Evidence from animal models has implied the direct involvement of gut microbiota in disease development, and some intestinal microbiota is associated with autoimmune diseases.https://live-biotherapeutic.creative-biolabs.com/autoimmune-disease.htm
Messenger ribonucleic acid (mRNA), a type of RNA molecule that can be found in various cells. In general, the structure of mRNA is often composed of a 5' cap, two untranslated regions (5' UTR and 3' UTR), a coding domain, a 3' poly(A) tail. mRNA can be produced during the process of transcription in the nucleus. Normally, primary transcript mRNA (pre-mRNA) will be created at the early stage of transcription. This pre-mRNA will be further processed into mature mRNA by RNA splicing and removing introns. Mature mRNA can be further transported into the cytoplasm to participate in protein synthesis. Moreover, two main types of RNA molecules, transfer RNA (tRNA) and ribosomal RNA (rRNA), have also been identified that play a critical role in translating codons into amino acids in the protein-manufacturing process.https://mrna.creative-biolabs.com/applications-of-mrna-as-research-tools.htm
Antibodies are immunoglobulins produced by B lymphocytes during their differentiation into plasma cells that bind specifically to the corresponding antigen. Antibodies can be divided into five major classes (IgG, IgA, IgM, IgD, IgE), which have a protective effect on the organism. Antibody mRNAs don't require nuclear localisation to mediate protein translation, but can be translated directly into target proteins or immunogenic activation of the immune response in vivo by using genetic sequence of the virus.https://mrna.creative-biolabs.com/category-antibody-mrna-479.htm
Cytokines are low molecular weight soluble proteins produced by cells stimulated by immunogens, mitogens or other factors, including interleukins, interferons (IFN), lymphokines, colony-stimulating factors (CSF), chemokines, monoclonal factors and other factors. https://mrna.creative-biolabs.com/category-cytokine-mrna-455.htm
In vitro transcription (IVT) is an elegant way to obtain highly pure and uniform mRNA oligonucleotides of lengths ranging from about 15 to several thousand nucleotides. It is transcribed from a double-stranded DNA template by RNA polymerase (T7, T3 or SP6 RNA polymerase).https://mrna.creative-biolabs.com/category-in-vitro-transcription-vector-452.htm
Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time. However, mRNA prepared with enzymatic synthesis may present transcriptional errors, which can only be produced at a laboratory scale, and products may not pure enough for the intended use. An efficient scalable non-enzymatic (chemical) method for mRNA production could solve these problems. https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm
Chemical synthesis of single-stranded mRNA molecules is a widely used laboratory procedure that is an alternative strategy of mRNA synthesis for RNA research as well as RNA biopharmaceuticals. This technique is versatile and allows the researcher to tailor the synthesis of short fragments of mRNA and introduce modifications to mRNA.https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm
Non-integrative mRNA reprogramming has proven to be the most efficient and clinically-relevant method for human induced pluripotent stem cells (iPSCs) reprogramming.
