The US healthcare system is in deep trouble and requires fundamental reengineering rather than single incremental reforms. Reengineering involves rethinking the entire care delivery process from the perspective of health outcomes and patient value. It requires abandoning long-established clinical approaches and entrusting generalist clinicians to lead interdisciplinary teams providing standardized, evidence-based care coordinated around patient needs. While challenging, reengineering following principles demonstrated by IBM could transform the system to dramatically improve quality and control unsustainable costs.