increased stress from nicotine exposure and withdrawal. Further studies are needed to examine CRF in the brain during repeated nicotine administration and abstinence periods.
Examining the Effectiveness of Observed & Derived Pathways of AvoidanceEllyn Moore
This study compared avoidance learning through observational learning (watching a video) versus derived relational learning. Sixty participants were randomly assigned to either the observed or inferred group. The observed group watched a video demonstrating avoidance learning, while the inferred group completed relational tasks to derive avoidance. Expectancy of shock, avoidance responses, and acceptance questionnaires were measured and compared between groups. The study aimed to examine the effectiveness of different pathways for acquiring avoidance learning.
This study examined functional connectivity of the medial temporal lobe (MTL) and its relation to learning and awareness. Participants completed a sensory learning task and were classified as AWARE or UNAWARE based on their ability to learn tone-visual stimulus associations. For AWARE participants, MTL activity correlated with learned discrimination and reversal, engaging dorsolateral prefrontal and occipital cortices. For UNAWARE participants, MTL activity correlated only with simple facilitation and engaged contralateral MTL, thalamus regions. This suggests the MTL contribution to learning depends on its pattern of interactions with other brain regions.
The document discusses key concepts in biology, including:
1. Organizing species using a binomial nomenclature system consisting of genus and specific epithet names.
2. The importance of taxonomy and the Linnaean system for classifying organisms.
3. How scientists conduct experiments to test hypotheses and uncover cause-and-effect relationships, minimizing bias through experimental design and evaluating statistical significance of results.
The document discusses key concepts in biology, including:
1. Organizing species using a binomial nomenclature system consisting of genus and specific epithet names.
2. The importance of taxonomy and the Linnaean system for classifying organisms.
3. How scientists conduct experiments to test hypotheses and uncover cause-and-effect relationships, minimizing bias through experimental design and evaluating statistical significance of results.
This document discusses response inhibition and delay aversion as two subtypes of impulsivity. Response inhibition is the ability to inhibit planned or ongoing behaviors when they are no longer appropriate. It can be measured using tasks like the stop-signal task. Delay aversion refers to an inability to wait for delayed rewards, causing the subjective value of rewards to decrease faster with delays. The document reviews evidence that these subtypes have distinct neural underpinnings and pharmacology, but may also interact in ways that can lead to impulsive behavior. It aims to establish the subtypes as separate concepts while proposing a framework for their integration.
This study assessed the feasibility of using vestibular evoked myogenic potentials (VEMPs) to test vestibular function in a pediatric population. VEMPs measure electrical activity in the sternocleidomastoid (SCM) and splenius capitis (SPL) muscles in response to auditory stimulation. The study found that both SCM and SPL VEMPs could be elicited in 3 child subjects through simple seated and standing neck turn postures, demonstrating the potential for easier vestibular testing in pediatric patients compared to current clinical methods. Recording VEMPs from the SCM and SPL simultaneously also allowed for direct comparison of responses between the two muscles. The results support further research into using alternative post
This study compared vestibular evoked myogenic potential (VEMP) responses elicited by click stimuli and short duration tone burst stimuli in 17 normal hearing individuals. VEMP responses were observed in 88% of ears for both stimuli. The latency of the p13 and n23 peaks was longer for tone bursts compared to clicks. The amplitude of the p13-n23 waveform was greater for tone bursts than clicks. Thus, clicks may be preferable for clinical assessment due to less variability, while low frequency tone bursts may be preferable for assessing presence or absence of VEMP responses.
John Tokarz- Psyc 494- Auditory Popout in Relation to TimbreJack Tokarz
This document summarizes a research study that aimed to test for the existence of an auditory popout effect using timbre as the salient feature. The study investigated three dimensions of timbre - attack time, spectral centroid, and attenuation of even harmonics. It presented participants with sequences of tones where one tone differed in one timbre dimension from the others. Response times and accuracy were measured. The study found evidence for an auditory popout effect but weak evidence of directional salience within the timbre dimensions. It provided background on visual popout research and previous inconclusive findings on directional salience in auditory features.
The study investigated the effects of beta-amyloid treatment on mouse behavior and brain anatomy later in life. Seventeen mice received beta-amyloid injections in the hippocampus as newborns, while seven controls received vehicle injections. As adults, mice underwent behavioral tests for memory and anxiety, then brain tissue was analyzed. Treated mice showed less acetylcholinesterase in the hippocampus, suggesting Alzheimer's-like changes. However, treated mice also exhibited less anxiety and better memory retention than controls, contradicting predictions. The contradictory behavioral results require further study.