https://mrna.creative-biolabs.com/custom-ips-cell-reprogramming-by-mrna.htm
Messenger ribonucleic acid (mRNA), a type of RNA molecule that can be found in various cells. In general, the structure of mRNA is often composed of a 5' cap, two untranslated regions (5' UTR and 3' UTR), a coding domain, a 3' poly(A) tail. mRNA can be produced during the process of transcription in the nucleus. Normally, primary transcript mRNA (pre-mRNA) will be created at the early stage of transcription. This pre-mRNA will be further processed into mature mRNA by RNA splicing and removing introns. Mature mRNA can be further transported into the cytoplasm to participate in protein synthesis. Moreover, two main types of RNA molecules, transfer RNA (tRNA) and ribosomal RNA (rRNA), have also been identified that play a critical role in translating codons into amino acids in the protein-manufacturing process.https://mrna.creative-biolabs.com/applications-of-mrna-as-research-tools.htm
Antibodies are immunoglobulins produced by B lymphocytes during their differentiation into plasma cells that bind specifically to the corresponding antigen. Antibodies can be divided into five major classes (IgG, IgA, IgM, IgD, IgE), which have a protective effect on the organism. Antibody mRNAs don't require nuclear localisation to mediate protein translation, but can be translated directly into target proteins or immunogenic activation of the immune response in vivo by using genetic sequence of the virus.https://mrna.creative-biolabs.com/category-antibody-mrna-479.htm
Cytokines are low molecular weight soluble proteins produced by cells stimulated by immunogens, mitogens or other factors, including interleukins, interferons (IFN), lymphokines, colony-stimulating factors (CSF), chemokines, monoclonal factors and other factors. https://mrna.creative-biolabs.com/category-cytokine-mrna-455.htm
In vitro transcription (IVT) is an elegant way to obtain highly pure and uniform mRNA oligonucleotides of lengths ranging from about 15 to several thousand nucleotides. It is transcribed from a double-stranded DNA template by RNA polymerase (T7, T3 or SP6 RNA polymerase).https://mrna.creative-biolabs.com/category-in-vitro-transcription-vector-452.htm
Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time. However, mRNA prepared with enzymatic synthesis may present transcriptional errors, which can only be produced at a laboratory scale, and products may not pure enough for the intended use. An efficient scalable non-enzymatic (chemical) method for mRNA production could solve these problems. https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm
Chemical synthesis of single-stranded mRNA molecules is a widely used laboratory procedure that is an alternative strategy of mRNA synthesis for RNA research as well as RNA biopharmaceuticals. This technique is versatile and allows the researcher to tailor the synthesis of short fragments of mRNA and introduce modifications to mRNA.https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm
Non-integrative mRNA reprogramming has proven to be the most efficient and clinically-relevant method for human induced pluripotent stem cells (iPSCs) reprogramming.
https://mrna.creative-biolabs.com/custom-ips-cell-reprogramming-by-mrna.htm
Hepatitis D (hepatitis delta) is a disease caused by the Hepatitis D Virus (HDV), a small spherical enveloped virusoid.https://www.creative-biolabs.com/vaccine/hepatitis-d-virus-vaccines.htm
Hepatitis is a general term for liver inflammation, caused by infectious or non-infectious factors. Hepatitis B virus (HBV) infection is the main cause of morbidity and mortality.https://www.creative-biolabs.com/vaccine/hbv-vaccines.htm
Guillain-Barré syndrome (GBS) is an autoimmune disease of the nervous system, which is accompanied by symmetric flaccid paralysis of the extremities, sensory abnormalities, and cranial nerve palsy.https://www.creative-biolabs.com/vaccine/vaccines-for-guillain-barre-syndrome.htm
The FIV genome is comprised of three main structural genes, gag, pol, and env, which encode internal structural proteins, viral enzymes and envelope glycoproteins, respectively. https://www.creative-biolabs.com/vaccine/feline-immunodeficiency-virus-vaccine.htm
Feline leukemia virus (FeLV) is retroviral in the family Oncovirinae and is one of the most feared causes of a highly contagious and potentially fatal retroviral infection that weakens a cat's immune system.https://www.creative-biolabs.com/vaccine/feline-leukemia-virus-vaccine.htm
Bovine coronaviruses (BCoVs) belong to the Coronaviridae family in the Nidovirales order which cause respiratory and enteric infections in cattle and wild ruminants. https://www.creative-biolabs.com/vaccine/bovine-coronavirus-vaccines.htm
Cytomegalovirus (CMV) is from the family of Herpesviridae. Humans and monkeys serve as natural hosts.https://www.creative-biolabs.com/vaccine/cytomegalovirus-vaccines.htm
Due to their surfactants or gelation properties, glycolipids can be used to encapsulate some drugs. Studies have shown that the sucrose esters ability to form various formulation systems for the loading of different active molecules. These results revealed that micro-particles can be obtained with sucrose esters and they exhibit efficient encapsulation properties for pharmaceuticals applications. Several other studies describe the preparation of hydrogels or solution stabilized by sucrose esters for drug dermal absorptions. Therefore, the glycolipid potential is huge in the pharmaceutical and biomedical field.https://www.creative-biolabs.com/glycoprotein/custom-glycolipid-synthesis.htm
D-Galactosamine pentaacetate
Dried by centrifugal evaporation from an aqueous solution.
