This document discusses various cases of acute low back pain and differential diagnoses. It describes 25 and 45 year old men who developed acute low back pain after lifting objects. Red flags for more serious underlying causes are described, including nocturnal pain, pain at rest, and neurological deficits. Conditions that can mimic back pain are outlined, such as pregnancy, infections, abdominal issues, and inflammatory diseases. Specific cases of conditions like pancreatitis, aneurysm, ankylosing spondylitis, and depression are also mentioned. The document provides guidance on evaluating for more serious potential causes of back pain like fractures, tumors, and epidural metastases.