EFFECT OF POSTURAL CONTROL BIOMECHANICAL GAIN ON PSYCHOPHYSICAL DETECTION THR...ijbbjournal
A Sliding Linear Investigative Platform for Assessing Lower Limb Stability (SLIP-FALLS) was employed to study postural control biomechanical reaction to external perturbations in a short ≤16mm postural perturbation. Head acceleration were evaluated while blindfolded subjects stood on a platform that was given a short anterior perturbation presented in one of 2 sequential 4s intervals (2-Alternative-ForcedChoice) for a set of 30 trials. Anterior-Posterior head acceleration (Head Accl AP) were investigated among the movement and non- movement intervals for the healthy adults. A strong ringing signal was observed in Head Accl AP movement interval that was absent in non-movement interval. A positive power
law trading relationship was found between Head Accl AP gain and move length standing blindfolded subjects. This could explain the observed negative power law relationship between translation length and peak acceleration threshold in previous psychophysical detection threshold studies.
Environmental enrichment reduces seizure frequency in a rodent model of reflex epilepsy. Long Evans rats were primed to develop audiogenic seizures through repeated exposure to loud tones. One group then received environmental enrichment through interaction with objects and other rats, while a control group did not. Rats receiving enrichment showed less severe seizures, with increased latency to seizures, shorter seizure durations, and a reduced occurrence of seizures, showing that environmental enrichment can counteract the progression of seizure disorders in this model.
1) The study examined the effects of light exposure at night on cognitive function in fruit flies. Flies were exposed to either dark nights or light at night for one week and then tested in a T-maze to assess learning.
2) Flies exposed to dark nights learned to suppress their natural attraction to light in the T-maze better than flies exposed to light at night, indicating light at night disrupted cognitive function.
3) No differences were found between the groups in basic locomotion or initial light attraction, suggesting the effect was on learning and memory rather than other behaviors.
Adaptationism And Molecular Biology An Example Based On ADHDFaith Brown
This document discusses issues with the adaptationist approach taken in evolutionary psychology research. It summarizes an alternative approach proposed by the authors that begins with identifying candidate genes associated with traits, then testing for patterns of selection at the DNA level before speculating about adaptations. As an example, the authors discuss research on the dopamine receptor D4 (DRD4) gene and its association with Attention Deficit Hyperactivity Disorder (ADHD). They found evidence that a specific allele of this gene (7R) may confer advantages in conflict resolution and is more prevalent in ADHD samples. The authors argue this molecular genetic approach can help limit the number of hypotheses about adaptations that need to be considered and avoid issues with relying solely on complex clinical literature.
This experiment investigated the effects of qualitative and quantitative changes to the unconditioned stimulus (US) on associative learning. 35 participants completed a computer task where they rated the safety of different foods for fictional patients. In stage one, foods were paired with specific reactions (vomiting, diarrhea, or no reaction). In stage two, new food pairings were introduced, and the US was either changed qualitatively, quantitatively, or not at all between stages. Ratings of food safety were analyzed to assess evidence of blocking and trans-reinforcer blocking. The experiment aimed to replicate previous research while also testing the impact of qualitative US changes.
B.F. Skinner developed the theory of operant conditioning which examines how behaviors are influenced by consequences. Operant conditioners use reinforcement schedules to shape behaviors by rewarding desired responses. They can train animals to perform tasks and detect sensory stimuli. Schedules of intermittent reinforcement produce stable, schedule-controlled behaviors useful for studying mechanisms of action. Skinner argued operant conditioning could improve education by emphasizing positive reinforcement over punishment, though his views on human nature were controversial.
Mechanical Stimulation of Tibial Companiform Sensilla of a Periplaneta americ...omarhallouda
A lab report written for BIO409(Laboratory Physiology) by Omar Hallouda on the varied electrical responses of mechanically stimulated companiform sensilla on American cockroaches (Before final edit).
