Recurrent somatic DICER1 mutations were found in nonepithelial ovarian cancers. These mutations occurred in codons encoding metal binding sites within the RNase IIIb catalytic centers of DICER1. The mutations were restricted to these sites and did not completely abolish DICER1 function, but instead disrupted microRNA processing in a cell-type specific manner, leading to oncogenesis in certain cell types like ovarian epithelial cells. Validation studies found these DICER1 mutations in a high percentage of additional nonepithelial ovarian tumor samples.
A web proxy server functions as a firewall by limiting outside access to client computers and protecting them from hackers. It allows clients connected to the proxy server to access the internet from behind the firewall with minimal effort and without compromising security. The proxy server listens for requests from clients and forwards them to remote internet servers, and also listens for responses to send back to clients. This allows the proxy server to cache frequently requested documents and control internet access at the protocol level.
Chase Hickey kept a detailed work log documenting his 37.5 hours spent over several months teaching Wesley Watkins how to hunt deer. The log details their activities such as shopping for supplies, sighting in bows, checking trail cameras, and multiple hunting trips in the fall and winter. Their efforts culminated in Wesley shooting and killing his first deer, a spike, during an evening hunt in late November during deer mating season.
Recurrent somatic DICER1 mutations were found in nonepithelial ovarian cancers. These mutations occurred in codons encoding metal binding sites within the RNase IIIb catalytic centers of DICER1. The mutations were restricted to these sites and did not completely abolish DICER1 function, but instead disrupted microRNA processing in a cell-type specific manner, leading to oncogenesis in certain cell types like ovarian epithelial cells. Validation studies found these DICER1 mutations in a high percentage of additional nonepithelial ovarian tumor samples.
A web proxy server functions as a firewall by limiting outside access to client computers and protecting them from hackers. It allows clients connected to the proxy server to access the internet from behind the firewall with minimal effort and without compromising security. The proxy server listens for requests from clients and forwards them to remote internet servers, and also listens for responses to send back to clients. This allows the proxy server to cache frequently requested documents and control internet access at the protocol level.
Chase Hickey kept a detailed work log documenting his 37.5 hours spent over several months teaching Wesley Watkins how to hunt deer. The log details their activities such as shopping for supplies, sighting in bows, checking trail cameras, and multiple hunting trips in the fall and winter. Their efforts culminated in Wesley shooting and killing his first deer, a spike, during an evening hunt in late November during deer mating season.
Blacksmithing has a long history dating back to the early 19th century. There are two main styles of blacksmithing - forging and fabricating. Forging involves shaping hot metal with hammers and anvils, while fabricating uses welding to join pre-shaped metal pieces. Both styles have advantages and disadvantages, and blacksmiths often debate which is superior. However, the two styles also complement each other and blacksmiths may outsource some work between forgers and fabricators to complete projects. Overall, blacksmithing is considered an artistic craft that has changed over time but remained an important form of creative expression.
Literary discussion kaffir boy education as liberationAlisha Punjwani
The document discusses the impacts of apartheid policies in South Africa that created an unequal education system along racial lines. Under the Bantu Education Act of 1953, the South African government took control of African schools and used them to teach apartheid ideology, limiting what black children could learn. Black children received only a few hours of basic education each day in overcrowded classrooms, while white children received a full curriculum. This unequal system was implemented by the white government to deliberately keep black South Africans in a subservient position. The passages from the book discuss the negative impacts of lack of education and illiteracy on individuals and communities, as well as the empowering effects of education and the value placed on it as a path
Ringkasan dokumen tersebut adalah sebagai berikut:
1. Dokumen tersebut membahas tentang pembuatan iklan komersial untuk makanan ringan jipang yang terbuat dari beras, jagung, asense, dan glukose.
2. Dokumen tersebut merinci langkah-langkah pembuatan iklan mulai dari merumuskan ide cerita, sinopsis, skenario, script hingga identifikasi kebutuhan dan anggaran yang dibutuhkan.
3. Iklan komersial
This document outlines the objectives and process of resource-based learning compared to traditional learning. The objectives are for students to differentiate between traditional and resource-based learning and develop creativity using technology. Resource-based learning involves students finding their own information from varied sources like print, video and the internet, with the teacher acting as a guide. Some examples of resource-based projects are provided. The key differences between the two models are described, with resource-based learning focusing on inquiry, varied sources, and emphasizing process over product.
