Image community 2019 03-04
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The DICOM Meetings & Educational Conference was held in Brisbane, Australia from September 25-28, 2018. The DICOM Standards Committee meeting summary reported on updates to strategic planning, artificial intelligence and machine learning initiatives, education and outreach activities, and new work items. The conference included 18 presentations over two days attended by around 90 people, mostly from Australia and Southeast Asia, covering topics from DICOM basics to more specialized areas.
NBIA Update
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
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Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Image community 2019 03-04
- 1. Imaging Community Call March 4, 2019
- 2. Agenda • Welcome – Bob Nordstrom • Remembering Ed Helton • PRISM Update – Postponed (June 3, 2019) – Fred Prior / PRISM team • HTT: high-throughput truthing project – Brandon Gallas • TCIA Update – Christina Vivelo • Announcements 2
- 4. HTT: high-throughput truthing project • Information about the project including the presentation can be found at • https://nciphub.org/groups/eedapstudies • https://nciphub.org/groups/eedapstudies/wiki 4
- 5. Announcements • Invitation to community call – https://groups.google.com/d/forum/nci-imaging-community- call • Imaging Community Call Wiki – https://wiki.nci.nih.gov/display/NICC • www.slideshare.net – imgcommcall – https://www.slideshare.net/imgcommcall/ – Next calls • April 1 call is canceled – No April fool’s joke • May 6, 2019 • June 3, 2019 – PRISM update 5