Females acquired auditory fear conditioning faster than males when exposed to 5 tone-shock pairings, freezing more during tones 3 and 5. Females also showed a preference for exploring a novel object compared to males. In the Morris water maze, females outperformed males in spatial learning when a prominent landmark cue was present, relying more on landmarks while males relied more on geometric cues. The results indicate sex differences in hippocampus-dependent tasks, with females dominating in some contexts. These findings should influence experimental designs and clinical treatments by considering potential sex-based differences.
1) The document discusses an experiment that examines the effects of extinction and temporal variability in context conditioning. It uses a 2x2 factorial design where participants are conditioned to a cue in one context and then receive extinction training or no extinction in a different context along with fixed or variable intervals of unsignaled outcomes.
2) The expectation is that extinction training will lead to faster context conditioning compared to no extinction. Participants in fixed interval conditions are also expected to show predictive timing abilities during a probe trial compared to variable interval conditions.
3) The group that receives extinction training with fixed intervals is predicted to show the least suppression during the probe trial due to attention to contexts and temporal cues learned during the experiment.
Repeated nicotine exposure and withdrawal in mice increased acoustic startle response, a measure of stress. Acoustic startle amplitudes increased during the third trial of nicotine exposure and at 24 hours and 120 hours of withdrawal. Administration of the CRF receptor antagonist antalarmin showed a trend of decreasing startle response at 95dB, suggesting CRF mediates increased stress from nicotine exposure and withdrawal. Further studies are needed to examine CRF in the brain during repeated nicotine administration and abstinence periods.
Examining the Effectiveness of Observed & Derived Pathways of AvoidanceEllyn Moore
This study compared avoidance learning through observational learning (watching a video) versus derived relational learning. Sixty participants were randomly assigned to either the observed or inferred group. The observed group watched a video demonstrating avoidance learning, while the inferred group completed relational tasks to derive avoidance. Expectancy of shock, avoidance responses, and acceptance questionnaires were measured and compared between groups. The study aimed to examine the effectiveness of different pathways for acquiring avoidance learning.
This study examined functional connectivity of the medial temporal lobe (MTL) and its relation to learning and awareness. Participants completed a sensory learning task and were classified as AWARE or UNAWARE based on their ability to learn tone-visual stimulus associations. For AWARE participants, MTL activity correlated with learned discrimination and reversal, engaging dorsolateral prefrontal and occipital cortices. For UNAWARE participants, MTL activity correlated only with simple facilitation and engaged contralateral MTL, thalamus regions. This suggests the MTL contribution to learning depends on its pattern of interactions with other brain regions.
The document discusses key concepts in biology, including:
1. Organizing species using a binomial nomenclature system consisting of genus and specific epithet names.
2. The importance of taxonomy and the Linnaean system for classifying organisms.
3. How scientists conduct experiments to test hypotheses and uncover cause-and-effect relationships, minimizing bias through experimental design and evaluating statistical significance of results.
The document discusses key concepts in biology, including:
1. Organizing species using a binomial nomenclature system consisting of genus and specific epithet names.
2. The importance of taxonomy and the Linnaean system for classifying organisms.
3. How scientists conduct experiments to test hypotheses and uncover cause-and-effect relationships, minimizing bias through experimental design and evaluating statistical significance of results.
This document discusses response inhibition and delay aversion as two subtypes of impulsivity. Response inhibition is the ability to inhibit planned or ongoing behaviors when they are no longer appropriate. It can be measured using tasks like the stop-signal task. Delay aversion refers to an inability to wait for delayed rewards, causing the subjective value of rewards to decrease faster with delays. The document reviews evidence that these subtypes have distinct neural underpinnings and pharmacology, but may also interact in ways that can lead to impulsive behavior. It aims to establish the subtypes as separate concepts while proposing a framework for their integration.
This study assessed the feasibility of using vestibular evoked myogenic potentials (VEMPs) to test vestibular function in a pediatric population. VEMPs measure electrical activity in the sternocleidomastoid (SCM) and splenius capitis (SPL) muscles in response to auditory stimulation. The study found that both SCM and SPL VEMPs could be elicited in 3 child subjects through simple seated and standing neck turn postures, demonstrating the potential for easier vestibular testing in pediatric patients compared to current clinical methods. Recording VEMPs from the SCM and SPL simultaneously also allowed for direct comparison of responses between the two muscles. The results support further research into using alternative post
This study compared vestibular evoked myogenic potential (VEMP) responses elicited by click stimuli and short duration tone burst stimuli in 17 normal hearing individuals. VEMP responses were observed in 88% of ears for both stimuli. The latency of the p13 and n23 peaks was longer for tone bursts compared to clicks. The amplitude of the p13-n23 waveform was greater for tone bursts than clicks. Thus, clicks may be preferable for clinical assessment due to less variability, while low frequency tone bursts may be preferable for assessing presence or absence of VEMP responses.
