SlideShare a Scribd company logo
EmergencyMedicineIreland.com
The Crashing Asthmatic
EmergencyMedicineIreland.com
The Basics
Beta2 agonists +++
EmergencyMedicineIreland.com
Non-response to salbutamol
Genetics vs Tachyphylaxis
EmergencyMedicineIreland.com
Why IV?
EmergencyMedicineIreland.com
Magnesium
2009
•7 Studies (5 Adult; 2 Kids)
•665 pts
EmergencyMedicineIreland.com
credit: http://www.freeimageslive.co.uk/
EmergencyMedicineIreland.com
Aminophylline
2012
•15 Studies
•817 pts
EmergencyMedicineIreland.com
2012
•3 Studies
•100 pts
IV Salbutamol
EmergencyMedicineIreland.com
IV Salbutamol
PMID: 16548805
EmergencyMedicineIreland.com
Now entering an evidence free zone...
EmergencyMedicineIreland.com
Adrenaline
Neb/IM/SC/IV
EmergencyMedicineIreland.com
2012
•5 Studies
•206 pts
Non-Invasive Ventilation
↑FRC
↓WOB
EmergencyMedicineIreland.com
When to intubate?
Wait till you would normally
intubate someone...
Wait some more...
But not too long...
EmergencyMedicineIreland.com
Intubation
Ketamine
•bronchodilator
•pre and for induction
•? problems with secretions
Lignocaine
•IV and inhaled
•reduced airway responsiveness
EmergencyMedicineIreland.com
Difficult Ventilation
Credit: http://emcrit.org/podcasts/severe-asthmatic/
EmergencyMedicineIreland.com
Ventilation
Low PEEP
Adequate flow rates
Really, really big I:E ratios
Deterioration?
•disconnect the vent
•squeeze the chest
•pleural decompression
•fluid loading
EmergencyMedicineIreland.com
Role for ECMO?
EmergencyMedicineIreland.com
thanks for watching

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