https://www.creative-biolabs.com/glycoprotein/d-galactosamine-pentaacetate-20.htm
Membrane carbohydrates, found on the extracellular surface, are complex and can display considerable variability in composition and structure. They are attached with embedded lipids forming glycolipids. Glycolipids constitute a complex family of amphipathic molecules structurally characterized by a hydrophilic mono- or oligo-saccharide moiety linked to a hydrophobic ceramide moiety.https://www.creative-biolabs.com/glycoprotein/custom-glycolipid-synthesis.htm
Glycosylation site mapping helps the identification of a glycosylation site, which can provide an indication of the function of that glycan. In addition, site-specific glycosylation analysis and assignment of a certain structure to a specific site can illuminate the protein’s glycosylation profile, microheterogeneity, and its activity. Glycosylation has great importance in the development of biological drugs because their glycan chains markedly affect product stability, activity, antigenicity, and pharmacodynamics. Glycosylation site mapping mainly contributes to glycan microheterogeneity.
https://www.creative-biolabs.com/glycoprotein/glycosylation-site-mapping.htm
Anticancer immunotherapy has emerged as a new exciting area for controlling tumors. Particularly, vaccination using synthetic tumor-associated carbohydrate antigens (TACAs)-based vaccine hold promise for generating a specific antitumor response by targeting cancer cells.https://www.creative-biolabs.com/glycoprotein/glycopeptide-based-cancer-vaccine-development.htm
Glycosylation is a fundamental modification of proteins, which plays an important role in many physiological and pathological processes, including protein folding and trafficking, cell-cell and cell-matrix interaction, cellular differentiation, fertilization, immune response, the initiation and metastasis of tumors. Thus, the analysis of glycoproteins structure allows characterization of important biological molecules, including antibodies, vaccines, enzymes, etc. What's more, glycoprotein structure analysis would be of great diagnostic and clinical importance.https://www.creative-biolabs.com/glycoprotein/glycoprotein-structure-analysis.htm
Glycoprotein Detection by Staining Procedures.pdfBetteElla
There are a number of staining methods that can be used to detect highly glycosylated proteins on SDS gels, among which, periodic acid-Schiff (PAS) staining is the simplest and low-cost way to estimate whether a protein is glycosylated.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection-by-staining-procedures.htm
Glycoprotein detection by PAS staining method.pdfBetteElla
Glycoproteins are extremely important to a variety of biological processes, including protein folding and trafficking, cell-cell and cell-matrix interaction, cellular differentiation, fertilization, immune response, the initiation and metastasis of tumors. However, the analysis of glycoproteins is a big challenge because of the low abundance, the complexity of the glycan structures, the multiple substitutions (microheterogeneity) at glycosylation sites, and the structural diversity associated with the protein backbone itself. We can provide a series of technologies for glycoprotein detection and analysis.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection-by-staining-procedures.htm
Glycoproteins are a group of proteins with oligosaccharide chains or glycans covalently attached to amino acid side-chains. These proteins are ubiquitously distributed and play an important role in various biological processes, such as cell signaling, cell-cell interaction, immune recognition, cell proliferation, and differentiation. Therefore, the alterations of glycoproteins possess a close relationship with the progression of diseases, such as autoimmune disease, Alzheimer’s disease, and cancer.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-biomarkers-research.htm
Must Know Postgres Extension for DBA and Developer during MigrationMydbops
Mydbops Opensource Database Meetup 16
Topic: Must-Know PostgreSQL Extensions for Developers and DBAs During Migration
Speaker: Deepak Mahto, Founder of DataCloudGaze Consulting
Date & Time: 8th June | 10 AM - 1 PM IST
Venue: Bangalore International Centre, Bangalore
Abstract: Discover how PostgreSQL extensions can be your secret weapon! This talk explores how key extensions enhance database capabilities and streamline the migration process for users moving from other relational databases like Oracle.