John Tokarz- Psyc 494- Auditory Popout in Relation to TimbreJack Tokarz
This document summarizes a research study that aimed to test for the existence of an auditory popout effect using timbre as the salient feature. The study investigated three dimensions of timbre - attack time, spectral centroid, and attenuation of even harmonics. It presented participants with sequences of tones where one tone differed in one timbre dimension from the others. Response times and accuracy were measured. The study found evidence for an auditory popout effect but weak evidence of directional salience within the timbre dimensions. It provided background on visual popout research and previous inconclusive findings on directional salience in auditory features.
The study investigated the effects of beta-amyloid treatment on mouse behavior and brain anatomy later in life. Seventeen mice received beta-amyloid injections in the hippocampus as newborns, while seven controls received vehicle injections. As adults, mice underwent behavioral tests for memory and anxiety, then brain tissue was analyzed. Treated mice showed less acetylcholinesterase in the hippocampus, suggesting Alzheimer's-like changes. However, treated mice also exhibited less anxiety and better memory retention than controls, contradicting predictions. The contradictory behavioral results require further study.
EFFECT OF POSTURAL CONTROL BIOMECHANICAL GAIN ON PSYCHOPHYSICAL DETECTION THR...ijbbjournal
A Sliding Linear Investigative Platform for Assessing Lower Limb Stability (SLIP-FALLS) was employed to study postural control biomechanical reaction to external perturbations in a short ≤16mm postural perturbation. Head acceleration were evaluated while blindfolded subjects stood on a platform that was given a short anterior perturbation presented in one of 2 sequential 4s intervals (2-Alternative-ForcedChoice) for a set of 30 trials. Anterior-Posterior head acceleration (Head Accl AP) were investigated among the movement and non- movement intervals for the healthy adults. A strong ringing signal was observed in Head Accl AP movement interval that was absent in non-movement interval. A positive power
law trading relationship was found between Head Accl AP gain and move length standing blindfolded subjects. This could explain the observed negative power law relationship between translation length and peak acceleration threshold in previous psychophysical detection threshold studies.
EFFECT OF POSTURAL CONTROL BIOMECHANICAL GAIN ON PSYCHOPHYSICAL DETECTION THR...
Ponce, Quintana et al 2011
1. Habituation of the eyeblink response in humans with stimuli
presented in a sequence of incremental intensity
Fernando P Ponce, Gonzalo R Quintana, Andrew S. Philominraj, Edgar H Vogel1
1 Universidad de Talca, Talca, Chile.
ABSTRACT
In an experiment we examined whether the repeated presentation of tones of gradually increasing intensities produces greater decrement
in the eyeblink reflex response in humans than the repetition of tones of constant intensities. Two groups of participants matched for their
initial level of response were exposed to 110 tones of 100-ms duration. For the participants in the incremental group, the tones increased
from 60- to 90- dB in 3-dB steps, whereas participants in the constant group received the tones at a fixed 90-dB intensity. The results
indicated that the level of response in the last block of 10 trials, in which both groups received 90-dB tones, was significantly lower in the
incremental group than in the constant group.
These findings support the data presented by Davis and Wagner (7) with the acoustic response in rats, but differ from several reports with
autonomic responses in humans, where the advantage of the incremental condition has not been observed unambiguously.
The discussion analyzes theoretical approaches to this phenomenon and the possible involvement of separate neural circuits.
Key words: habituation, incremental stimulus intensity effect, sensitization.
INTRODUCTION
When a stimulus is systematically repeated, the predominant
result is a progressive diminution in the frequency or amplitude
of the response. When it is proved that this decrement is
prolonged over time and that it is not caused by either muscular
fatigue or sensorial adaptation, it is inferred that a learning
phenomenon known as habituation has occurred (14, 27).
