Glycoprotein-based Vaccine Development.pdf
•
0 likes•8 views
Anticancer immunotherapy has emerged as a new exciting area for controlling tumors. Particularly, vaccination using synthetic tumor-associated carbohydrate antigens (TACAs)-based vaccine hold promise for generating a specific antitumor response by targeting cancer cells.https://www.creative-biolabs.com/glycoprotein/glycopeptide-based-cancer-vaccine-development.htm
Report
Share
Report
Share
Download to read offline
Recommended
mRNA molecule as research tools
Messenger ribonucleic acid (mRNA), a type of RNA molecule that can be found in various cells. In general, the structure of mRNA is often composed of a 5' cap, two untranslated regions (5' UTR and 3' UTR), a coding domain, a 3' poly(A) tail. mRNA can be produced during the process of transcription in the nucleus. Normally, primary transcript mRNA (pre-mRNA) will be created at the early stage of transcription. This pre-mRNA will be further processed into mature mRNA by RNA splicing and removing introns. Mature mRNA can be further transported into the cytoplasm to participate in protein synthesis. Moreover, two main types of RNA molecules, transfer RNA (tRNA) and ribosomal RNA (rRNA), have also been identified that play a critical role in translating codons into amino acids in the protein-manufacturing process.https://mrna.creative-biolabs.com/applications-of-mrna-as-research-tools.htm
Antibody mRNA
Antibodies are immunoglobulins produced by B lymphocytes during their differentiation into plasma cells that bind specifically to the corresponding antigen. Antibodies can be divided into five major classes (IgG, IgA, IgM, IgD, IgE), which have a protective effect on the organism. Antibody mRNAs don't require nuclear localisation to mediate protein translation, but can be translated directly into target proteins or immunogenic activation of the immune response in vivo by using genetic sequence of the virus.https://mrna.creative-biolabs.com/category-antibody-mrna-479.htm
Cytokine mRNA
Cytokines are low molecular weight soluble proteins produced by cells stimulated by immunogens, mitogens or other factors, including interleukins, interferons (IFN), lymphokines, colony-stimulating factors (CSF), chemokines, monoclonal factors and other factors. https://mrna.creative-biolabs.com/category-cytokine-mrna-455.htm
In vitro transcription vector
In vitro transcription (IVT) is an elegant way to obtain highly pure and uniform mRNA oligonucleotides of lengths ranging from about 15 to several thousand nucleotides. It is transcribed from a double-stranded DNA template by RNA polymerase (T7, T3 or SP6 RNA polymerase).https://mrna.creative-biolabs.com/category-in-vitro-transcription-vector-452.htm
mRNA products
mRNA products include reagents for mRNA delivery, genome editing mRNA, reporter gene mRNA, growth factor mRNA, mRNA kits, enzymes for mRNA research, and nucleotide products for mRNA research.
https://mrna.creative-biolabs.com/category-mrna-products-443.htm
mRNA Chemical Synthesis
Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time. However, mRNA prepared with enzymatic synthesis may present transcriptional errors, which can only be produced at a laboratory scale, and products may not pure enough for the intended use. An efficient scalable non-enzymatic (chemical) method for mRNA production could solve these problems. https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm
synthetic mRNA
Chemical synthesis of single-stranded mRNA molecules is a widely used laboratory procedure that is an alternative strategy of mRNA synthesis for RNA research as well as RNA biopharmaceuticals. This technique is versatile and allows the researcher to tailor the synthesis of short fragments of mRNA and introduce modifications to mRNA.https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm
iPS Cell Reprogramming by mRNA
Non-integrative mRNA reprogramming has proven to be the most efficient and clinically-relevant method for human induced pluripotent stem cells (iPSCs) reprogramming.