Key Takeaways:
* Learn about crucial extensions like oracle_fdw, pgtt, and pg_audit that ease migration complexities.
* Gain valuable strategies for implementing these extensions in PostgreSQL to achieve license freedom.
* Discover how these key extensions can empower both developers and DBAs during the migration process.
* Don't miss this chance to gain practical knowledge from an industry expert and stay updated on the latest open-source database trends.
Mydbops Managed Services specializes in taking the pain out of database management while optimizing performance. Since 2015, we have been providing top-notch support and assistance for the top three open-source databases: MySQL, MongoDB, and PostgreSQL.
Our team offers a wide range of services, including assistance, support, consulting, 24/7 operations, and expertise in all relevant technologies. We help organizations improve their database's performance, scalability, efficiency, and availability.
Contact us: info@mydbops.com
Visit: https://www.mydbops.com/
Follow us on LinkedIn: https://in.linkedin.com/company/mydbops
For more details and updates, please follow up the below links.
Meetup Page : https://www.meetup.com/mydbops-databa...
Twitter: https://twitter.com/mydbopsofficial
Blogs: https://www.mydbops.com/blog/
Facebook(Meta): https://www.facebook.com/mydbops/
Hepatitis D (hepatitis delta) is a disease caused by the Hepatitis D Virus (HDV), a small spherical enveloped virusoid.https://www.creative-biolabs.com/vaccine/hepatitis-d-virus-vaccines.htm
Hepatitis is a general term for liver inflammation, caused by infectious or non-infectious factors. Hepatitis B virus (HBV) infection is the main cause of morbidity and mortality.https://www.creative-biolabs.com/vaccine/hbv-vaccines.htm
Guillain-Barré syndrome (GBS) is an autoimmune disease of the nervous system, which is accompanied by symmetric flaccid paralysis of the extremities, sensory abnormalities, and cranial nerve palsy.https://www.creative-biolabs.com/vaccine/vaccines-for-guillain-barre-syndrome.htm
The FIV genome is comprised of three main structural genes, gag, pol, and env, which encode internal structural proteins, viral enzymes and envelope glycoproteins, respectively. https://www.creative-biolabs.com/vaccine/feline-immunodeficiency-virus-vaccine.htm
Feline leukemia virus (FeLV) is retroviral in the family Oncovirinae and is one of the most feared causes of a highly contagious and potentially fatal retroviral infection that weakens a cat's immune system.https://www.creative-biolabs.com/vaccine/feline-leukemia-virus-vaccine.htm
Bovine coronaviruses (BCoVs) belong to the Coronaviridae family in the Nidovirales order which cause respiratory and enteric infections in cattle and wild ruminants. https://www.creative-biolabs.com/vaccine/bovine-coronavirus-vaccines.htm
Cytomegalovirus (CMV) is from the family of Herpesviridae. Humans and monkeys serve as natural hosts.https://www.creative-biolabs.com/vaccine/cytomegalovirus-vaccines.htm
Due to their surfactants or gelation properties, glycolipids can be used to encapsulate some drugs. Studies have shown that the sucrose esters ability to form various formulation systems for the loading of different active molecules. These results revealed that micro-particles can be obtained with sucrose esters and they exhibit efficient encapsulation properties for pharmaceuticals applications. Several other studies describe the preparation of hydrogels or solution stabilized by sucrose esters for drug dermal absorptions. Therefore, the glycolipid potential is huge in the pharmaceutical and biomedical field.https://www.creative-biolabs.com/glycoprotein/custom-glycolipid-synthesis.htm
D-Galactosamine pentaacetate
Dried by centrifugal evaporation from an aqueous solution.
