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MAKROPOROUs
Hidroksiapatit
TSS
Serpong, 01 10 13
Kriteria Porous Ceramic
3D femur
Porositas tinggi (≥55%)
Ukuran Pori : 100-500 µm
Ukuran pori seragam
Compressive strength : 2-12MPa
Inert/Biokompatibel/Biodegradabel
Gas
Setting
Drying
Sintering
Suspensi keramik
Prekursor keramik
Foaming
Sujin et al. (2011)
H2O2
Proses Pembuatan Makroporous HA
Foaming agent : peroksida, soda kue
Penumbalan
Material Tumbal
Drying,
Pirolisis/Penguapan
Leaching
Sintering
Penambahan
Fase Tumbal
Gula
Sumber : Amera (2011) Sumber : Amera (2011)
Naftalena
Sumber : Tadic (2004)
NaCl & PVA
Material tumbal :
Buatan : PMMA, PVB, PVC, PS, nilon, selulosa asetat, naftalena, PVA
Alami : pati, alginat, selulosa, dekstrin, sukrosa, wax, gelatin, air, minyak.
Sumber : Sanjaya (2009) Sumber : Cunningham et al. (2011)
Spons
Sumber: Studart (2003)
koral
Sumber : Colombo&Helllmann (2002)
Strut
Replikasi
Cetakan Sintesis
Spons (poliuretan, selulosa)
Cetakan Alami (Koral, Kayu)
Impregnasi
Suspensi keramik
Prekursor Keramik
Drying
Sintering
Sumber: Studart (2003)
Contoh:
Bahan-bahan:
Anonim, kuning Spontex, kuning Anonim, biru Anonim, hitam SB, kuning
Bahan-Bahan
HA H2O2 CMC
NN-dimetil
formida CNT MW
Penampakan spons di bawah mikroskop 4x dan 10x
Prosedur Singkat
Produk tak jadi
Kurang dibolak-balik
Terlalu banyak tekanan
Suspensi terlalu kental
Salah pilih spons
Spons tidak dibolak-balik
Fleksibilitas spons tak bagus
Pra Pasca
Compressive strength = 1,94  0.68 MPa
HA : 15 gr Aquades : 10 gr ; Duramax D3021 : 0.1 %
Replika
makropori
Porositas:54,47%
Compressive strength = 1,94  0.68 MPa
HA : 15 gr Aquades : 10 gr ; Duramax D3021 : 0.1 %
Pra gelatin Pasca gelatin
Compressive strength : Pra=1,8 Mpa pasca=3,9 MPa
HA : 35% duramax : 0,5% Gelatin = 10% (b/b)
Komposisi HA dan duramax Kode Sampel Kisaran porositas
(HA 25%; Duramax 5%) PG08.2P1 (rerata:77,33%)
(HA 25%; Duramax 5%) PG08.2P2 (rerata : 76,74%)
(HA 25%; Duramax 7%) PG08.2P3 (rerata : 74,18%)
(HA 25%; Duramax 5%) PG08.2P4 (rerata : 76,84%)
(HA 25%; Duramax 7%) PG08.2P5 (rerata : 74,90%)
(HA 25%; Duramax 2%) PG08.2P6 (rerata : 69,17%)
(HA 27.29% ; Duramax 5.6%) PG08.2P7 (rerata : 71,88%)
(HA 25% ; Duramax 5%) PG08.3P1 (rerata : 79,53%)
(HA 27.5% ; Duramax 5%) PG08.3P2 (rerata : 74,06%)
Porositas
2P1
2P2
2P3
2P4
2P6
3P1
3P2
2P5
Duramax : 5% PVA : 2% HA : 20% H2O2 (1:2,6) CNT MW : 0.53%
Efek CNT MW
Duramax : 5% PVA : 2% HA : 20% H2O2 (1:2,6)
Kamera Pasca 4x Pasca 10x
Duramax = (5%) HA = (20%) PVA = (2%) H2O2 35% = 20% Spons biru anonim tanpa dipencet
Kamera Pasca 4x Pasca 10x
Duramax = (5%) HA = (20%) PVA = (2%) H2O2 35% = 20% Spons kuning anonim tanpa dipencet
Kamera Pasca 4x Pasca 10x
Duramax = (5%) HA = (20%) PVA = (2%) H2O2 35% = 20% Spons biru anonim dipencet
Efek Spons atau Tekanan
Kamera Pasca 4x Pasca 10x
Duramax = (5%) HA = (20%) PVA = (2%) H2O2 35% spons biru anonim
Pasca 4x Pasca 10xPra 4x
Duramax = (5%) HA = (20%) PVA = (2%) H2O2 10% spons biru anonim
Duramax = (5%) HA = (20%) PVA = (2%) H2O2 20% spons biru anonim
Efek Peroksida
Terima kasih
Makroporous   copy

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Makroporous copy

  • 2. Kriteria Porous Ceramic 3D femur Porositas tinggi (≥55%) Ukuran Pori : 100-500 µm Ukuran pori seragam Compressive strength : 2-12MPa Inert/Biokompatibel/Biodegradabel
  • 3. Gas Setting Drying Sintering Suspensi keramik Prekursor keramik Foaming Sujin et al. (2011) H2O2 Proses Pembuatan Makroporous HA Foaming agent : peroksida, soda kue
  • 4. Penumbalan Material Tumbal Drying, Pirolisis/Penguapan Leaching Sintering Penambahan Fase Tumbal Gula Sumber : Amera (2011) Sumber : Amera (2011) Naftalena Sumber : Tadic (2004) NaCl & PVA Material tumbal : Buatan : PMMA, PVB, PVC, PS, nilon, selulosa asetat, naftalena, PVA Alami : pati, alginat, selulosa, dekstrin, sukrosa, wax, gelatin, air, minyak.
