The document provides instructions for a genetics assignment involving celebrities Angelina Jolie and Brad Pitt. Students are asked to: 1) Use a Punnett square to determine the odds of Angelina and Brad's potential child getting a modeling contract based on whether it has a widow's peak. 2) Label their own facial traits and determine their genotype using provided information on gene locations and expressions. 3) Do the same for a celebrity of the opposite sex and create a poster showing the results.

1. Celebrity Genetics Assignment Name _______________ Complete the various parts of the booklet as you go through the assignment. IMPORTANT DATES: Draft point: Preferred Date: Due Date: 21 34 Investigating Science (IS) Understanding Science (US) Grade % Marks

2. Angelina and Brad! Part A Hollywood is a buzz with news about Hollywood's hottest couple, Angelina and Brad! Rumours of Angelina being pregnant has resulted in a modelling agency offering the couple a contract for the child as long as it doesn’t have a widow’s peak. Use punnet square (s) to determine the odds of the child getting the modelling contract. How can I have a widow’s peak I have no hair! Widow’s Peak No Widow’s Peak

3. Punnet Square (s) The child has a _____ % chance of getting a modelling contract 6 Marks (US)

5. Genotype to Phenotype Use the rest of this booklet assist you in answering Parts A to D It’s my parents fault I’m so UGLY! Blank chromosome sheets are found at the back of the booklet, feel free to tear them off BUT make sure you don’t loose them!

6. Gender If you have an X and Y chromosome, then the baby is a boy! If you have two X chromosomes, then the baby is a girl! X X X Y

7. Face Shape Chromosome #1 contains the genetic information in a gene we will call “R”. This information determines the general shape of the face. Chin Prominence Chromosome #2 contains the chin prominence gin, “L”. The genotype “ll” prevents the expression of the next two pairs of genes. This control of another gene’s expression is called epistasis . If you have the genotype “ll” skip the next two and start at skin colour. Very prominent (LL, Ll) Less prominent (ll) 1 1 2 2

8. Chin Shape Chromosome #3 contains the “S” gene. This controls the shape of the chin, round or square. Chin Cleft Chromosome #5 carries the “C” gene responsible for the development of a chin cleft. Round (SS, Ss) Square (ss) Absent (CC, Cc) Present (cc) 3 3 5 5

9. Skin Colour Skin colour is determined by three sets of genes on chromosomes # 1, 2 and 4 . The dominant genetic code, gene A makes a protein called melanin ( a dark pigment that assists in blocking UV light). The greater number of dominant alleles “A” the darker the skin. Count the number of dominant alleles “A” and use the table below to determine the skin colour. Hair Colour HHHHHH hhhhhh HHHhhh Jet Black Brown Blonde White Hhhhhh HHhhhh Light Brown HHHHhh Dark brown HHHHHh Black Hair colour like skin colour is polygenic, with the same gene found on more than one chromosome ( 3, 6 and 10 ). The dominant allele encodes for a dark pigment, the greater number of dominant alleles the darker the hair. Cream, nearly white skin 0 Dominant alleles (“A”) Light tan / pink skin 1 Dominant alleles (“A”) Tan skin 2 Dominant alleles (“A”) Light brown skin 3 Dominant alleles (“A”) Brown skin 4 Dominant alleles (“A”) Dark brown skin 5 Dominant alleles (“A”) Very dark brown, nearly black skin 6 Dominant alleles (“A”) 1 1 2 2 4 4 6 6 10 10 3 3 18 18

10. Red Hair Colour Red hair is encoded by another gene on a different chromosome ( 4 ). It blends with other hair colours. The darker hair colours mask the red pigment. GG = Heavy red pigment Gg = Medium red pigment gg = No red pigment If you have blonde or white hair and have GG you will have flaming red hair! Types of hair Chromosome #7 contains the gene for hair type. The dominant allele encodes for amino acids containing a sulphur atom which causes cross linking between the amino acids in the hair….giving you curls. Straight hair lacks these cross links. Curly (WW) Wavy (Ww) Straight (ww) 4 4 7 7

11. Widow’s Peak Chromosome #8 contains the gene for the widow’s peak. Eye Brow Thickness Chromosome #9 carries the gene for eye brow thickness Present (PP, Pp) Not Present (pp) Bushy (TT, Tt) Fine (tt) 8 8 9 9