https://www.creative-biolabs.com/glycoprotein/d-galactosamine-pentaacetate-20.htm
Membrane carbohydrates, found on the extracellular surface, are complex and can display considerable variability in composition and structure. They are attached with embedded lipids forming glycolipids. Glycolipids constitute a complex family of amphipathic molecules structurally characterized by a hydrophilic mono- or oligo-saccharide moiety linked to a hydrophobic ceramide moiety.https://www.creative-biolabs.com/glycoprotein/custom-glycolipid-synthesis.htm
Glycosylation site mapping helps the identification of a glycosylation site, which can provide an indication of the function of that glycan. In addition, site-specific glycosylation analysis and assignment of a certain structure to a specific site can illuminate the protein’s glycosylation profile, microheterogeneity, and its activity. Glycosylation has great importance in the development of biological drugs because their glycan chains markedly affect product stability, activity, antigenicity, and pharmacodynamics. Glycosylation site mapping mainly contributes to glycan microheterogeneity.
https://www.creative-biolabs.com/glycoprotein/glycosylation-site-mapping.htm
Anticancer immunotherapy has emerged as a new exciting area for controlling tumors. Particularly, vaccination using synthetic tumor-associated carbohydrate antigens (TACAs)-based vaccine hold promise for generating a specific antitumor response by targeting cancer cells.https://www.creative-biolabs.com/glycoprotein/glycopeptide-based-cancer-vaccine-development.htm
Glycosylation is a fundamental modification of proteins, which plays an important role in many physiological and pathological processes, including protein folding and trafficking, cell-cell and cell-matrix interaction, cellular differentiation, fertilization, immune response, the initiation and metastasis of tumors. Thus, the analysis of glycoproteins structure allows characterization of important biological molecules, including antibodies, vaccines, enzymes, etc. What's more, glycoprotein structure analysis would be of great diagnostic and clinical importance.https://www.creative-biolabs.com/glycoprotein/glycoprotein-structure-analysis.htm
Glycoprotein Detection by Staining Procedures.pdfBetteElla
There are a number of staining methods that can be used to detect highly glycosylated proteins on SDS gels, among which, periodic acid-Schiff (PAS) staining is the simplest and low-cost way to estimate whether a protein is glycosylated.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection-by-staining-procedures.htm
Glycoprotein detection by PAS staining method.pdfBetteElla
Glycoproteins are extremely important to a variety of biological processes, including protein folding and trafficking, cell-cell and cell-matrix interaction, cellular differentiation, fertilization, immune response, the initiation and metastasis of tumors. However, the analysis of glycoproteins is a big challenge because of the low abundance, the complexity of the glycan structures, the multiple substitutions (microheterogeneity) at glycosylation sites, and the structural diversity associated with the protein backbone itself. We can provide a series of technologies for glycoprotein detection and analysis.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection-by-staining-procedures.htm
Glycoproteins are a group of proteins with oligosaccharide chains or glycans covalently attached to amino acid side-chains. These proteins are ubiquitously distributed and play an important role in various biological processes, such as cell signaling, cell-cell interaction, immune recognition, cell proliferation, and differentiation. Therefore, the alterations of glycoproteins possess a close relationship with the progression of diseases, such as autoimmune disease, Alzheimer’s disease, and cancer.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-biomarkers-research.htm
Must Know Postgres Extension for DBA and Developer during MigrationMydbops
Mydbops Opensource Database Meetup 16
Topic: Must-Know PostgreSQL Extensions for Developers and DBAs During Migration
Speaker: Deepak Mahto, Founder of DataCloudGaze Consulting
Date & Time: 8th June | 10 AM - 1 PM IST
Venue: Bangalore International Centre, Bangalore
Abstract: Discover how PostgreSQL extensions can be your secret weapon! This talk explores how key extensions enhance database capabilities and streamline the migration process for users moving from other relational databases like Oracle.
