The document discusses three topics:
1. NWT-02, a product containing lutein from egg yolks that has shown to efficiently increase lutein levels in the blood and macula, leading to stabilization of eye functions. Clinical trials show little effect on cholesterol.
2. NWT-03, bioactive peptides from egg proteins designed to reduce blood pressure and maintain vascular flexibility. Studies in animals confirm these effects.
3. Newtricious' role in cross-sector prevention by developing specialized foods and linking science, innovation, lifestyle and healthcare through partnerships.
Ini adalah perbandingan harga obat ARV generik lokal dan ARV generik Import. ARV adalah nama obat yang digunakan bagi terapi Orang terinfeksi HIV (ODHA)
Disease modifying treatments for multiple sclerosis have evolved significantly over time. Early treatments focused on interferon-beta, which showed moderate effectiveness in reducing relapses and disability progression. Newer monoclonal antibody treatments such as natalizumab provided greater reductions in disease activity but also carried increased safety risks. The latest oral therapies including fingolimod, teriflunomide, dimethyl fumarate, and laquinimod provide over 50% reductions in relapse rates compared to earlier treatments with generally improved safety profiles. Ongoing research continues to evaluate new mechanisms of action to more effectively treat multiple sclerosis.
กองทุนส่งเสริมป้องกันสุขภาพ53 โดย ทพ.กวี วีระเศรษฐกุล (31มีค53)Nithimar Or
1. The document provides financial and population data for a public primary care program over multiple years. It includes line item expenses, population targets, and allocation of funds across different service areas.
2. The data is broken down by year and includes figures for expenses, target populations, allocation of funds for different primary care services, and comparisons across years.
3. Key services covered include antenatal care, immunizations, family planning, non-communicable diseases, and pap smears. Population targets, expenses per service, and allocation of funds are provided for each service area.
The document summarizes antiretroviral drug prices negotiated by the Clinton Health Access Initiative (CHAI) for its Procurement Consortium members. It lists ceiling prices per year, pack, and unit for various HIV drugs and combinations from eight generic drug manufacturers. The prices are available to over 70 member countries to support public HIV treatment programs.
This document describes a methodology for evaluating ABX indices by projecting the monthly losses and months-to-writedown of the underlying mortgage deals. It involves creating a roll rate matrix to project the monthly states of each mortgage, deriving the monthly losses from the states, and calculating months-to-writedown by comparing the losses to the credit enhancement level. The methodology can be implemented in Excel and provides a framework for evaluating ABX performance over time in a simple way. Enhancements to improve the accuracy of the projections are also discussed.
Gay men who have undergone treatment for prostate cancer reported significantly worse health-related quality of life outcomes compared to heterosexual men based on a study of 92 gay men. Specifically, the gay men reported worse urinary, bowel, hormonal and sexual functioning as well as more bothersome urinary, bowel and hormonal symptoms. They also reported significantly worse mental health and higher fear of cancer recurrence compared to other published studies. The results suggest gay men may be more vulnerable to quality of life impacts following prostate cancer treatment.
Capping is one of the most complex phenomena in the pharmaceutical industry it is one of the mechanical defects in the tableting process in which catastrophic failure of the compact can occur. Understanding what influences tablet capping in terms of process variables, material properties, and density/stress distributions in tablets and developing specialized techniques to correlate these variables with mechanical failures are practical interests of the pharmaceutical industry. In this presentation, we describe a nondestructive ultrasonic device/methodology to predict the capping tendencies of tablet formulations based on their manufacturing performances.
David Wennberg, MD, MPH, describes a recent randomized trial he was involved with that studied the potential of shared decision making to reduce costs among preference-sensitive conditions. David also explains the vision of the 20-member High Value Healthcare Collaborative.
This presentation was part of the Shared Decision Making Month webinar "Turning Shared Decision Making Policy into a Reality."
Ini adalah perbandingan harga obat ARV generik lokal dan ARV generik Import. ARV adalah nama obat yang digunakan bagi terapi Orang terinfeksi HIV (ODHA)
Disease modifying treatments for multiple sclerosis have evolved significantly over time. Early treatments focused on interferon-beta, which showed moderate effectiveness in reducing relapses and disability progression. Newer monoclonal antibody treatments such as natalizumab provided greater reductions in disease activity but also carried increased safety risks. The latest oral therapies including fingolimod, teriflunomide, dimethyl fumarate, and laquinimod provide over 50% reductions in relapse rates compared to earlier treatments with generally improved safety profiles. Ongoing research continues to evaluate new mechanisms of action to more effectively treat multiple sclerosis.