https://mrna.creative-biolabs.com/custom-ips-cell-reprogramming-by-mrna.htm
Recommended
mRNA molecule as research tools
Messenger ribonucleic acid (mRNA), a type of RNA molecule that can be found in various cells. In general, the structure of mRNA is often composed of a 5' cap, two untranslated regions (5' UTR and 3' UTR), a coding domain, a 3' poly(A) tail. mRNA can be produced during the process of transcription in the nucleus. Normally, primary transcript mRNA (pre-mRNA) will be created at the early stage of transcription. This pre-mRNA will be further processed into mature mRNA by RNA splicing and removing introns. Mature mRNA can be further transported into the cytoplasm to participate in protein synthesis. Moreover, two main types of RNA molecules, transfer RNA (tRNA) and ribosomal RNA (rRNA), have also been identified that play a critical role in translating codons into amino acids in the protein-manufacturing process.https://mrna.creative-biolabs.com/applications-of-mrna-as-research-tools.htm
Antibody mRNA
Antibodies are immunoglobulins produced by B lymphocytes during their differentiation into plasma cells that bind specifically to the corresponding antigen. Antibodies can be divided into five major classes (IgG, IgA, IgM, IgD, IgE), which have a protective effect on the organism. Antibody mRNAs don't require nuclear localisation to mediate protein translation, but can be translated directly into target proteins or immunogenic activation of the immune response in vivo by using genetic sequence of the virus.https://mrna.creative-biolabs.com/category-antibody-mrna-479.htm
Cytokine mRNA
Cytokines are low molecular weight soluble proteins produced by cells stimulated by immunogens, mitogens or other factors, including interleukins, interferons (IFN), lymphokines, colony-stimulating factors (CSF), chemokines, monoclonal factors and other factors. https://mrna.creative-biolabs.com/category-cytokine-mrna-455.htm
In vitro transcription vector
In vitro transcription (IVT) is an elegant way to obtain highly pure and uniform mRNA oligonucleotides of lengths ranging from about 15 to several thousand nucleotides. It is transcribed from a double-stranded DNA template by RNA polymerase (T7, T3 or SP6 RNA polymerase).https://mrna.creative-biolabs.com/category-in-vitro-transcription-vector-452.htm
mRNA products
mRNA products include reagents for mRNA delivery, genome editing mRNA, reporter gene mRNA, growth factor mRNA, mRNA kits, enzymes for mRNA research, and nucleotide products for mRNA research.
https://mrna.creative-biolabs.com/category-mrna-products-443.htm
mRNA Chemical Synthesis
Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time. However, mRNA prepared with enzymatic synthesis may present transcriptional errors, which can only be produced at a laboratory scale, and products may not pure enough for the intended use. An efficient scalable non-enzymatic (chemical) method for mRNA production could solve these problems. https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm
synthetic mRNA
Chemical synthesis of single-stranded mRNA molecules is a widely used laboratory procedure that is an alternative strategy of mRNA synthesis for RNA research as well as RNA biopharmaceuticals. This technique is versatile and allows the researcher to tailor the synthesis of short fragments of mRNA and introduce modifications to mRNA.https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm
iPS Cell Reprogramming by mRNA
Non-integrative mRNA reprogramming has proven to be the most efficient and clinically-relevant method for human induced pluripotent stem cells (iPSCs) reprogramming.
https://mrna.creative-biolabs.com/custom-ips-cell-reprogramming-by-mrna.htm
hepatitis d vaccines
Hepatitis D (hepatitis delta) is a disease caused by the Hepatitis D Virus (HDV), a small spherical enveloped virusoid.https://www.creative-biolabs.com/vaccine/hepatitis-d-virus-vaccines.htm
hbv vaccines
Hepatitis is a general term for liver inflammation, caused by infectious or non-infectious factors. Hepatitis B virus (HBV) infection is the main cause of morbidity and mortality.https://www.creative-biolabs.com/vaccine/hbv-vaccines.htm
guillain barre syndrome vaccines
Guillain-Barré syndrome (GBS) is an autoimmune disease of the nervous system, which is accompanied by symmetric flaccid paralysis of the extremities, sensory abnormalities, and cranial nerve palsy.https://www.creative-biolabs.com/vaccine/vaccines-for-guillain-barre-syndrome.htm
fiv vaccines
The FIV genome is comprised of three main structural genes, gag, pol, and env, which encode internal structural proteins, viral enzymes and envelope glycoproteins, respectively. https://www.creative-biolabs.com/vaccine/feline-immunodeficiency-virus-vaccine.htm
feline leukemia vaccines
Feline leukemia virus (FeLV) is retroviral in the family Oncovirinae and is one of the most feared causes of a highly contagious and potentially fatal retroviral infection that weakens a cat's immune system.https://www.creative-biolabs.com/vaccine/feline-leukemia-virus-vaccine.htm
egg vaccines
Chicken-egg-based vaccine production remains the most effective manufacturing method available.