Key Takeaways:
* Learn about crucial extensions like oracle_fdw, pgtt, and pg_audit that ease migration complexities.
* Gain valuable strategies for implementing these extensions in PostgreSQL to achieve license freedom.
* Discover how these key extensions can empower both developers and DBAs during the migration process.
* Don't miss this chance to gain practical knowledge from an industry expert and stay updated on the latest open-source database trends.
Mydbops Managed Services specializes in taking the pain out of database management while optimizing performance. Since 2015, we have been providing top-notch support and assistance for the top three open-source databases: MySQL, MongoDB, and PostgreSQL.
Our team offers a wide range of services, including assistance, support, consulting, 24/7 operations, and expertise in all relevant technologies. We help organizations improve their database's performance, scalability, efficiency, and availability.
Contact us: info@mydbops.com
Visit: https://www.mydbops.com/
Follow us on LinkedIn: https://in.linkedin.com/company/mydbops
For more details and updates, please follow up the below links.
Meetup Page : https://www.meetup.com/mydbops-databa...
Twitter: https://twitter.com/mydbopsofficial
Blogs: https://www.mydbops.com/blog/
Facebook(Meta): https://www.facebook.com/mydbops/
What is an RPA CoE? Session 2 – CoE RolesDianaGray10
In this session, we will review the players involved in the CoE and how each role impacts opportunities.
Topics covered:
• What roles are essential?
• What place in the automation journey does each role play?
Speaker:
Chris Bolin, Senior Intelligent Automation Architect Anika Systems
Northern Engraving | Nameplate Manufacturing Process - 2024Northern Engraving
Manufacturing custom quality metal nameplates and badges involves several standard operations. Processes include sheet prep, lithography, screening, coating, punch press and inspection. All decoration is completed in the flat sheet with adhesive and tooling operations following. The possibilities for creating unique durable nameplates are endless. How will you create your brand identity? We can help!
How information systems are built or acquired puts information, which is what they should be about, in a secondary place. Our language adapted accordingly, and we no longer talk about information systems but applications. Applications evolved in a way to break data into diverse fragments, tightly coupled with applications and expensive to integrate. The result is technical debt, which is re-paid by taking even bigger "loans", resulting in an ever-increasing technical debt. Software engineering and procurement practices work in sync with market forces to maintain this trend. This talk demonstrates how natural this situation is. The question is: can something be done to reverse the trend?
Essentials of Automations: Exploring Attributes & Automation ParametersSafe Software
Building automations in FME Flow can save time, money, and help businesses scale by eliminating data silos and providing data to stakeholders in real-time. One essential component to orchestrating complex automations is the use of attributes & automation parameters (both formerly known as “keys”). In fact, it’s unlikely you’ll ever build an Automation without using these components, but what exactly are they?
Attributes & automation parameters enable the automation author to pass data values from one automation component to the next. During this webinar, our FME Flow Specialists will cover leveraging the three types of these output attributes & parameters in FME Flow: Event, Custom, and Automation. As a bonus, they’ll also be making use of the Split-Merge Block functionality.
You’ll leave this webinar with a better understanding of how to maximize the potential of automations by making use of attributes & automation parameters, with the ultimate goal of setting your enterprise integration workflows up on autopilot.
In our second session, we shall learn all about the main features and fundamentals of UiPath Studio that enable us to use the building blocks for any automation project.
📕 Detailed agenda:
Variables and Datatypes
Workflow Layouts
Arguments
Control Flows and Loops
Conditional Statements
💻 Extra training through UiPath Academy:
Variables, Constants, and Arguments in Studio
Control Flow in Studio
Introduction of Cybersecurity with OSS at Code Europe 2024Hiroshi SHIBATA
I develop the Ruby programming language, RubyGems, and Bundler, which are package managers for Ruby. Today, I will introduce how to enhance the security of your application using open-source software (OSS) examples from Ruby and RubyGems.