The document outlines Chase Hickey's plan to teach Wesley Watkins how to hunt deer using Indian techniques. It details the typical hunting day process of checking times, using cameras, scent control products, target practice, and waiting in a stand. The project is facilitated by avid hunter Kirk Mooney, who will teach traditional hunting techniques. Some potential problems are noted as waking up on time, dealing with the weather, and scheduling. The key lessons are that hunting can provide food, is primarily a hobby rather than profession, and requires great patience.
This document discusses typography in ebooks. It begins by defining typography and its purpose of enhancing content readability, legibility and aesthetics. It addresses common misconceptions that ebooks cannot look as good as print or have poor quality. However, the document explains that with careful design following typographical standards, ebooks can survive issues like device fragmentation and user customization. It provides examples of typographical elements that are possible in ebooks like drop caps, small caps, embedded fonts, columns and more. It encourages creators to be creative and raise the standard for ebook design.
This document discusses foil characters in literature using examples from Albert Camus' novel The Stranger. It defines foil characters as those who contrast and emphasize the qualities of another character. It analyzes several characters from the novel as potential foil characters for the protagonist Meursault, focusing on how they contrast with him in their emotions, relationships, and actions. The document concludes that analyzing foil relationships can help readers better understand the main character.
Blacksmithing has a long history dating back to the early 19th century. There are two main styles of blacksmithing - forging and fabricating. Forging involves shaping hot metal with hammers and anvils, while fabricating uses welding to join pre-shaped metal pieces. Both styles have advantages and disadvantages, and blacksmiths often debate which is superior. However, the two styles also complement each other and blacksmiths may outsource some work between forgers and fabricators to complete projects. Overall, blacksmithing is considered an artistic craft that has changed over time but remained an important form of creative expression.
Literary discussion kaffir boy education as liberationAlisha Punjwani
The document discusses the impacts of apartheid policies in South Africa that created an unequal education system along racial lines. Under the Bantu Education Act of 1953, the South African government took control of African schools and used them to teach apartheid ideology, limiting what black children could learn. Black children received only a few hours of basic education each day in overcrowded classrooms, while white children received a full curriculum. This unequal system was implemented by the white government to deliberately keep black South Africans in a subservient position. The passages from the book discuss the negative impacts of lack of education and illiteracy on individuals and communities, as well as the empowering effects of education and the value placed on it as a path
Ringkasan dokumen tersebut adalah sebagai berikut:
1. Dokumen tersebut membahas tentang pembuatan iklan komersial untuk makanan ringan jipang yang terbuat dari beras, jagung, asense, dan glukose.
2. Dokumen tersebut merinci langkah-langkah pembuatan iklan mulai dari merumuskan ide cerita, sinopsis, skenario, script hingga identifikasi kebutuhan dan anggaran yang dibutuhkan.
3. Iklan komersial
This document outlines the objectives and process of resource-based learning compared to traditional learning. The objectives are for students to differentiate between traditional and resource-based learning and develop creativity using technology. Resource-based learning involves students finding their own information from varied sources like print, video and the internet, with the teacher acting as a guide. Some examples of resource-based projects are provided. The key differences between the two models are described, with resource-based learning focusing on inquiry, varied sources, and emphasizing process over product.
The document outlines Chase Hickey's plan to teach Wesley Watkins how to hunt deer using Indian techniques. It details the typical hunting day process of checking times, using cameras, scent control products, target practice, and waiting in a stand. The project is facilitated by avid hunter Kirk Mooney, who will teach traditional hunting techniques. Some potential problems are noted as waking up on time, dealing with the weather, and scheduling. The key lessons are that hunting can provide food, is primarily a hobby rather than profession, and requires great patience.
This document discusses typography in ebooks. It begins by defining typography and its purpose of enhancing content readability, legibility and aesthetics. It addresses common misconceptions that ebooks cannot look as good as print or have poor quality. However, the document explains that with careful design following typographical standards, ebooks can survive issues like device fragmentation and user customization. It provides examples of typographical elements that are possible in ebooks like drop caps, small caps, embedded fonts, columns and more. It encourages creators to be creative and raise the standard for ebook design.
This document discusses foil characters in literature using examples from Albert Camus' novel The Stranger. It defines foil characters as those who contrast and emphasize the qualities of another character. It analyzes several characters from the novel as potential foil characters for the protagonist Meursault, focusing on how they contrast with him in their emotions, relationships, and actions. The document concludes that analyzing foil relationships can help readers better understand the main character.