cow vaccines
Bovine coronaviruses (BCoVs) belong to the Coronaviridae family in the Nidovirales order which cause respiratory and enteric infections in cattle and wild ruminants. https://www.creative-biolabs.com/vaccine/bovine-coronavirus-vaccines.htm
cmv vaccines
Cytomegalovirus (CMV) is from the family of Herpesviridae. Humans and monkeys serve as natural hosts.https://www.creative-biolabs.com/vaccine/cytomegalovirus-vaccines.htm
glycolipid synthesis.pdf
Due to their surfactants or gelation properties, glycolipids can be used to encapsulate some drugs. Studies have shown that the sucrose esters ability to form various formulation systems for the loading of different active molecules. These results revealed that micro-particles can be obtained with sucrose esters and they exhibit efficient encapsulation properties for pharmaceuticals applications. Several other studies describe the preparation of hydrogels or solution stabilized by sucrose esters for drug dermal absorptions. Therefore, the glycolipid potential is huge in the pharmaceutical and biomedical field.https://www.creative-biolabs.com/glycoprotein/custom-glycolipid-synthesis.htm
D-Galactosamine pentaacetate
D-Galactosamine pentaacetate
Dried by centrifugal evaporation from an aqueous solution.
https://www.creative-biolabs.com/glycoprotein/d-galactosamine-pentaacetate-20.htm
Galactoarabinan.pdf
Dried by centrifugal evaporation from an aqueous solution.
https://www.creative-biolabs.com/glycoprotein/galactoarabinan-202.htm
custom synthesis services.pdf
Membrane carbohydrates, found on the extracellular surface, are complex and can display considerable variability in composition and structure. They are attached with embedded lipids forming glycolipids. Glycolipids constitute a complex family of amphipathic molecules structurally characterized by a hydrophilic mono- or oligo-saccharide moiety linked to a hydrophobic ceramide moiety.https://www.creative-biolabs.com/glycoprotein/custom-glycolipid-synthesis.htm
Anti-Glycoprotein Antibody Development.pdf
Phage Display Technology for Anti-Glycoprotein mAbs Discovery
Hybridoma Technology for Anti-Glycoprotein mAbs Discovery
Antigen-Specific B Lymphocytes Sorting Technology for Anti-Glycoprotein mAbs Discovery
https://www.creative-biolabs.com/glycoprotein/anti-glycoprotein-antibody-development.htm
Glycosylation Site Mapping.pdf
Glycosylation site mapping helps the identification of a glycosylation site, which can provide an indication of the function of that glycan. In addition, site-specific glycosylation analysis and assignment of a certain structure to a specific site can illuminate the protein’s glycosylation profile, microheterogeneity, and its activity. Glycosylation has great importance in the development of biological drugs because their glycan chains markedly affect product stability, activity, antigenicity, and pharmacodynamics. Glycosylation site mapping mainly contributes to glycan microheterogeneity.
https://www.creative-biolabs.com/glycoprotein/glycosylation-site-mapping.htm
Glycoprotein Structure Analysis.pdf
Glycosylation is a fundamental modification of proteins, which plays an important role in many physiological and pathological processes, including protein folding and trafficking, cell-cell and cell-matrix interaction, cellular differentiation, fertilization, immune response, the initiation and metastasis of tumors. Thus, the analysis of glycoproteins structure allows characterization of important biological molecules, including antibodies, vaccines, enzymes, etc. What's more, glycoprotein structure analysis would be of great diagnostic and clinical importance.https://www.creative-biolabs.com/glycoprotein/glycoprotein-structure-analysis.htm
Glycoprotein Detection.pdf
Glycoprotein detection is an important part of glycosylation engineering. https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection.htm
Glycoprotein Detection by Staining Procedures.pdf
There are a number of staining methods that can be used to detect highly glycosylated proteins on SDS gels, among which, periodic acid-Schiff (PAS) staining is the simplest and low-cost way to estimate whether a protein is glycosylated.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection-by-staining-procedures.htm
Glycoprotein detection by PAS staining method.pdf
Glycoproteins are extremely important to a variety of biological processes, including protein folding and trafficking, cell-cell and cell-matrix interaction, cellular differentiation, fertilization, immune response, the initiation and metastasis of tumors. However, the analysis of glycoproteins is a big challenge because of the low abundance, the complexity of the glycan structures, the multiple substitutions (microheterogeneity) at glycosylation sites, and the structural diversity associated with the protein backbone itself. We can provide a series of technologies for glycoprotein detection and analysis.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection-by-staining-procedures.htm
Glycoprotein Biomarker.pdf
Glycoproteins are a group of proteins with oligosaccharide chains or glycans covalently attached to amino acid side-chains. These proteins are ubiquitously distributed and play an important role in various biological processes, such as cell signaling, cell-cell interaction, immune recognition, cell proliferation, and differentiation. Therefore, the alterations of glycoproteins possess a close relationship with the progression of diseases, such as autoimmune disease, Alzheimer’s disease, and cancer.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-biomarkers-research.htm
Glycoprotein Analysis.pdf
Glycoprotein analysis is a big challenge because of the complexity of carbohydrate structures and their derivatives. https://www.creative-biolabs.com/glycoprotein/glycoprotein-analysis.htm
Introduction of Cybersecurity with OSS at Code Europe 2024
I develop the Ruby programming language, RubyGems, and Bundler, which are package managers for Ruby. Today, I will introduce how to enhance the security of your application using open-source software (OSS) examples from Ruby and RubyGems.