กองทุนส่งเสริมป้องกันสุขภาพ53 โดย ทพ.กวี วีระเศรษฐกุล (31มีค53)Nithimar Or
1. The document provides financial and population data for a public primary care program over multiple years. It includes line item expenses, population targets, and allocation of funds across different service areas.
2. The data is broken down by year and includes figures for expenses, target populations, allocation of funds for different primary care services, and comparisons across years.
3. Key services covered include antenatal care, immunizations, family planning, non-communicable diseases, and pap smears. Population targets, expenses per service, and allocation of funds are provided for each service area.
The document summarizes antiretroviral drug prices negotiated by the Clinton Health Access Initiative (CHAI) for its Procurement Consortium members. It lists ceiling prices per year, pack, and unit for various HIV drugs and combinations from eight generic drug manufacturers. The prices are available to over 70 member countries to support public HIV treatment programs.
This document describes a methodology for evaluating ABX indices by projecting the monthly losses and months-to-writedown of the underlying mortgage deals. It involves creating a roll rate matrix to project the monthly states of each mortgage, deriving the monthly losses from the states, and calculating months-to-writedown by comparing the losses to the credit enhancement level. The methodology can be implemented in Excel and provides a framework for evaluating ABX performance over time in a simple way. Enhancements to improve the accuracy of the projections are also discussed.
Gay men who have undergone treatment for prostate cancer reported significantly worse health-related quality of life outcomes compared to heterosexual men based on a study of 92 gay men. Specifically, the gay men reported worse urinary, bowel, hormonal and sexual functioning as well as more bothersome urinary, bowel and hormonal symptoms. They also reported significantly worse mental health and higher fear of cancer recurrence compared to other published studies. The results suggest gay men may be more vulnerable to quality of life impacts following prostate cancer treatment.
Capping is one of the most complex phenomena in the pharmaceutical industry it is one of the mechanical defects in the tableting process in which catastrophic failure of the compact can occur. Understanding what influences tablet capping in terms of process variables, material properties, and density/stress distributions in tablets and developing specialized techniques to correlate these variables with mechanical failures are practical interests of the pharmaceutical industry. In this presentation, we describe a nondestructive ultrasonic device/methodology to predict the capping tendencies of tablet formulations based on their manufacturing performances.
David Wennberg, MD, MPH, describes a recent randomized trial he was involved with that studied the potential of shared decision making to reduce costs among preference-sensitive conditions. David also explains the vision of the 20-member High Value Healthcare Collaborative.
This presentation was part of the Shared Decision Making Month webinar "Turning Shared Decision Making Policy into a Reality."
Health and fitness apps and devices collect users' personal data, but it is unclear how user data is monetized and who earns from it. A proposed solution is a personal health record platform with an open app store that crowd-sources app development and takes a percentage of app store revenues, while providing platform-level privacy and easy data access. This could form the basis of a new business model for personal health and healthcare data.
This document discusses using ELISA without washing steps by developing a switchable reporter enzyme system. It describes tuning a beta-lactamase enzyme and its inhibitor protein to have high affinity binding and then using this system for wash-free ELISA assays. The goal is to create assays that are faster and require less hands-on time by eliminating washing steps traditionally required in ELISA.
Six students started Pack-iTS to provide nutritious lunches for children, targeting working families with busy schedules. The business offers flexibility in food selection for both parents and children. The partners are considering fundraising to deal with high competition in the market and help expand their operations.
Jack Schalken has co-founded two companies - NovioGendix in 2006 and Oncodrone in 2013 - to translate his translational research into clinical applications and products. As an "entrepreneurial scientist", he learned important lessons about negotiating terms with his academic institution, building a management team, securing financing, and acquiring business skills to successfully launch and grow these ventures. Both companies have worked to bridge the gap between research and clinical validation or product development for cancer diagnostics and therapeutics.
Workshop Co-creatie in de zorg: Embedded Field labsHealth Valley
Presentatie over Embedded Fieldlabs van Dorine Pluimers en Greetje de Kleuver op het Health Valley Event 2014 tijdens de workshop Co-creatie in de zorg.
Health and fitness apps and devices collect users' personal data, but it is unclear how user data is monetized and who earns from it. A proposed solution is a personal health record platform with an open app store that crowd-sources app development and takes a percentage of app store revenues, while providing platform-level privacy and easy data access. This could form the basis of a new business model for personal health and healthcare data.
