This dissertation examines how variations in railroad track stiffness and inclusions within rails can impact fatigue life. A computational model uses finite element analysis of hundreds of rail sections across representative track geometries. Field measurement data is used to estimate model parameters. Results show nonuniform track beds can reduce fatigue life up to 100 times compared to uniform tracks. Inclusion location and stiffness also influence fatigue life and crack propagation direction. Understanding these factors could help improve rail maintenance and inspection scheduling.