The first topic is CVE (Common Vulnerabilities and Exposures). I have published CVEs many times. But what exactly is a CVE? I'll provide a basic understanding of CVEs and explain how to detect and handle vulnerabilities in OSS.
Next, let's discuss package managers. Package managers play a critical role in the OSS ecosystem. I'll explain how to manage library dependencies in your application.
I'll share insights into how the Ruby and RubyGems core team works to keep our ecosystem safe. By the end of this talk, you'll have a better understanding of how to safeguard your code.
"$10 thousand per minute of downtime: architecture, queues, streaming and fin...
Direct losses from downtime in 1 minute = $5-$10 thousand dollars. Reputation is priceless.
As part of the talk, we will consider the architectural strategies necessary for the development of highly loaded fintech solutions. We will focus on using queues and streaming to efficiently work and manage large amounts of data in real-time and to minimize latency.
We will focus special attention on the architectural patterns used in the design of the fintech system, microservices and event-driven architecture, which ensure scalability, fault tolerance, and consistency of the entire system.
More Related Content
More from BetteElla
hepatitis d vaccines
Hepatitis D (hepatitis delta) is a disease caused by the Hepatitis D Virus (HDV), a small spherical enveloped virusoid.https://www.creative-biolabs.com/vaccine/hepatitis-d-virus-vaccines.htm
hbv vaccines
Hepatitis is a general term for liver inflammation, caused by infectious or non-infectious factors. Hepatitis B virus (HBV) infection is the main cause of morbidity and mortality.https://www.creative-biolabs.com/vaccine/hbv-vaccines.htm
guillain barre syndrome vaccines
Guillain-Barré syndrome (GBS) is an autoimmune disease of the nervous system, which is accompanied by symmetric flaccid paralysis of the extremities, sensory abnormalities, and cranial nerve palsy.https://www.creative-biolabs.com/vaccine/vaccines-for-guillain-barre-syndrome.htm
fiv vaccines
The FIV genome is comprised of three main structural genes, gag, pol, and env, which encode internal structural proteins, viral enzymes and envelope glycoproteins, respectively. https://www.creative-biolabs.com/vaccine/feline-immunodeficiency-virus-vaccine.htm
feline leukemia vaccines
Feline leukemia virus (FeLV) is retroviral in the family Oncovirinae and is one of the most feared causes of a highly contagious and potentially fatal retroviral infection that weakens a cat's immune system.https://www.creative-biolabs.com/vaccine/feline-leukemia-virus-vaccine.htm
egg vaccines
Chicken-egg-based vaccine production remains the most effective manufacturing method available.
cow vaccines
Bovine coronaviruses (BCoVs) belong to the Coronaviridae family in the Nidovirales order which cause respiratory and enteric infections in cattle and wild ruminants. https://www.creative-biolabs.com/vaccine/bovine-coronavirus-vaccines.htm
cmv vaccines
Cytomegalovirus (CMV) is from the family of Herpesviridae. Humans and monkeys serve as natural hosts.https://www.creative-biolabs.com/vaccine/cytomegalovirus-vaccines.htm
glycolipid synthesis.pdf
Due to their surfactants or gelation properties, glycolipids can be used to encapsulate some drugs. Studies have shown that the sucrose esters ability to form various formulation systems for the loading of different active molecules. These results revealed that micro-particles can be obtained with sucrose esters and they exhibit efficient encapsulation properties for pharmaceuticals applications. Several other studies describe the preparation of hydrogels or solution stabilized by sucrose esters for drug dermal absorptions. Therefore, the glycolipid potential is huge in the pharmaceutical and biomedical field.https://www.creative-biolabs.com/glycoprotein/custom-glycolipid-synthesis.htm
D-Galactosamine pentaacetate
D-Galactosamine pentaacetate
Dried by centrifugal evaporation from an aqueous solution.