12. Eye Brow Placement Not connected (EE, Ee) Connected (ee) Chromosome #10 has the gene for eye brow placement. The dominant alleles separates the eye brows. Eye Placement Chromosome #11 has the gene for eye placement. Average distance (Oo) Far apart (oo) Close together (OO) 10 10 11 11

13. Eye Size Chromosome #12 besides carrying the gene for eye colour it also carries the gene for eye size. % indicates a recessive allele while % indicates a dominant allele. Eye Shape Chromosome #13 has the gene for eye shape. Large (I I ) Medium ( I i ) Small ( i i ) Almond (VV, Vv) Round (vv) 12 12 13 13

14. Eyelashes Movie star eyelashes are found on chromosome #15 . The dominant allele gives you long eyelashes. Eye Colour Chromosomes #11 and 12 contain the eye colour genes. Dark eyes are produced in the presence of more active alleles. In this case dominant alleles F and B are active in depositing dark pigments. Alleles f and b deposit little pigment. Two pairs of genes are involved, one for pigment deposit at the front of the iris, the other at the back. Long (MM, Mm) Short (mm) Blue Ffbb Green ffBb Green ffBB Light brown Ffbb Brown FfBb Brown FfBB Brown FFbb Brown FFBb Dark Brown FFBB 15 15 11 11 12 12

15. Width of mouth Wide Mouth (QQ) Medium Mouth (Qq) Small Mouth (qq) Chromosome #17 has the gene that controls mouth width. Lip thickness Chromosome #18 has the gene that controls lip thickness. Thick (JJ, Jj) Thin (jj) 17 17 18 18

16. Dimples when smiling Chromosome #16 contains the gene that enables dimples to form when smiling. Nose Size Chromosome #19 carries the gene that contains information regarding nose size Dimples (KK, Kk) No Dimples (kk) Nose Shape Rounded (UU, Uu) Pointed (uu) Chromosome #14 contains the gene that encodes nose shape. 14 14 16 16 19 19

17. Free Earlobes Chromosome #22 carries the gene for free ears. The dominant allele causes the lobe to hang freely. Free (ZZ, Zz) Attached (zz) Hairy Ears Chromosome #20 contains the gene that causes hairy ears. No Hair (DD, Dd) Hairy (dd) 20 20 22 22

18. Freckles on cheek Freckles on cheek ($$, $ $) No Freckles on cheek ( $$ ) Chromosome #21 contains a gene which causes uneven pigment to form in the cheek region. ( $ indicates recessive allele). Freckles on forehead Chromosome #9 there is a gene that causes freckles on the forehead to occur. No freckles forehead dominant ( # ) Freckles on forehead recessive ( # ) 9 9 Colour Blindness This trait is said to be sex linked . The gene encoding colour blindness is found on the X chromosome but NOT on the Y chromosome. The recessive allele encodes for colour blindness ( * ) the dominant allele for normal vision ( * ). 21 21 X X

19. Julia Robert’s Chromosomes a a L L H H A a G g c c H H W w p p @ @ T T H H E E F F o o I I B B V V U U 2 2 4 4 5 5 6 6 7 7 8 8 9 9 10 10 11 11 12 12 13 13 14 14 1 1 r r a a 3 3 s s

20. Julia Roberts’ Chromosomes M M K K Q q H h J j N n $ $ Z z * * 15 15 16 16 17 17 18 18 19 19 21 21 22 22 X X 20 20 d d

21. George Clooney’s Chromosomes R r A a A a L L S s H H A a g g C c H H w w P p T t @ @ H H E e O o F F B B I i V v U u 1 1 2 2 4 4 5 5 6 6 7 7 8 8 9 9 10 10 11 11 12 12 13 13 14 14 3 3

22. George Clooney’s Chromosomes M M K k Q q H H J j n n D d $ $ Z z * 15 15 16 16 17 17 18 18 19 19 20 20 21 21 22 22 X Y

23. Your Chromosomes 1 1 2 2 4 4 5 5 6 6 7 7 8 8 9 9 10 10 11 11 12 12 13 13 14 14 3 3

24. If female use these chromosomes If male use these chromosomes Your Chromosomes 15 15 16 16 17 17 18 18 19 19 20 20 21 21 22 22 X X X Y

25. Your Celeb’s Chromosomes 1 1 2 2 4 4 5 5 6 6 7 7 8 8 9 9 10 10 11 11 12 12 13 13 14 14 3 3

26. If female use these chromosomes If male use these chromosomes Your Celeb’s Chromosomes 15 15 16 16 17 17 18 18 19 19 20 20 21 21 22 22 X X X Y