The universality of this simple form of learning has been
demonstrated in a broad range of organisms such as protozoa
(33), birds (8), fish (22), mollusks (11), rats (3), rabbits (32), cats
(13, 27), dogs (23) and humans (9), just to name a few. A good
deal of research has focused on determining the conditions
or parameters that lead to habituation (26, 27). Although
it seems to be a well-established fact that the effectiveness
of habituation depends on the number and spacing of the
repetitions, the experimental evidence is less clear regarding
other factors, such as the intensity of the stimulus.
In this last category, there is a phenomenon known as
“incremental stimulus intensity effect” (ISIE), which refers to
the observation that habituation is more effective when the
repetition of the stimulus involves progressive increments in its
intensity than when the intensity is constant (13). The existence
of this effect has been taken as evidence favoring the so-called
Dual-Process Theories of Habituation (e.g., 13), which argues
that in addition to the decremental tendencies that are specific
to the stimulus in question (habituation), the repetition of the
stimulus also produces generalized decrements in the form of
loss of arousal or desensitization, the latter explaining ISIE.
The first systematic observations of ISIE were made in
experiments on instrumental conditioning, in which animals
were trained to produce an operant response rewarded with
food, which was presented simultaneously with an electric
shock (1, 16, 18). The results indicated that even though the
punishment provoked a suppressing effect over the rewarded
behavior, this effect progressively disappeared over the trials,
and that this decrement was stronger when the punishment
was delivered with shocks of incremental rather than constant
intensities. Despite the suggestive character of these findings,
it is not clear whether the decrement in “aversiveness” to the
electric shock was due to habituation, since this might also be
interpreted as the development of antagonistic behavior that
aided the animals to avoid the shocks, or as the formation of an
association between the shock and the reward (7).
These difficulties led to studies in which the stimulus
in question was repeated under conditions in which there
were neither rewards nor obvious possibilities to avoid the
aversive stimulus by expressing certain behaviors. The first of
these studies was conducted by Church, LoLordo, Overmier,
Solomon and Turner (2), who demonstrated that habituation to
a cardiac acceleration response provoked by electric shock was
greater in a group of dogs that received shocks of increasing
intensities (from 0.5- to 6- mA) than another group that
received the stimuli at a fixed intensity. Davis and Wagner (7,
Experiment 2) studied the same effect in rats by comparing
the acoustic startle response to 120-dB tones in groups of rats
that had been exposed to 750 stimuli at either a constant 120-
dB, a constant 100-dB, a random order of intensities between
85 and 120-dB, or a gradually increasing order of intensities
between 85 and 120-dB. The findings indicated that there was
substantially less response in the test with a 120-dB tone in the
group that had experienced gradually increasing intensities
than in any of the other three groups. Groves and Thompson
(13, Experiment 3) essentially replicated these findings with the
limb flexion reflex in the spinal cat.
In contrast to studies with dogs, rats and cats, the
evidence in humans is not very clear. For example, O’Gorman
and Jamieson (20, 21) demonstrated that the progressive
presentation of an acoustic stimulus (between 80- and 100-
dB, Experiment 1, 20; between 64- and 100-dB, 21) caused
a higher decrement in electrodermal response than did
constant presentations (100-dB). However, such an effect was
* Corresponding author: Edgar H. Vogel, Universidad de Talca, Casilla N° 747, Talca/Chile. Tel: (5671) 201566 - Fax: (5671) 201510. E-mail: evogel@utalca.cl
Received: November 29, 2010. In revised form: January 11, 2011. Accepted: January 13, 2011.
Biol Res 44: 295-299, 2011
2. VOGEL ET AL. Biol Res 44, 2011, 295-299296
not replicated when they measured the finger blood volume
response (20, Experiment 1) and the cardiac response (20,
Experiment 2). Similar difficulties to find this effect have
been reported in procedures that employed galvanic skin and
cardiac responses to phobic images (12) and electrodermal
response to acoustic stimuli (17).
The absence of robust evidence of ISIE in humans casts
doubts on its generality. Facing this ambiguity of results, it
is necessary to take a look at the differences and similarities
between studies that have found the effect and those that
have not. On the one hand, most of the positive results have
been obtained by examining skeletal responses in animals,
such as the startle response in rats (7) and the limb flexion
reflex in the spinal cat (13), which are typically of slow
habituation. On the other hand, studies that have tested ISIE
in autonomic responses, such as electrodermal and cardiac
responses, which are both of more rapid habituation, have
only demonstrated ISIE when the constant group has not
shown detectable habituation (2, 20, 21). In contrast, when
the habituation has been achieved in the constant group, the
effect tends to disappear (17), possibly due to a floor effect
that could complicate the detection of differences between the
constant and incremental procedures. Thus, it could be argued
that the ISIE can only be detected when the response is of slow
habituation (skeletal) or when it is tested in the early stages
in the development of habituation of autonomic responses. Of
course, given the limited number of studies in this area, this is
only speculation.