https://www.creative-biolabs.com/glycoprotein/d-galactosamine-pentaacetate-20.htm
Galactoarabinan.pdf
Dried by centrifugal evaporation from an aqueous solution.
https://www.creative-biolabs.com/glycoprotein/galactoarabinan-202.htm
custom synthesis services.pdf
Membrane carbohydrates, found on the extracellular surface, are complex and can display considerable variability in composition and structure. They are attached with embedded lipids forming glycolipids. Glycolipids constitute a complex family of amphipathic molecules structurally characterized by a hydrophilic mono- or oligo-saccharide moiety linked to a hydrophobic ceramide moiety.https://www.creative-biolabs.com/glycoprotein/custom-glycolipid-synthesis.htm
Anti-Glycoprotein Antibody Development.pdf
Phage Display Technology for Anti-Glycoprotein mAbs Discovery
Hybridoma Technology for Anti-Glycoprotein mAbs Discovery
Antigen-Specific B Lymphocytes Sorting Technology for Anti-Glycoprotein mAbs Discovery
https://www.creative-biolabs.com/glycoprotein/anti-glycoprotein-antibody-development.htm
Glycosylation Site Mapping.pdf
Glycosylation site mapping helps the identification of a glycosylation site, which can provide an indication of the function of that glycan. In addition, site-specific glycosylation analysis and assignment of a certain structure to a specific site can illuminate the protein’s glycosylation profile, microheterogeneity, and its activity. Glycosylation has great importance in the development of biological drugs because their glycan chains markedly affect product stability, activity, antigenicity, and pharmacodynamics. Glycosylation site mapping mainly contributes to glycan microheterogeneity.
https://www.creative-biolabs.com/glycoprotein/glycosylation-site-mapping.htm
Glycoprotein Structure Analysis.pdf
Glycosylation is a fundamental modification of proteins, which plays an important role in many physiological and pathological processes, including protein folding and trafficking, cell-cell and cell-matrix interaction, cellular differentiation, fertilization, immune response, the initiation and metastasis of tumors. Thus, the analysis of glycoproteins structure allows characterization of important biological molecules, including antibodies, vaccines, enzymes, etc. What's more, glycoprotein structure analysis would be of great diagnostic and clinical importance.https://www.creative-biolabs.com/glycoprotein/glycoprotein-structure-analysis.htm
Glycoprotein Detection.pdf
Glycoprotein detection is an important part of glycosylation engineering. https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection.htm
Glycoprotein Detection by Staining Procedures.pdf
There are a number of staining methods that can be used to detect highly glycosylated proteins on SDS gels, among which, periodic acid-Schiff (PAS) staining is the simplest and low-cost way to estimate whether a protein is glycosylated.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection-by-staining-procedures.htm
Glycoprotein detection by PAS staining method.pdf
Glycoproteins are extremely important to a variety of biological processes, including protein folding and trafficking, cell-cell and cell-matrix interaction, cellular differentiation, fertilization, immune response, the initiation and metastasis of tumors. However, the analysis of glycoproteins is a big challenge because of the low abundance, the complexity of the glycan structures, the multiple substitutions (microheterogeneity) at glycosylation sites, and the structural diversity associated with the protein backbone itself. We can provide a series of technologies for glycoprotein detection and analysis.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-detection-by-staining-procedures.htm
Glycoprotein Biomarker.pdf
Glycoproteins are a group of proteins with oligosaccharide chains or glycans covalently attached to amino acid side-chains. These proteins are ubiquitously distributed and play an important role in various biological processes, such as cell signaling, cell-cell interaction, immune recognition, cell proliferation, and differentiation. Therefore, the alterations of glycoproteins possess a close relationship with the progression of diseases, such as autoimmune disease, Alzheimer’s disease, and cancer.
https://www.creative-biolabs.com/glycoprotein/glycoprotein-biomarkers-research.htm
Glycoprotein Analysis.pdf
Glycoprotein analysis is a big challenge because of the complexity of carbohydrate structures and their derivatives. https://www.creative-biolabs.com/glycoprotein/glycoprotein-analysis.htm
More from BetteElla (20)
Recently uploaded
Introduction of Cybersecurity with OSS at Code Europe 2024
I develop the Ruby programming language, RubyGems, and Bundler, which are package managers for Ruby. Today, I will introduce how to enhance the security of your application using open-source software (OSS) examples from Ruby and RubyGems.
