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Introduction to the
 Distributed Annotation System
                Biohackathon 2
Alberto Labarga –alberto.labarga@scientifik.info
Distributed Annotation System

• Developed in 1999/2000 by Lincoln Stein (CSHL) and 
  collaborators as a GFF‐based web service.

• Biodas.org (http://www.biodas.org):
• A client‐server system in which a single client 
  integrates information from multiple servers.
• It allows a single machine to gather up genome 
  annotation information from multiple distant websites, 
  collate the information, and display it to the user in a 
  single view.
General Feature Format
    Genome annotations, especially structural annotations, are often stored in 
•
    GFF (General Feature Format) files.

    GFF is a simple tab‐delimited data format.
•

    Fields are: 
•
    <seqname> <source> <feature> <start> <end> <score> <strand> <frame> [attributes] [comments]




    See also: http://www.sanger.ac.uk/Software/formats/GFF/
•
DAS Concept
Annotation server A   Annotation server B   Annotation server C




                             Client                    Reference server
DAS Registry




http://www.dasregistry.org
DAS Server
• DAS request to retrieve the data sources
• http://das.ensembl.org/das/dsn
• Result:
DAS Server
    DAS request to retrieve features on a segment:
•
    http://das.ensembl.org/das/ens_36_omim_genes/features?segment=1:1,1000000
•
    Result:
•
Das viewer




http://www.ebi.ac.uk/dasty

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