Taking into consideration the theoretical and empirical
importance of this phenomenon, the methodological
difficulties to observe pre-asymptotic habituation of autonomic
responses and the absence of studies with human skeletal
responses, this investigation examined the ISIE with a skeletal
response typically used in studies of human habituation,
eyeblink response. The habituation of this response has been
relatively well studied in humans and has the advantage of
requiring a considerable number of trials to reach asymptotic
levels of habituation (9).
METHOD
Participants
A total of 72 male and female undergraduate students of the
University of Talca, with a mean age of 18.2 years (SD = 0.23),
participated in the experiment for course credit. They were
tested individually and had no previous experience in similar
research.
Apparatus
The experiment was carried out in a dimly illuminated (18
w bulb) and acoustically isolated room (2.5 m x 2.7 m x 2.4
m). The presentation of the stimulus and the recording of
responses were controlled by the Eyeblink Conditioning
System (San Diego Instruments, San Diego, CA), which
administered the acoustic stimulus and registered eyeblink
responses. The acoustic stimulus was a 100-ms tone, presented
through MAICO earphones.
The eyeblink response was measured by a low power
infrared photoelectric emitter/receiver that measures the
amount of light reflected as the eyelid closes. The changes in
reflected light as blinks occurred were converted to changes in
electrical signals that were analyzed by a computer program.
The photoelectric cell was located in front of the participant’s
right eye and was supported by a headband to keep it in a
fixed position throughout the experiment.
Procedure
The experiment consisted of 4 phases: adaptation, pretest,
habituation and post-test. In the adaptation phase, the
researcher placed the headband with the stimulation and
registration devices on the participant’s head and calibrated
its position to obtain a detectable eyeblink response. The
experimenter then left the room and allowed the participants
to adapt to the situation for 3 minutes without stimulation.
In the pretest phase the participants received 5 tones of 90-
dB at 40 sec intervals. The objective of the pretest was to
determine the average level of response to the 90-dB tone
before habituation. In the habituation phase, the participants
were exposed to 100 presentations of a tone at 40-sec intervals.
The constant group received these habituation sequences in
a constant intensity of 90-dB, whereas the incremental group
began with 10 tones of 60-dB rising gradually by 3-dB to the
successive blocks of 10 sequences, until reaching a maximum
of 87-dB. Finally, during the post-test phase, the participants in
both groups received 10 trials of 90-dB tones.
Scoring
Movements of the participant’s eyelid were recorded with a
frequency of one sample every 1-ms, which were expressed
as changes in the voltage transmitted by the transducer.
A standardization trial was conducted with one naive
volunteer to obtain a measure of the amplitude of a typical
eyelid response to the tone. The maximal voltage obtained
during the 200-ms following the onset of the stimulus was
regarded as a response amplitude of l00. The responses
of all participants were expressed as a percentage of this
standardization value.
The measure of the evoked responses was based on the
maximal amplitude occurring within the 200-ms following the
onset of the stimulus. An eyelid response was scored only if the
record indicated an amplitude of 5% or more within the 100-ms
of stimulus duration. A valid trial was defined as one in which
the amplitude of response was lower than 5% within the 200-
ms window that preceded the onset of the stimulus.
Results
Figure 1 shows the mean amplitude of response of the two
groups during the pretest with the 90-dB tones, over blocks of
10 trials when the groups received different intensities of the
tones, and on the post-test in which each group was exposed
again to the 90-dB tones. First, it is observed that both groups
experienced a considerable decrement in responding to the
90-dB tone from pretest to post-test, indicating that the 100
habituation trials were effective in producing habituation in
both conditions. Second, it can be seen that although the two
groups exhibited similar amplitudes of responses during the
pretest, there was considerably more response in the constant
than in the incremental group in the post-test. This greater
decrease in response in the incremental group supports
3. 297VOGEL ET AL. Biol Res 44, 2011, 295-299
the idea that the incremental sequence is more efficient in
producing habituation than the constant sequence.