The first topic is CVE (Common Vulnerabilities and Exposures). I have published CVEs many times. But what exactly is a CVE? I'll provide a basic understanding of CVEs and explain how to detect and handle vulnerabilities in OSS.
Next, let's discuss package managers. Package managers play a critical role in the OSS ecosystem. I'll explain how to manage library dependencies in your application.
I'll share insights into how the Ruby and RubyGems core team works to keep our ecosystem safe. By the end of this talk, you'll have a better understanding of how to safeguard your code.
"$10 thousand per minute of downtime: architecture, queues, streaming and fin...
Direct losses from downtime in 1 minute = $5-$10 thousand dollars. Reputation is priceless.
As part of the talk, we will consider the architectural strategies necessary for the development of highly loaded fintech solutions. We will focus on using queues and streaming to efficiently work and manage large amounts of data in real-time and to minimize latency.
We will focus special attention on the architectural patterns used in the design of the fintech system, microservices and event-driven architecture, which ensure scalability, fault tolerance, and consistency of the entire system.
"Scaling RAG Applications to serve millions of users", Kevin Goedecke
How we managed to grow and scale a RAG application from zero to thousands of users in 7 months. Lessons from technical challenges around managing high load for LLMs, RAGs and Vector databases.
Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
Simplify your search for a reliable Python development partner! This list presents the top 10 trusted US providers offering comprehensive Python development services, ensuring your project's success from conception to completion.
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...
This LF Energy webinar took place June 20, 2024. It featured:
-Alex Thornton, LF Energy
-Hallie Cramer, Google
-Daniel Roesler, UtilityAPI
-Henry Richardson, WattTime
In response to the urgency and scale required to effectively address climate change, open source solutions offer significant potential for driving innovation and progress. Currently, there is a growing demand for standardization and interoperability in energy data and modeling. Open source standards and specifications within the energy sector can also alleviate challenges associated with data fragmentation, transparency, and accessibility. At the same time, it is crucial to consider privacy and security concerns throughout the development of open source platforms.
This webinar will delve into the motivations behind establishing LF Energy’s Carbon Data Specification Consortium. It will provide an overview of the draft specifications and the ongoing progress made by the respective working groups.
Three primary specifications will be discussed:
-Discovery and client registration, emphasizing transparent processes and secure and private access
-Customer data, centering around customer tariffs, bills, energy usage, and full consumption disclosure
-Power systems data, focusing on grid data, inclusive of transmission and distribution networks, generation, intergrid power flows, and market settlement data
GNSS spoofing via SDR (Criptored Talks 2024)
In the realm of cybersecurity, offensive security practices act as a critical shield. By simulating real-world attacks in a controlled environment, these techniques expose vulnerabilities before malicious actors can exploit them. This proactive approach allows manufacturers to identify and fix weaknesses, significantly enhancing system security.
This presentation delves into the development of a system designed to mimic Galileo's Open Service signal using software-defined radio (SDR) technology. We'll begin with a foundational overview of both Global Navigation Satellite Systems (GNSS) and the intricacies of digital signal processing.
The presentation culminates in a live demonstration. We'll showcase the manipulation of Galileo's Open Service pilot signal, simulating an attack on various software and hardware systems. This practical demonstration serves to highlight the potential consequences of unaddressed vulnerabilities, emphasizing the importance of offensive security practices in safeguarding critical infrastructure.
Astute Business Solutions | Oracle Cloud Partner |
Your goto partner for Oracle Cloud, PeopleSoft, E-Business Suite, and Ellucian Banner. We are a firm specialized in managed services and consulting.
[OReilly Superstream] Occupy the Space: A grassroots guide to engineering (an...
The typical problem in product engineering is not bad strategy, so much as “no strategy”. This leads to confusion, lack of motivation, and incoherent action. The next time you look for a strategy and find an empty space, instead of waiting for it to be filled, I will show you how to fill it in yourself. If you’re wrong, it forces a correction. If you’re right, it helps create focus. I’ll share how I’ve approached this in the past, both what works and lessons for what didn’t work so well.
High performance Serverless Java on AWS- GoTo Amsterdam 2024
Java is for many years one of the most popular programming languages, but it used to have hard times in the Serverless community. Java is known for its high cold start times and high memory footprint, comparing to other programming languages like Node.js and Python. In this talk I'll look at the general best practices and techniques we can use to decrease memory consumption, cold start times for Java Serverless development on AWS including GraalVM (Native Image) and AWS own offering SnapStart based on Firecracker microVM snapshot and restore and CRaC (Coordinated Restore at Checkpoint) runtime hooks. I'll also provide a lot of benchmarking on Lambda functions trying out various deployment package sizes, Lambda memory settings, Java compilation options and HTTP (a)synchronous clients and measure their impact on cold and warm start times.
