Natoli Engineering is a leading provider of tablet compression equipment and services, operating for almost 50 years. It offers a full range of tablet compression tools and presses, as well as refurbishing, replacement parts, analytical software, technical training, and consultation services. Natoli has manufacturing and technical facilities across the United States and in Poland and California. It assists customers with tablet design, tooling selection, process troubleshooting, and other services to optimize tablet production.

1. © Natoli EngineeringCompany2020.
NATOLI ENGINEERING
Leading the Tablet Compression Industry
for Almost a Half Century

2. © Natoli EngineeringCompany2020.
Our Full Spectrum of Products & Services:
• Tablet Compression Tooling
• Tablet Presses
• Tablet Press Replacement Parts and Turrets
• Tablet Press Refurbishing
• Tablet Compression and Encapsulation Accessories Catalog
• Encapsulation Replacement Parts
• Scientific Services
• Natoli AIM™ Analytical Software for Tablet Compression,
Encapsulation, Roller Compaction, and Blending
• Hands-on Technical Training
• E-Training Software
• Process Troubleshooting
• Natoli Advantage Support Services

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Technical Training &
Press Manufacturing Facility
Steel Preparation Facility
World Headquarters
& Tool ManufacturingFacility
NATOLI ENGINEERING CAMPUS
St. Charles, Missouri USA
Process R&D and Production
Facility
Turret & Replacement Part
Manufacturing Facility

4. REGIONAL TECHNICAL CENTERS
© Natoli EngineeringCompany2020.
New York
California
Poland

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Tablet Compression Tooling
• Multi-tip
• Lined Dies
• Expedited Services
• Die Segments
• Punch Coatings

6. Automation Provides
Consistent Quality and Process Efficiency
© Natoli EngineeringCompany2020.

7. Tablet Press Line:
R&D to Medium Production
© Natoli EngineeringCompany2020.
NP-500
NP-400
NP-255
NP-155
NP-RD30
NP-RD10A
NP-P20A

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Tablet Press Replacement Parts and Turrets

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Encapsulation Replacement Parts
and Change Kits

10. Technical Support
© Natoli EngineeringCompany2020.
• Tablet and Tooling Design
• Proper Steel Selection
• Steel and Coating Selection
• Consultation on Tooling Options
• Metallurgical Full-Service Lab
• Tool Failure Analysis
NatoliMetallurgy

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Tablet Compression and Encapsulation
Accessories Catalog

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Natoli Scientific & Natoli Institute
• FormulationDevelopment
• AnalyticalServices
• Data AcquisitionSystems
• Tablet Press & CalibrationServices
• TechnicalTraining
• ToolingRecommendations
• Small Batch Production/ManufacturingSupport

13. Natoli AIM™ Analytical Software
for compression, blending, encapsulation, & roller compactors
© Natoli EngineeringCompany2020.
• Obtainsdatadirectly from the R&D tablet press
• Features intuitive,highly flexible user interface
• Acquires and analyzes data,quickly displaysresults
• Displaysforce and pressure in real-time
• Stores data in SQL-driven databasefor easy retrieval
• Generates and exports easy-to-read reports

14. Technical Training Since 1984
© Natoli EngineeringCompany2020.
• Hands-on and classroom training
• Custom on-site trainings

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Natoli Advantage
Setting a Global Standard for Efficiency
• Standardized Training
• SOP Creation/Refinement
• Maintenance Procedures
• Tablet Design & Tooling Support
• Inventory Management
• Equipment Assessment & Services

16. © Natoli EngineeringCompany2020.
Tooling Tech Tip
For the first time measure what matters, punch tip wear!
Punch tip diameters are engineered using a tight tolerance
and critical for tablet quality and press operation.
Tool maintenance manuals and most SOPs refer to a
measuring instrument called a micrometer to
inspect and manage this critical dimension…

17. © Natoli EngineeringCompany2020.
Actual punch tip wear not
measured by a micrometer
• It measure the largest diameter between the anvils
• Can not measure wear below the tip plane
However, although the micrometer is acceptable
for checking new punches, it can not measure
actual punch tip wear responsible for poor
tablet quality.
And Tip Wear is often related to……

18. Tablet Deficiencies such as…
© Natoli EngineeringCompany2020.
CAPPING LAMINATION DARK SPECKS
STICKING EXCESSIVE FLASHING COATING CONTAMINENT

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Back Angle Head Wear Upper Raising Cam
…as well as Poor Press Operation & Associated
Damage

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Surprisingly, it’s a dimension that is
typically NEVER inspected!
A common occurrence…

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How to Properly Inspect for Tip Wear:
Horizontal OpticalComparator
OpticalComparator
View
OpticalComparator
Measurement
Actual tip wear
measurement
0.005”

22. New Natoli Laser Vision System
automatically checks
critical tip wear.
© Natoli EngineeringCompany2020.
Tip Wear
0.0143

23. Method for Checking Die Wear
© Natoli EngineeringCompany2020.

24. Proper Method for Checking Die Wear
to be continued…
© Natoli EngineeringCompany2020.

25. Choose the expertise and dependability of
Natoli Engineering to provide the right solution.
© Natoli EngineeringCompany2020.
636.926.8900 | natoli.com | info@Natoli.com
THANK YOU!