The reliability of these observations was confirmed by a 2
(test: pretest, posttest) x 2 (group: constant, incremental) mixed
design ANOVA. In order to avoid a loss of statistical power if
the amplitude of response in the post-test were more uniform
than in the pretest, a blocking factor of 2 levels based on the
participants’ initial amplitude of response was introduced (19).
The blocking factor was obtained by dividing the participants
into two groups using the median amplitude of response in the
pretest as a cut-off point.
The ANOVA showed a significant main effect of test
(F(1, 38) =186.363; p <0.001; η2 partial =0.831) and blocking
(F(1, 38) =69.332; p <0.001; η2 partial =0.646), and no reliable
main effect of the group (F(1, 38) =0.664; p =0.420; η2 partial
=0.017). There were also reliable interactions between test and
group (F(1, 38) =6.376; p =0.016; η2 partial =0.144) and between
test and blocking (F(1, 38) =56.641; p <0.001; η2 partial =0.598).
The interactions between group and blocking and between
group, blocking and test were non-reliable (ps >0.901).
All the effects related to the blocking factor confirm the
utility of this procedure, especially the interaction between
blocking and test, since it reflects the fact that the differences
between the high and low responders tend to disappear in
the post-test. The most interesting effects are the main effect
of test and the interaction between group and test. On the one
hand, the effect of the test reveals the existence of a decrement
in both groups from pretest to post-test, which confirms the
effectiveness of both procedures in producing habituation. On
the other hand, the interaction between group and test was
assessed by evaluating the simple effects of group in each
test. This analysis indicated that the two groups showed no
differences between them in the pretest (p =0.339), but did
differ in the post-test, where the incremental group responded
significantly less than the constant group (p =0.037).
An interesting aspect of the data shown in Figure 1 is
the demonstration of the incremental intensity effect, even
though substantial evidence of habituation in both groups
was obtained. This is contrary to the observations in which
the incremental effect appears only when habituation had not
yet occurred in the constant group (2, 20). In addition, Figure
1 shows extra evidence of habituation in both groups in that
the data indicated a progressive decrement in the amplitude
of the response within the 10 blocks of the habituation phase.
Naturally, this drop is less marked in the incremental group
since the decremental tendencies compete with the progressive
increase in the stimulus intensity, although in the end, the
decrease tends to predominate.
DISCUSSION
The results of this investigation provide positive evidence
of the existence of the incremental stimulus intensity effect
in the habituation of the eyeblink response in humans. This
information represents the first demonstration of this effect
with skeletal responses in humans and is in agreement with
the studies reported by Davis and Wagner (7) and Groves and
Thompson (13) on the startle response in rats and the limb
flexion reflex in the spinal cat, respectively.
As mentioned above, even though there is some evidence
of the ISIE in the habituation of the autonomic responses,
such as the cardiac response in dogs (2) and the electrodermal
response in humans (20, 21), there is also evidence of null
effects (with the electrodermal response, 17, and with the blood
volume response, 20). Remarkably, the positive effects seen
in the literature tend to match with poor habituation in the
constant group.
It could be inferred that what produces controversial
results is the quickness of the habituation of autonomic
responses. If this were the case, the absence of the effect
Figure 1. Mean amplitude of eyeblink response of the constant group (black dots, n=36) and incremental group (white dots; n=36) during
the pretest, training and post-test phases. The error bars represent the standard error of the mean.
4. VOGEL ET AL. Biol Res 44, 2011, 295-299298
would be a detection problem. According to this reasoning, it
is important to distinguish between asymptotic habituation
and non-detectable habituation, since it has been proven that
habituation often continues beyond the detection margin,
which has been called “below-zero habituation” (27). Thus, to
detect the possible differences between the incremental and
constant conditions when below-zero habituation is produced,
further investigations should employ more sensitive measures,
such as the comparison of differential levels of spontaneous
recovery.