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Join us to learn how UiPath Apps can directly and easily interact with prebuilt connectors via Integration Service--including Salesforce, ServiceNow, Open GenAI, and more.
The best part is you can achieve this without building a custom workflow! Say goodbye to the hassle of using separate automations to call APIs. By seamlessly integrating within App Studio, you can now easily streamline your workflow, while gaining direct access to our Connector Catalog of popular applications.
We’ll discuss and demo the benefits of UiPath Apps and connectors including:
Creating a compelling user experience for any software, without the limitations of APIs.
Accelerating the app creation process, saving time and effort
Enjoying high-performance CRUD (create, read, update, delete) operations, for
seamless data management.
Speakers:
Russell Alfeche, Technology Leader, RPA at qBotic and UiPath MVP
Charlie Greenberg, host
AppSec PNW: Android and iOS Application Security with MobSF
Mobile Security Framework - MobSF is a free and open source automated mobile application security testing environment designed to help security engineers, researchers, developers, and penetration testers to identify security vulnerabilities, malicious behaviours and privacy concerns in mobile applications using static and dynamic analysis. It supports all the popular mobile application binaries and source code formats built for Android and iOS devices. In addition to automated security assessment, it also offers an interactive testing environment to build and execute scenario based test/fuzz cases against the application.
This talk covers:
Using MobSF for static analysis of mobile applications.
Interactive dynamic security assessment of Android and iOS applications.
Solving Mobile app CTF challenges.
Reverse engineering and runtime analysis of Mobile malware.
How to shift left and integrate MobSF/mobsfscan SAST and DAST in your build pipeline.
Dandelion Hashtable: beyond billion requests per second on a commodity server
This slide deck presents DLHT, a concurrent in-memory hashtable. Despite efforts to optimize hashtables, that go as far as sacrificing core functionality, state-of-the-art designs still incur multiple memory accesses per request and block request processing in three cases. First, most hashtables block while waiting for data to be retrieved from memory. Second, open-addressing designs, which represent the current state-of-the-art, either cannot free index slots on deletes or must block all requests to do so. Third, index resizes block every request until all objects are copied to the new index. Defying folklore wisdom, DLHT forgoes open-addressing and adopts a fully-featured and memory-aware closed-addressing design based on bounded cache-line-chaining. This design offers lock-free index operations and deletes that free slots instantly, (2) completes most requests with a single memory access, (3) utilizes software prefetching to hide memory latencies, and (4) employs a novel non-blocking and parallel resizing. In a commodity server and a memory-resident workload, DLHT surpasses 1.6B requests per second and provides 3.5x (12x) the throughput of the state-of-the-art closed-addressing (open-addressing) resizable hashtable on Gets (Deletes).
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
Folding is a recent technique for building efficient recursive SNARKs. Several elegant folding protocols have been proposed, such as Nova, Supernova, Hypernova, Protostar, and others. However, all of them rely on an additively homomorphic commitment scheme based on discrete log, and are therefore not post-quantum secure. In this work we present LatticeFold, the first lattice-based folding protocol based on the Module SIS problem. This folding protocol naturally leads to an efficient recursive lattice-based SNARK and an efficient PCD scheme. LatticeFold supports folding low-degree relations, such as R1CS, as well as high-degree relations, such as CCS. The key challenge is to construct a secure folding protocol that works with the Ajtai commitment scheme. The difficulty, is ensuring that extracted witnesses are low norm through many rounds of folding. We present a novel technique using the sumcheck protocol to ensure that extracted witnesses are always low norm no matter how many rounds of folding are used. Our evaluation of the final proof system suggests that it is as performant as Hypernova, while providing post-quantum security.
Paper Link: https://eprint.iacr.org/2024/257
What is an RPA CoE? Session 1 – CoE Vision
In the first session, we will review the organization's vision and how this has an impact on the COE Structure.
Topics covered:
• The role of a steering committee
• How do the organization’s priorities determine CoE Structure?
Speaker:
Chris Bolin, Senior Intelligent Automation Architect Anika Systems
Monitoring and Managing Anomaly Detection on OpenShift.pdf
Monitoring and Managing Anomaly Detection on OpenShift
Overview
Dive into the world of anomaly detection on edge devices with our comprehensive hands-on tutorial. This SlideShare presentation will guide you through the entire process, from data collection and model training to edge deployment and real-time monitoring. Perfect for those looking to implement robust anomaly detection systems on resource-constrained IoT/edge devices.