This document discusses using ELISA without washing steps by developing a switchable reporter enzyme system. It describes tuning a beta-lactamase enzyme and its inhibitor protein to have high affinity binding and then using this system for wash-free ELISA assays. The goal is to create assays that are faster and require less hands-on time by eliminating washing steps traditionally required in ELISA.
Six students started Pack-iTS to provide nutritious lunches for children, targeting working families with busy schedules. The business offers flexibility in food selection for both parents and children. The partners are considering fundraising to deal with high competition in the market and help expand their operations.
Jack Schalken has co-founded two companies - NovioGendix in 2006 and Oncodrone in 2013 - to translate his translational research into clinical applications and products. As an "entrepreneurial scientist", he learned important lessons about negotiating terms with his academic institution, building a management team, securing financing, and acquiring business skills to successfully launch and grow these ventures. Both companies have worked to bridge the gap between research and clinical validation or product development for cancer diagnostics and therapeutics.
Workshop Co-creatie in de zorg: Embedded Field labsHealth Valley
Presentatie over Embedded Fieldlabs van Dorine Pluimers en Greetje de Kleuver op het Health Valley Event 2014 tijdens de workshop Co-creatie in de zorg.
16. Pharmaceutical approach
Aangepast op regelgeving
Senior farma medewerkers
Klinische studies
Product ontwikkeling
Kwaliteits standaard
– Good Clinical Practice
– Good Laboratory Practice
– Good Manufacturing Practice
20. Egg yolk is the superior carrier for lutein
Chung, HY, et al, J. Nutr. 134:1887-1893, 2004
21. NWT-02 status
2007 2012 2014
PCT
National
Patents EU filing PCT filing grant
authorizations
ed
EFSA/
Regulatory Lab Volunteers People “at risk’’
FDA
Production Lab scale Pilot scale Industrial
Market
Marketing definition
Product definition Preparations Partnering Sales
22. Clinical trial program
Human 1 - pivotal study on visual function
12 months | 100 subjects with early stage AMD
Human 2 - study on cholesterol & AMD
3 months | 120 healthy volunteers
Human 3 - study on bioavailability of ‘EyePowder’
formulations vs NWT-02
2 months | 100 healthy volunteers
Human 4 - pivotal study on visual function
12 months | 120 subjects - early stage AMD
23.
24. NWT-02 results – pilot study
Blood lutein level Total Cholesterol
2,00 1,04
1,03
1,80
1,02
Change vs base line
Change vs base line
Normal egg Normal egg
1,60 1,01
NWT-02 NWT-02
1,00
1,40
NWT-01 (lutein 0,99 NWT-01 (lutein
egg) egg)
1,20 Control 0,98 Control
0,97
1,00
0,96
0,80 0,95
0w 6,5 w 13 weeks 0w 6,5 w 13 weeks
Time Time
25.
26. Results
NWT-02 does very efficiently bring lutein and other valuable
nutrients in the blood stream and into the macula.
This leads to stabilization (often even improvement) of eye
functions such as visual acuity and light- dark adaptation.
Although egg yolk is used, there is no or little effect on
blood cholesterol.
27. NWT-03: “the new approach
for maintaining (vascular) health”
Development of bioactive peptides as functional food or nutraceutical for
the prevention of vascular damage and related disorders
28. NWT-03 Project
Hydrolysate – produced via enzymatic treatment of lysozyme, an egg-
derived protein
Designed based on bioinformatics-model of the University Wageningen;
aiming for a beneficial effect on the arterial vascular wall
First tested in pharmacology models to confirm the effect and elucidate
the mechanisms
Subsequently tested in animal experiments:
– Confirming reduction in bloodpressure in Hypertensive rats
– Demonstrating maintenance of the flexibility of the vascular wall in
ZDF-rats, which suffer from Diabetes melllitus; model for ageing
29. NWT-03 status
2006 2012 2015
Patents PCT National
EU filing PCT filing
granted authorizations
Regulatory Lab Animals Volunteers Patients EFSA/ FDA
Production Lab scale Pilot scale Industrial
Market
Marketing definition
Product definition Preparations Partnering Sales
37. Secundaire preventie
Vroege diagnostiek Medische technologie
– Kan leiden tot
– Kan leiden tot
Vroege behandeling Diagnostische apparatuur
– Met als doel
– Met als doel
Secundaire preventie Vroege diagnostiek
– Gebruik makend van
– Gebruik makend van
Food Scanning Laser Optics
– Milde effecten
– Milde methode
– Zonder neven effecten
– Zonder neven effecten
– Op professionele wijze
– Op professionele wijze
ontwikkeld (farma)
ontwikkeld (Qserve)