Another interesting aspect of the ISIE is the type of
habituation theory required to explain it. Several researchers
(e.g., 13, 26), have pointed out that this phenomenon poses
serious difficulties for certain habituation theories, such as
the so-called comparator theory of Sokolov (24, 25). Sokolov
suggested that stimulus repetition leads to the formation of
a neuronal model in the cerebral cortex and that each new
presentation of the stimulus is compared to the model. The
greater the difference between the stimulus and the model,
the greater is the expected response to the stimulus. Therefore,
as these representations develop, the stimulus becomes more
similar to the model, and progressively losses its capacity to
produce the response. This theory fails to explain the ISIE
because it assumes that the repetition of a stimulus with
incremental intensities is equivalent to the repetition of
different stimuli, which would always produce a difference
between the model and the actual stimulus.
Groves and Thompson (13) have pointed out that their
dual theory of habituation is better prepared to explain the
ISIE. According to these authors, the presentation of a stimulus
produces two opposite and interacting tendencies, a specific
decremental tendency (or habituation, which is subordinated
to the stimulus-response system) and a global incremental
tendency (or sensitization, which is subordinated to the
activation state or arousal of the organism), which combine to
produce the observed behavior. When a stimulus is repeated,
both tendencies change their magnitude depending on various
factors, such as the intensity of the stimulus and the number
of repetitions. The sensitization process dominates over the
habituation process with more intense stimulus but decreases
with the number of repetitions, while the habituation process
develops more easily with lower intensities and increases
with stimulus repetition. Following this logic, Groves and
Thompson explain the ISIE by suggesting that the constant
group suffers a higher sensitization and lower habituation than
the incremental group, because the latter group receives less
intense stimuli in each block.
Wagner and Vogel (31) used the associative machinery
of the SOP (29) and AESOP (30) models to describe how
incremental and decremental processes may interact in
habituation procedures. According to the SOP model, when a
stimulus is repeatedly presented in a context, the context acts
as a conditioned stimulus that develops an association with
the habituating stimulus, which in turns plays the role of the
unconditioned stimulus. As this association develops, the
stimulus becomes progressively more expected in the context.
SOP further assumes that an expected or pre-processed
stimulus is not as effectively processed, as it otherwise would
be, which would explain the decremental tendencies that
resulted from the repetition of the stimulus. On the other
hand, according to the additional principles contained in
the AESOP model, certain emotional responses provoked
by the stimulus, like fear, can also be conditioned to the
context, which would acquire the property of potentiating
the response to the habituating stimulus. The AESOP model
assumes that decremental and incremental tendencies develop
simultaneously and obey to different associative parameters.
A shared aspect between the dual theory of Groves and
Thompson (13) and the Wagner’s approach (29-31) is the
assumption that the decremental process is assumed to
be specific to the stimulus-response system, whereas the
incremental process is global, affecting multiple response
systems simultaneously. According to this, it would be
possible to evaluate whether the advantage of the incremental
group over the constant group is due to differential
habituation or differential sensitization, if it were possible
to employ two different stimuli, perhaps one acoustic and
the other tactile, that have been demonstrated to have at
least partially separable startle-producing features. Then it
would be possible to determine whether the exposure to one
of the stimuli in the incremental versus constant conditions
produced less responding in the incremental condition specific
to the exposed stimulus (due to differences in habituation to
the repeated stimulus) or less responding to the two stimuli
(due to differences in sensitization). This sort of experiments
needs preparations that show robust stimulus specific
habituation, which has not been demonstrated systematically
yet in the procedures in which the ISIE effect has been
observed (9, 28).
Another methodological strategy to uncover the real
nature of the ISIE might be to examine the neural pathways of
incremental and decremental processes involved in habituation
procedures. This could be based in the fact that neural circuit
of the startle response is clearly drawn to the level of the
sensory-motor connections with the reticular system (5). It has
also been demonstrated that the habituation of this response
is seriously affected by lesions in this pathway (15). On the
other hand, there is substantial evidence that the acquisition of
different levels of sensitization occur in different neural circuit,
which has been proven by studies that demonstrated that
the startle response could be enhanced by the experimental
activation of the amygdala (4, 6, 10). By means of the structural
or chemical deactivation of one of these circuits it could be
clarified if the differences between the two experimental
conditions are due to differences in the habituation or
sensitization circuits.
The habituation theories and the understanding of this
phenomenon will be able to move beyond the current state,
to the extent that some procedures are developed to allow
separating the different influences that underlie this apparently
simple type of learning.
ACKNOWLEDGEMENTS
This work was supported by grants from Fondecyt Nº 1090640
to Edgar Vogel and from the University of Talca to the Program
of Research on the Quality of Life (Res. 387/2007).
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