Key Topics Covered
1. Introduction to Anomaly Detection
- Understand the fundamentals of anomaly detection and its importance in identifying unusual behavior or failures in systems.
2. Understanding Edge (IoT)
- Learn about edge computing and IoT, and how they enable real-time data processing and decision-making at the source.
3. What is ArgoCD?
- Discover ArgoCD, a declarative, GitOps continuous delivery tool for Kubernetes, and its role in deploying applications on edge devices.
4. Deployment Using ArgoCD for Edge Devices
- Step-by-step guide on deploying anomaly detection models on edge devices using ArgoCD.
5. Introduction to Apache Kafka and S3
- Explore Apache Kafka for real-time data streaming and Amazon S3 for scalable storage solutions.
6. Viewing Kafka Messages in the Data Lake
- Learn how to view and analyze Kafka messages stored in a data lake for better insights.
7. What is Prometheus?
- Get to know Prometheus, an open-source monitoring and alerting toolkit, and its application in monitoring edge devices.
8. Monitoring Application Metrics with Prometheus
- Detailed instructions on setting up Prometheus to monitor the performance and health of your anomaly detection system.
9. What is Camel K?
- Introduction to Camel K, a lightweight integration framework built on Apache Camel, designed for Kubernetes.
10. Configuring Camel K Integrations for Data Pipelines
- Learn how to configure Camel K for seamless data pipeline integrations in your anomaly detection workflow.
11. What is a Jupyter Notebook?
- Overview of Jupyter Notebooks, an open-source web application for creating and sharing documents with live code, equations, visualizations, and narrative text.
12. Jupyter Notebooks with Code Examples
- Hands-on examples and code snippets in Jupyter Notebooks to help you implement and test anomaly detection models.
Taking AI to the Next Level in Manufacturing.pdf
Read Taking AI to the Next Level in Manufacturing to gain insights on AI adoption in the manufacturing industry, such as:
1. How quickly AI is being implemented in manufacturing.
2. Which barriers stand in the way of AI adoption.
3. How data quality and governance form the backbone of AI.
4. Organizational processes and structures that may inhibit effective AI adoption.
6. Ideas and approaches to help build your organization's AI strategy.
Choosing The Best AWS Service For Your Website + API.pptx
Have you ever been confused by the myriad of choices offered by AWS for hosting a website or an API?
Lambda, Elastic Beanstalk, Lightsail, Amplify, S3 (and more!) can each host websites + APIs. But which one should we choose?
Which one is cheapest? Which one is fastest? Which one will scale to meet our needs?
Join me in this session as we dive into each AWS hosting service to determine which one is best for your scenario and explain why!
Recently uploaded (20)
Introduction of Cybersecurity with OSS at Code Europe 2024
Introduction of Cybersecurity with OSS at Code Europe 2024
"$10 thousand per minute of downtime: architecture, queues, streaming and fin...
"$10 thousand per minute of downtime: architecture, queues, streaming and fin...
"Scaling RAG Applications to serve millions of users", Kevin Goedecke
"Scaling RAG Applications to serve millions of users", Kevin Goedecke
Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
Your One-Stop Shop for Python Success: Top 10 US Python Development Providers
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...
Astute Business Solutions | Oracle Cloud Partner |
Astute Business Solutions | Oracle Cloud Partner |
Overcoming the PLG Trap: Lessons from Canva's Head of Sales & Head of EMEA Da...
Overcoming the PLG Trap: Lessons from Canva's Head of Sales & Head of EMEA Da...
[OReilly Superstream] Occupy the Space: A grassroots guide to engineering (an...
[OReilly Superstream] Occupy the Space: A grassroots guide to engineering (an...
High performance Serverless Java on AWS- GoTo Amsterdam 2024
High performance Serverless Java on AWS- GoTo Amsterdam 2024
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
AppSec PNW: Android and iOS Application Security with MobSF
AppSec PNW: Android and iOS Application Security with MobSF
Dandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity server
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
zkStudyClub - LatticeFold: A Lattice-based Folding Scheme and its Application...
Monitoring and Managing Anomaly Detection on OpenShift.pdf
Monitoring and Managing Anomaly Detection on OpenShift.pdf
Choosing The Best AWS Service For Your Website + API.pptx
Choosing The Best AWS Service For Your Website + API.pptx