The first topic is CVE (Common Vulnerabilities and Exposures). I have published CVEs many times. But what exactly is a CVE? I'll provide a basic understanding of CVEs and explain how to detect and handle vulnerabilities in OSS.
Next, let's discuss package managers. Package managers play a critical role in the OSS ecosystem. I'll explain how to manage library dependencies in your application.
I'll share insights into how the Ruby and RubyGems core team works to keep our ecosystem safe. By the end of this talk, you'll have a better understanding of how to safeguard your code.
What is an RPA CoE? Session 1 – CoE VisionDianaGray10
In the first session, we will review the organization's vision and how this has an impact on the COE Structure.
Topics covered:
• The role of a steering committee
• How do the organization’s priorities determine CoE Structure?
Speaker:
Chris Bolin, Senior Intelligent Automation Architect Anika Systems
High performance Serverless Java on AWS- GoTo Amsterdam 2024Vadym Kazulkin
Java is for many years one of the most popular programming languages, but it used to have hard times in the Serverless community. Java is known for its high cold start times and high memory footprint, comparing to other programming languages like Node.js and Python. In this talk I'll look at the general best practices and techniques we can use to decrease memory consumption, cold start times for Java Serverless development on AWS including GraalVM (Native Image) and AWS own offering SnapStart based on Firecracker microVM snapshot and restore and CRaC (Coordinated Restore at Checkpoint) runtime hooks. I'll also provide a lot of benchmarking on Lambda functions trying out various deployment package sizes, Lambda memory settings, Java compilation options and HTTP (a)synchronous clients and measure their impact on cold and warm start times.
Freshworks Rethinks NoSQL for Rapid Scaling & Cost-EfficiencyScyllaDB
Freshworks creates AI-boosted business software that helps employees work more efficiently and effectively. Managing data across multiple RDBMS and NoSQL databases was already a challenge at their current scale. To prepare for 10X growth, they knew it was time to rethink their database strategy. Learn how they architected a solution that would simplify scaling while keeping costs under control.
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...Alex Pruden
Folding is a recent technique for building efficient recursive SNARKs. Several elegant folding protocols have been proposed, such as Nova, Supernova, Hypernova, Protostar, and others. However, all of them rely on an additively homomorphic commitment scheme based on discrete log, and are therefore not post-quantum secure. In this work we present LatticeFold, the first lattice-based folding protocol based on the Module SIS problem. This folding protocol naturally leads to an efficient recursive lattice-based SNARK and an efficient PCD scheme. LatticeFold supports folding low-degree relations, such as R1CS, as well as high-degree relations, such as CCS. The key challenge is to construct a secure folding protocol that works with the Ajtai commitment scheme. The difficulty, is ensuring that extracted witnesses are low norm through many rounds of folding. We present a novel technique using the sumcheck protocol to ensure that extracted witnesses are always low norm no matter how many rounds of folding are used. Our evaluation of the final proof system suggests that it is as performant as Hypernova, while providing post-quantum security.
Paper Link: https://eprint.iacr.org/2024/257
"NATO Hackathon Winner: AI-Powered Drug Search", Taras KlobaFwdays
This is a session that details how PostgreSQL's features and Azure AI Services can be effectively used to significantly enhance the search functionality in any application.
In this session, we'll share insights on how we used PostgreSQL to facilitate precise searches across multiple fields in our mobile application. The techniques include using LIKE and ILIKE operators and integrating a trigram-based search to handle potential misspellings, thereby increasing the search accuracy.
We'll also discuss how the azure_ai extension on PostgreSQL databases in Azure and Azure AI Services were utilized to create vectors from user input, a feature beneficial when users wish to find specific items based on text prompts. While our application's case study involves a drug search, the techniques and principles shared in this session can be adapted to improve search functionality in a wide range of applications. Join us to learn how PostgreSQL and Azure AI can be harnessed to enhance your application's search capability.