4. Looks can be deceiving
(Pages 5-10)
-Fluorescein angiography shows less florid leakage 2 days after intravitreal
injection of VEGF in rabbit compared to one week after injection (page 5).
Similar results can be shown by fluorescein channel (Page 6).
-40KDa channel (page 8) shows leakage at day 2 and no leakage at 1 week. This
indicates that at day 2 post VEGF injection, the BRB is more permeable to 40
KDa particles than at one week. Which suggests a more severe BRB dysfunction
-This in turn suggests the presence of a discrepancy between the qualitative
assessment of fluorescein angiography leakage (based on area of distribution
and intensity of color) and permeability to macromolecules.
-FA leakage grading may not be directly correlated to BRB status.
-PCA may provide new information about BRB dysfunction not provided by FA
Angiography 2.0 4
11. “to some journey…
to some a destination…”
-PCA shows different patterns of flows for different components.
-Smaller particles (400 Da and 10 KDa) go through an arterial phase,
neovascular membrane (NVM phase) followed by leakage and with no venous
phase. (pages 12, 13)
-40 Kda particles (page 14) travel from artery followed by a venous & NVM
(almost simultaneously) phase and no leakage.
-70 Kda particles (page 15) show an arterial phase followed by a venous phase
and delayed staining of the NVM.
Angiography 2.0 11
20. Please Join
PolyChromatic Angiography
Group
We would like this group to become a discussion forum for PCA and a
communication channel between retina researchers and PCAsso to
improve and facilitate the development of this new technology
Angiography 2.0 20