  • 5. Sumber : Sanjaya (2009) Sumber : Cunningham et al. (2011) Spons Sumber: Studart (2003) koral Sumber : Colombo&Helllmann (2002) Strut Replikasi Cetakan Sintesis Spons (poliuretan, selulosa) Cetakan Alami (Koral, Kayu) Impregnasi Suspensi keramik Prekursor Keramik Drying Sintering Sumber: Studart (2003)
  • 7. Bahan-bahan: Anonim, kuning Spontex, kuning Anonim, biru Anonim, hitam SB, kuning Bahan-Bahan HA H2O2 CMC NN-dimetil formida CNT MW Penampakan spons di bawah mikroskop 4x dan 10x
  • 9. Produk tak jadi Kurang dibolak-balik Terlalu banyak tekanan Suspensi terlalu kental Salah pilih spons Spons tidak dibolak-balik Fleksibilitas spons tak bagus
  • 10. Pra Pasca Compressive strength = 1,94  0.68 MPa HA : 15 gr Aquades : 10 gr ; Duramax D3021 : 0.1 % Replika makropori Porositas:54,47% Compressive strength = 1,94  0.68 MPa HA : 15 gr Aquades : 10 gr ; Duramax D3021 : 0.1 % Pra gelatin Pasca gelatin Compressive strength : Pra=1,8 Mpa pasca=3,9 MPa HA : 35% duramax : 0,5% Gelatin = 10% (b/b)
  • 11. Komposisi HA dan duramax Kode Sampel Kisaran porositas (HA 25%; Duramax 5%) PG08.2P1 (rerata:77,33%) (HA 25%; Duramax 5%) PG08.2P2 (rerata : 76,74%) (HA 25%; Duramax 7%) PG08.2P3 (rerata : 74,18%) (HA 25%; Duramax 5%) PG08.2P4 (rerata : 76,84%) (HA 25%; Duramax 7%) PG08.2P5 (rerata : 74,90%) (HA 25%; Duramax 2%) PG08.2P6 (rerata : 69,17%) (HA 27.29% ; Duramax 5.6%) PG08.2P7 (rerata : 71,88%) (HA 25% ; Duramax 5%) PG08.3P1 (rerata : 79,53%) (HA 27.5% ; Duramax 5%) PG08.3P2 (rerata : 74,06%) Porositas 2P1 2P2 2P3 2P4 2P6 3P1 3P2 2P5
  • 12. Duramax : 5% PVA : 2% HA : 20% H2O2 (1:2,6) CNT MW : 0.53% Efek CNT MW Duramax : 5% PVA : 2% HA : 20% H2O2 (1:2,6)
  • 13. Kamera Pasca 4x Pasca 10x Duramax = (5%) HA = (20%) PVA = (2%) H2O2 35% = 20% Spons biru anonim tanpa dipencet Kamera Pasca 4x Pasca 10x Duramax = (5%) HA = (20%) PVA = (2%) H2O2 35% = 20% Spons kuning anonim tanpa dipencet Kamera Pasca 4x Pasca 10x Duramax = (5%) HA = (20%) PVA = (2%) H2O2 35% = 20% Spons biru anonim dipencet Efek Spons atau Tekanan
  • 14. Kamera Pasca 4x Pasca 10x Duramax = (5%) HA = (20%) PVA = (2%) H2O2 35% spons biru anonim Pasca 4x Pasca 10xPra 4x Duramax = (5%) HA = (20%) PVA = (2%) H2O2 10% spons biru anonim Duramax = (5%) HA = (20%) PVA = (2%) H2O2 20% spons biru anonim Efek Peroksida